Search for Cheap Deals onHotels in Byron
Choose from 377 Byron Hotel Deals
Kahler Grand Hotel
"Staff is helpful and friendly. Room is clean, comfortable and relaxing."
Reviewed on Jul 10, 2026
Kahler Inn and Suites - Mayo Clinic Area
"Rooms had an odor to them that wasn’t appealing, outlets were scarce."
Reviewed on Jul 10, 2026
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
"The room itself was a good size, but the humidity was unbearable. It was so damp that even the bed sheets felt wet. I left my suitcase open overnight, and by the next morning all of my clothes felt humid and had developed a musty smell after just one night. The rooms are carpeted, and because of ..."
Reviewed on Jul 10, 2026
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
"Dedicated gluten free kitchen for dining at Twig restaurant"
Reviewed on Jul 11, 2026
Med City Inn & Suites - Mayo Clinic Area
"Affordable stay close to Mayo Clinic."
Reviewed on Jul 10, 2026
AmericInn by Wyndham Rochester Near Mayo Clinic
"Ok"
Reviewed on Jul 11, 2026
EVEN Hotel Rochester - Mayo Clinic Area by IHG
"Great staff and guest"
Reviewed on Jul 10, 2026
Hampton Inn Rochester-South
"I stayed here two nights while preparing for surgery on the third day. Our room was clean and quiet at night. Air conditioning worked well. Staff was very pleasant. Breakfast was typical, offering basic protein and carbohydrate choices. I met several other individuals connected with Mayo’s exemplary ..."
Reviewed on Jul 7, 2026
Hyatt House Rochester/Mayo Clinic Area
"Quiet, clean rooms."
Reviewed on Jul 10, 2026
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
"Breakfast service was unwelcoming. Items were not getting replenished. People were eating and the servers just started shutting down and taking all the amenities away just because they were 10 mins to close. Sorry service without management oversight and control. Will not stay here again"
Reviewed on Jul 10, 2026
Hotel Indigo Rochester – Mayo Clinic Area by IHG
"Nice quick walk over to Mayo whether you went outside on streets or used the Skyway. Motel was quiet and clean."
Reviewed on Jul 8, 2026
The Berkman
"Wonderful property with a few caveats. The amenities are great, and the location is ideal for St Mary’s. The apartment is large and parking safe and easy. That said, the bed is very hard and pillows aren’t great. The vents also hit directly on your face in the bed, so that was hard to get used to. ..."
Reviewed on Jul 2, 2026
Find cheap hotels in Byron
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Byron hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in Byron.
Choosing the right hotel in Minnesota has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Byron’s 377 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $87. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Byron hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Byron. No matter your reason for visiting Byron, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Byron hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Byron for as low as $87.
How many hotels are there in Byron?
With over 377 hotels in Byron, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $87.
How to find cheap car rentals in Byron?
Finding a cheap car rental deal in Byron is as easy as scoring cheap hotels in Byron. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
- Rochester Hotels
- Lake City Hotels
- Austin Hotels
- Owatonna Hotels
- Southern Minnesota Hotels
- Zumbrota Hotels
- Stewartville Hotels
- Spring Valley Hotels
- Chatfield Hotels
- Kasson Hotels
- Oronoco Hotels
- Goodhue Hotels
- Plainview Hotels
- Zumbro Falls Hotels
- Eyota Hotels
- Southeast Minnesota Hotels
- Central United States Hotels
- Blooming Prairie Hotels
- Kenyon Hotels
- Mantorville Hotels
