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Lake City

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Lake City Flights as Low as $296

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Wed, Jun 3 - Wed, Jun 17
LGA
LaGuardia
FLO
Florence Regional
$296 Roundtrip, found 5 days ago
$296
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Jun 3 from LaGuardia to Florence Regional, returning Wed, Jun 17, priced at $296 found 5 days ago
American Airlines
Tue, Jul 21 - Tue, Jul 28
LGA
LaGuardia
FLO
Florence Regional
$299 Roundtrip, found 6 hours ago
$299
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Tue, Jul 21 from LaGuardia to Florence Regional, returning Tue, Jul 28, priced at $299 found 6 hours ago
American Airlines
Tue, Jul 14 - Thu, Jul 30
LGA
LaGuardia
FLO
Florence Regional
$306 Roundtrip, found 1 day ago
$306
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jul 14 from LaGuardia to Florence Regional, returning Thu, Jul 30, priced at $306 found 1 day ago
American Airlines
Wed, Sep 30 - Sun, Oct 4
LGA
LaGuardia
FLO
Florence Regional
$344 Roundtrip, found 6 days ago
$344
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Sep 30 from LaGuardia to Florence Regional, returning Sun, Oct 4, priced at $344 found 6 days ago
American Airlines
Tue, Jul 21 - Tue, Jul 28
LGA
LaGuardia
FLO
Florence Regional
$372 Roundtrip, found 6 hours ago
$372
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Tue, Jul 21 from LaGuardia to Florence Regional, returning Tue, Jul 28, priced at $372 found 6 hours ago
American Airlines
Wed, Jun 3 - Wed, Jun 17
LGA
LaGuardia
FLO
Florence Regional
$376 Roundtrip, found 5 days ago
$376
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Jun 3 from LaGuardia to Florence Regional, returning Wed, Jun 17, priced at $376 found 5 days ago
American Airlines
Wed, Jun 3 - Wed, Jun 17
LGA
LaGuardia
FLO
Florence Regional
$377 Roundtrip, found 5 days ago
$377
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Jun 3 from LaGuardia to Florence Regional, returning Wed, Jun 17, priced at $377 found 5 days ago
American Airlines
Tue, Jul 21 - Tue, Jul 28
LGA
LaGuardia
FLO
Florence Regional
$379 Roundtrip, found 6 hours ago
$379
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Tue, Jul 21 from LaGuardia to Florence Regional, returning Tue, Jul 28, priced at $379 found 6 hours ago
American Airlines
Tue, Jul 14 - Thu, Jul 30
LGA
LaGuardia
FLO
Florence Regional
$381 Roundtrip, found 1 day ago
$381
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jul 14 from LaGuardia to Florence Regional, returning Thu, Jul 30, priced at $381 found 1 day ago
American Airlines
Wed, Jun 3 - Wed, Jun 17
LGA
LaGuardia
FLO
Florence Regional
$384 Roundtrip, found 5 days ago
$384
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Jun 3 from LaGuardia to Florence Regional, returning Wed, Jun 17, priced at $384 found 5 days ago
American Airlines
Wed, Jun 3 - Wed, Jun 17
LGA
LaGuardia
FLO
Florence Regional
$386 Roundtrip, found 5 days ago
$386
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Jun 3 from LaGuardia to Florence Regional, returning Wed, Jun 17, priced at $386 found 5 days ago
American Airlines
Tue, Jul 14 - Thu, Jul 30
LGA
LaGuardia
FLO
Florence Regional
$388 Roundtrip, found 1 day ago
$388
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jul 14 from LaGuardia to Florence Regional, returning Thu, Jul 30, priced at $388 found 1 day ago
American Airlines
Wed, Sep 30 - Sun, Oct 4
LGA
LaGuardia
FLO
Florence Regional
$422 Roundtrip, found 6 days ago
$422
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Sep 30 from LaGuardia to Florence Regional, returning Sun, Oct 4, priced at $422 found 6 days ago
American Airlines
Sun, Sep 27 - Wed, Oct 7
LGA
LaGuardia
FLO
Florence Regional
$424 Roundtrip, found 6 days ago
$424
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Sep 27 from LaGuardia to Florence Regional, returning Wed, Oct 7, priced at $424 found 6 days ago
American Airlines
Wed, Jun 3 - Wed, Jun 17
LGA
LaGuardia
FLO
Florence Regional
$464 Roundtrip, found 5 days ago
$464
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Jun 3 from LaGuardia to Florence Regional, returning Wed, Jun 17, priced at $464 found 5 days ago
American Airlines
Wed, Jun 3 - Wed, Jun 17
LGA
LaGuardia
FLO
Florence Regional
$465 Roundtrip, found 5 days ago
$465
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Jun 3 from LaGuardia to Florence Regional, returning Wed, Jun 17, priced at $465 found 5 days ago

