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Knoxville

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Knoxville Flights as Low as $160

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, May 21 - Fri, May 30
DEN
Denver Intl.
DSM
Des Moines Intl.
$160 Roundtrip, found 3 days ago
$160
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Wed, May 21 from Denver Intl. to Des Moines Intl., returning Fri, May 30, priced at $160 found 3 days ago
American Airlines
Tue, Jun 24 - Tue, Jul 22
PHX
Sky Harbor Intl.
DSM
Des Moines Intl.
$183 Roundtrip, found 4 days ago
$183
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Jun 24 from Sky Harbor Intl. to Des Moines Intl., returning Tue, Jul 22, priced at $183 found 4 days ago
American Airlines
Fri, Aug 1 - Mon, Aug 4
ORD
O'Hare Intl.
DSM
Des Moines Intl.
$189 Roundtrip, just found
$189
Roundtrip
just found
Select American Airlines flight, departing Fri, Aug 1 from O'Hare Intl. to Des Moines Intl., returning Mon, Aug 4, priced at $189 just found
United
Fri, Aug 1 - Mon, Aug 4
ORD
O'Hare Intl.
DSM
Des Moines Intl.
$189 Roundtrip, just found
$189
Roundtrip
just found
Select United flight, departing Fri, Aug 1 from O'Hare Intl. to Des Moines Intl., returning Mon, Aug 4, priced at $189 just found
Bargain Flight
Tue, Aug 12 - Tue, Aug 19
CLE
Hopkins Intl.
DSM
Des Moines Intl.
$200 Roundtrip, found 8 hours ago
$200
Roundtrip
found 8 hours ago
Select Bargain Flight flight, departing Tue, Aug 12 from Hopkins Intl. to Des Moines Intl., returning Tue, Aug 19, priced at $200 found 8 hours ago
Frontier Airlines
Mon, May 19 - Wed, May 21
DFW
Dallas-Fort Worth Intl.
DSM
Des Moines Intl.
$202 Roundtrip, found 4 days ago
$202
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Mon, May 19 from Dallas-Fort Worth Intl. to Des Moines Intl., returning Wed, May 21, priced at $202 found 4 days ago
Frontier Airlines
Fri, May 30 - Mon, Jun 2
DCA
Ronald Reagan Washington National
DSM
Des Moines Intl.
$214 Roundtrip, found 13 hours ago
$214
Roundtrip
found 13 hours ago
Select Frontier Airlines flight, departing Fri, May 30 from Ronald Reagan Washington National to Des Moines Intl., returning Mon, Jun 2, priced at $214 found 13 hours ago
Delta
Tue, Jun 17 - Tue, Jun 24
DEN
Denver Intl.
DSM
Des Moines Intl.
$226 Roundtrip, found 1 day ago
$226
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Jun 17 from Denver Intl. to Des Moines Intl., returning Tue, Jun 24, priced at $226 found 1 day ago
Delta
Tue, Jun 17 - Tue, Jun 24
IAH
George Bush Intercontinental
DSM
Des Moines Intl.
$233 Roundtrip, found 16 hours ago
$233
Roundtrip
found 16 hours ago
Select Delta flight, departing Tue, Jun 17 from George Bush Intercontinental to Des Moines Intl., returning Tue, Jun 24, priced at $233 found 16 hours ago
Bargain Flight
Wed, Sep 17 - Tue, Sep 30
SLC
Salt Lake City Intl.
DSM
Des Moines Intl.
$236 Roundtrip, found 13 hours ago
$236
Roundtrip
found 13 hours ago
Select Bargain Flight flight, departing Wed, Sep 17 from Salt Lake City Intl. to Des Moines Intl., returning Tue, Sep 30, priced at $236 found 13 hours ago
Delta
Wed, May 28 - Tue, Jun 3
IAD
Washington Dulles Intl.
DSM
Des Moines Intl.
$261 Roundtrip, found 13 hours ago
$261
Roundtrip
found 13 hours ago
Select Delta flight, departing Wed, May 28 from Washington Dulles Intl. to Des Moines Intl., returning Tue, Jun 3, priced at $261 found 13 hours ago
Bargain Flight
Tue, Jun 3 - Sat, Jun 14
MCO
Orlando Intl.
DSM
Des Moines Intl.
$264 Roundtrip, found 1 day ago
$264
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Tue, Jun 3 from Orlando Intl. to Des Moines Intl., returning Sat, Jun 14, priced at $264 found 1 day ago
Delta
Wed, Jun 25 - Wed, Jul 9
PNS
Pensacola Intl.
DSM
Des Moines Intl.
$275 Roundtrip, found 2 days ago
$275
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Jun 25 from Pensacola Intl. to Des Moines Intl., returning Wed, Jul 9, priced at $275 found 2 days ago
United
Wed, Jun 25 - Wed, Jul 2
PDX
Portland Intl.
DSM
Des Moines Intl.
$303 Roundtrip, found 21 hours ago
$303
Roundtrip
found 21 hours ago
Select United flight, departing Wed, Jun 25 from Portland Intl. to Des Moines Intl., returning Wed, Jul 2, priced at $303 found 21 hours ago
Delta
Tue, Jun 24 - Sat, Jun 28
DAL
Love Field
DSM
Des Moines Intl.
$382 Roundtrip, found 5 days ago
$382
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Jun 24 from Love Field to Des Moines Intl., returning Sat, Jun 28, priced at $382 found 5 days ago
Delta
Fri, May 23 - Mon, May 26
HOU
William P. Hobby
DSM
Des Moines Intl.
$727 Roundtrip, found 17 hours ago
$727
Roundtrip
found 17 hours ago
Select Delta flight, departing Fri, May 23 from William P. Hobby to Des Moines Intl., returning Mon, May 26, priced at $727 found 17 hours ago

Cheap Flights to Knoxville

Fall in love at first flight with your vacation to Knoxville by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Knoxville on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Knoxville, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Knoxville

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Knoxville with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the DSM airport.

