Hotels Near
Santa Cruz

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Featured Santa Cruz Hotels

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

5 out of 5
San Fernando 2 Seville Seville
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Seville. Enjoy 2 restaurants, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff in our ...
9.4/10 Exceptional! (1,000 reviews)
"The breakfast bar offered a nice selection of foods. For dinner, I had the best Flan I’ve ever eaten"

Reviewed on May 17, 2026

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
Hotel Murillo

Hotel Murillo

2 out of 5
Calle Lope de Rueda, 7-9 Seville Seville
Fully refundableReserve now, pay when you stay
Book a stay at this family-friendly hotel in Seville. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,006 reviews)
"Excellent little hotel that is run as well as one in a much higher price category. The friendly, helpful staff had thoughtfully allocated a quiet room but happily changed it to our preferred street view so we could soak up the buzzing atmosphere. The location couldn’t be better for easily dipping ..."

Reviewed on Jun 7, 2026

Hotel Murillo
Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
Book a stay at this spa hotel in Seville. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the pool and the helpful staff in our reviews. ...
9.4/10 Exceptional! (1,009 reviews)
"Beautiful unique property with so much character right in the heart of Seville! The staff was so helpful and kind from check-in to check-out. Our highlights were having a massive room with a separate space, going through the tunnel and beautifully decorated houses, and listening to beautiful music ..."

Reviewed on Jun 7, 2026

Las Casas de la Judería, Sevilla Historic City Center
Hotel Amadeus Sevilla

Hotel Amadeus Sevilla

4 out of 5
Calle Farnesio 6 Seville Seville
Fully refundableReserve now, pay when you stay
Book a stay at this boutique hotel in Seville. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the breakfast and the bar in ...
9.6/10 Exceptional! (1,230 reviews)
"This hotel was amazing! Absolutely beautiful and the location was excellent! We loved the breakfast every morning also. Highly recommend!"

Reviewed on Jun 7, 2026

Hotel Amadeus Sevilla
Hotel Fernando III

Hotel Fernando III

4 out of 5
San Jose 21 Seville Seville
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seville. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the breakfast and the pool ...
9.6/10 Exceptional! (1,507 reviews)
"Excellent in all ways. We attended for a wedding and cannot be faulted. Ex cellent staff, rooms, hospitality, pool, pool service and views. Highly recommend."

Reviewed on Jun 3, 2026

Hotel Fernando III
Hotel Rey Alfonso X

Hotel Rey Alfonso X

4 out of 5
Calle Ximenez De Enciso, 35 Seville Seville
Fully refundableReserve now, pay when you stay
Stay at this hotel in Seville. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the breakfast and the pool in our reviews. Popular ...
9.6/10 Exceptional! (1,194 reviews)
"Clean room, good location, nice hotel."

Reviewed on Jun 2, 2026

Hotel Rey Alfonso X
Hotel Doña Maria

Hotel Doña Maria

4 out of 5
Don Remondo 19 Seville Seville
Fully refundableReserve now, pay when you stay
Book a stay at this historic hotel in Seville. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular ...
9/10 Wonderful! (1,003 reviews)
"Absolutely loved this hotel! The location was perfect and so central to the iconic sites. The staff were very friendly and very helpful. The rooms were surprisingly soundproof, clean, and spacious. Will definitely be back."

Reviewed on Jun 6, 2026

Hotel Doña Maria
Hotel Murillo Reinoso

Hotel Murillo Reinoso

2 out of 5
Lope de Rueda, 16 Seville Seville
Fully refundableReserve now, pay when you stay
Stay at this hotel in Seville. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the property condition ...
9.6/10 Exceptional! (141 reviews)
"Pillows were a bit too flat for my liking."

Reviewed on May 30, 2026

Hotel Murillo Reinoso
Petit Palace Santa Cruz

Petit Palace Santa Cruz

4 out of 5
Munoz y Pabón 18 Seville Seville
Fully refundableReserve now, pay when you stay
Stay at this hotel in Seville. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular ...
9/10 Wonderful! (1,004 reviews)
"Staff was very helpful. Air condition was old & noisy"

Reviewed on Jun 5, 2026

Petit Palace Santa Cruz
Hotel Boutique Casa del Poeta Sevilla

Hotel Boutique Casa del Poeta Sevilla

4 out of 5
Don Carlos Alonso Chaparro 3 Seville Seville
Fully refundableReserve now, pay when you stay
Book a stay at this boutique hotel in Seville. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the property ...
9.8/10 Exceptional! (928 reviews)
"Great location, quiet and secure yet close to the attractions. Amazing staff."

Reviewed on Jun 6, 2026

Hotel Boutique Casa del Poeta Sevilla
Hotel Doña Lina

Hotel Doña Lina

2 out of 5
Calle Gloria 7 Seville Seville
Fully refundableReserve now, pay when you stay
Stay at this hotel in Seville. Enjoy free WiFi, a rooftop terrace, and daily housekeeping. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.6/10 Excellent! (285 reviews)
"Perfectly located. Cozy and quiet but at 2 min walk from the cathedral area with all bodegas. Orange trees park just aside with cafe."

Reviewed on Jun 7, 2026

Hotel Doña Lina
Suites Murillo Catedral

Suites Murillo Catedral

3.5 out of 5
Calle Segovias, 2 Seville
Fully refundableReserve now, pay when you stay
Stay at this aparthotel in Seville. Enjoy free WiFi, a rooftop terrace, and daily housekeeping. Our guests praise the helpful staff and the clean rooms in our ...
9.4/10 Exceptional! (688 reviews)
"We had a problem with noise from construction that woke us at 7:30am and really no support."

Reviewed on Jun 5, 2026

Suites Murillo Catedral
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Santa Cruz

Seville is a city that has a lot going on, but you have your sights set on Santa Cruz. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Santa Cruz has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Santa Cruz hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Seville so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Santa Cruz underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Santa Cruz city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Santa Cruz cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Santa Cruz at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $74
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Santa Cruz hotel you want, book it, and never look back. Because your great escape is ahead of you.