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Knoxville

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Knoxville Flights as Low as $172

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Mon, Aug 11 - Mon, Aug 18
DEN
Denver Intl.
DSM
Des Moines Intl.
$172 Roundtrip, found 4 days ago
$172
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Mon, Aug 11 from Denver Intl. to Des Moines Intl., returning Mon, Aug 18, priced at $172 found 4 days ago
United
Thu, Aug 21 - Thu, Aug 21
DEN
Denver Intl.
DSM
Des Moines Intl.
$187 Roundtrip, found 2 days ago
$187
Roundtrip
found 2 days ago
Select United flight, departing Thu, Aug 21 from Denver Intl. to Des Moines Intl., returning Thu, Aug 21, priced at $187 found 2 days ago
American Airlines
Mon, Aug 18 - Thu, Aug 21
DEN
Denver Intl.
DSM
Des Moines Intl.
$200 Roundtrip, found 7 hours ago
$200
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Mon, Aug 18 from Denver Intl. to Des Moines Intl., returning Thu, Aug 21, priced at $200 found 7 hours ago
Bargain Flight
Wed, Nov 12 - Sat, Nov 15
TYS
McGhee Tyson
DSM
Des Moines Intl.
$214 Roundtrip, found 1 day ago
$214
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Wed, Nov 12 from McGhee Tyson to Des Moines Intl., returning Sat, Nov 15, priced at $214 found 1 day ago
United
Tue, Aug 12 - Tue, Aug 19
BUF
Buffalo Niagara Intl.
DSM
Des Moines Intl.
$220 Roundtrip, found 5 hours ago
$220
Roundtrip
found 5 hours ago
Select United flight, departing Tue, Aug 12 from Buffalo Niagara Intl. to Des Moines Intl., returning Tue, Aug 19, priced at $220 found 5 hours ago
Bargain Flight
Wed, Jul 23 - Tue, Jul 29
PHL
Philadelphia Intl.
DSM
Des Moines Intl.
$227 Roundtrip, found 3 days ago
$227
Roundtrip
found 3 days ago
Select Bargain Flight flight, departing Wed, Jul 23 from Philadelphia Intl. to Des Moines Intl., returning Tue, Jul 29, priced at $227 found 3 days ago
American Airlines
Thu, Jul 17 - Sun, Jul 20
IAH
George Bush Intercontinental
DSM
Des Moines Intl.
$229 Roundtrip, found 22 hours ago
$229
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Thu, Jul 17 from George Bush Intercontinental to Des Moines Intl., returning Sun, Jul 20, priced at $229 found 22 hours ago
Bargain Flight
Wed, Oct 15 - Sat, Oct 25
CLT
Charlotte-Douglas Intl.
DSM
Des Moines Intl.
$234 Roundtrip, found 2 days ago
$234
Roundtrip
found 2 days ago
Select Bargain Flight flight, departing Wed, Oct 15 from Charlotte-Douglas Intl. to Des Moines Intl., returning Sat, Oct 25, priced at $234 found 2 days ago
Bargain Flight
Fri, Jul 25 - Tue, Jul 29
TPA
Tampa Intl.
DSM
Des Moines Intl.
$251 Roundtrip, found 1 day ago
$251
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Fri, Jul 25 from Tampa Intl. to Des Moines Intl., returning Tue, Jul 29, priced at $251 found 1 day ago
American Airlines
Fri, Jul 18 - Mon, Jul 21
JAX
Jacksonville Intl.
DSM
Des Moines Intl.
$265 Roundtrip, found 16 hours ago
$265
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Fri, Jul 18 from Jacksonville Intl. to Des Moines Intl., returning Mon, Jul 21, priced at $265 found 16 hours ago
Bargain Flight
Wed, Jul 9 - Tue, Jul 15
DFW
Dallas-Fort Worth Intl.
DSM
Des Moines Intl.
$265 Roundtrip, found 2 days ago
$265
Roundtrip
found 2 days ago
Select Bargain Flight flight, departing Wed, Jul 9 from Dallas-Fort Worth Intl. to Des Moines Intl., returning Tue, Jul 15, priced at $265 found 2 days ago
Delta
Sat, Aug 9 - Tue, Aug 12
ABE
Lehigh Valley Intl.
DSM
Des Moines Intl.
$274 Roundtrip, found 1 day ago
$274
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Aug 9 from Lehigh Valley Intl. to Des Moines Intl., returning Tue, Aug 12, priced at $274 found 1 day ago
Delta
Tue, Jul 15 - Tue, Jul 22
SAV
Savannah - Hilton Head Intl.
DSM
Des Moines Intl.
$297 Roundtrip, found 20 hours ago
$297
Roundtrip
found 20 hours ago
Select Delta flight, departing Tue, Jul 15 from Savannah - Hilton Head Intl. to Des Moines Intl., returning Tue, Jul 22, priced at $297 found 20 hours ago
Delta
Tue, Jul 8 - Tue, Jul 15
JAN
Evers Intl.
DSM
Des Moines Intl.
$323 Roundtrip, found 4 days ago
$323
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Jul 8 from Evers Intl. to Des Moines Intl., returning Tue, Jul 15, priced at $323 found 4 days ago
Delta
Sat, Jul 19 - Mon, Jul 21
ATL
Hartsfield-Jackson Atlanta Intl.
DSM
Des Moines Intl.
$346 Roundtrip, found 16 hours ago
$346
Roundtrip
found 16 hours ago
Select Delta flight, departing Sat, Jul 19 from Hartsfield-Jackson Atlanta Intl. to Des Moines Intl., returning Mon, Jul 21, priced at $346 found 16 hours ago
Delta
Wed, Jul 9 - Tue, Jul 15
DAL
Love Field
DSM
Des Moines Intl.
$418 Roundtrip, found 6 days ago
$418
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Jul 9 from Love Field to Des Moines Intl., returning Tue, Jul 15, priced at $418 found 6 days ago

Cheap Flights to Knoxville

Fall in love at first flight with your vacation to Knoxville by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Knoxville on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Knoxville, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Knoxville

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Knoxville with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the DSM airport.

