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Santa Clara Vacation Packages

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A beach with waves, a boat, and palm trees.

Santa Clara
Rio Hato
Coclé
Panama
Mexico and Central America
Hotwire.com

Santa Clara Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.

Metro Hotel Panama

3.5 out of 5

Price was $906, price is now $700 per person

$700

per person

Oct 2 - Oct 9

found 1 day ago

Roundtrip flight included

Nassau (NAS) to Panama City (PTY)

Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

Central Hotel Panama Casco Viejo

4 out of 5

Save 100% on your flight

Price was $1,851, price is now $937 per person

$937

per person

Oct 8 - Oct 13

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

I really enjoyed my stay at Casco Viejo. I recommend purchasing the breakfast plan. The food was great. I enjoyed the area for walking. Not too far from Panama City.

Reviewed on Jul 13, 2026

Megapolis Hotel Panamá

4.5 out of 5

Price was $1,482, price is now $879 per person

$879

per person

Sep 30 - Oct 5

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Nice hotel clean and large room very good breakfast I loved the pool and the polite staff

Reviewed on Jul 19, 2026

Riande Aeropuerto Hotel & Casino

4 out of 5

Price was $1,269, price is now $851 per person

$851

per person

Sep 30 - Oct 5

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Metromall Panama and Los Pueblos Commercial Center are located nearby.

si tienes que hacer escala en panama. este lugar es perfecto. super cerca. te da transporte de aeropuerto hotel y viceversa. Y me toco comer ahi y todo rico. Dormi bien y volveria para ir de compras a panama

Reviewed on Jul 19, 2026

Hotel Riu Plaza Panama

5 out of 5

Price was $1,231, price is now $891 per person

$891

per person

Sep 30 - Oct 5

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

I don’t know where to start! This hotel was amazing! Nice clean rooms, pool nice and clean, breakfast amazing, and drinks were strong. The area is in prime area and I can’t wait to come Back!

Reviewed on Jul 19, 2026

Decapolis Hotel Panama City

4 out of 5

Price was $1,166, price is now $868 per person

$868

per person

Sep 30 - Oct 5

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Casa Mallet by Wynwood House

4 out of 5

Price was $1,561, price is now $1,195 per person

$1,195

per person

Oct 8 - Oct 13

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this apartment in Panama City. Enjoy free WiFi, parking (surcharge), and premium bedding. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

In the middle of the old town, lovely rooftop. Beautiful apartment. Easy check in. WhatsApp line is available if anything was needed or if we had questions.

Reviewed on Mar 12, 2026

Hyatt Regency Panama City

5 out of 5

Price was $1,249, price is now $968 per person

$968

per person

Sep 30 - Oct 5

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and 2 restaurants. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

Absolutely amazing!!! Loved every aspect of it. 10/10 stay and WILL be coming back. The staff were helpful and efficient. The food at breakfast was incredibly fresh and so delicious. The room was perfect and clean.

Reviewed on Jul 18, 2026

Santa Clara Vacation Packages 3-4 Night Stays

Price found within the past 48 hours. Click for updated prices.

Decapolis Hotel Panama City

4 out of 5

San Francisco

Price was $942, price is now $727 per person

$727

per person

Sep 5 - Sep 8

found 13 hours ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)