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Santa Clara Vacation Packages

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A beach with waves, a boat, and palm trees.

Santa Clara
Rio Hato
Coclé
Panama
Mexico and Central America
Hotwire.com

Santa Clara Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.

Riande Aeropuerto Hotel & Casino

4 out of 5

Price was $1,001, price is now $724 per person

$724

per person

Oct 22 - Oct 25

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Metromall Panama and Los Pueblos Commercial Center are located nearby.

Central Hotel Panama Casco Viejo

4 out of 5

Price was $2,083, price is now $952 per person

$952

per person

Nov 14 - Nov 19

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Don’t expect to sleep Upon checkin I was out in my “Jr Suite”. It was just a room. But worse, I tried to soon and heard a rhythmic banging that was impossible to sleep through. It was so bad that I decided to see what it was. My room was DIRECTLY UNDER the gym, in a centuries old building?! If anyone is on the treadmill- you’re screwed! Anyone dropping weights, anything. Walls were paper thin. Outside of that… the place was beautiful, and fantastic location!

Reviewed on Aug 29, 2026

Megapolis Hotel Panamá

4.5 out of 5

Price was $1,378, price is now $773 per person

$773

per person

Oct 22 - Oct 25

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

El agua caliente no funcionaba me cambiaron de habitación y no funcionaba el control del TV y no hubo quien lo arreglara

Reviewed on Aug 28, 2026

Hotel Riu Plaza Panama

5 out of 5

Price was $1,475, price is now $974 per person

$974

per person

Oct 6 - Oct 13

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

The breakfast was excellent and the staff was great. All in all, the hotel is an A+

Reviewed on Aug 29, 2026

Decapolis Hotel Panama City

4 out of 5

Price was $1,263, price is now $880 per person

$880

per person

Nov 13 - Nov 19

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

The property is excellent the fact that it’s connected to the mall and casino put it over the top. The staff are polite and always ready to assist you. Will definitely stay again.

Reviewed on Aug 28, 2026

Hyatt Regency Panama City

5 out of 5

Price was $1,465, price is now $1,050 per person

$1,050

per person

Nov 13 - Nov 19

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and 2 restaurants. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Great place and great personal, hope to be back some time soon

Reviewed on Aug 28, 2026

Sheraton Grand Panama

4 out of 5

Price was $1,383, price is now $1,036 per person

$1,036

per person

Oct 6 - Oct 13

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Multiplaza Pacific Mall are located nearby.

Bristol Panama, a Registry Collection Hotel

5 out of 5

Price was $1,496, price is now $1,133 per person

$1,133

per person

Nov 13 - Nov 19

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Reviewed on Aug 28, 2026

Santa Clara Vacation Packages 3-4 Night Stays

Price found within the past 48 hours. Click for updated prices.

Hotel Coral Suites

3.5 out of 5

Bella Vista

Price was $944, price is now $662 per person

$662

per person

Oct 11 - Oct 14

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)