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Byron

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Byron Flights as Low as $308

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Delta
Thu, Nov 12 - Thu, Nov 19
DTW
Detroit Metropolitan Wayne County
RST
Rochester Intl.
$308 Roundtrip, found 9 hours ago
$308
Roundtrip
found 9 hours ago
Select Delta flight, departing Thu, Nov 12 from Detroit Metropolitan Wayne County to Rochester Intl., returning Thu, Nov 19, priced at $308 found 9 hours ago
American Airlines
Tue, Nov 10 - Tue, Nov 17
DTW
Detroit Metropolitan Wayne County
RST
Rochester Intl.
$314 Roundtrip, found 15 hours ago
$314
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Tue, Nov 10 from Detroit Metropolitan Wayne County to Rochester Intl., returning Tue, Nov 17, priced at $314 found 15 hours ago
American Airlines
Sat, Nov 7 - Tue, Nov 10
EWR
Newark Liberty Intl. Airport
RST
Rochester Intl.
$325 Roundtrip, found 3 hours ago
$325
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Sat, Nov 7 from Newark Liberty Intl. Airport to Rochester Intl., returning Tue, Nov 10, priced at $325 found 3 hours ago
American Airlines
Sat, Oct 31 - Mon, Nov 9
CLE
Hopkins Intl.
RST
Rochester Intl.
$328 Roundtrip, found 23 hours ago
$328
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Sat, Oct 31 from Hopkins Intl. to Rochester Intl., returning Mon, Nov 9, priced at $328 found 23 hours ago
American Airlines
Fri, Nov 20 - Sun, Dec 6
CLE
Hopkins Intl.
RST
Rochester Intl.
$334 Roundtrip, found 2 hours ago
$334
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Fri, Nov 20 from Hopkins Intl. to Rochester Intl., returning Sun, Dec 6, priced at $334 found 2 hours ago
Delta
Fri, Oct 30 - Sun, Nov 1
BNA
Nashville Intl.
RST
Rochester Intl.
$343 Roundtrip, found 11 hours ago
$343
Roundtrip
found 11 hours ago
Select Delta flight, departing Fri, Oct 30 from Nashville Intl. to Rochester Intl., returning Sun, Nov 1, priced at $343 found 11 hours ago
American Airlines
Sat, Oct 31 - Sat, Nov 14
CLE
Hopkins Intl.
RST
Rochester Intl.
$343 Roundtrip, found 4 hours ago
$343
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Sat, Oct 31 from Hopkins Intl. to Rochester Intl., returning Sat, Nov 14, priced at $343 found 4 hours ago
American Airlines
Wed, Nov 4 - Sat, Nov 7
JFK
John F. Kennedy Intl.
RST
Rochester Intl.
$345 Roundtrip, found 1 hour ago
$345
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Wed, Nov 4 from John F. Kennedy Intl. to Rochester Intl., returning Sat, Nov 7, priced at $345 found 1 hour ago
American Airlines
Tue, Nov 3 - Mon, Nov 16
MIA
Miami Intl.
RST
Rochester Intl.
$348 Roundtrip, found 6 days ago
$348
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Nov 3 from Miami Intl. to Rochester Intl., returning Mon, Nov 16, priced at $348 found 6 days ago
Delta
Thu, Dec 24 - Tue, Jan 5
SAV
Savannah - Hilton Head Intl.
RST
Rochester Intl.
$349 Roundtrip, found 1 day ago
$349
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Dec 24 from Savannah - Hilton Head Intl. to Rochester Intl., returning Tue, Jan 5, priced at $349 found 1 day ago
American Airlines
Thu, Nov 5 - Mon, Nov 9
CLE
Hopkins Intl.
RST
Rochester Intl.
$350 Roundtrip, found 3 hours ago
$350
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Thu, Nov 5 from Hopkins Intl. to Rochester Intl., returning Mon, Nov 9, priced at $350 found 3 hours ago
Delta
Tue, Oct 13 - Tue, Oct 20
MCO
Orlando Intl.
RST
Rochester Intl.
$434 Roundtrip, found 22 hours ago
$434
Roundtrip
found 22 hours ago
Select Delta flight, departing Tue, Oct 13 from Orlando Intl. to Rochester Intl., returning Tue, Oct 20, priced at $434 found 22 hours ago
American Airlines
Tue, Nov 17 - Mon, Nov 30
SRQ
Sarasota-Bradenton Intl.
RST
Rochester Intl.
$516 Roundtrip, found 9 hours ago
$516
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Tue, Nov 17 from Sarasota-Bradenton Intl. to Rochester Intl., returning Mon, Nov 30, priced at $516 found 9 hours ago
American Airlines
Wed, Oct 14 - Sat, Oct 24
BRO
Brownsville-South Padre Island Intl.
RST
Rochester Intl.
$647 Roundtrip, found 10 hours ago
$647
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Wed, Oct 14 from Brownsville-South Padre Island Intl. to Rochester Intl., returning Sat, Oct 24, priced at $647 found 10 hours ago
American Airlines
Wed, Oct 14 - Tue, Oct 20
MFE
Miller Intl.
RST
Rochester Intl.
$663 Roundtrip, found 10 hours ago
$663
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Wed, Oct 14 from Miller Intl. to Rochester Intl., returning Tue, Oct 20, priced at $663 found 10 hours ago
American Airlines
Wed, Oct 14 - Sat, Oct 17
HRL
Valley Intl.
RST
Rochester Intl.
$678 Roundtrip, found 10 hours ago
$678
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Wed, Oct 14 from Valley Intl. to Rochester Intl., returning Sat, Oct 17, priced at $678 found 10 hours ago

