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Florence

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Florence Flights as Low as $387

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Tue, Jun 17 - Sun, Jun 22
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$387 Roundtrip, found 22 hours ago
$387
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Tue, Jun 17 from O'Hare Intl. to Northwest Alabama Regional, returning Sun, Jun 22, priced at $387 found 22 hours ago
American Airlines
Sat, Jun 21 - Sun, Jun 22
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$398 Roundtrip, found 22 hours ago
$398
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Sat, Jun 21 from O'Hare Intl. to Northwest Alabama Regional, returning Sun, Jun 22, priced at $398 found 22 hours ago
Contour Airlines
Mon, Jun 16 - Tue, Jun 24
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$402 Roundtrip, found 22 hours ago
$402
Roundtrip
found 22 hours ago
Select Contour Airlines flight, departing Mon, Jun 16 from O'Hare Intl. to Northwest Alabama Regional, returning Tue, Jun 24, priced at $402 found 22 hours ago
Contour Airlines
Mon, Jun 16 - Sun, Jun 22
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$403 Roundtrip, found 22 hours ago
$403
Roundtrip
found 22 hours ago
Select Contour Airlines flight, departing Mon, Jun 16 from O'Hare Intl. to Northwest Alabama Regional, returning Sun, Jun 22, priced at $403 found 22 hours ago
American Airlines
Wed, Jun 18 - Fri, Jun 20
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$407 Roundtrip, found 22 hours ago
$407
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Wed, Jun 18 from O'Hare Intl. to Northwest Alabama Regional, returning Fri, Jun 20, priced at $407 found 22 hours ago
Contour Airlines
Mon, Jun 16 - Fri, Jun 20
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$413 Roundtrip, found 22 hours ago
$413
Roundtrip
found 22 hours ago
Select Contour Airlines flight, departing Mon, Jun 16 from O'Hare Intl. to Northwest Alabama Regional, returning Fri, Jun 20, priced at $413 found 22 hours ago
American Airlines
Tue, Jun 17 - Wed, Jun 25
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$417 Roundtrip, found 22 hours ago
$417
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Tue, Jun 17 from O'Hare Intl. to Northwest Alabama Regional, returning Wed, Jun 25, priced at $417 found 22 hours ago
Contour Airlines
Thu, Jun 19 - Mon, Jun 23
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$422 Roundtrip, found 22 hours ago
$422
Roundtrip
found 22 hours ago
Select Contour Airlines flight, departing Thu, Jun 19 from O'Hare Intl. to Northwest Alabama Regional, returning Mon, Jun 23, priced at $422 found 22 hours ago
American Airlines
Sat, Jun 21 - Wed, Jun 25
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$428 Roundtrip, found 22 hours ago
$428
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Sat, Jun 21 from O'Hare Intl. to Northwest Alabama Regional, returning Wed, Jun 25, priced at $428 found 22 hours ago
Contour Airlines
Mon, Jun 16 - Wed, Jun 25
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$432 Roundtrip, found 22 hours ago
$432
Roundtrip
found 22 hours ago
Select Contour Airlines flight, departing Mon, Jun 16 from O'Hare Intl. to Northwest Alabama Regional, returning Wed, Jun 25, priced at $432 found 22 hours ago
American Airlines
Thu, Jun 19 - Sun, Jun 22
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$434 Roundtrip, found 22 hours ago
$434
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Thu, Jun 19 from O'Hare Intl. to Northwest Alabama Regional, returning Sun, Jun 22, priced at $434 found 22 hours ago
American Airlines
Thu, Jun 19 - Wed, Jun 25
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$437 Roundtrip, found 22 hours ago
$437
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Thu, Jun 19 from O'Hare Intl. to Northwest Alabama Regional, returning Wed, Jun 25, priced at $437 found 22 hours ago
American Airlines
Thu, Jun 19 - Thu, Jun 19
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$442 Roundtrip, found 22 hours ago
$442
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Thu, Jun 19 from O'Hare Intl. to Northwest Alabama Regional, returning Thu, Jun 19, priced at $442 found 22 hours ago
American Airlines
Thu, Jun 19 - Sun, Jun 22
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$454 Roundtrip, found 22 hours ago
$454
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Thu, Jun 19 from O'Hare Intl. to Northwest Alabama Regional, returning Sun, Jun 22, priced at $454 found 22 hours ago
American Airlines
Thu, Jun 19 - Fri, Jun 20
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$457 Roundtrip, found 22 hours ago
$457
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Thu, Jun 19 from O'Hare Intl. to Northwest Alabama Regional, returning Fri, Jun 20, priced at $457 found 22 hours ago
Contour Airlines
Fri, Jun 20 - Tue, Jun 24
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$461 Roundtrip, found 22 hours ago
$461
Roundtrip
found 22 hours ago
Select Contour Airlines flight, departing Fri, Jun 20 from O'Hare Intl. to Northwest Alabama Regional, returning Tue, Jun 24, priced at $461 found 22 hours ago

Cheap Flights to Florence

Fall in love at first flight with your vacation to Florence by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Florence on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Florence, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Florence

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Florence with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the MSL airport.

