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Hotels in Southern Minnesota

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Choose from 1200 Southern Minnesota Hotel Deals

Treasure Island Resort & Casino

Treasure Island Resort & Casino

3 out of 5
5734 Sturgeon Lake Road Welch MN
  • 2 hours drive from Mayo Clinic
Book a stay at this spa hotel in Welch. Enjoy free WiFi, free parking, and a full-service spa. Popular attractions Treasure Island Casino and Island Xtreme Bowl ...
8.6/10 Excellent! (411 reviews)
"Love the adult only water park area. Room was clean and remodeled. Unfortunately I had a bad experience at the restaurant since they were ready to close but still took my group in and then did not provide a good service. Check-in process can take about an hour. It was my first time and had to get ..."

Reviewed on Jul 3, 2026

Treasure Island Resort & Casino
Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
  • 2 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.4/10 Very Good! (2,179 reviews)
"It’s nothing special. It’s like being in an upgraded hospital room. They charge you a $50 incidental fee for I don’t know what? It not like they have a mini bar in the room and who goes to Rochester to party? Most people like me are there to go to the Mayo Clinic. It’s been a week and I’m still waiting ..."

Reviewed on Jul 3, 2026

Kahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
  • 3 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,605 reviews)
"Room was fine. Comfy bed. Pool area was a disaster. Took the kids down there for a morning swim and it had not been cleaned from the night before. Used towels laying around everywhere and band aids floating in the pool. And this was at 10am, so plenty of time to get things cleaned up from the night ..."

Reviewed on Jul 3, 2026

Kahler Inn and Suites - Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
401 6th St Sw Rochester MN
  • 8 min walk from Mayo Clinic
Book a stay at this golf hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant in our reviews. ...
8.6/10 Excellent! (1,004 reviews)
"Room was dated and waste can had not been emptied. Front desk staff were not especially helpful."

Reviewed on Jul 2, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw Rochester MN
  • 26 min walk from Mayo Clinic
Book a stay at this family-friendly motel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,004 reviews)
"The room was very clean. Excellent stay for the price."

Reviewed on Jun 30, 2026

Med City Inn & Suites - Mayo Clinic Area
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2.5 out of 5
1517 16th St Sw Rochester MN
  • 5 min drive from Mayo Clinic
Book a stay at this family-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.2/10 Very Good! (967 reviews)
"Loved our stay here. The pool was a hit with the kids. The staff were amazing, helpful, and friendly. Slept great. Didn't love the lighting (cold white light) and obvious wear and tear in the room, but was clean and comfortable. Would stay again."

Reviewed on Jul 3, 2026

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

3 out of 5
4353 Canal Pl SE Rochester MN
  • 11 min drive from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.4/10 Good! (1,067 reviews)
"My go to hotel in Rochester now. Always excellent in all areas"

Reviewed on Jul 1, 2026

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW Rochester MN
  • 7 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,000 reviews)
"The good: Clean room, comfortable bed, very kind staff, great breakfast, convenient parking garage. The bad: Wall outlets in the room were all very loose and nothing would stay plugged in (the weight of the plug would cause it to fall out). There were no bath towels in the room (I assume the cleaning ..."

Reviewed on Jul 1, 2026

Hyatt House Rochester/Mayo Clinic Area
Express Suites Riverport Inn & Suites

Express Suites Riverport Inn & Suites

3 out of 5
900 Bruski Dr Winona MN
  • 2 hours drive from Mayo Clinic
Book a stay at this business-friendly hotel in Winona. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (1,003 reviews)
"The room had not been cleaned and it was 8:00 pm"

Reviewed on Jun 30, 2026

Express Suites Riverport Inn & Suites
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW Rochester MN
  • 17 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
9.4/10 Exceptional! (1,001 reviews)
"Staff is great. Hot-tub WAY too hot. And every time I stay there, the pool heater is broken and no one uses it, because it is ice cold. Also they have a happy hour Mon-Wed with wine beer and food at no cost. I am sober and asked if they have any lemon tea. The little snotty girl with the Niki headband ..."

Reviewed on Jul 3, 2026

EVEN Hotel Rochester - Mayo Clinic Area by IHG
Hampton Inn Rochester-South

Hampton Inn Rochester-South

2.5 out of 5
1755 S Broadway Rochester MN
  • 4 min drive from Mayo Clinic
Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9/10 Wonderful! (1,003 reviews)
"The rooms were clean and comfortable. There were two kinds of excellent soups being served when we arrived at 6pm with bread and crackers... we've never seen a hotel do that before! The breakfast was great, too!"

Reviewed on Jul 2, 2026

Hampton Inn Rochester-South
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
  • 4 min drive from Mayo Clinic
Book a stay at this spa hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful staff in our ...
8/10 Very Good! (1,374 reviews)
"They don’t clean the fridge, it was dirty and old and also rusty. They didn’t turned on the AC, the room was so hot when we get in there."

Reviewed on Jul 3, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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