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Lake City

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Lake City Flights as Low as $298

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Wed, Jul 16 - Tue, Jul 22
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$298 Roundtrip, found 18 hours ago
$298
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Wed, Jul 16 from Newark Liberty Intl. Airport to Florence Regional, returning Tue, Jul 22, priced at $298 found 18 hours ago
American Airlines
Tue, Jul 15 - Wed, Jul 23
LGA
LaGuardia
FLO
Florence Regional
$298 Roundtrip, found 1 hour ago
$298
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Tue, Jul 15 from LaGuardia to Florence Regional, returning Wed, Jul 23, priced at $298 found 1 hour ago
American Airlines
Wed, Jul 16 - Sat, Jul 19
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$299 Roundtrip, found 1 day ago
$299
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jul 16 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 19, priced at $299 found 1 day ago
American Airlines
Tue, Jul 1 - Thu, Jul 10
ICT
Wichita Dwight D. Eisenhower National
FLO
Florence Regional
$342 Roundtrip, found 1 day ago
$342
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jul 1 from Wichita Dwight D. Eisenhower National to Florence Regional, returning Thu, Jul 10, priced at $342 found 1 day ago
American Airlines
Wed, Jul 16 - Sun, Jul 20
LGA
LaGuardia
FLO
Florence Regional
$346 Roundtrip, just found
$346
Roundtrip
just found
Select American Airlines flight, departing Wed, Jul 16 from LaGuardia to Florence Regional, returning Sun, Jul 20, priced at $346 just found
American Airlines
Fri, Jul 18 - Sat, Jul 19
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$348 Roundtrip, found 1 day ago
$348
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Jul 18 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 19, priced at $348 found 1 day ago
American Airlines
Mon, Jun 30 - Thu, Jul 10
ICT
Wichita Dwight D. Eisenhower National
FLO
Florence Regional
$350 Roundtrip, found 2 days ago
$350
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Jun 30 from Wichita Dwight D. Eisenhower National to Florence Regional, returning Thu, Jul 10, priced at $350 found 2 days ago
American Airlines
Wed, Jul 16 - Sun, Jul 20
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$352 Roundtrip, found 20 hours ago
$352
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Wed, Jul 16 from John F. Kennedy Intl. to Florence Regional, returning Sun, Jul 20, priced at $352 found 20 hours ago
American Airlines
Tue, Jul 1 - Thu, Jul 10
ICT
Wichita Dwight D. Eisenhower National
FLO
Florence Regional
$352 Roundtrip, found 15 hours ago
$352
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Tue, Jul 1 from Wichita Dwight D. Eisenhower National to Florence Regional, returning Thu, Jul 10, priced at $352 found 15 hours ago
American Airlines
Mon, Jun 30 - Thu, Jul 10
ICT
Wichita Dwight D. Eisenhower National
FLO
Florence Regional
$359 Roundtrip, found 4 hours ago
$359
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Mon, Jun 30 from Wichita Dwight D. Eisenhower National to Florence Regional, returning Thu, Jul 10, priced at $359 found 4 hours ago
American Airlines
Tue, Jul 15 - Wed, Jul 23
LGA
LaGuardia
FLO
Florence Regional
$361 Roundtrip, found 1 hour ago
$361
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Tue, Jul 15 from LaGuardia to Florence Regional, returning Wed, Jul 23, priced at $361 found 1 hour ago
American Airlines
Tue, Oct 7 - Sat, Oct 11
PHL
Philadelphia Intl.
FLO
Florence Regional
$363 Roundtrip, found 1 day ago
$363
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Oct 7 from Philadelphia Intl. to Florence Regional, returning Sat, Oct 11, priced at $363 found 1 day ago
American Airlines
Tue, Jul 15 - Wed, Jul 23
LGA
LaGuardia
FLO
Florence Regional
$370 Roundtrip, found 1 hour ago
$370
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Tue, Jul 15 from LaGuardia to Florence Regional, returning Wed, Jul 23, priced at $370 found 1 hour ago
American Airlines
Fri, Jul 4 - Sat, Jul 12
SAT
San Antonio Intl.
FLO
Florence Regional
$413 Roundtrip, found 5 days ago
$413
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Jul 4 from San Antonio Intl. to Florence Regional, returning Sat, Jul 12, priced at $413 found 5 days ago
American Airlines
Tue, Nov 4 - Sat, Nov 8
ABQ
Albuquerque Intl. Sunport
FLO
Florence Regional
$417 Roundtrip, found 1 day ago
$417
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Nov 4 from Albuquerque Intl. Sunport to Florence Regional, returning Sat, Nov 8, priced at $417 found 1 day ago
American Airlines
Mon, Jun 16 - Sat, Jun 21
TPA
Tampa Intl.
FLO
Florence Regional
$472 Roundtrip, found 1 day ago
$472
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Jun 16 from Tampa Intl. to Florence Regional, returning Sat, Jun 21, priced at $472 found 1 day ago

