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Choose from 388 Byron Hotel Deals
Kahler Grand Hotel
Beautiful hotel with a lot of history.
Reviewed on Jan 2, 2026
Kahler Inn and Suites - Mayo Clinic Area
Clean big room close to the Mayo
Reviewed on Dec 31, 2025
Hotel Indigo Rochester – Mayo Clinic Area by IHG
The hotel was clean and a friendly staff at check in. We love that the hotel skyway is connected to Mayo, so could walk to appts. inside on a cold day. We also appreciated a noon check out.
Reviewed on Jan 1, 2026
Hampton Inn Rochester-South
Although the room was a little smaller than I had expected, it was ver clean and comfortable. The hotel serves a full hot breakfast and has a soup hour M-Th which was very nice. Pool is open 24 hours.. Location was close to everything
Reviewed on Dec 28, 2025
EVEN Hotel Rochester - Mayo Clinic Area by IHG
Great clean and friendly hotel. Rooms were spacious and had a notably nice smell when you first walk in.
Reviewed on Jan 1, 2026
Aspen Suites
Clean room
Reviewed on Dec 30, 2025
Hyatt House Rochester/Mayo Clinic Area
Breakfast to go was offered for the volleyball players.
Reviewed on Jan 4, 2026
AmericInn by Wyndham Rochester Near Mayo Clinic
Good value for what you get. Clean room, comfortable bed, nice location, and good breakfast. Pool / hot tub area could use better ventilation and updating.
Reviewed on Jan 4, 2026
The Berkman
It was a bit tricky finding our area we could park in but it worked out.
Reviewed on Jan 1, 2026
Spark by Hilton Rochester South
Nice place to stay. No hot breakfast though only Complimentary breakfast offered.
Reviewed on Jan 2, 2026
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Friendly staff and very clean
Reviewed on Jan 1, 2026
Holiday Inn Express Rochester South - Mayo Area by IHG
Staff nice. Breakfast excellent. Beds a little hard for my liking but room was very nice and clean
Reviewed on Dec 29, 2025
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