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Knoxville

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Knoxville Flights as Low as $148

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Mon, Aug 18 - Thu, Aug 21
DEN
Denver Intl.
DSM
Des Moines Intl.
$148 Roundtrip, found 1 day ago
$148
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Mon, Aug 18 from Denver Intl. to Des Moines Intl., returning Thu, Aug 21, priced at $148 found 1 day ago
American Airlines
Tue, Jul 29 - Wed, Jul 30
PHX
Sky Harbor Intl.
DSM
Des Moines Intl.
$189 Roundtrip, found 9 hours ago
$189
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Tue, Jul 29 from Sky Harbor Intl. to Des Moines Intl., returning Wed, Jul 30, priced at $189 found 9 hours ago
American Airlines
Mon, Jul 14 - Sat, Jul 19
ORD
O'Hare Intl.
DSM
Des Moines Intl.
$192 Roundtrip, found 2 days ago
$192
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Jul 14 from O'Hare Intl. to Des Moines Intl., returning Sat, Jul 19, priced at $192 found 2 days ago
Bargain Flight
Tue, Jun 10 - Tue, Jun 17
DAY
James M. Cox Dayton Intl.
DSM
Des Moines Intl.
$200 Roundtrip, found 1 day ago
$200
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Tue, Jun 10 from James M. Cox Dayton Intl. to Des Moines Intl., returning Tue, Jun 17, priced at $200 found 1 day ago
Bargain Flight
Wed, Aug 13 - Tue, Aug 19
CLE
Hopkins Intl.
DSM
Des Moines Intl.
$201 Roundtrip, found 1 day ago
$201
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Wed, Aug 13 from Hopkins Intl. to Des Moines Intl., returning Tue, Aug 19, priced at $201 found 1 day ago
United
Tue, Jun 17 - Tue, Jun 24
IAH
George Bush Intercontinental
DSM
Des Moines Intl.
$213 Roundtrip, found 17 hours ago
$213
Roundtrip
found 17 hours ago
Select United flight, departing Tue, Jun 17 from George Bush Intercontinental to Des Moines Intl., returning Tue, Jun 24, priced at $213 found 17 hours ago
Bargain Flight
Fri, Jul 4 - Sat, Jul 5
COS
Colorado Springs
DSM
Des Moines Intl.
$215 Roundtrip, found 3 days ago
$215
Roundtrip
found 3 days ago
Select Bargain Flight flight, departing Fri, Jul 4 from Colorado Springs to Des Moines Intl., returning Sat, Jul 5, priced at $215 found 3 days ago
Delta
Sun, Jul 27 - Tue, Jul 29
PHL
Philadelphia Intl.
DSM
Des Moines Intl.
$237 Roundtrip, found 1 day ago
$237
Roundtrip
found 1 day ago
Select Delta flight, departing Sun, Jul 27 from Philadelphia Intl. to Des Moines Intl., returning Tue, Jul 29, priced at $237 found 1 day ago
Frontier Airlines
Mon, Jun 9 - Mon, Jun 16
DFW
Dallas-Fort Worth Intl.
DSM
Des Moines Intl.
$245 Roundtrip, found 2 days ago
$245
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Mon, Jun 9 from Dallas-Fort Worth Intl. to Des Moines Intl., returning Mon, Jun 16, priced at $245 found 2 days ago
Bargain Flight
Sat, Sep 6 - Sat, Sep 13
LAX
Los Angeles Intl.
DSM
Des Moines Intl.
$255 Roundtrip, found 1 day ago
$255
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Sat, Sep 6 from Los Angeles Intl. to Des Moines Intl., returning Sat, Sep 13, priced at $255 found 1 day ago
Delta
Thu, Jun 19 - Tue, Jun 24
EWR
Newark Liberty Intl. Airport
DSM
Des Moines Intl.
$259 Roundtrip, found 1 day ago
$259
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Jun 19 from Newark Liberty Intl. Airport to Des Moines Intl., returning Tue, Jun 24, priced at $259 found 1 day ago
Bargain Flight
Wed, Jul 9 - Tue, Jul 15
DCA
Ronald Reagan Washington National
DSM
Des Moines Intl.
$263 Roundtrip, found 1 day ago
$263
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Wed, Jul 9 from Ronald Reagan Washington National to Des Moines Intl., returning Tue, Jul 15, priced at $263 found 1 day ago
Bargain Flight
Tue, Jul 22 - Tue, Jul 29
MCO
Orlando Intl.
DSM
Des Moines Intl.
$271 Roundtrip, found 13 hours ago
$271
Roundtrip
found 13 hours ago
Select Bargain Flight flight, departing Tue, Jul 22 from Orlando Intl. to Des Moines Intl., returning Tue, Jul 29, priced at $271 found 13 hours ago
Delta
Wed, Jun 25 - Tue, Jul 1
LGA
LaGuardia
DSM
Des Moines Intl.
$300 Roundtrip, found 22 hours ago
$300
Roundtrip
found 22 hours ago
Select Delta flight, departing Wed, Jun 25 from LaGuardia to Des Moines Intl., returning Tue, Jul 1, priced at $300 found 22 hours ago
Bargain Flight
Wed, Sep 17 - Tue, Sep 30
SLC
Salt Lake City Intl.
DSM
Des Moines Intl.
$302 Roundtrip, found 10 hours ago
$302
Roundtrip
found 10 hours ago
Select Bargain Flight flight, departing Wed, Sep 17 from Salt Lake City Intl. to Des Moines Intl., returning Tue, Sep 30, priced at $302 found 10 hours ago
Bargain Flight
Sun, Jun 8 - Tue, Jun 10
JAX
Jacksonville Intl.
DSM
Des Moines Intl.
$321 Roundtrip, found 1 day ago
$321
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Sun, Jun 8 from Jacksonville Intl. to Des Moines Intl., returning Tue, Jun 10, priced at $321 found 1 day ago

