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Hotels in Santa Clara

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Choose from 505 Santa Clara Hotel Deals

Villa Botero By Casa Mojito B&B

Villa Botero By Casa Mojito B&B

3 out of 5
Calle Central, 5 Rio Hato Cocle
  • 6 min drive from Playa Blanca
Book a stay at this golf B&B in Rio Hato. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Playa Blanca and Santa Clara Beach are ...
9.8/10 Exceptional! (69 reviews)
"Christophe and his family were amazing hosts. The breakfast was incredible and fit for a king. The grounds, room and pool were decorated beautifully and very well maintained. We would stay here again in a heartbeat. We highly recommend this place."

Reviewed on Jun 17, 2026

Villa Botero By Casa Mojito B&B
Gran Evenia Bijao - All Inclusive

Gran Evenia Bijao - All Inclusive

3.5 out of 5
Carretera Interamericana km 108, guias de Anton Rio Hato Coclé
  • 10 min drive from Playa Blanca
Book a stay at this beach hotel in Rio Hato. Enjoy free WiFi, free parking, and 3 outdoor pools. Our guests praise the helpful staff in our reviews. Popular ...
8.2/10 Very Good! (1,000 reviews)
"La comida excelente, quedamos súper satisfechos. Sería excelente que tuvieran alguna otra dinámica en la noche para niños, cine o teatro. Y el snack de la madrugada también seria bueno que estuviera más completo, la comida estaba muy dura, y poquitas opciones. Pero por lo demás todo estuvo excelente, ..."

Reviewed on Jun 22, 2026

Gran Evenia Bijao - All Inclusive
Hotel Riu Playa Blanca - All Inclusive

Hotel Riu Playa Blanca - All Inclusive

3.5 out of 5
Finca 43.668 Rio Hato Cocle
  • 19 min walk from Playa Blanca
Book a stay at this beach property in Rio Hato. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
8/10 Very Good! (1,001 reviews)
"Asegúrense de saber que tan lejos está la habitación de los lugares a donde ir, nos tocó una habitación a 5 minutos caminando desde el ascensor si hubiera estado sola creo que no me hubiera importado peor tenía un bebé y cuidarlo requiere atención rápida, regresar a la habitación era un problema ..."

Reviewed on Jun 26, 2026

Hotel Riu Playa Blanca - All Inclusive
 Grand Decameron Panama, A Trademark All Inclusive Resort

Grand Decameron Panama, A Trademark All Inclusive Resort

3.5 out of 5
Avenida Principal Farallon Kilometro 115 Rio Hato Cocle
  • 23 min walk from Playa Blanca
Book a stay at this beach property in Rio Hato. Enjoy free parking, 6 outdoor pools, and a full-service spa. Popular attractions Playa Blanca and Santa Clara ...
7.4/10 Good! (1,000 reviews)
"The staff is kind and helpful...extremely."

Reviewed on Jun 19, 2026

Grand Decameron Panama, A Trademark All Inclusive Resort
Playa Blanca Beach Resort - All Inclusive

Playa Blanca Beach Resort - All Inclusive

4 out of 5
115 Km Via Interamericana Rio Hato Cocle
  • 4 min walk from Playa Blanca
Book a stay at this beach property in Rio Hato. Enjoy free breakfast, free parking, and 3 outdoor pools. Popular attractions Playa Blanca and Santa Clara Beach ...
6.8/10 (235 reviews)
"My experience wasn't pleasant when I checked in. One member of the hotel who approached me was very aggressive trying to show us the hotel, for some kind of membership, and because, we refused to do it, didn't let us do early check in and wait at the lobby for an hour and a half or I had to pay $12:00 ..."

