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Hotels in Southern Minnesota

Choose from 1180 Southern Minnesota Hotel Deals

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw, Rochester, MN
  • 2 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.2/10 Very Good! (1,614 reviews)
"Connected to the tunnel system with Mayo. Fantastic!"

Reviewed on Sep 22, 2025

Kahler Grand Hotel
Spark by Hilton Rochester South

Spark by Hilton Rochester South

3 out of 5
4165 Maine Ave SE, Rochester, MN
  • 10 min drive from Mayo Clinic
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (163 reviews)
"Check in was easy and staff was extremely helpful! We'll definitely stay here again."

Reviewed on Sep 23, 2025

Spark by Hilton Rochester South
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S, Rochester, MN
  • 4 min drive from Mayo Clinic
Book a stay at this spa hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful staff in our ...
8/10 Very Good! (1,042 reviews)
hot tub
"The help and the motel was awesome however it would have been nice f they had told us the hot tub did not work when we checked in - instead of us getting our suits on and getting down to the pool room to find out and giving us a chance to decide if we wanted to go ahead and stay there"

Reviewed on Sep 23, 2025

AmericInn by Wyndham Rochester Near Mayo Clinic
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw, Rochester, MN
  • 3 min walk from Mayo Clinic
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
7.8/10 Good! (1,441 reviews)
"Gym area much improved from my last stay."

Reviewed on Sep 22, 2025

Kahler Inn and Suites - Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW, Rochester, MN
  • 7 min walk from Mayo Clinic
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,005 reviews)
"The hotel was clean and the room was clean. However, the couch had a definite smell of urine. It was very strong. It is a pet friendly hotel so I was assuming it was animal urine? It was bothersome, but I did not mention it to the hotel staff."

Reviewed on Sep 12, 2025

Hyatt House Rochester/Mayo Clinic Area
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW, Suite A, Rochester, MN
  • 17 min walk from Mayo Clinic
Stay at this 4-star business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
9.4/10 Exceptional! (898 reviews)
"This was our first stay but definitely won’t be our last. The staff was very professional and courteous us our entire stay! The room was spacious and very clean! It was a pleasant stay!"

Reviewed on Sep 15, 2025

EVEN Hotel Rochester - Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway, Rochester, MN
  • 6 min walk from Mayo Clinic
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (830 reviews)
"We just stayed one night for a show at the Civic Center. It was nice that we could walk to restaurants and to the center. The parking was a hassle, due to construction in the parking facility. When we went to leave, the machine will not take our card. I push the help button and somebody came to help ..."

Reviewed on Sep 23, 2025

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Express Suites Riverport Inn & Suites

Express Suites Riverport Inn & Suites

3 out of 5
900 Bruski Dr, Winona, MN
  • 2 hours drive from Mayo Clinic
Stay at this 3-star business-friendly hotel in Winona. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,007 reviews)
"TV positioned such that you can't watch it from the suite seating area???"

Reviewed on Sep 23, 2025

Express Suites Riverport Inn & Suites
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

3 out of 5
4353 Canal Pl SE, Rochester, MN
  • 11 min drive from Mayo Clinic
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.2/10 Good! (1,016 reviews)
"The front desk staff was very friendly and accommodating. The guy in the breakfast area is so great to talk to, very kind, keeps the area very clean. Even the cleaning guy was friendly and happy, blessing your daykialways happy. k!"

Reviewed on Sep 19, 2025

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

3 out of 5
1125 2nd St Sw, Rochester, MN
  • 19 min walk from Mayo Clinic
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (883 reviews)
"When I checked and last night at 8:30, it was dark and pouring down rain, and the guy working behind the counter was not helpful at all and I have a daughter that’s in a wheelchair plus a service dog. It would’ve been nice if he could at least help us with the doors, but the morning staff was amazing ..."

Reviewed on Sep 22, 2025

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw, Rochester, MN
  • 26 min walk from Mayo Clinic
Book a stay at this family-friendly motel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,012 reviews)
"Med city was convenient and affordable for our trip to Mayo Clinic. Serviced by a shuttle ti and frim for appointments. Famous Dave bbq accessible from lobby"

Reviewed on Sep 17, 2025

Med City Inn & Suites - Mayo Clinic Area
St James Hotel, a Historic Hotel of America

St James Hotel, a Historic Hotel of America

3.5 out of 5
406 Main St., Red Wing, MN
  • 2 hours drive from Mayo Clinic
Stay at this 3.5-star spa hotel in Red Wing. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the comfy rooms in ...
9.2/10 Wonderful! (1,009 reviews)
"Loved it!"

Reviewed on Sep 22, 2025

St James Hotel, a Historic Hotel of America
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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