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Choose from 374 Byron Hotel Deals
Kahler Grand Hotel
"The staff was helpful when we forgot some items in our room after checking out"
Reviewed on Jul 16, 2026
Kahler Inn and Suites - Mayo Clinic Area
"The breakfast was very good with a lot of options. The parking is convenient, although the immediate roads are under construction so you have to deal with lane closures and detours, but at least you can still utilize their parking lot. The thing I was mostly disappointed with was the dirty carpet ..."
Reviewed on Jul 16, 2026
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area
"It was very clean. We did get the executive queen room for the recliner. It was super comfortable. Really good shower, too. Didn't really care for the soap. Nice to have a frig & microwave in the room. We liked it so well, we booked two more nights!"
Reviewed on Jul 16, 2026
AmericInn by Wyndham Rochester Near Mayo Clinic
"Everything thing was wonderful"
Reviewed on Jul 15, 2026
EVEN Hotel Rochester - Mayo Clinic Area by IHG
"Great staff and guest"
Reviewed on Jul 10, 2026
Hampton Inn Rochester-South
"Great hotel with friendly staff!"
Reviewed on Jul 15, 2026
Hyatt House Rochester/Mayo Clinic Area
"The room was not clean and no maid service in a week. I’ve machines did not work."
Reviewed on Jul 15, 2026
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
"Clean room good breakfast"
Reviewed on Jul 15, 2026
Hotel Indigo Rochester – Mayo Clinic Area by IHG
"The indigo"
Reviewed on Jul 16, 2026
The Berkman
"Wonderful property with a few caveats. The amenities are great, and the location is ideal for St Mary’s. The apartment is large and parking safe and easy. That said, the bed is very hard and pillows aren’t great. The vents also hit directly on your face in the bed, so that was hard to get used to. ..."
Reviewed on Jul 2, 2026
Find cheap hotels in Byron
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Frequently Asked Questions About Byron hotels
Where can I find the best last-minute travel deals?
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How many hotels are there in Byron?
With over 374 hotels in Byron, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $87.
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