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Hotels in Southern Minnesota

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Tonight Dec 10 - Dec 11Next weekend Dec 15 - Dec 17

Choose from 1059 Southern Minnesota Hotel Deals

GuestHouse Inn & Suites Rochester
GuestHouse Inn & Suites Rochester
2.5 out of 5
435 16th Ave Nw, Rochester, MN
  • 26 min walk from Mayo Clinic
The price is $73 per night from Dec 13 to Dec 14
$73
per night
Dec 13 - Dec 14
Stay at this family-friendly motel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in ...
7.8/10 Good! (1,001 reviews)
"The hotel was accommodating and the stahl friendly."

Reviewed on Dec 3, 2023

GuestHouse Inn & Suites Rochester
Kahler Inn and Suites - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area
3.5 out of 5
9 3rd Ave Nw, Rochester, MN
  • 3 min walk from Mayo Clinic
The price is $102 per night from Dec 11 to Dec 12
$102
per night
Dec 11 - Dec 12
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free WiFi, a fitness center, and onsite parking. Our guests praise the helpful staff and the ...
7.4/10 Good! (1,135 reviews)
"liked all"

Reviewed on Dec 5, 2023

Kahler Inn and Suites - Mayo Clinic Area
AmericInn by Wyndham Rochester Near Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Clinic
3 out of 5
1625 Broadway Ave S, Rochester, MN
  • 4 min drive from Mayo Clinic
The price is $80 per night from Dec 14 to Dec 15
$80
per night
Dec 14 - Dec 15
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (88 reviews)
Great stay but awful breakfast
"Really enjoyed the hotel. Very clean and comfortable. The breakfast was awful though. No real hot options other than toasting some bread. English muffins were soggy. The orange juice from their dispenser tasted like the lines/pipes were moldy and unclean. It was really bad. It’s unfortunate because ..."

Reviewed on Dec 7, 2023

AmericInn by Wyndham Rochester Near Mayo Clinic
Kahler Grand Hotel
Kahler Grand Hotel
3 out of 5
20 2nd Ave Sw, Rochester, MN
  • 2 min walk from Mayo Clinic
The price is $111 per night from Dec 11 to Dec 12
$111
per night
Dec 11 - Dec 12
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free WiFi, 3 restaurants, and breakfast. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (1,005 reviews)
"Location to Mayo Clinic"

Reviewed on Dec 6, 2023

Kahler Grand Hotel
Hotel Indigo Rochester – Mayo Clinic Area, an IHG Hotel
Hotel Indigo Rochester – Mayo Clinic Area, an IHG Hotel
3.5 out of 5
220 S Broadway, Rochester, MN
  • 6 min walk from Mayo Clinic
The price is $94 per night from Dec 24 to Dec 25
$94
per night
Dec 24 - Dec 25
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast. Our guests praise the restaurant and the helpful ...
8.6/10 Excellent! (438 reviews)
"So convenient to Mayo Clinic, especially in winter when you can walk through the skyway system. Restaurants nearby as well as nice shops. Hotel is new, modern and well appointed. The price is reasonable, too."

Reviewed on Dec 6, 2023

Hotel Indigo Rochester – Mayo Clinic Area, an IHG Hotel
Hyatt House Rochester/Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area
3.5 out of 5
110 Civic Center Drive NW, Rochester, MN
  • 7 min walk from Mayo Clinic
The price is $109 per night from Dec 22 to Dec 23
$109
per night
Dec 22 - Dec 23
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free breakfast, a free area shuttle, and a fitness center. Our guests praise the breakfast ...
9/10 Wonderful! (453 reviews)
"Cleanly and Staff was exceptional"

Reviewed on Nov 25, 2023

Hyatt House Rochester/Mayo Clinic Area
Aspen Select
Aspen Select
3.5 out of 5
1215 2nd St SW, Rochester, MN
  • 21 min walk from Mayo Clinic
The price is $125 per night from Dec 11 to Dec 12
$125
per night
Dec 11 - Dec 12
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (937 reviews)
"Right across the street from the hospital and side door entrance."

Reviewed on Nov 30, 2023

Aspen Select
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3 out of 5
4353 Canal Pl SE, Rochester, MN
  • 11 min drive from Mayo Clinic
The price is $77 per night from Dec 24 to Dec 25
$77
per night
Dec 24 - Dec 25
Stay at this 3-star family-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,004 reviews)
"Hotel was clean and inviting. Parking lot was clean and well lined. Had good breakfasts the days we stayed and staff in the cafeteria was very friendly and prompt on keeping items filled that i observed."

Reviewed on Dec 6, 2023

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Hampton Inn Rochester-South
Hampton Inn Rochester-South
2.5 out of 5
1755 S Broadway, Rochester, MN
  • 4 min drive from Mayo Clinic
The price is $94 per night from Dec 29 to Dec 30
$94
per night
Dec 29 - Dec 30
Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (943 reviews)
"There was an issue with our check-in. Q done a great job of fixing it."

Reviewed on Dec 9, 2023

Hampton Inn Rochester-South
St James Hotel, a Historic Hotel of America
St James Hotel, a Historic Hotel of America
3.5 out of 5
406 Main St., Red Wing, MN
  • 2 hours drive from Mayo Clinic
The price is $140 per night from Dec 11 to Dec 12
$140
per night
Dec 11 - Dec 12
Stay at this 3.5-star spa hotel in Red Wing. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the restaurant and the helpful staff in ...
9/10 Wonderful! (948 reviews)
Quality reassured
"Returned to the St. James for my wife's birthday because we know we're going to get a wonderful experience, both in quality and cleanliness of the room and the professionalism and friendliness of the staff. A must stay in the area!"

Reviewed on Dec 1, 2023

St James Hotel, a Historic Hotel of America
EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
3.5 out of 5
101 11TH AVENUE SW, SUITE A, Rochester, MN
  • 17 min walk from Mayo Clinic
The price is $119 per night from Dec 15 to Dec 16
$119
per night
Dec 15 - Dec 16
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free WiFi, breakfast, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (465 reviews)
Perfect for Mayo Clinic visits
"Fantastic stay - the reception staff are outstanding. Loved the mini-gym in the room. Perfect if going to the Mayo Clinic because the shuttle is great. Can't recommend the cafe. Other than that, I give it 100%"

Reviewed on Dec 6, 2023

EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
AmericInn by Wyndham Mankato Event Center
AmericInn by Wyndham Mankato Event Center
2.5 out of 5
240 Stadium Road, Mankato, MN
  • 4 hours drive from Mayo Clinic
The price is $93 per night from Jan 2 to Jan 3
$93
per night
Jan 2 - Jan 3
Stay at this business-friendly hotel in Mankato. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (1,002 reviews)
"We were not aware that the motel does not provide cleaning services to your room daily. They have a policy to provide it every 3 days. linens were available at the desk but vacuuming etc did not happen."

Reviewed on Dec 2, 2023

AmericInn by Wyndham Mankato Event Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in Southern Minnesota

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southern Minnesota.

Choosing the right hotel in Minnesota has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southern Minnesota’s 1,059 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $73. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Southern Minnesota hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southern Minnesota. No matter your reason for visiting Southern Minnesota, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Southern Minnesota hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southern Minnesota for as low as $73.

How many hotels are there in Southern Minnesota?

With over 1,059 hotels in Southern Minnesota, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $73.

How to find cheap car rentals in Southern Minnesota?

Finding a cheap car rental deal in Southern Minnesota is as easy as scoring cheap hotels in Southern Minnesota. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Southern Minnesota now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Southern Minnesota right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.