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Knoxville

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Knoxville Flights as Low as $138

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Thu, Nov 26 - Thu, Dec 3
DEN
Denver Intl.
DSM
Des Moines Intl.
$138 Roundtrip, found 1 hour ago
$138
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Thu, Nov 26 from Denver Intl. to Des Moines Intl., returning Thu, Dec 3, priced at $138 found 1 hour ago
Allegiant Air
Fri, Oct 23 - Mon, Oct 26
AZA
Phoenix - Mesa Gateway
DSM
Des Moines Intl.
$236 Roundtrip, found 5 days ago
$236
Roundtrip
found 5 days ago
Select Allegiant Air flight, departing Fri, Oct 23 from Phoenix - Mesa Gateway to Des Moines Intl., returning Mon, Oct 26, priced at $236 found 5 days ago
Bargain Flight
Wed, Jan 6 - Sun, Jan 24
TYS
McGhee Tyson
DSM
Des Moines Intl.
$247 Roundtrip, found 4 days ago
$247
Roundtrip
found 4 days ago
Select Bargain Flight flight, departing Wed, Jan 6 from McGhee Tyson to Des Moines Intl., returning Sun, Jan 24, priced at $247 found 4 days ago
Bargain Flight
Sat, Apr 3 - Sat, Apr 10
ATL
Hartsfield-Jackson Atlanta Intl.
DSM
Des Moines Intl.
$276 Roundtrip, found 23 hours ago
$276
Roundtrip
found 23 hours ago
Select Bargain Flight flight, departing Sat, Apr 3 from Hartsfield-Jackson Atlanta Intl. to Des Moines Intl., returning Sat, Apr 10, priced at $276 found 23 hours ago
Frontier Airlines
Thu, Dec 24 - Thu, Dec 31
SMF
Sacramento Intl.
DSM
Des Moines Intl.
$279 Roundtrip, found 1 day ago
$279
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Dec 24 from Sacramento Intl. to Des Moines Intl., returning Thu, Dec 31, priced at $279 found 1 day ago
Frontier Airlines
Sun, Nov 8 - Fri, Nov 13
SAT
San Antonio Intl.
DSM
Des Moines Intl.
$279 Roundtrip, found 4 days ago
$279
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Sun, Nov 8 from San Antonio Intl. to Des Moines Intl., returning Fri, Nov 13, priced at $279 found 4 days ago
American Airlines
Fri, Jan 1 - Tue, Jan 5
ORD
O'Hare Intl.
DSM
Des Moines Intl.
$287 Roundtrip, found 12 hours ago
$287
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Fri, Jan 1 from O'Hare Intl. to Des Moines Intl., returning Tue, Jan 5, priced at $287 found 12 hours ago
Bargain Flight
Sat, Oct 24 - Tue, Oct 27
PIT
Pittsburgh Intl.
DSM
Des Moines Intl.
$293 Roundtrip, found 4 days ago
$293
Roundtrip
found 4 days ago
Select Bargain Flight flight, departing Sat, Oct 24 from Pittsburgh Intl. to Des Moines Intl., returning Tue, Oct 27, priced at $293 found 4 days ago
Bargain Flight
Sun, Nov 22 - Thu, Nov 26
DCA
Ronald Reagan Washington National
DSM
Des Moines Intl.
$296 Roundtrip, found 2 days ago
$296
Roundtrip
found 2 days ago
Select Bargain Flight flight, departing Sun, Nov 22 from Ronald Reagan Washington National to Des Moines Intl., returning Thu, Nov 26, priced at $296 found 2 days ago
Bargain Flight
Mon, Nov 23 - Tue, Dec 8
CHS
Charleston Intl.
DSM
Des Moines Intl.
$308 Roundtrip, found 12 hours ago
$308
Roundtrip
found 12 hours ago
Select Bargain Flight flight, departing Mon, Nov 23 from Charleston Intl. to Des Moines Intl., returning Tue, Dec 8, priced at $308 found 12 hours ago
Frontier Airlines
Sat, Nov 21 - Sun, Dec 13
SEA
Seattle - Tacoma Intl.
DSM
Des Moines Intl.
$310 Roundtrip, found 4 days ago
$310
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Sat, Nov 21 from Seattle - Tacoma Intl. to Des Moines Intl., returning Sun, Dec 13, priced at $310 found 4 days ago
Bargain Flight
Tue, Nov 3 - Thu, Nov 12
BOS
Logan Intl.
DSM
Des Moines Intl.
$317 Roundtrip, found 11 hours ago
$317
Roundtrip
found 11 hours ago
Select Bargain Flight flight, departing Tue, Nov 3 from Logan Intl. to Des Moines Intl., returning Thu, Nov 12, priced at $317 found 11 hours ago
Frontier Airlines
Mon, Nov 16 - Sun, Nov 22
IAH
George Bush Intercontinental
DSM
Des Moines Intl.
$318 Roundtrip, found 11 hours ago
$318
Roundtrip
found 11 hours ago
Select Frontier Airlines flight, departing Mon, Nov 16 from George Bush Intercontinental to Des Moines Intl., returning Sun, Nov 22, priced at $318 found 11 hours ago
American Airlines
Tue, Nov 24 - Tue, Dec 1
CAE
Columbia Metropolitan
DSM
Des Moines Intl.
$321 Roundtrip, found 12 hours ago
$321
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Tue, Nov 24 from Columbia Metropolitan to Des Moines Intl., returning Tue, Dec 1, priced at $321 found 12 hours ago
Bargain Flight
Mon, Oct 26 - Mon, Nov 2
LAX
Los Angeles Intl.
DSM
Des Moines Intl.
$324 Roundtrip, found 9 hours ago
$324
Roundtrip
found 9 hours ago
Select Bargain Flight flight, departing Mon, Oct 26 from Los Angeles Intl. to Des Moines Intl., returning Mon, Nov 2, priced at $324 found 9 hours ago
Delta
Sat, Nov 14 - Mon, Nov 16
SDF
Louisville Intl.
DSM
Des Moines Intl.
$335 Roundtrip, found 1 day ago
$335
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Nov 14 from Louisville Intl. to Des Moines Intl., returning Mon, Nov 16, priced at $335 found 1 day ago