Reviewed on Jun 26, 2026

Playa Blanca Beach Resort - All Inclusive
The Buenaventura Golf & Beach Resort Panama, Autograph Collection

The Buenaventura Golf & Beach Resort Panama, Autograph Collection

5 out of 5
340 Calle 3ra Buenaventura El Chiru Cocle
  • 22 min walk from Playa Blanca
Book a stay at this luxury resort in El Chiru. Enjoy free WiFi, free parking, and 12 outdoor pools. Our guests praise the helpful staff in our reviews. Popular ...
9.2/10 Wonderful! (754 reviews)
"Ok"

Reviewed on Jun 22, 2026

The Buenaventura Golf & Beach Resort Panama, Autograph Collection
Hotel La Compania Del Valle

Hotel La Compania Del Valle

5 out of 5
C. El Ciclo El Valle de Anton
  • 43 min drive from Playa Blanca
Book a stay at this luxury hotel in El Valle de Anton. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Anton Valley Historical and Cultural ...
9.8/10 Exceptional! (122 reviews)
"The statues are unique, the property and the room beautiful, restaurants i gave mixed reviews, the toilet paper needs to be changed but overall a good stay and the staff are super nice…"

Reviewed on Jun 15, 2026

Hotel La Compania Del Valle
The Golden Frog Inn

The Golden Frog Inn

3 out of 5
Calle Las Veraneras El Valle de Anton Panama
  • 44 min drive from Playa Blanca
Stay at this hotel in El Valle de Anton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.6/10 Exceptional! (282 reviews)
"I love it! It was clean, the staff was friendly and surprisingly spoke English very well, which was great for me as I’m not a Spanish speaker. The grounds were so beautiful with butterflies and hummingbirds all over the place. I didn’t go in the pool, but it looked very inviting. The complementary ..."

Reviewed on Jun 20, 2026

The Golden Frog Inn
Casa Caracol Boutique Hotel

Casa Caracol Boutique Hotel

2 out of 5
C. Corona 21, Playa Corona Las Uvas Panamá Oeste
  • 18 min drive from Playa Blanca
Book a stay at this beach hotel in Las Uvas. Enjoy free WiFi, free parking, and a beach locale. Popular attractions Playa El Palmar and La Ensenada Beach are ...
8.8/10 Excellent! (33 reviews)
"Under new absentee management. Nightmare check-in. Beautiful property. The host refused my request for property info 7-days before check-in, saying everything would be emailed 24-hours before check-in. By the morning of check-in, I had received no information, not even the property address. Beginning ..."

Reviewed on Jun 23, 2026

Casa Caracol Boutique Hotel
Hotel Campestre

Hotel Campestre

3 out of 5
Calle El Hato El Valle de Anton
  • 44 min drive from Playa Blanca
Stay at this hotel in El Valle de Anton. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Square Trees Nature Trail and Anton Valley ...
8.4/10 Very Good! (266 reviews)
"Bonitos paisajes. Habitación limpia Me parece que la caminata de sendero y lo de la rana dorada y otras especies el precio no está acorde para lo que realmente es. El restaurante puede mejorar."

Reviewed on Jun 8, 2026

Hotel Campestre
Nomada Republic Hotel El Valle

Nomada Republic Hotel El Valle

3 out of 5
Valle de Anton El Valle de Anton Coclé Province
  • 47 min drive from Playa Blanca
Stay at this hotel in El Valle de Anton. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Chorro Macho Waterfall and El Chorro Macho are ...
9.4/10 Exceptional! (69 reviews)
"The rooms have an amazing view. The restaurant above was also excellent with amazing views and friendly staff."

Reviewed on Jun 3, 2026

Nomada Republic Hotel El Valle
Town Center Paradise in Playa Blanca

Town Center Paradise in Playa Blanca

2.5 out of 5
Town Center Building Rio Hato Cocle
  • 5 min walk from Playa Blanca
Book a stay at this family-friendly guesthouse in Rio Hato. Enjoy free parking, a garden, and a snack bar/deli. Popular attractions Playa Blanca and Santa Clara ...
Town Center Paradise in Playa Blanca
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santa Clara

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Santa Clara.

Choosing the right hotel in Coclé has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Santa Clara’s 505 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $108. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Santa Clara hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Santa Clara. No matter your reason for visiting Santa Clara, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Santa Clara hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Santa Clara for as low as $108.

How many hotels are there in Santa Clara?

With over 505 hotels in Santa Clara, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $108.

How to find cheap car rentals in Santa Clara?

Finding a cheap car rental deal in Santa Clara is as easy as scoring cheap hotels in Santa Clara. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.