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Lake City

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Lake City Flights as Low as $283

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Tue, Jul 14 - Sat, Jul 25
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$283 Roundtrip, found 17 hours ago
$283
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Tue, Jul 14 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 25, priced at $283 found 17 hours ago
American Airlines
Tue, Jul 14 - Sat, Jul 25
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$365 Roundtrip, found 17 hours ago
$365
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Tue, Jul 14 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 25, priced at $365 found 17 hours ago
American Airlines
Tue, Jul 14 - Sat, Jul 25
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$377 Roundtrip, found 17 hours ago
$377
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Tue, Jul 14 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 25, priced at $377 found 17 hours ago
American Airlines
Wed, Jun 10 - Sat, Jun 13
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$438 Roundtrip, found 13 hours ago
$438
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Wed, Jun 10 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jun 13, priced at $438 found 13 hours ago
American Airlines
Tue, Jul 14 - Sat, Jul 25
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$459 Roundtrip, found 17 hours ago
$459
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Tue, Jul 14 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 25, priced at $459 found 17 hours ago
American Airlines
Tue, Jul 14 - Sat, Jul 25
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$467 Roundtrip, found 17 hours ago
$467
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Tue, Jul 14 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 25, priced at $467 found 17 hours ago
American Airlines
Wed, Jun 10 - Sat, Jun 13
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$470 Roundtrip, found 13 hours ago
$470
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Wed, Jun 10 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jun 13, priced at $470 found 13 hours ago
American Airlines
Sat, Jun 13 - Mon, Jun 15
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$488 Roundtrip, found 13 hours ago
$488
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Sat, Jun 13 from John F. Kennedy Intl. to Florence Regional, returning Mon, Jun 15, priced at $488 found 13 hours ago
American Airlines
Tue, Jul 14 - Sat, Jul 25
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$490 Roundtrip, found 17 hours ago
$490
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Tue, Jul 14 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 25, priced at $490 found 17 hours ago
American Airlines
Tue, Jul 14 - Sat, Jul 25
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$508 Roundtrip, found 17 hours ago
$508
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Tue, Jul 14 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 25, priced at $508 found 17 hours ago
American Airlines
Tue, Jun 9 - Mon, Jun 15
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$510 Roundtrip, found 13 hours ago
$510
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Tue, Jun 9 from John F. Kennedy Intl. to Florence Regional, returning Mon, Jun 15, priced at $510 found 13 hours ago
American Airlines
Wed, Jun 10 - Mon, Jun 15
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$520 Roundtrip, found 13 hours ago
$520
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Wed, Jun 10 from John F. Kennedy Intl. to Florence Regional, returning Mon, Jun 15, priced at $520 found 13 hours ago
American Airlines
Mon, Jun 8 - Mon, Jun 15
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$538 Roundtrip, found 13 hours ago
$538
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Mon, Jun 8 from John F. Kennedy Intl. to Florence Regional, returning Mon, Jun 15, priced at $538 found 13 hours ago
American Airlines
Wed, Jun 10 - Sat, Jun 13
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$552 Roundtrip, found 13 hours ago
$552
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Wed, Jun 10 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jun 13, priced at $552 found 13 hours ago
American Airlines
Sat, Jun 13 - Sun, Jun 14
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$556 Roundtrip, found 13 hours ago
$556
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Sat, Jun 13 from John F. Kennedy Intl. to Florence Regional, returning Sun, Jun 14, priced at $556 found 13 hours ago
American Airlines
Tue, Jul 14 - Sat, Jul 25
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$562 Roundtrip, found 17 hours ago
$562
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Tue, Jul 14 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 25, priced at $562 found 17 hours ago

Cheap Flights to Lake City

Fall in love at first flight with your vacation to Lake City by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Lake City on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Lake City, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Lake City

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Lake City with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the ADR airport.

What is the cheapest month to fly to Lake City?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Lake City are in July, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Lake City?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Lake City.

What airport is best to fly into Lake City?

When you’re planning your trip to Lake City, convenience is the name of the game. Luckily, Lake City Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Lake City must-do list.

How much are flights to Lake City?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Lake City on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $283, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Lake City?

The trick to saving a stack of cash on your flight to Lake City? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $283 right now, why wait?

Lake City Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$283

Last Minute Hotel Deals in Lake City

The Inn at the Crossroads

The Inn at the Crossroads

2 out of 5
128 West Main Street Lake City SC
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (897 reviews)
"Hotel was very clean and spacious."

Reviewed on May 20, 2026

Get rates
The Inn at the Crossroads
Quality Inn & Suites Lake City

Quality Inn & Suites Lake City

2.5 out of 5
202 N Ron Mcnair Blvd Lake City SC
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.2/10 Good! (185 reviews)
"The room has sand on the floor and no toilet paper. We had to go purchase toilet paper"

Reviewed on May 24, 2026

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Quality Inn & Suites Lake City
Days Inn by Wyndham Lake City

Days Inn by Wyndham Lake City

2 out of 5
170 S Ron Mcnair Blvd Lake City SC
Book a stay at this business-friendly motel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Lynches Lake Historical Society ...
6.4/10 (259 reviews)
"The room was great. Very clean. The staff needs lessons in etiquette."

Reviewed on May 17, 2026

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Days Inn by Wyndham Lake City
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (176 reviews)
"The property was clean and the rooms were also clean the bed was very comfortable, and plenty of parking and very a quiet area, will be back!"

Reviewed on Jun 5, 2026

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Quality Inn & Suites Florence Civic Center
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,298 reviews)
"Clean room and breakfast was great"

Reviewed on Jun 3, 2026

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Comfort Inn & Suites Florence Center Area
Hampton Inn & Suites Florence Center

Hampton Inn & Suites Florence Center

2.5 out of 5
3000 W Radio Dr Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9/10 Wonderful! (894 reviews)
"Front desk was professional and friendly. Lounge chair in room appeared worm and dirty. All wooden surfaces in the roo9m were sticky, departure staff said it could be the wax they use... For the charge of #133.00 including tax my wife and I were disappointed in the room. Breakfast was OK, nothing ..."

Reviewed on Jun 4, 2026

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Hampton Inn & Suites Florence Center
Aloft by Marriott Florence

Aloft by Marriott Florence

3 out of 5
820 WOODY JONES BOULEVARD Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Popular attractions Regal Swamp ...
8.6/10 Excellent! (340 reviews)
"Never before in my life have I had such a horrible experience at a hotel. Poop in the bed. Just disgusting"

Reviewed on May 30, 2026

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Aloft by Marriott Florence
Staybridge Suites Florence - Civic Center by IHG

Staybridge Suites Florence - Civic Center by IHG

3 out of 5
150 Westpark Drive Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,003 reviews)
"Staff are outstanding, however we had to move rooms (3) times. First time was due to missed bedsheets that were not changed out, the second time the AC was out in the room. We had to pack up and move (4) kids each time after a 10 hour drive , not fun. And we weren’t given a discount, just an apology. ..."

Reviewed on Jun 4, 2026

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Staybridge Suites Florence - Civic Center by IHG
See all 94 properties in Lake City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.