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Lake City

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Lake City Flights as Low as $347

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Wed, Feb 26 - Sat, Mar 1
TPA
Tampa Intl.
FLO
Florence Regional
$347 Roundtrip, found 2 days ago
$347
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Feb 26 from Tampa Intl. to Florence Regional, returning Sat, Mar 1, priced at $347 found 2 days ago
American Airlines
Tue, Feb 25 - Tue, Mar 4
TPA
Tampa Intl.
FLO
Florence Regional
$367 Roundtrip, found 10 hours ago
$367
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Tue, Feb 25 from Tampa Intl. to Florence Regional, returning Tue, Mar 4, priced at $367 found 10 hours ago
American Airlines
Mon, May 5 - Thu, May 8
TPA
Tampa Intl.
FLO
Florence Regional
$377 Roundtrip, found 12 hours ago
$377
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Mon, May 5 from Tampa Intl. to Florence Regional, returning Thu, May 8, priced at $377 found 12 hours ago
American Airlines
Tue, Feb 25 - Tue, Mar 4
TPA
Tampa Intl.
FLO
Florence Regional
$396 Roundtrip, found 10 hours ago
$396
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Tue, Feb 25 from Tampa Intl. to Florence Regional, returning Tue, Mar 4, priced at $396 found 10 hours ago
American Airlines
Tue, Feb 25 - Tue, Mar 4
TPA
Tampa Intl.
FLO
Florence Regional
$405 Roundtrip, found 10 hours ago
$405
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Tue, Feb 25 from Tampa Intl. to Florence Regional, returning Tue, Mar 4, priced at $405 found 10 hours ago
American Airlines
Mon, May 5 - Thu, May 8
TPA
Tampa Intl.
FLO
Florence Regional
$432 Roundtrip, found 12 hours ago
$432
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Mon, May 5 from Tampa Intl. to Florence Regional, returning Thu, May 8, priced at $432 found 12 hours ago
American Airlines
Wed, Feb 26 - Sat, Mar 1
TPA
Tampa Intl.
FLO
Florence Regional
$437 Roundtrip, found 2 days ago
$437
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Feb 26 from Tampa Intl. to Florence Regional, returning Sat, Mar 1, priced at $437 found 2 days ago
American Airlines
Tue, May 6 - Sat, May 10
TPA
Tampa Intl.
FLO
Florence Regional
$444 Roundtrip, found 1 day ago
$444
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, May 6 from Tampa Intl. to Florence Regional, returning Sat, May 10, priced at $444 found 1 day ago
American Airlines
Mon, May 5 - Thu, May 8
TPA
Tampa Intl.
FLO
Florence Regional
$446 Roundtrip, found 12 hours ago
$446
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Mon, May 5 from Tampa Intl. to Florence Regional, returning Thu, May 8, priced at $446 found 12 hours ago
American Airlines
Tue, Feb 25 - Tue, Mar 4
TPA
Tampa Intl.
FLO
Florence Regional
$453 Roundtrip, found 10 hours ago
$453
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Tue, Feb 25 from Tampa Intl. to Florence Regional, returning Tue, Mar 4, priced at $453 found 10 hours ago
American Airlines
Mon, May 5 - Thu, May 8
TPA
Tampa Intl.
FLO
Florence Regional
$457 Roundtrip, found 1 day ago
$457
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, May 5 from Tampa Intl. to Florence Regional, returning Thu, May 8, priced at $457 found 1 day ago
American Airlines
Tue, Feb 25 - Tue, Mar 4
TPA
Tampa Intl.
FLO
Florence Regional
$459 Roundtrip, found 10 hours ago
$459
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Tue, Feb 25 from Tampa Intl. to Florence Regional, returning Tue, Mar 4, priced at $459 found 10 hours ago
American Airlines
Thu, May 8 - Sat, May 10
TPA
Tampa Intl.
FLO
Florence Regional
$459 Roundtrip, found 1 day ago
$459
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, May 8 from Tampa Intl. to Florence Regional, returning Sat, May 10, priced at $459 found 1 day ago
American Airlines
Mon, May 5 - Thu, May 8
TPA
Tampa Intl.
FLO
Florence Regional
$463 Roundtrip, found 12 hours ago
$463
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Mon, May 5 from Tampa Intl. to Florence Regional, returning Thu, May 8, priced at $463 found 12 hours ago
American Airlines
Tue, Feb 25 - Tue, Mar 4
TPA
Tampa Intl.
FLO
Florence Regional
$464 Roundtrip, found 2 days ago
$464
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Feb 25 from Tampa Intl. to Florence Regional, returning Tue, Mar 4, priced at $464 found 2 days ago
American Airlines
Sun, Feb 23 - Tue, Mar 4
TPA
Tampa Intl.
FLO
Florence Regional
$467 Roundtrip, found 2 days ago
$467
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sun, Feb 23 from Tampa Intl. to Florence Regional, returning Tue, Mar 4, priced at $467 found 2 days ago

Cheap Flights to Lake City

Fall in love at first flight with your vacation to Lake City by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Lake City on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Lake City, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Lake City

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Lake City with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the ADR airport.

