Search Cheap Flights to
Lake City

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Lake City Flights as Low as $436

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Tue, May 27 - Tue, Jun 3
ORD
O'Hare Intl.
FLO
Florence Regional
$436 Roundtrip, found 4 days ago
$436
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, May 27 from O'Hare Intl. to Florence Regional, returning Tue, Jun 3, priced at $436 found 4 days ago
American Airlines
Mon, May 26 - Tue, Jun 3
ORD
O'Hare Intl.
FLO
Florence Regional
$478 Roundtrip, found 1 day ago
$478
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, May 26 from O'Hare Intl. to Florence Regional, returning Tue, Jun 3, priced at $478 found 1 day ago
American Airlines
Sun, May 25 - Fri, Jun 6
ORD
O'Hare Intl.
FLO
Florence Regional
$482 Roundtrip, found 4 days ago
$482
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sun, May 25 from O'Hare Intl. to Florence Regional, returning Fri, Jun 6, priced at $482 found 4 days ago
American Airlines
Fri, May 30 - Fri, Jun 6
ORD
O'Hare Intl.
FLO
Florence Regional
$482 Roundtrip, found 4 days ago
$482
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, May 30 from O'Hare Intl. to Florence Regional, returning Fri, Jun 6, priced at $482 found 4 days ago
American Airlines
Wed, May 28 - Fri, Jun 6
ORD
O'Hare Intl.
FLO
Florence Regional
$488 Roundtrip, found 4 days ago
$488
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, May 28 from O'Hare Intl. to Florence Regional, returning Fri, Jun 6, priced at $488 found 4 days ago
American Airlines
Sun, May 25 - Thu, Jun 5
ORD
O'Hare Intl.
FLO
Florence Regional
$493 Roundtrip, found 4 days ago
$493
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sun, May 25 from O'Hare Intl. to Florence Regional, returning Thu, Jun 5, priced at $493 found 4 days ago
American Airlines
Fri, May 30 - Thu, Jun 5
ORD
O'Hare Intl.
FLO
Florence Regional
$493 Roundtrip, found 4 days ago
$493
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, May 30 from O'Hare Intl. to Florence Regional, returning Thu, Jun 5, priced at $493 found 4 days ago
American Airlines
Tue, May 27 - Fri, Jun 6
ORD
O'Hare Intl.
FLO
Florence Regional
$495 Roundtrip, found 4 days ago
$495
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, May 27 from O'Hare Intl. to Florence Regional, returning Fri, Jun 6, priced at $495 found 4 days ago
American Airlines
Wed, May 28 - Thu, Jun 5
ORD
O'Hare Intl.
FLO
Florence Regional
$499 Roundtrip, found 4 days ago
$499
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, May 28 from O'Hare Intl. to Florence Regional, returning Thu, Jun 5, priced at $499 found 4 days ago
American Airlines
Tue, May 27 - Thu, Jun 5
ORD
O'Hare Intl.
FLO
Florence Regional
$507 Roundtrip, found 4 days ago
$507
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, May 27 from O'Hare Intl. to Florence Regional, returning Thu, Jun 5, priced at $507 found 4 days ago
American Airlines
Mon, May 26 - Fri, Jun 6
ORD
O'Hare Intl.
FLO
Florence Regional
$539 Roundtrip, found 4 days ago
$539
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, May 26 from O'Hare Intl. to Florence Regional, returning Fri, Jun 6, priced at $539 found 4 days ago
American Airlines
Mon, May 26 - Tue, Jun 3
ORD
O'Hare Intl.
FLO
Florence Regional
$549 Roundtrip, found 1 day ago
$549
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, May 26 from O'Hare Intl. to Florence Regional, returning Tue, Jun 3, priced at $549 found 1 day ago
American Airlines
Mon, May 26 - Thu, Jun 5
ORD
O'Hare Intl.
FLO
Florence Regional
$550 Roundtrip, found 4 days ago
$550
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, May 26 from O'Hare Intl. to Florence Regional, returning Thu, Jun 5, priced at $550 found 4 days ago
American Airlines
Fri, May 23 - Tue, May 27
SFO
San Francisco Intl.
FLO
Florence Regional
$568 Roundtrip, found 1 day ago
$568
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, May 23 from San Francisco Intl. to Florence Regional, returning Tue, May 27, priced at $568 found 1 day ago
American Airlines
Sat, May 24 - Sun, May 25
SFO
San Francisco Intl.
FLO
Florence Regional
$572 Roundtrip, found 9 hours ago
$572
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Sat, May 24 from San Francisco Intl. to Florence Regional, returning Sun, May 25, priced at $572 found 9 hours ago
American Airlines
Fri, May 23 - Tue, May 27
SFO
San Francisco Intl.
FLO
Florence Regional
$588 Roundtrip, found 9 hours ago
$588
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Fri, May 23 from San Francisco Intl. to Florence Regional, returning Tue, May 27, priced at $588 found 9 hours ago