Cheap Flights to Knoxville

Fall in love at first flight with your vacation to Knoxville by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Knoxville on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Knoxville, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Knoxville

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Knoxville with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the DSM airport.

What is the cheapest month to fly to Knoxville?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Knoxville are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Knoxville?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 8 to choose from for your flight to Knoxville.

What airport is best to fly into Knoxville?

When you’re planning your trip to Knoxville, convenience is the name of the game. Luckily, Knoxville Des Moines Intl. Airport is nearby so you can deplane and get going on checking off everything on your Knoxville must-do list.

How much are flights to Knoxville?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Knoxville on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $148, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Knoxville?

The trick to saving a stack of cash on your flight to Knoxville? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $148 right now, why wait?

Knoxville Flight Information
Destination airport
Des Moines Intl.
Destination airport IATA code
DSM
Roundtrip price
$148

Last Minute Hotel Deals in Knoxville

Cobblestone Hotel & Suites - Knoxville
Cobblestone Hotel & Suites - Knoxville
2.5 out of 5
1212 Eric Dr, Knoxville, IA
Book a stay at this business-friendly hotel in Knoxville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (414 reviews)
"Nice"

Reviewed on May 21, 2025

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Cobblestone Hotel & Suites - Knoxville
Super 8 by Wyndham Knoxville
Super 8 by Wyndham Knoxville
2 out of 5
2205 N Lincoln St, Knoxville, IA
Book a stay at this business-friendly motel in Knoxville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions National Sprint Car Hall of ...
6.6/10 (274 reviews)
"-"

Reviewed on May 4, 2025

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Super 8 by Wyndham Knoxville
Charming Iowa Abode Near Knoxville Raceway!
Charming Iowa Abode Near Knoxville Raceway!
3 out of 5
Knoxville
Stay at this 3-star cottage in Knoxville. Enjoy free parking, a marina, and air conditioning. Popular attractions Peace Tree Brewing Company and National Sprint ...
Nice place- would stay again
"There are no pet friendly hotels in Knoxville so we were very happy to find this pretty house for our stay when back for a family funeral. Pros: ample parking, good location, very clean, large space, nice kitchen, large yard, DISH TV, pet friendly, rapid response from owner, sleeps multiple people ..."

Reviewed on Nov 10, 2023

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Charming Iowa Abode Near Knoxville Raceway!
Hot Tub, Water Access: Cabin Near Lake Red Rock!
Hot Tub, Water Access: Cabin Near Lake Red Rock!
3 out of 5
Knoxville
Stay at this 3-star cottage in Knoxville. Enjoy free parking, balconies, and air conditioning. Popular attractions Bos Landen Golf Club and Lake Red Rock are ...
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Hot Tub, Water Access: Cabin Near Lake Red Rock!
Baymont by Wyndham Pella
Baymont by Wyndham Pella
2.5 out of 5
2104 Washington St, Pella, IA
Book a stay at this business-friendly hotel in Pella. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (915 reviews)
"Great location for our trip, close to other areas we’re going to visit."

Reviewed on May 14, 2025

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Baymont by Wyndham Pella
Country Inn & Suites by Radisson, Indianola, IA
Country Inn & Suites by Radisson, Indianola, IA
2.5 out of 5
501 E Trail Ridge Avenue, Indianola, IA
Book a stay at this business-friendly hotel in Indianola. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (633 reviews)
"Business related and chose this location as it had a gym. I arrived and the gym was closed for repairs. Sad….it should be updated daily on your website and links through secondary booking options!"

Reviewed on May 21, 2025

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Country Inn & Suites by Radisson, Indianola, IA
Days Inn by Wyndham Newton
Days Inn by Wyndham Newton
2 out of 5
1605 W 19th St S, Newton, IA
Book a stay at this business-friendly hotel in Newton. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Jasper County Historical Museum ...
7.4/10 Good! (463 reviews)
"the room was comfortable, clean and quiet and the bed was extremely comfortable!"

Reviewed on May 23, 2025

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Days Inn by Wyndham Newton
Links Bos Landen Hotel & Spa of Pella, Trademark by Wyndham
Links Bos Landen Hotel & Spa of Pella, Trademark by Wyndham
2.5 out of 5
2508 Bos Landen Dr, Pella, IA
Book a stay at this golf hotel in Pella. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.4/10 Very Good! (572 reviews)
"Fair price, clean well managed facility near very good golf course"

Reviewed on May 21, 2025

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Links Bos Landen Hotel & Spa of Pella, Trademark by Wyndham
See all 100 properties in Knoxville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.