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Choose from 1224 Southern Minnesota Hotel Deals
Kahler Grand Hotel
Med City Inn & Suites - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area
"Clean, spacious rooms."
Reviewed on Aug 31, 2026
AmericInn by Wyndham Rochester Near Mayo Clinic
"Property had a very good restaurant. Staff was very friendly."
Reviewed on Aug 31, 2026
Hotel Indigo Rochester – Mayo Clinic Area by IHG
"This is my first time staying at Hotel Indigo. The staff was amazing. I had to keep adding nights and they were so accommodating. The room was just right. It was clean , well stocked and easy access to the Mayo Clinic. I really liked the front desk people. Super friendly and helpful. Love the attached ..."
Reviewed on Aug 23, 2026
EVEN Hotel Rochester - Mayo Clinic Area by IHG
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
"The shuttle is a huge time and money saver. The motel is very well run and maintained by a friendly and courteous staff. Excellent breakfast. Also very convenient having the restaurant Twiggs attached to the hotel. Good food and good service. Highly recommended."
Reviewed on Aug 31, 2026
Express Suites Riverport Inn & Suites
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
"The room we origin were told we’d checked into was already in use so we were moved to another room. Once we got into the room the floors were damp from how humid it was in the room & the one bed was broken, sunk down where your butt would be when laying down to the point that you had to sleep on ..."
Reviewed on Aug 29, 2026
Hyatt House Rochester/Mayo Clinic Area
"Easy place to get to; helpful staff. We had a large room. The hotel was quiet. Hot tub out of order and our room was ovwrlooking the train track which, unfortunately, had a train come through in the middle of the night and woke us all up. It had a nice terrace on our floor for relaxing."
Reviewed on Aug 30, 2026
The Berkman
Find cheap hotels in Southern Minnesota
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- Hotels near Mayo Clinic
- Hotels near Mayo Clinic Hospital - Saint Marys Campus
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