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Choose from 397 Byron Hotel Deals
Kahler Grand Hotel
Old and outdated hotel, parking is expensive, room service is inadequate.
Reviewed on Apr 27, 2026
Kahler Inn and Suites - Mayo Clinic Area
Very convenient to Mayo Clinic. Staff was very helpful and pleasant
Reviewed on Apr 27, 2026
Med City Inn & Suites - Mayo Clinic Area
Cool employees Kyle is awesome and a asset to the company
Reviewed on Apr 26, 2026
AmericInn by Wyndham Rochester Near Mayo Clinic
Clean hotel and rooms, and quiet.
Reviewed on Apr 27, 2026
Hyatt House Rochester/Mayo Clinic Area
Spacious and updated room. Really comfortable and staff was friendly and helpful. Within walking distance of food and bars. Would stay here again:)
Reviewed on Apr 26, 2026
EVEN Hotel Rochester - Mayo Clinic Area by IHG
One of the best hotels I've ever stayed at. The staff were very friendly and helpful. The only downside would be the parking situation, which the staff was very helpful in explaining it. I also love how i cant hear people out in the hallway or next door. Lots of privacy and rest.
Reviewed on Apr 25, 2026
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
My room was clean, with a nicely updated, modern feel. I didn't have an opportunity to use the pool, hot tub or fitness room, but they looked great. I didn't need the shuttle service to Mayo - but that is a great amenity! Staff was very friendly and helpful with questions / area recommendations. ...
Reviewed on Apr 27, 2026
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Staff there is amazing and and on top of there game and go above and beyond, I would also like to add that Nyiesha the supervisor at the front desk is an amazing asset to your hotel with all the choas with groups and kids last night and the incident that took place she handled her self very well ...
Reviewed on Apr 26, 2026
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Good stay
Reviewed on Apr 22, 2026
The Berkman
Really the best place I've stayed in Rochester and being across the street from St Mary's was very helpful in getting in and out of the hospital. The staff and accommodations were perfect.
Reviewed on Apr 27, 2026
Hampton Inn Rochester-South
Nice variey for breakfast
Reviewed on Apr 26, 2026
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
Cookies in the afternoon are great. So is the fruited water.
Reviewed on Apr 24, 2026
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