Cheap Flights to Knoxville

Fall in love at first flight with your vacation to Knoxville by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Knoxville on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Knoxville, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Knoxville

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Knoxville with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the DSM airport.

What is the cheapest month to fly to Knoxville?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Knoxville are in November, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Knoxville?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 9 to choose from for your flight to Knoxville.

What airport is best to fly into Knoxville?

When you’re planning your trip to Knoxville, convenience is the name of the game. Luckily, Knoxville Des Moines Intl. Airport is nearby so you can deplane and get going on checking off everything on your Knoxville must-do list.

How much are flights to Knoxville?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Knoxville on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $138, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Knoxville?

The trick to saving a stack of cash on your flight to Knoxville? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $138 right now, why wait?

Knoxville Flight Information
Destination airport
Des Moines Intl.
Destination airport IATA code
DSM
Roundtrip price
$138

Last Minute Hotel Deals in Knoxville

Cobblestone Hotel & Suites - Knoxville

Cobblestone Hotel & Suites - Knoxville

2.5 out of 5
1212 Eric Dr Knoxville IA
Book a stay at this business-friendly hotel in Knoxville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (551 reviews)
"There is not one thing that detracts from how nice this place is and I've traveled a bit recently. The staff exceeded expectations.. we've gotten so used to people that clearly don't want to be at their job that the smiles, politeness and genuine interest in how our room was surprised us all. We ..."

Reviewed on Oct 15, 2026

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Cobblestone Hotel & Suites - Knoxville
Super 8 by Wyndham Knoxville

Super 8 by Wyndham Knoxville

2 out of 5
2205 N Lincoln St Knoxville IA
Book a stay at this business-friendly motel in Knoxville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions National Sprint Car Hall of ...
6.8/10 (324 reviews)
"Don't waste your time with this place"

Reviewed on Sep 29, 2026

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Super 8 by Wyndham Knoxville
Links Bos Landen Hotel & Spa of Pella, Trademark by Wyndham

Links Bos Landen Hotel & Spa of Pella, Trademark by Wyndham

2.5 out of 5
2508 Bos Landen Dr Pella IA
Book a stay at this golf hotel in Pella. Enjoy free breakfast, free parking, and a 24-hour fitness center. Our guests praise the helpful staff and the clean ...
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Links Bos Landen Hotel & Spa of Pella, Trademark by Wyndham
Days Inn by Wyndham Newton

Days Inn by Wyndham Newton

2 out of 5
1605 W 19th St S Newton IA
Book a stay at this business-friendly hotel in Newton. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Jasper County Historical Museum ...
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Days Inn by Wyndham Newton
EverSpring Inn & Suites

EverSpring Inn & Suites

2.5 out of 5
2401 A Ave West Oskaloosa IA
Book a stay at this business-friendly hotel in Oskaloosa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8/10 Very Good! (760 reviews)
"Room was clean, bed and pillows were comfy, pool and hot tub not available, and haven't been for quite some time. Seem to be short on staff, those that they have seem to be trying hard. Breakfast was ok, food could be hotter, and waffle batter was all liquid one day and wouldn't come out of the dispenser ..."

Reviewed on Oct 15, 2026

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EverSpring Inn & Suites
Cobblestone Inn & Suites - Newton

Cobblestone Inn & Suites - Newton

2.5 out of 5
4222 S 22nd Avenue E Newton IA
Book a stay at this business-friendly hotel in Newton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (912 reviews)
"This was a homerun "winner" hotel until new ownership took over. I'll refrain from specifically disparaging a particular demographic, but our experience with this ownership matches everything we've experienced at other properties owned by similar people. They come from a culture where the standards ..."

Reviewed on Oct 16, 2026

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Cobblestone Inn & Suites - Newton
Fairfield Inn & Suites by Marriott Oskaloosa

Fairfield Inn & Suites by Marriott Oskaloosa

3 out of 5
2325 COAL MINE LOOP Oskaloosa IA
Book a stay at this business-friendly hotel in Oskaloosa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
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Fairfield Inn & Suites by Marriott Oskaloosa
Baymont by Wyndham Pella

Baymont by Wyndham Pella

2.5 out of 5
2104 Washington St Pella IA
Book a stay at this business-friendly hotel in Pella. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
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Baymont by Wyndham Pella
See all 113 properties in Knoxville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.