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Hotels in Southern Minnesota

Choose from 1205 Southern Minnesota Hotel Deals

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
  • 2 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.4/10 Very Good! (2,084 reviews)
We did not eat at the hotel or use the pool.

Reviewed on May 12, 2026

Kahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
  • 3 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,563 reviews)
Room needs better attention. Vacuum in corners and along walls. Whomever hung pictures and mirror, didn't know what they were doing. Hire a professional next time. Mirror totally in wrong spot. Breakfast and staff helpful and pleasant. Parking, awful!! Signage badly needs updating. Diagrams on where ...

Reviewed on May 12, 2026

Kahler Inn and Suites - Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW Rochester MN
  • 7 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,015 reviews)
Room was comfortable and clean. Pool area was clean. Breakfast buffet was stocked and fresh with a variety of hot and cold items. Overall enjoyable stay within walking distance to Mayo and restaurants.

Reviewed on May 12, 2026

Hyatt House Rochester/Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
401 6th St Sw Rochester MN
  • 8 min walk from Mayo Clinic
Book a stay at this golf hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant in our reviews. ...
8.6/10 Excellent! (1,014 reviews)
Breakfast was very good. Many selections, fresh. Room was very quiet.

Reviewed on May 12, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
  • 4 min drive from Mayo Clinic
Book a stay at this spa hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful staff in our ...
8/10 Very Good! (1,321 reviews)
This hotel is NOT for anyone using a wheelchair. Although it is advertised as wheelchair accessible, it is not easy. The only automatic door was the front lobby entrance, side doors did not have easy access and the threshold of these doors were nearly impossible to get over. Our room was on the first ...

Reviewed on May 12, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

3 out of 5
1125 2nd St Sw Rochester MN
  • 18 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff ...
8.6/10 Excellent! (1,000 reviews)
It was an ok place. Old dirty small parking area. Suits for a quick overnight

Reviewed on May 7, 2026

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW Rochester MN
  • 17 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
9.4/10 Exceptional! (1,008 reviews)
Very clean contemporary room. Nice decent vanity in bathroom for two people to have room for their personal toiletries. Awesome comfy pillows. Very delicious free light breakfast.

Reviewed on May 9, 2026

EVEN Hotel Rochester - Mayo Clinic Area by IHG
Redwood Lodge

Redwood Lodge

2 out of 5
1382 E Bridge St Redwood Falls MN
  • 7 hours drive from Mayo Clinic
Stay at this hotel in Redwood Falls. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
9/10 Wonderful! (870 reviews)
Nice hotel, clean. Great breakfast!!

Reviewed on May 11, 2026

Redwood Lodge
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2.5 out of 5
1517 16th St Sw Rochester MN
  • 5 min drive from Mayo Clinic
Book a stay at this family-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.2/10 Very Good! (913 reviews)
Our first room was so dirty that the floors in the bathroom had hair and fake lashes all over. The curtains had blood on them. The hide-abed mattress was stained with what looked like blood. And blood on the pillows. The room was marked clean. I would say not. Asked for a new room and when I went ...

Reviewed on May 12, 2026

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway Rochester MN
  • 6 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (1,009 reviews)
Front desk person was there to collect a paycheck. Seemed annoyed I had some questions about parking after I checked in. No smile. Choppy personality.

Reviewed on May 12, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw Rochester MN
  • 26 min walk from Mayo Clinic
Book a stay at this family-friendly motel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,019 reviews)
Good place to stay

Reviewed on May 11, 2026

Med City Inn & Suites - Mayo Clinic Area
Express Suites Riverport Inn & Suites

Express Suites Riverport Inn & Suites

3 out of 5
900 Bruski Dr Winona MN
  • 2 hours drive from Mayo Clinic
Book a stay at this business-friendly hotel in Winona. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (1,000 reviews)
The room was large and clean with comfortable beds. Appreciated the on-site restaurant and bar, and staff were welcoming and friendly. The breakfast was good, too. Would stay here again.

Reviewed on May 12, 2026

Express Suites Riverport Inn & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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