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Santa Cruz

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Featured Santa Cruz Hotels

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

5 out of 5
San Fernando 2 Seville Seville
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Seville. Enjoy 2 restaurants, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff in our ...
9.4/10 Exceptional! (1,000 reviews)
"The breakfast bar offered a nice selection of foods. For dinner, I had the best Flan I’ve ever eaten"

Reviewed on May 17, 2026

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
Hotel Murillo

Hotel Murillo

2 out of 5
Calle Lope de Rueda, 7-9 Seville Seville
Fully refundable
Book a stay at this family-friendly hotel in Seville. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,006 reviews)
"We were offered an upgrade for 15 Euros and it was 1000% worth it. We had access to the pool (it was 105° F when we checked in) and the room was extremely spacious."

Reviewed on Jun 11, 2026

Hotel Murillo
Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
Book a stay at this spa hotel in Seville. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the pool and the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,011 reviews)
"One of the best hotels I've ever stayed in. Smelt amazing, wonderfully clean. Great shower and amenities. The only place I would stay in Seville if I went back."

Reviewed on Jun 9, 2026

Las Casas de la Judería, Sevilla Historic City Center
Hotel Amadeus Sevilla

Hotel Amadeus Sevilla

4 out of 5
Calle Farnesio 6 Seville Seville
Fully refundableReserve now, pay when you stay
Book a stay at this boutique hotel in Seville. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the breakfast and the bar in ...
9.6/10 Exceptional! (1,239 reviews)
"Clean room. Staff are nice. Very good location. Walkable. Room is small."

Reviewed on Jun 10, 2026

Hotel Amadeus Sevilla
Hotel Fernando III

Hotel Fernando III

4 out of 5
San Jose 21 Seville Seville
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seville. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the breakfast and the pool ...
9.6/10 Exceptional! (1,508 reviews)
"So lovely to be able to go back to the hotel in the afternoon and have a dip in the pool and cool off after being out in the heat and visiting the great sites! Really loved this hotel."

Reviewed on Jun 11, 2026

Hotel Fernando III
Hotel Rey Alfonso X

Hotel Rey Alfonso X

4 out of 5
Calle Ximenez De Enciso, 35 Seville Seville
Fully refundableReserve now, pay when you stay
Stay at this hotel in Seville. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the breakfast and the pool in our reviews. Popular ...
9.6/10 Exceptional! (1,198 reviews)
"Loved the central location and abundance of nearby restaurants to choose from!"

Reviewed on Jun 9, 2026

Hotel Rey Alfonso X
Hotel Doña Maria

Hotel Doña Maria

4 out of 5
Don Remondo 19 Seville Seville
Fully refundableReserve now, pay when you stay
Book a stay at this historic hotel in Seville. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular ...
9/10 Wonderful! (1,002 reviews)
"Great friendly staff! This hotel is exactly where you want to be in Seville ."

Reviewed on Jun 12, 2026

Hotel Doña Maria
Hotel Murillo Reinoso

Hotel Murillo Reinoso

2 out of 5
Lope de Rueda, 16 Seville Seville
Fully refundableReserve now, pay when you stay
Stay at this hotel in Seville. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the property condition ...
9.6/10 Exceptional! (145 reviews)
"Friendly staff, clean and great location"

Reviewed on Jun 10, 2026

Hotel Murillo Reinoso
Petit Palace Santa Cruz

Petit Palace Santa Cruz

4 out of 5
Munoz y Pabón 18 Seville Seville
Fully refundableReserve now, pay when you stay
Stay at this hotel in Seville. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular ...
9/10 Wonderful! (1,000 reviews)
"Very satisfied .nice room ,good locations. Good breakfasts and great services and staffs."

Reviewed on Jun 9, 2026

Petit Palace Santa Cruz
Hotel Boutique Casa del Poeta Sevilla

Hotel Boutique Casa del Poeta Sevilla

4 out of 5
Don Carlos Alonso Chaparro 3 Seville Seville
Fully refundableReserve now, pay when you stay
Book a stay at this boutique hotel in Seville. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the property ...
9.8/10 Exceptional! (930 reviews)
"CHARMING AND ENCHANTING OASIS DEEP INSIDE THE HEART OF SEVILLA SPAIN. ELEGANT, SOPHISTICATED AND WE CANNOT WAIT TO RETURN"

Reviewed on Jun 9, 2026

Hotel Boutique Casa del Poeta Sevilla
EME Catedral Mercer Hotel

EME Catedral Mercer Hotel

5 out of 5
Calle Alemanes 27 Seville Seville
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Seville. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,002 reviews)
"Location fantastic opposite the cathedral couldn’t be closer Small thing but no full length mirror in the room"

Reviewed on Jun 9, 2026

EME Catedral Mercer Hotel
Hotel Doña Lina

Hotel Doña Lina

2 out of 5
Calle Gloria 7 Seville Seville
Stay at this hotel in Seville. Enjoy free WiFi, a rooftop terrace, and daily housekeeping. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.6/10 Excellent! (286 reviews)
"It felt like home; the air conditioning unit kept the room cool from the unbearable heat outside, the small but colorful lobby was cozy, and the staff gave us nice suggestions about places to go for lunch."

Reviewed on Jun 8, 2026

Hotel Doña Lina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Santa Cruz

Seville is a city that has a lot going on, but you have your sights set on Santa Cruz. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Santa Cruz has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Santa Cruz hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Seville so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Santa Cruz underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Santa Cruz city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Santa Cruz cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Santa Cruz at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $74
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Santa Cruz hotel you want, book it, and never look back. Because your great escape is ahead of you.