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Hotels in Southern Minnesota

Choose from 1204 Southern Minnesota Hotel Deals

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
  • 2 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.4/10 Very Good! (1,937 reviews)
Every was great . Old school place. Loved

Reviewed on Mar 3, 2026

Kahler Grand Hotel
Aspen Suites

Aspen Suites

3 out of 5
1211 2nd Street Rochester MN
  • 21 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (748 reviews)
Clean room and friendly staff

Reviewed on Mar 3, 2026

Aspen Suites
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
  • 3 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,535 reviews)
Friendly

Reviewed on Mar 4, 2026

Kahler Inn and Suites - Mayo Clinic Area
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW Rochester MN
  • 17 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
9.4/10 Exceptional! (1,002 reviews)
Clean, great staff & close to St Mary’s hospital

Reviewed on Feb 28, 2026

EVEN Hotel Rochester - Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway Rochester MN
  • 6 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (949 reviews)
Yes, everything was great!!

Reviewed on Mar 2, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW Rochester MN
  • 7 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,001 reviews)
Staff, location, clean & soup in the evenings.

Reviewed on Feb 25, 2026

Hyatt House Rochester/Mayo Clinic Area
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
  • 4 min drive from Mayo Clinic
Book a stay at this spa hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful staff in our ...
8.2/10 Very Good! (1,221 reviews)
The hotel was fine. Some towels were dirty/were not properly washed/ stains. And i know this is not the Hotels fault, but all day /evening kids were running through the hallways and yelling.

Reviewed on Mar 2, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
Spark by Hilton Rochester South

Spark by Hilton Rochester South

3 out of 5
4165 Maine Ave SE Rochester MN
  • 10 min drive from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (389 reviews)
Room was clean and spacious. TV offerings were limited and unreliable. Breakfast was limited. But overall, an excellent value.

Reviewed on Mar 3, 2026

Spark by Hilton Rochester South
Brentwood Inn & Suites

Brentwood Inn & Suites

2.5 out of 5
123 Fourth Ave. NW Rochester MN
  • 5 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,002 reviews)
Very convenient for a Mayo clinic visit. Connected to underground passages to the clinic. Free parking. Older building but good value for a room within walking distance to Mayo.

Reviewed on Mar 4, 2026

Brentwood Inn & Suites
The Berkman

The Berkman

3 out of 5
217 14th Ave SW Rochester MN
  • 24 min walk from Mayo Clinic
Book a stay at this golf aparthotel in Rochester. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
The Berkman
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2.5 out of 5
1517 16th St Sw Rochester MN
  • 5 min drive from Mayo Clinic
Book a stay at this family-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.4/10 Very Good! (836 reviews)
Nice room, hot tub not working

Reviewed on Mar 3, 2026

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
St James Hotel, a Historic Hotel of America

St James Hotel, a Historic Hotel of America

3.5 out of 5
406 Main St. Red Wing MN
  • 2 hours drive from Mayo Clinic
Book a stay at this spa hotel in Red Wing. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the comfy rooms in ...
9.2/10 Wonderful! (1,001 reviews)
Wonderful experience in the historic part of the hotel!

Reviewed on Feb 27, 2026

St James Hotel, a Historic Hotel of America
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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