Byron Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.

Hotel Indigo Rochester – Mayo Clinic Area by IHG

$315

per person

Jan 29 - Feb 1

found 1 day ago

Roundtrip flight included

Chicago (ORD) to Rochester (RST)

Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and the helpful staff in our reviews. Popular attractions Mayo Civic Center and Rochester Public Library are located nearby.

Hyatt House Rochester/Mayo Clinic Area

$374

per person

Jan 29 - Feb 1

found 1 day ago

Roundtrip flight included

Chicago (ORD) to Rochester (RST)

Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Mayo Civic Center and Shops University Square are located nearby.

Great spot especially for anyone with Mayo appts.

Reviewed on Nov 11, 2026

Kahler Inn and Suites - Mayo Clinic Area

$388

per person

Jan 29 - Feb 1

found 1 day ago

Roundtrip flight included

Chicago (ORD) to Rochester (RST)

Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Mayo Civic Center and Plummer Building are located nearby.

Kahler Grand Hotel

$401

per person

Jan 29 - Feb 1

found 1 day ago

Roundtrip flight included

Chicago (ORD) to Rochester (RST)

Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Mayo Civic Center and Plummer Building are located nearby.

We just had an unusual problem with our room. We had hot water to the toilet and to the cold water faucets on sink and shower. I’m sure they have repaired that by now. They did move us to another room immediately.

Reviewed on Nov 12, 2026

TownePlace Suites by Marriott Rochester Mayo Clinic Area

$411

per person

Jan 29 - Feb 1

found 1 day ago

Roundtrip flight included

Chicago (ORD) to Rochester (RST)

Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Mayo Civic Center and Plummer Building are located nearby.

This location is awesome if you are going to Mayo Clinic. What an easy walk to the clinic. Several great restaurants are also within walking distance.

Reviewed on Nov 10, 2026

Alexander Mansion Bed and Breakfast

$866

per person

Dec 14 - Dec 18

found 15 hours ago

Roundtrip non-stop flight included

New York (LGA) to Rochester (RST)

Stay at this B&B in Winona. Enjoy free parking, a business center, and daily housekeeping. Popular attractions Winona Arts Center and Watkins Heritage Museum are located nearby.

Wonderful host Richard and the beautiful home

Reviewed on Nov 2, 2026

EVEN Hotel Rochester - Mayo Clinic Area by IHG

$404

per person

Jan 29 - Feb 1

found 1 day ago

Roundtrip flight included

Chicago (ORD) to Rochester (RST)

Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Mayo Civic Center and Kutzky Park Tennis Center are located nearby.

Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

$931

per person

Dec 14 - Dec 18

found 15 hours ago

Roundtrip non-stop flight included

New York (LGA) to Rochester (RST)

Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free parking, and a free area shuttle. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Mayo Civic Center and Kutzky Park Tennis Center are located nearby.

Byron Vacation Packages 3-4 Night Stays

Price found within the past 48 hours. Click for updated prices.