What is the cheapest month to fly to Florence?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Florence are in June, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Florence?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Florence.

What airport is best to fly into Florence?

When you’re planning your trip to Florence, convenience is the name of the game. Luckily, Florence Northwest Alabama Regional Airport is nearby so you can deplane and get going on checking off everything on your Florence must-do list.

How much are flights to Florence?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Florence on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $387, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Florence?

The trick to saving a stack of cash on your flight to Florence? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $387 right now, why wait?

Florence Flight Information
Destination airport
Florence
Destination airport IATA code
MSL

Last Minute Hotel Deals in Florence

Renaissance Shoals Resort and Spa
Renaissance Shoals Resort and Spa
3.5 out of 5
10 Hightower Place, Florence, AL
The price is $263 per night from Apr 16 to Apr 17
$263
includes taxes & fees
Apr 16 - Apr 17
Stay at this 3.5-star spa resort in Florence. Enjoy free parking, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (696 reviews)
"Everything about this place is excellent. The staff was above and beyond helpful in every possible way. This is just a really great place and we love it."

Reviewed on Mar 24, 2025

Renaissance Shoals Resort and Spa
The Stricklin Hotel
The Stricklin Hotel
3.5 out of 5
317 N Court St, Florence, AL
The price is $218 per night from Apr 17 to Apr 18
$218
includes taxes & fees
Apr 17 - Apr 18
Stay at this 3.5-star business-friendly hotel in Florence. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (664 reviews)
"Cute hotel in downtown"

Reviewed on Mar 28, 2025

The Stricklin Hotel
Comfort Suites Florence Shoals Area
Comfort Suites Florence Shoals Area
2.5 out of 5
140 Matthew Paul Ct, Florence, AL
The price is $144 per night from Apr 19 to Apr 20
$144
includes taxes & fees
Apr 19 - Apr 20
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (670 reviews)
"Nothing unique"

Reviewed on Apr 1, 2025

Comfort Suites Florence Shoals Area
Baymont by Wyndham Florence/Muscle Shoals
Baymont by Wyndham Florence/Muscle Shoals
2.5 out of 5
115 Ana Drive, Florence, AL
The price is $89 per night from Apr 16 to Apr 17
$89
includes taxes & fees
Apr 16 - Apr 17
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the property ...
7.4/10 Good! (772 reviews)
"Nice Place and nice staff"

Reviewed on Apr 12, 2025

Baymont by Wyndham Florence/Muscle Shoals
Holiday Inn Express Hotel & Suites FLORENCE NORTHEAST by IHG
Holiday Inn Express Hotel & Suites FLORENCE NORTHEAST by IHG
2.5 out of 5
180 Etta Gray Street, Florence, AL
The price is $124 per night from May 4 to May 5
$124
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (531 reviews)
Would stay again.
"Super smooth and fast check in. Hotel was super clean and beds were comfortable."

Reviewed on Mar 23, 2025

Holiday Inn Express Hotel & Suites FLORENCE NORTHEAST by IHG
Hampton Inn Florence Midtown near University of North Alabama
Hampton Inn Florence Midtown near University of North Alabama
2.5 out of 5
2281 Florence Blvd, Florence, AL
The price is $159 per night from Apr 27 to Apr 28
$159
includes taxes & fees
Apr 27 - Apr 28
Stay at this hotel in Florence. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (525 reviews)
"I don't like travel but I love this location and it was very clean and quiet. My daughter loved the breakfast. DRSTEED"

Reviewed on Mar 31, 2025

Hampton Inn Florence Midtown near University of North Alabama
Residence Inn Florence Marriott
Residence Inn Florence Marriott
3 out of 5
1000 Sweetwater Ave, Florence, AL
The price is $154 per night from Apr 27 to Apr 28
$154
includes taxes & fees
Apr 27 - Apr 28
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Regency Square Mall and Children's ...
9/10 Wonderful! (298 reviews)
Excellent all the way
"Hotel staff were effective, efficient and friendly. They made our stay so very enjoyable."

Reviewed on Apr 12, 2025

Residence Inn Florence Marriott
Budget Inn & Suites
Budget Inn & Suites
2.5 out of 5
1238 Florence Boulevard, Florence, AL
The price is $73 per night from Apr 22 to Apr 23
$73
includes taxes & fees
Apr 22 - Apr 23
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
7.4/10 Good! (102 reviews)
"Convenient location, central Florence."

Reviewed on Mar 23, 2025

Budget Inn & Suites
See all 377 properties in Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.