What is the cheapest month to fly to Lake City?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Lake City are in February, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Lake City?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Lake City.

What airport is best to fly into Lake City?

When you’re planning your trip to Lake City, convenience is the name of the game. Luckily, Lake City Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Lake City must-do list.

How much are flights to Lake City?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Lake City on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $347, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Lake City?

The trick to saving a stack of cash on your flight to Lake City? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $347 right now, why wait?

Lake City Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$347

Last Minute Hotel Deals in Lake City

The Inn at the Crossroads
The Inn at the Crossroads
2 out of 5
128 West Main Street, Lake City, SC
The price is $189 per night from Feb 9 to Feb 10
$189
includes taxes & fees
Feb 9 - Feb 10
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (662 reviews)
"My husband and I booked an overnight away from the kids to celebrate our anniversary, and this was the perfect spot for that. We live close but had not been here before and we enjoyed the relaxing atmosphere and spacious room. The staff was so friendly and informative, and it was a much needed break ..."

Reviewed on Feb 3, 2025

The Inn at the Crossroads
Quality Inn & Suites
Quality Inn & Suites
2.5 out of 5
202 N Ron Mcnair Blvd, Lake City, SC
The price is $132 per night from Feb 23 to Feb 24
$132
includes taxes & fees
Feb 23 - Feb 24
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.2/10 Good! (144 reviews)
"The updates and very quiet."

Reviewed on Dec 31, 2024

Quality Inn & Suites
Days Inn by Wyndham Lake City
Days Inn by Wyndham Lake City
2 out of 5
170 S Ron Mcnair Blvd, Lake City, SC
The price is $129 per night from Feb 12 to Feb 13
$129
includes taxes & fees
Feb 12 - Feb 13
Book a stay at this business-friendly motel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Lynches Lake Historical Society ...
6.4/10 (225 reviews)
"Good"

Reviewed on Jul 7, 2024

Days Inn by Wyndham Lake City
Security inn & suites
Security inn & suites
2 out of 5
319 Sumter St, Lake City, SC
The price is $127 per night from Feb 15 to Feb 16
$127
includes taxes & fees
Feb 15 - Feb 16
Stay at this hotel in Lake City. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Lynches Lake Historical Society and The Bean Market ...
Security inn & suites
Quality Inn & Suites Florence Civic Center
Quality Inn & Suites Florence Civic Center
2.5 out of 5
150 Dunbarton Dr, Florence, SC
The price is $100 per night from Mar 9 to Mar 10
$100
includes taxes & fees
Mar 9 - Mar 10
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,087 reviews)
"Friendly staff, clean and comfortable room. Multiple restaurants within walking distance. I would stay here again."

Reviewed on Jan 30, 2025

Quality Inn & Suites Florence Civic Center
Comfort Inn & Suites
Comfort Inn & Suites
2.5 out of 5
527 Woody Jones Blvd, Florence, SC
The price is $108 per night from Feb 23 to Feb 24
$108
includes taxes & fees
Feb 23 - Feb 24
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,000 reviews)
"The breakfast was great. Lots of options. Hot eggs and meat every morning along with grits and oatmeal. Plus the usual pastry, yogurt and cereal."

Reviewed on Feb 4, 2025

Comfort Inn & Suites
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr, an IHG Hotel
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr, an IHG Hotel
2.5 out of 5
3440 W Radio Dr, Florence, SC
The price is $111 per night from Mar 9 to Mar 10
$111
includes taxes & fees
Mar 9 - Mar 10
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,002 reviews)
"Only stayed one night. Hotel met my expectations."

Reviewed on Feb 5, 2025

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr, an IHG Hotel
Staybridge Suites Florence - Civic Center, an IHG Hotel
Staybridge Suites Florence - Civic Center, an IHG Hotel
3 out of 5
150 Westpark Drive, Florence, SC
The price is $156 per night from Mar 2 to Mar 3
$156
includes taxes & fees
Mar 2 - Mar 3
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (800 reviews)
"Great facility! Great staff!"

Reviewed on Feb 6, 2025

Staybridge Suites Florence - Civic Center, an IHG Hotel
See all 75 properties in Lake City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.