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4 Star Hotels in Main Street Hyannis

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Featured 4 Star Main Street Hyannis Hotels

Doubletree by Hilton Cape Cod - Hyannis
4 out of 5
Fully refundableReserve now, pay when you stay
  • 13 min walk from John F. Kennedy Hyannis Museum
The price is $192 per night from Oct 23 to Oct 24
$192
includes taxes & fees
Oct 23 - Oct 24
Stay at this 4-star hotel in Hyannis. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. Popular attractions ...
Doubletree by Hilton Cape Cod - Hyannis
The Mansion at Ocean Edge
4 out of 5
  • 32 min drive from John F. Kennedy Hyannis Museum
The price is $350 per night from Oct 20 to Oct 21
$350
includes taxes & fees
Oct 20 - Oct 21
Book a stay at this luxury hotel in Brewster. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
The Mansion at Ocean Edge
Chatham Wayside Inn
4 out of 5
  • 37 min drive from John F. Kennedy Hyannis Museum
The price is $348 per night from Sep 29 to Sep 30
$348
includes taxes & fees
Sep 29 - Sep 30
Stay at this 4-star golf hotel in Chatham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our ...
Chatham Wayside Inn
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Winstead Inn
4 out of 5
  • 24 min drive from John F. Kennedy Hyannis Museum
The price is $279 per night from Sep 23 to Sep 24
$279
includes taxes & fees
Sep 23 - Sep 24
Stay at this 4-star beach guesthouse in Harwich. Enjoy free breakfast, free parking, and an outdoor pool. Popular attractions Cape Cod Lavender Farm and Harwich ...
Winstead Inn
Captain's House Inn
4 out of 5
  • 38 min drive from John F. Kennedy Hyannis Museum
The price is $399 per night from Sep 29 to Sep 30
$399
includes taxes & fees
Sep 29 - Sep 30
Stay at this 4-star B&B in Chatham. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Chatham Fish Pier and Chatham Shark Center are located ...
Captain's House Inn
Winstead Beach Resort
4 out of 5
  • 24 min drive from John F. Kennedy Hyannis Museum
The price is $279 per night from Sep 23 to Sep 24
$279
includes taxes & fees
Sep 23 - Sep 24
Stay at this 4-star beach B&B in Harwich Port. Enjoy free breakfast, free parking, and a private beach. Popular attractions Bank Street Beach and Harwich Port ...
Winstead Beach Resort
The Inn At Cape Cod
4 out of 5
  • 10 min drive from John F. Kennedy Hyannis Museum
Stay at this 4-star beach B&B in Yarmouth Port. Enjoy free breakfast, free parking, and daily housekeeping. Popular attractions Cape Codder Water Park and Hyannis ...
The Inn At Cape Cod
The Inn at Yarmouth Port
4 out of 5
  • 10 min drive from John F. Kennedy Hyannis Museum
The price is $354 per night from Oct 1 to Oct 2
$354
includes taxes & fees
Oct 1 - Oct 2
Stay at this 4-star B&B in Yarmouth Port. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Codder Water Park and Hyannis Harbor are ...
The Inn at Yarmouth Port
Queen Anne Inn
4 out of 5
  • 36 min drive from John F. Kennedy Hyannis Museum
Stay at this 4-star business-friendly hotel in Chatham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Queen Anne Inn
The Old Manse Inn
4.5 out of 5
  • 28 min drive from John F. Kennedy Hyannis Museum
The price is $304 per night from Sep 26 to Sep 27
$304
includes taxes & fees
Sep 26 - Sep 27
Stay at this 4.5-star luxury B&B in Brewster. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Breakwater Beach and Robbins Hill Beach ...
The Old Manse Inn
Brewster by the Sea Inn
4 out of 5
  • 24 min drive from John F. Kennedy Hyannis Museum
The price is $361 per night from Sep 29 to Sep 30
$361
includes taxes & fees
Sep 29 - Sep 30
Stay at this 4-star B&B in Brewster. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Cod Museum of Natural History and Breakwater ...
Brewster by the Sea Inn
Candleberry Inn on Cape Cod
4.5 out of 5
  • 28 min drive from John F. Kennedy Hyannis Museum
The price is $468 per night from Sep 25 to Sep 26
$468
includes taxes & fees
Sep 25 - Sep 26
Stay at this 4.5-star luxury B&B in Brewster. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Breakwater Beach and Robbins Hill Beach ...
Candleberry Inn on Cape Cod
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4-star hotels in Main Street Hyannis

When you want to live it up, but not bust your bank account, then there’s nothing better than a 4-star hotel in Main Street Hyannis for your next trip. You’ll get all the amenities you can think of (and then some) at a rate within your means.

No fault in our stars

So what’s with the star rating anyway? Good question. The star rating has little to do with the price, and more to do with the amenities. 4-Star hotels in Main Street Hyannis as well as everywhere else, usually have all those thoughtful touches that make you go “Ooh,” “Ahh,” and ”YES!” Think amenities like luxury bedding, high-end electronics, concierge service, and restaurants that make eating in a gourmet experience.

Stars that shine

You know there are as many underground spots, inviting lounges, memory-making music venues as there are stars in the sky. But you’ll need the funds to check them all off. That’s why we give you the chance to take us up on the Hotwire Hot Rate. You can snag Main Street Hyannis 4-star hotels and still have plenty of leftover cash to paint the town whatever color you want. Filter hotels by:

  • Hotwire Hot Rate: We’ll snag you a crazy deal on a room by finding your hotel name after you book.
  • Price: You know that paying full price is for suckers? You can get a cheap 4-star hotel in Main Street Hyannis starting at $192 per night.
  • Amenities: What makes you flip for your trip? Full-service spa? Heated pool? 24-hour room service? Get a hotel that’ll send you over the moon.

Do you deserve a swanky hotel with a ton of amenities? Yes, yes you do. And you also deserve a sweet deal on it. Book with Hotwire today and get that star-studded Main Street Hyannis 4-star hotel and have plenty of cash left over to spend at that secret super star joint in the city.