Cheap Flights to Byron

Fall in love at first flight with your vacation to Byron by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Byron on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Byron, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Byron

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Byron with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the RST airport.

What is the cheapest month to fly to Byron?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Byron are in November, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Byron?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Byron.

What airport is best to fly into Byron?

When you’re planning your trip to Byron, convenience is the name of the game. Luckily, Byron Rochester Intl. Airport is nearby so you can deplane and get going on checking off everything on your Byron must-do list.

How much are flights to Byron?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Byron on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $308, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Byron?

The trick to saving a stack of cash on your flight to Byron? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $308 right now, why wait?

Byron Flight Information
Destination airport
Rochester Intl.
Destination airport IATA code
RST
Roundtrip price
$308

Last Minute Hotel Deals in Byron

Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw Rochester MN
Book a stay at this family-friendly motel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,036 reviews)
"Room itself was clean some dishes were dirty but they supplied dish soap and dish washing powder so it was an easy fix. Towels were switched out regularly along with trash taken out regularly. Hallways were clean. Sometimes a faint odor of smoke in the halls but otherwise not a bad place. Staff were ..."

Reviewed on Oct 12, 2026

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Med City Inn & Suites - Mayo Clinic Area
Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.4/10 Very Good! (2,348 reviews)
"Staff at the Kahler Grand were wonderful! The ease of access to all Mayo buildings from the hotel cannot be overstated. Definitely recommend!👍"

Reviewed on Oct 11, 2026

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Kahler Grand Hotel
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
Book a stay at this spa hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful staff in our ...
8.2/10 Very Good! (1,534 reviews)
"Place was pretty decent for the price and the bar/grill attached was good. The breakfast area is waaaay too small and breakfast was average but I’d stay there again."

Reviewed on Oct 12, 2026

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AmericInn by Wyndham Rochester Near Mayo Clinic
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
401 6th St Sw Rochester MN
Book a stay at this golf hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant in our reviews. ...
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Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
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Kahler Inn and Suites - Mayo Clinic Area
Brentwood Inn & Suites

Brentwood Inn & Suites

2.5 out of 5
123 Fourth Ave. NW Rochester MN
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a 24-hour front desk. Our guests praise the breakfast and the ...
8.8/10 Excellent! (1,006 reviews)
"I definitely recommend staying at the Brentwood if you have Mayo apts . Free parking, clean rooms, excellent staff, and of course location make this a great place. I would recommend too if your just on holiday in Rochester because of the shops and other bustling activity around."

Reviewed on Oct 12, 2026

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Brentwood Inn & Suites
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2.5 out of 5
1517 16th St Sw Rochester MN
Book a stay at this family-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.2/10 Very Good! (1,002 reviews)
"Decent with a good price including breakfast for a 2 days trip to Rochester. Close to downtown and Mayo Clinic."

Reviewed on Oct 11, 2026

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Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
The Berkman

The Berkman

3 out of 5
217 14th Ave SW Rochester MN
Book a stay at this golf aparthotel in Rochester. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
9.6/10 Exceptional! (448 reviews)
"Room was awesome! We had the 3 bedroom unit, which had a large and spacious balcony. Plenty of sunlight came through those windows. We couldn’t had had a better room!"

Reviewed on Oct 9, 2026

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The Berkman
See all 383 properties in Byron
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.