What is the cheapest month to fly to Knoxville?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Knoxville are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Knoxville?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 11 to choose from for your flight to Knoxville.

What airport is best to fly into Knoxville?

When you’re planning your trip to Knoxville, convenience is the name of the game. Luckily, Knoxville Des Moines Intl. Airport is nearby so you can deplane and get going on checking off everything on your Knoxville must-do list.

How much are flights to Knoxville?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Knoxville on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $172, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Knoxville?

The trick to saving a stack of cash on your flight to Knoxville? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $172 right now, why wait?

Knoxville Flight Information
Destination airport
Des Moines Intl.
Destination airport IATA code
DSM
Roundtrip price
$171

Last Minute Hotel Deals in Knoxville

Cobblestone Hotel & Suites - Knoxville
Cobblestone Hotel & Suites - Knoxville
2.5 out of 5
1212 Eric Dr, Knoxville, IA
Book a stay at this business-friendly hotel in Knoxville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (421 reviews)
"A/C didn't keep the room very cool."

Reviewed on Jun 16, 2025

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Cobblestone Hotel & Suites - Knoxville
Super 8 by Wyndham Knoxville
Super 8 by Wyndham Knoxville
2 out of 5
2205 N Lincoln St, Knoxville, IA
Book a stay at this business-friendly motel in Knoxville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions National Sprint Car Hall of ...
6.6/10 (277 reviews)
"The shower head did not work properly because water was continually running somewhere behind the wall causing very low pressure."

Reviewed on Jun 16, 2025

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Super 8 by Wyndham Knoxville
Charming Iowa Abode Near Knoxville Raceway!
Charming Iowa Abode Near Knoxville Raceway!
3 out of 5
Knoxville
Stay at this 3-star cottage in Knoxville. Enjoy free parking, a marina, and air conditioning. Popular attractions Peace Tree Brewing Company and National Sprint ...
Nice place- would stay again
"There are no pet friendly hotels in Knoxville so we were very happy to find this pretty house for our stay when back for a family funeral. Pros: ample parking, good location, very clean, large space, nice kitchen, large yard, DISH TV, pet friendly, rapid response from owner, sleeps multiple people ..."

Reviewed on Nov 10, 2023

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Charming Iowa Abode Near Knoxville Raceway!
Hot Tub, Water Access: Cabin Near Lake Red Rock!
Hot Tub, Water Access: Cabin Near Lake Red Rock!
3 out of 5
Knoxville
Stay at this 3-star cottage in Knoxville. Enjoy free parking, balconies, and air conditioning. Popular attractions Bos Landen Golf Club and Lake Red Rock are ...
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Hot Tub, Water Access: Cabin Near Lake Red Rock!
EverSpring Inn & Suites
EverSpring Inn & Suites
2.5 out of 5
2401 A Ave West, Oskaloosa, IA
Book a stay at this business-friendly hotel in Oskaloosa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8/10 Very Good! (595 reviews)
"The staff were lovely and friendly. Breakfast was more hit and miss over the weekend. Cutlery out of a dispenser was very hygienic, but coming from the UK I could not get used to the lack of recycling and throwaway culture of breakfast. I would go back and stay, and for anyone going for graduation ..."

Reviewed on Jun 3, 2025

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EverSpring Inn & Suites
Baymont by Wyndham Pella
Baymont by Wyndham Pella
2.5 out of 5
2104 Washington St, Pella, IA
Book a stay at this business-friendly hotel in Pella. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (928 reviews)
"nice bed"

Reviewed on Jun 16, 2025

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Baymont by Wyndham Pella
Country Inn & Suites by Radisson, Indianola, IA
Country Inn & Suites by Radisson, Indianola, IA
2.5 out of 5
501 E Trail Ridge Avenue, Indianola, IA
Book a stay at this business-friendly hotel in Indianola. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (637 reviews)
"Very nice. Clean. Friendly staff"

Reviewed on Jun 9, 2025

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Country Inn & Suites by Radisson, Indianola, IA
Links Bos Landen Hotel & Spa of Pella, Trademark by Wyndham
Links Bos Landen Hotel & Spa of Pella, Trademark by Wyndham
2.5 out of 5
2508 Bos Landen Dr, Pella, IA
Book a stay at this golf hotel in Pella. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.4/10 Very Good! (581 reviews)
"A clean modern oasis in a sea of older, smaller, motels. The food is better here and there are plenty of electrical outlets."

Reviewed on Jun 17, 2025

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Links Bos Landen Hotel & Spa of Pella, Trademark by Wyndham
See all 100 properties in Knoxville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.