Search for Cheap Deals on
Hotels in Southern Minnesota

Check Last Minute Southern Minnesota Hotel Deals

Tonight Apr 25 - Apr 26Next weekend May 1 - May 3

Choose from 1208 Southern Minnesota Hotel Deals

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
  • 2 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.4/10 Very Good! (2,015 reviews)
Room was clean , staff very helpful best part was dinners Ruth Chris steak house located inside hotel ! And location from mayo clinic right across street !

Reviewed on Apr 24, 2026

Kahler Grand Hotel
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
  • 4 min drive from Mayo Clinic
Book a stay at this spa hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful staff in our ...
8.2/10 Very Good! (1,282 reviews)
Very run down. Breakfast was dismal. Got what we paid for, but don't expect typical AmericInn quality.

Reviewed on Apr 25, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
  • 3 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,561 reviews)
Clean rooms, free breakfast, nice pool, paid parking

Reviewed on Apr 24, 2026

Kahler Inn and Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw Rochester MN
  • 26 min walk from Mayo Clinic
Book a stay at this family-friendly motel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,001 reviews)
This has truly become my home away from home while navigating surgeries and appointments at the Mayo Clinic. The staff is incredibly friendly, helpful, and genuinely caring. A special thank you to Kesley, Dequan, and Angel—they each went above and beyond to make sure I felt comfortable and supported. ...

Reviewed on Apr 23, 2026

Med City Inn & Suites - Mayo Clinic Area
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

3 out of 5
1125 2nd St Sw Rochester MN
  • 18 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff ...
8.6/10 Excellent! (991 reviews)
Cookies in the afternoon are great. So is the fruited water.

Reviewed on Apr 24, 2026

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW Rochester MN
  • 17 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
9.4/10 Exceptional! (1,002 reviews)
Very nicr

Reviewed on Apr 23, 2026

EVEN Hotel Rochester - Mayo Clinic Area by IHG
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW Rochester MN
  • 7 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,002 reviews)
The rooms were spacious and clean. The front desk and all staff were very helpful and kind to us. The breakfast had alot of good options and good healthy choices! The kids had a wonderful time in the pool. I didnt get to use the gym but it was also very nice and clean. Overall our stay was wonderful ...

Reviewed on Apr 25, 2026

Hyatt House Rochester/Mayo Clinic Area
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2.5 out of 5
1517 16th St Sw Rochester MN
  • 5 min drive from Mayo Clinic
Book a stay at this family-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.2/10 Very Good! (890 reviews)
Good breakfast

Reviewed on Apr 23, 2026

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway Rochester MN
  • 6 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (1,000 reviews)
Good stay

Reviewed on Apr 22, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
401 6th St Sw Rochester MN
  • 8 min walk from Mayo Clinic
Book a stay at this golf hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant in our reviews. ...
8.6/10 Excellent! (1,003 reviews)
Great place with clean rooms and a great breakfast!

Reviewed on Apr 23, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
The Berkman

The Berkman

3 out of 5
217 14th Ave SW Rochester MN
  • 24 min walk from Mayo Clinic
Book a stay at this golf aparthotel in Rochester. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
9.6/10 Exceptional! (408 reviews)
It’s absolutely incredible!! Best place ever!! I highly recommend it!!

Reviewed on Apr 18, 2026

The Berkman
Hampton Inn Rochester-South

Hampton Inn Rochester-South

2.5 out of 5
1755 S Broadway Rochester MN
  • 4 min drive from Mayo Clinic
Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9/10 Wonderful! (1,001 reviews)
Breakfast healthy and good. Parking is never a problem. I always try and stay at this Hampton Inn when traveling to Rochester.

Reviewed on Apr 24, 2026

Hampton Inn Rochester-South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Southern Minnesota

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Southern Minnesota hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southern Minnesota.

Choosing the right hotel in Minnesota has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southern Minnesota’s 1,208 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $87. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southern Minnesota hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southern Minnesota. No matter your reason for visiting Southern Minnesota, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Southern Minnesota hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southern Minnesota for as low as $87.

How many hotels are there in Southern Minnesota?

With over 1,208 hotels in Southern Minnesota, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $87.

How to find cheap car rentals in Southern Minnesota?

Finding a cheap car rental deal in Southern Minnesota is as easy as scoring cheap hotels in Southern Minnesota. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.