Cheap Flights to Lake City

Fall in love at first flight with your vacation to Lake City by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Lake City on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Lake City, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Lake City

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Lake City with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the ADR airport.

What is the cheapest month to fly to Lake City?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Lake City are in June, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Lake City?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Lake City.

What airport is best to fly into Lake City?

When you’re planning your trip to Lake City, convenience is the name of the game. Luckily, Lake City Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Lake City must-do list.

How much are flights to Lake City?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Lake City on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $296, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Lake City?

The trick to saving a stack of cash on your flight to Lake City? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $296 right now, why wait?

Lake City Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$295

Last Minute Hotel Deals in Lake City

The Inn at the Crossroads

The Inn at the Crossroads

2 out of 5
128 West Main Street Lake City SC
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (894 reviews)
Everything and everyone was Nice

Reviewed on May 16, 2026

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The Inn at the Crossroads
Quality Inn & Suites Lake City

Quality Inn & Suites Lake City

2.5 out of 5
202 N Ron Mcnair Blvd Lake City SC
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.2/10 Good! (182 reviews)
Hotel was just ok. It was clean, but minimal and basic

Reviewed on May 7, 2026

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Quality Inn & Suites Lake City
Days Inn by Wyndham Lake City

Days Inn by Wyndham Lake City

2 out of 5
170 S Ron Mcnair Blvd Lake City SC
Book a stay at this business-friendly motel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Lynches Lake Historical Society ...
6.4/10 (256 reviews)
the staff was wonderfully accommodating.

Reviewed on Apr 29, 2026

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Days Inn by Wyndham Lake City
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (144 reviews)
Best night’s sleep I’ve had in forever!! Very pleasant staff! Clean! Will definitely be making this our go to for our trips to Florida and back!!!

Reviewed on May 14, 2026

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Quality Inn & Suites Florence Civic Center
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,279 reviews)
The property was very nice and in a quiet location while being close to many restaurants and amenities. There is a nice walking trail across from the property. The front desk employee who checked us in was very sweet. The young lady that checked us out was less than friendly and didn't even say thank ...

Reviewed on May 16, 2026

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Comfort Inn & Suites Florence Center Area
SpringHill Suites by Marriott Florence

SpringHill Suites by Marriott Florence

3 out of 5
2670 Hospitality Blvd Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (1,006 reviews)
Friendly. Breafast great

Reviewed on May 15, 2026

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SpringHill Suites by Marriott Florence
Aloft Florence

Aloft Florence

3 out of 5
820 WOODY JONES BOULEVARD Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Regal Swamp Fox and Florence ...
8.6/10 Excellent! (331 reviews)
Make a different choice! The place is dirty!

Reviewed on May 16, 2026

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Aloft Florence
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,007 reviews)
Provide scramble eggs and bacon

Reviewed on May 16, 2026

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Days Inn by Wyndham Florence Near Civic Center
See all 94 properties in Lake City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.