Search for Cheap Deals on
Hotels in Semmes

Check Last Minute Semmes Hotel Deals

Tonight Jul 20 - Jul 21Next weekend Jul 25 - Jul 27

Choose from 453 Semmes Hotel Deals

The Admiral, Downtown Historic District

The Admiral, Downtown Historic District

4 out of 5
251 Government Street, Mobile, AL
  • 31 min drive from Semmes Health Center
Stay at this 4-star hotel in Mobile. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (713 reviews)
Royalty treatment.
"This place was amazing! I will be going back for sure. It was just a random trip with my best friend and I loved it."

Reviewed on Jul 15, 2025

The Admiral, Downtown Historic District
Fairfield Inn & Suites by Marriott Mobile

Fairfield Inn & Suites by Marriott Mobile

2.5 out of 5
950-A W I-65 Service Road South, Mobile, AL
  • 24 min drive from Semmes Health Center
Book a stay at this business-friendly hotel in Mobile. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,002 reviews)
"Amazing"

Reviewed on Jul 14, 2025

Fairfield Inn & Suites by Marriott Mobile
Hampton Inn Mobile-East Bay/Daphne

Hampton Inn Mobile-East Bay/Daphne

2.5 out of 5
29451 Us Highway 98, Daphne, AL
  • 48 min drive from Semmes Health Center
Book a stay at this business-friendly hotel in Daphne. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.2/10 Very Good! (1,006 reviews)
"Hamptons always have good beds and are relatively clean, even when they are old. However clean, this Hampton just was dingy, the worst I’ve been in. The carpets were stained, the bathroom vanity was very worn and chipped, the shower yellowed, and the chair in the room looked like a chair in your ..."

Reviewed on Jul 14, 2025

Hampton Inn Mobile-East Bay/Daphne
La Quinta Inn & Suites by Wyndham Mobile

La Quinta Inn & Suites by Wyndham Mobile

3 out of 5
3650 Airport Blvd, Mobile, AL
  • 23 min drive from Semmes Health Center
Stay at this 3-star business-friendly hotel in Mobile. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (1,003 reviews)
"The property had dogs staying but it was very clean. The breakfast was amazing. The room was very clean"

Reviewed on Jul 16, 2025

La Quinta Inn & Suites by Wyndham Mobile
Hilton Garden Inn Mobile East Bay / Daphne

Hilton Garden Inn Mobile East Bay / Daphne

3 out of 5
29546 N Main St, Daphne, AL
  • 49 min drive from Semmes Health Center
Stay at this 3-star hotel in Daphne. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our ...
9/10 Wonderful! (1,003 reviews)
"One of the best hotel experiences I ever had; thank you!"

Reviewed on Jul 18, 2025

Hilton Garden Inn Mobile East Bay / Daphne
Holiday Inn Mobile-Dwtn/Hist. District by IHG

Holiday Inn Mobile-Dwtn/Hist. District by IHG

3 out of 5
301 Government St, Mobile, AL
  • 31 min drive from Semmes Health Center
Stay at this 3-star business-friendly hotel in Mobile. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (1,002 reviews)
"Convenient location."

Reviewed on Jul 5, 2025

Holiday Inn Mobile-Dwtn/Hist. District by IHG
Hyatt Studios Mobile/Tillmans Corner

Hyatt Studios Mobile/Tillmans Corner

2 out of 5
5195 Motel Ct, Mobile, AL
  • 33 min drive from Semmes Health Center
Book a stay at this business-friendly hotel in Mobile. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Westgate Plaza and Boykin Park ...
9.4/10 Exceptional! (207 reviews)
"Only complaint is patio door wouldn’t unlock to let us back in. Had to walk around the building. Also no pool. Great place other than that."

Reviewed on Jul 17, 2025

Hyatt Studios Mobile/Tillmans Corner
Baymont by Wyndham Mobile/Tillmans Corner

Baymont by Wyndham Mobile/Tillmans Corner

2.5 out of 5
5634 Tillmans Corner Pkwy, Mobile, AL
  • 33 min drive from Semmes Health Center
Book a stay at this business-friendly motel in Mobile. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.2/10 Good! (496 reviews)
"Clean, safe"

Reviewed on Jul 14, 2025

Baymont by Wyndham Mobile/Tillmans Corner
Quality Inn & Suites at Airport Blvd I-65

Quality Inn & Suites at Airport Blvd I-65

2.5 out of 5
150 W I-65 Service Road, Mobile, AL
  • 23 min drive from Semmes Health Center
Book a stay at this business-friendly hotel in Mobile. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Mobile Cruise Terminal and Herndon ...
7.6/10 Good! (172 reviews)
"The property was conveniently located off the main highway. It was clean and the room was very big for 2 guests."

Reviewed on Jul 18, 2025

Quality Inn & Suites at Airport Blvd I-65
Renaissance Mobile Riverview Plaza Hotel

Renaissance Mobile Riverview Plaza Hotel

3.5 out of 5
64 S Water St, Mobile, AL
  • 32 min drive from Semmes Health Center
Book a stay at this business-friendly hotel in Mobile. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (1,001 reviews)
"We enjoyed our stay here. The staff are extra friendly and very helpful. The hotel is clean in all areas. We stay here every year and it never fails!!"

Reviewed on Jul 16, 2025

Renaissance Mobile Riverview Plaza Hotel
Courtyard by Marriott Mobile

Courtyard by Marriott Mobile

3 out of 5
1000 West I-65 Service Road South, Mobile, AL
  • 24 min drive from Semmes Health Center
Stay at this 3-star business-friendly hotel in Mobile. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the property ...
8.2/10 Very Good! (364 reviews)
"Excellent customer service.... Friendly staff very helpful."

Reviewed on Jun 27, 2025

Courtyard by Marriott Mobile
Eastern Shore Motel

Eastern Shore Motel

2 out of 5
29070 U.S 98, Daphne, AL
  • 49 min drive from Semmes Health Center
Stay at this motel in Daphne. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Gator Boardwalk and American Sport Art Museum and ...
6.8/10 (197 reviews)
"Its was nice"

Reviewed on Jul 11, 2025

Eastern Shore Motel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Semmes

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Semmes hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Semmes.

Choosing the right hotel in Alabama has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Semmes’s 453 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $76. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Semmes hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Semmes. No matter your reason for visiting Semmes, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Semmes hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Semmes for as low as $76.

How many hotels are there in Semmes?

With over 453 hotels in Semmes, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $76.

How to find cheap car rentals in Semmes?

Finding a cheap car rental deal in Semmes is as easy as scoring cheap hotels in Semmes. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.