What is the cheapest month to fly to Knoxville?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Knoxville are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Knoxville?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 13 to choose from for your flight to Knoxville.

What airport is best to fly into Knoxville?

When you’re planning your trip to Knoxville, convenience is the name of the game. Luckily, Knoxville Des Moines Intl. Airport is nearby so you can deplane and get going on checking off everything on your Knoxville must-do list.

How much are flights to Knoxville?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Knoxville on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $160, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Knoxville?

The trick to saving a stack of cash on your flight to Knoxville? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $160 right now, why wait?

Knoxville Flight Information
Destination airport
Des Moines Intl.
Destination airport IATA code
DSM
Roundtrip price
$160

Last Minute Hotel Deals in Knoxville

Cobblestone Hotel & Suites - Knoxville
Cobblestone Hotel & Suites - Knoxville
2.5 out of 5
1212 Eric Dr, Knoxville, IA
The price is $122 per night from May 11 to May 12
$122
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Knoxville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (405 reviews)
"Everything was good!"

Reviewed on May 2, 2025

Cobblestone Hotel & Suites - Knoxville
Super 8 by Wyndham Knoxville
Super 8 by Wyndham Knoxville
2 out of 5
2205 N Lincoln St, Knoxville, IA
The price is $90 per night from Jun 2 to Jun 3
$90
includes taxes & fees
Jun 2 - Jun 3
Book a stay at this business-friendly motel in Knoxville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions National Sprint Car Hall of ...
6.6/10 (265 reviews)
"Very clean and modern rooms. Extra blankets in the room would have been nice."

Reviewed on Mar 5, 2025

Super 8 by Wyndham Knoxville
Charming Iowa Abode Near Knoxville Raceway!
Charming Iowa Abode Near Knoxville Raceway!
3 out of 5
Knoxville
Stay at this 3-star cottage in Knoxville. Enjoy free parking, a marina, and air conditioning. Popular attractions Peace Tree Brewing Company and National Sprint ...
8/10 Very Good! (1 review)
Nice place- would stay again
"There are no pet friendly hotels in Knoxville so we were very happy to find this pretty house for our stay when back for a family funeral. Pros: ample parking, good location, very clean, large space, nice kitchen, large yard, DISH TV, pet friendly, rapid response from owner, sleeps multiple people ..."

Reviewed on Nov 10, 2023

Get rates
Charming Iowa Abode Near Knoxville Raceway!
Red Carpet Motel
Red Carpet Motel
2 out of 5
1702 North Lincoln Street, Knoxville, IA
Book a stay at this business-friendly motel in Knoxville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in our ...
5.8/10 (108 reviews)
"Yes"

Reviewed on Jul 28, 2024

Get rates
Red Carpet Motel
Country Inn & Suites by Radisson, Indianola, IA
Country Inn & Suites by Radisson, Indianola, IA
2.5 out of 5
501 E Trail Ridge Avenue, Indianola, IA
The price is $132 per night from May 25 to May 26
$132
includes taxes & fees
May 25 - May 26
Book a stay at this business-friendly hotel in Indianola. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (623 reviews)
"The room we stayed in had drywall missing due to water damage in the bathroom. Carpet in hallway was old and had areas where it was loose. The facility was clean. Bed was too soft for my liking."

Reviewed on May 3, 2025

Country Inn & Suites by Radisson, Indianola, IA
Baymont by Wyndham Pella
Baymont by Wyndham Pella
2.5 out of 5
2104 Washington St, Pella, IA
The price is $85 per night from May 12 to May 13
$85
includes taxes & fees
May 12 - May 13
Book a stay at this business-friendly hotel in Pella. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (904 reviews)
"Nice place to stay"

Reviewed on May 4, 2025

Baymont by Wyndham Pella
Links Bos Landen Hotel & Spa of Pella, Trademark by Wyndham
Links Bos Landen Hotel & Spa of Pella, Trademark by Wyndham
2.5 out of 5
2508 Bos Landen Dr, Pella, IA
The price is $105 per night from May 7 to May 8
$105
includes taxes & fees
May 7 - May 8
Book a stay at this golf hotel in Pella. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.4/10 Very Good! (565 reviews)
"Having a two room suite was wonderful with a baby. All conveniences in kitchen! Cute pool area, water warm and clean. Staff kind and attentive. Very close to Pella"

Reviewed on May 3, 2025

Links Bos Landen Hotel & Spa of Pella, Trademark by Wyndham
Days Inn by Wyndham Newton
Days Inn by Wyndham Newton
2 out of 5
1605 W 19th St S, Newton, IA
The price is $67 per night from May 7 to May 8
$67
includes taxes & fees
May 7 - May 8
Book a stay at this business-friendly hotel in Newton. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Jasper County Historical Museum ...
7.4/10 Good! (454 reviews)
"Safe and quiet"

Reviewed on Apr 13, 2025

Days Inn by Wyndham Newton
See all 96 properties in Knoxville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.