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Hotels in Southeast Minnesota

Choose from 902 Southeast Minnesota Hotel Deals

AmericInn by Wyndham Rochester Near Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Clinic
3 out of 5
1625 Broadway Ave S, Rochester, MN
  • 4 min drive from Mayo Clinic
Book a stay at this spa hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful staff in our ...
8/10 Very Good! (926 reviews)
"Staff was very nice. Comfortable bed. Nice shower. Fairly quiet for being on a busy street. Adequate bkft. No laundry or computer room."

Reviewed on Jul 11, 2025

AmericInn by Wyndham Rochester Near Mayo Clinic
Kahler Grand Hotel
Kahler Grand Hotel
3 out of 5
20 2nd Ave Sw, Rochester, MN
  • 2 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.2/10 Very Good! (1,440 reviews)
"Everything was really good. Will stay again."

Reviewed on Jul 10, 2025

Kahler Grand Hotel
Med City Inn & Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area
2.5 out of 5
435 16th Ave Nw, Rochester, MN
  • 26 min walk from Mayo Clinic
Book a stay at this family-friendly motel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,009 reviews)
Comfortable
"Rooms are comfortable."

Reviewed on Jul 13, 2025

Med City Inn & Suites - Mayo Clinic Area
Spark by Hilton Rochester South
Spark by Hilton Rochester South
3 out of 5
4165 Maine Ave SE, Rochester, MN
  • 10 min drive from Mayo Clinic
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (73 reviews)
"Pros The location is great. The rooms are clean. Air conditioner works properly. Nice scenery from the window. Breakfast area is clean. Amenities are great. Cons: The plug in the bathtub falls and prevents the water from draining. And it's very hard to set it on the open position. Therefore I was ..."

Reviewed on Jul 13, 2025

Spark by Hilton Rochester South
Hyatt House Rochester/Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area
3 out of 5
110 Civic Center Drive NW, Rochester, MN
  • 7 min walk from Mayo Clinic
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (964 reviews)
"The room was clean and spacious, beds were comfortable and it had a little kitchenette. The parking garage was full, and we had to park on the street where we could see broken bottles and intoxicated people walking around. It wasn’t the safest area to leave a vehicle."

Reviewed on Jul 12, 2025

Hyatt House Rochester/Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area
3.5 out of 5
9 3rd Ave Nw, Rochester, MN
  • 3 min walk from Mayo Clinic
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
7.8/10 Good! (1,368 reviews)
"Location to Mayo"

Reviewed on Jul 11, 2025

Kahler Inn and Suites - Mayo Clinic Area
Aspen Select
Aspen Select
3.5 out of 5
1215 2nd St SW, Rochester, MN
  • 21 min walk from Mayo Clinic
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (1,002 reviews)
"Highly recommended"

Reviewed on Jul 8, 2025

Aspen Select
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3 out of 5
4353 Canal Pl SE, Rochester, MN
  • 11 min drive from Mayo Clinic
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.2/10 Good! (1,023 reviews)
"Friendly staff , clean inside and outside property"

Reviewed on Jul 11, 2025

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 out of 5
220 S Broadway, Rochester, MN
  • 6 min walk from Mayo Clinic
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (790 reviews)
"Nice place will stay again"

Reviewed on Jul 13, 2025

Hotel Indigo Rochester – Mayo Clinic Area by IHG
EVEN Hotel Rochester - Mayo Clinic Area by IHG
EVEN Hotel Rochester - Mayo Clinic Area by IHG
4 out of 5
101 11TH Avenue SW, Suite A, Rochester, MN
  • 17 min walk from Mayo Clinic
Stay at this 4-star business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
9.4/10 Exceptional! (848 reviews)
"Lots of constructio"

Reviewed on Jul 13, 2025

EVEN Hotel Rochester - Mayo Clinic Area by IHG
St James Hotel, a Historic Hotel of America
St James Hotel, a Historic Hotel of America
3.5 out of 5
406 Main St., Red Wing, MN
  • 2 hours drive from Mayo Clinic
Stay at this 3.5-star spa hotel in Red Wing. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the comfy rooms in ...
9/10 Wonderful! (1,004 reviews)
Lovely historical hotel!
"This hotel is absolutely stunning and a must-stay when in Red Wing. So much to explore within the building itself. Wonderful on-site restaurant with a patio and weekend music. Within walking distance of everything you need. The complimentary YMCA pass is a plus."

Reviewed on Jul 6, 2025

St James Hotel, a Historic Hotel of America
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
2.5 out of 5
1517 16th St Sw, Rochester, MN
  • 5 min drive from Mayo Clinic
Book a stay at this family-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.2/10 Very Good! (643 reviews)
"The service was good"

Reviewed on Jul 12, 2025

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Southeast Minnesota

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Choosing the right hotel in Minnesota has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southeast Minnesota’s 902 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $80. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southeast Minnesota hotel deals at the last minute.

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Frequently Asked Questions About Southeast Minnesota hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Southeast Minnesota?

With over 902 hotels in Southeast Minnesota, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $80.

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