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Choose from 396 Byron Hotel Deals
Kahler Grand Hotel
Great dinner
Reviewed on Apr 14, 2026
Kahler Inn and Suites - Mayo Clinic Area
Proximity to the Mayo Clinic was so convenient. You could connect the subway level from our hotel.
Reviewed on Apr 13, 2026
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Bar
Reviewed on Apr 14, 2026
EVEN Hotel Rochester - Mayo Clinic Area by IHG
Parking lot was full and had to park on street, did get a parking ticket.
Reviewed on Apr 11, 2026
AmericInn by Wyndham Rochester Near Mayo Clinic
Hot tub stays open until 11 PM. To bad the hot water in the shower by the pool area doesn't work.
Reviewed on Apr 13, 2026
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Great place
Reviewed on Apr 13, 2026
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
The eggs seemed undercooked but options were good. The pool was great. Beds in the room were uncomfortable. Wish the tv had the option to have Netflix etc. overall was a decent hotel for the price.
Reviewed on Apr 14, 2026
Aspen Suites
Great for the price. free underground parking. It’s across the street from St Mary’s hospital and .9 miles from the Mayo complex which you could walk if you are able or, take the shuttle or drive and valet. The rooms have full kitchens with a full size refrigerator. Plus many good restaurants close ...
Reviewed on Apr 14, 2026
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
Room was clean and comfortable Staff was friendly and helpful
Reviewed on Apr 13, 2026
Spark by Hilton Rochester South
The room was super clean. Check-in was a breeze; the staff was super friendly and helpful. The room was so quiet, I didn’t hear anything in the hall. Check out was quick and super easy.
Reviewed on Apr 14, 2026
Brentwood Inn & Suites
Great location to clinic but room was tiny and air conditioning was incredibly loud. Super outdated and breakfast was very basic. Has potential to be great if updates are done
Reviewed on Apr 14, 2026
Hyatt House Rochester/Mayo Clinic Area
Breakfast was great and the staff was so friendly! Would highly recommend.
Reviewed on Apr 13, 2026
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