Cheap Flights to Lake City

Fall in love at first flight with your vacation to Lake City by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Lake City on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Lake City, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Lake City

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Lake City with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the ADR airport.

What is the cheapest month to fly to Lake City?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Lake City are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Lake City?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Lake City.

What airport is best to fly into Lake City?

When you’re planning your trip to Lake City, convenience is the name of the game. Luckily, Lake City Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Lake City must-do list.

How much are flights to Lake City?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Lake City on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $436, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Lake City?

The trick to saving a stack of cash on your flight to Lake City? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $436 right now, why wait?

Lake City Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$435

Last Minute Hotel Deals in Lake City

The Inn at the Crossroads
The Inn at the Crossroads
2 out of 5
128 West Main Street, Lake City, SC
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (714 reviews)
Trip for ArtFields Competition
"This is the best place to stay if you want to attend the ArtFields event! It is centrally located so we could walk to everything, and the staff was great!"

Reviewed on May 15, 2025

Get rates
The Inn at the Crossroads
Quality Inn & Suites
Quality Inn & Suites
2.5 out of 5
202 N Ron Mcnair Blvd, Lake City, SC
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
"Stayed here only because all hotels in Florence SC, our intended destination were booked. Checked in after 11PM, didn't even enter in lobby, but passed my ID through to the employee on duty, who, in turn, passed me the keys. Room was clean, and provided a place to sleep for 7 hours before leaving ..."

Reviewed on Feb 27, 2025

Get rates
Quality Inn & Suites
Days Inn by Wyndham Lake City
Days Inn by Wyndham Lake City
2 out of 5
170 S Ron Mcnair Blvd, Lake City, SC
Book a stay at this business-friendly motel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Lynches Lake Historical Society ...
"Great hotel, stayed for art fields. It’s not the nicest but it gets the job done. Safe and clean"

Reviewed on May 5, 2025

Get rates
Days Inn by Wyndham Lake City
Security inn & suites
Security inn & suites
2 out of 5
319 Sumter St, Lake City, SC
Stay at this hotel in Lake City. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Lynches Lake Historical Society and The Bean Market ...
Get rates
Security inn & suites
Quality Inn & Suites Florence Civic Center
Quality Inn & Suites Florence Civic Center
2.5 out of 5
150 Dunbarton Dr, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,204 reviews)
"Very nice and great help"

Reviewed on May 16, 2025

Get rates
Quality Inn & Suites Florence Civic Center
Comfort Inn & Suites
Comfort Inn & Suites
2.5 out of 5
527 Woody Jones Blvd, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,020 reviews)
"The hotel was convenient for traveling on I95, clean and comfortable. The problem we had was with payment. I booked prior to arrival through Expedia, using both Expedia credit on our account and paying the balance with my credit card. When we checked in we showed the Expedia receipt and booking, ..."

Reviewed on May 20, 2025

Get rates
Comfort Inn & Suites
Days Inn by Wyndham Florence Near Civic Center
Days Inn by Wyndham Florence Near Civic Center
2.5 out of 5
140 Dunbarton Dr, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,000 reviews)
"Front desk service was fantastic! At check in and check out."

Reviewed on May 17, 2025

Get rates
Days Inn by Wyndham Florence Near Civic Center
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
2.5 out of 5
3440 W Radio Dr, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9/10 Wonderful! (1,006 reviews)
Great value!
"Very good location, facility and amenities."

Reviewed on May 19, 2025

Get rates
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
See all 83 properties in Lake City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.