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Santa Cruz Vacation Packages

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Santa Cruz
Chiriquí Province
Panama
Mexico and Central America
Hotwire.com

Santa Cruz Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.

Villa Marina Lodge & Condos

3.5 out of 5

Save 100% on your flight

Price was $1,124, price is now $674 per person

$674

per person

Dec 13 - Dec 21

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this 3.5-star beach inn in Las Escobas del Venado. Enjoy free WiFi, free parking, and a beach locale. Our guests praise the helpful staff in our reviews. Popular attraction Venao Beach is located nearby.

La Coralina Island House

3.5 out of 5

Save 100% on your flight

Price was $1,629, price is now $1,005 per person

$1,005

per person

Nov 15 - Nov 22

found 18 hours ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this 3.5-star beach hotel in Bocas del Toro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Paunch Beach and Tortuga Beach are located nearby.

Bristol Panama, a Registry Collection Hotel

5 out of 5

Save 100% on your flight

Price was $1,704, price is now $1,084 per person

$1,084

per person

Dec 10 - Dec 16

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

Central Hotel Panama Casco Viejo

4 out of 5

Price was $1,251, price is now $811 per person

$811

per person

Dec 5 - Dec 8

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Tropical Suites Hotel

3.5 out of 5

Save 100% on your flight

Price was $1,181, price is now $781 per person

$781

per person

Nov 15 - Nov 22

found 18 hours ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this 3.5-star business-friendly hotel in Bocas del Toro. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Bolivar Park and Bocas del Toro Ferry Terminal are located nearby.

Bambuda Bocas Town - Hostel

2.5 out of 5

Save 100% on your flight

Price was $1,088, price is now $730 per person

$730

per person

Nov 15 - Nov 22

found 18 hours ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this hostel in Bocas del Toro. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Popular attractions Lil' Spa Shop by the Sea and Playa El Istmito are located nearby.

NAYARA Bocas del Toro

4 out of 5

Save 100% on your flight

Price was $5,076, price is now $3,412 per person

$3,412

per person

Nov 15 - Nov 22

found 18 hours ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this 4-star spa hotel in Isla Frangipani. Enjoy free breakfast, free WiFi, and a full-service spa. Our guests praise the helpful staff in our reviews.

Red Frog Beach Island Resort

4 out of 5

Save 100% on your flight

Price was $1,691, price is now $1,155 per person

$1,155

per person

Nov 15 - Nov 22

found 18 hours ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this 4-star beach resort in Bastimentos. Enjoy free WiFi, private pools, and a full-service spa. Popular attractions Red Frog Beach and Bastimentos Sky Zipline are located nearby.