Cheap Flights to Lake City

Fall in love at first flight with your vacation to Lake City by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Lake City on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Lake City, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Lake City

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Lake City with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the ADR airport.

What is the cheapest month to fly to Lake City?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Lake City are in July, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Lake City?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Lake City.

What airport is best to fly into Lake City?

When you’re planning your trip to Lake City, convenience is the name of the game. Luckily, Lake City Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Lake City must-do list.

How much are flights to Lake City?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Lake City on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $298, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Lake City?

The trick to saving a stack of cash on your flight to Lake City? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $298 right now, why wait?

Lake City Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$298

Last Minute Hotel Deals in Lake City

The Inn at the Crossroads
The Inn at the Crossroads
2 out of 5
128 West Main Street, Lake City, SC
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (724 reviews)
"Very clean and friendly staff"

Reviewed on Jun 9, 2025

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The Inn at the Crossroads
Days Inn by Wyndham Lake City
Days Inn by Wyndham Lake City
2 out of 5
170 S Ron Mcnair Blvd, Lake City, SC
Book a stay at this business-friendly motel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Lynches Lake Historical Society ...
6.2/10 (234 reviews)
"Great hotel, stayed for art fields. It’s not the nicest but it gets the job done. Safe and clean"

Reviewed on May 5, 2025

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Days Inn by Wyndham Lake City
Quality Inn & Suites
Quality Inn & Suites
2.5 out of 5
202 N Ron Mcnair Blvd, Lake City, SC
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7/10 Good! (153 reviews)
"Stayed here only because all hotels in Florence SC, our intended destination were booked. Checked in after 11PM, didn't even enter in lobby, but passed my ID through to the employee on duty, who, in turn, passed me the keys. Room was clean, and provided a place to sleep for 7 hours before leaving ..."

Reviewed on Feb 27, 2025

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Quality Inn & Suites
Security inn & suites
Security inn & suites
2 out of 5
319 Sumter St, Lake City, SC
Stay at this hotel in Lake City. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Lynches Lake Historical Society and The Bean Market ...
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Security inn & suites
Quality Inn & Suites Florence Civic Center
Quality Inn & Suites Florence Civic Center
2.5 out of 5
150 Dunbarton Dr, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,220 reviews)
"Everything was excellent. There was nothing bad about the property. The staff was excellent."

Reviewed on Jun 9, 2025

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Quality Inn & Suites Florence Civic Center
Comfort Inn & Suites
Comfort Inn & Suites
2.5 out of 5
527 Woody Jones Blvd, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,013 reviews)
"It's clean, safe and close to the hospital."

Reviewed on Jun 10, 2025

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Comfort Inn & Suites
TownePlace Suites by Marriott Florence
TownePlace Suites by Marriott Florence
3 out of 5
2650 Hospitality Boulevard, Florence, SC
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free parking, and a 24-hour fitness center. Our guests praise the helpful staff ...
8.8/10 Excellent! (590 reviews)
"Customer service was amazing. Rolms were clean and breakfast was delicious!"

Reviewed on Jun 9, 2025

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TownePlace Suites by Marriott Florence
Days Inn by Wyndham Florence Near Civic Center
Days Inn by Wyndham Florence Near Civic Center
2.5 out of 5
140 Dunbarton Dr, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,000 reviews)
"The stay was nice"

Reviewed on May 31, 2025

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Days Inn by Wyndham Florence Near Civic Center
See all 83 properties in Lake City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.