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Lake City

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Lake City Flights as Low as $481

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Fri, May 2 - Sun, May 4
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$481 Roundtrip, found 1 day ago
$481
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, May 2 from John F. Kennedy Intl. to Florence Regional, returning Sun, May 4, priced at $481 found 1 day ago
American Airlines
Fri, May 2 - Sun, May 4
LGA
LaGuardia
FLO
Florence Regional
$481 Roundtrip, found 1 day ago
$481
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, May 2 from LaGuardia to Florence Regional, returning Sun, May 4, priced at $481 found 1 day ago
American Airlines
Fri, May 2 - Sun, May 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$481 Roundtrip, found 1 day ago
$481
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, May 2 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, May 4, priced at $481 found 1 day ago
American Airlines
Tue, Nov 4 - Sat, Nov 8
ABQ
Albuquerque Intl. Sunport
FLO
Florence Regional
$507 Roundtrip, found 8 hours ago
$507
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Tue, Nov 4 from Albuquerque Intl. Sunport to Florence Regional, returning Sat, Nov 8, priced at $507 found 8 hours ago
American Airlines
Wed, Nov 5 - Sat, Nov 8
ABQ
Albuquerque Intl. Sunport
FLO
Florence Regional
$537 Roundtrip, found 8 hours ago
$537
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Wed, Nov 5 from Albuquerque Intl. Sunport to Florence Regional, returning Sat, Nov 8, priced at $537 found 8 hours ago
American Airlines
Fri, May 2 - Sun, May 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$552 Roundtrip, found 1 day ago
$552
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, May 2 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, May 4, priced at $552 found 1 day ago
American Airlines
Fri, May 2 - Sun, May 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$571 Roundtrip, found 1 day ago
$571
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, May 2 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, May 4, priced at $571 found 1 day ago
American Airlines
Fri, Nov 7 - Tue, Nov 11
ABQ
Albuquerque Intl. Sunport
FLO
Florence Regional
$622 Roundtrip, found 8 hours ago
$622
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Fri, Nov 7 from Albuquerque Intl. Sunport to Florence Regional, returning Tue, Nov 11, priced at $622 found 8 hours ago
American Airlines
Sat, Nov 8 - Thu, Nov 13
ABQ
Albuquerque Intl. Sunport
FLO
Florence Regional
$628 Roundtrip, found 8 hours ago
$628
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Sat, Nov 8 from Albuquerque Intl. Sunport to Florence Regional, returning Thu, Nov 13, priced at $628 found 8 hours ago
American Airlines
Sat, Nov 8 - Sun, Nov 9
ABQ
Albuquerque Intl. Sunport
FLO
Florence Regional
$648 Roundtrip, found 8 hours ago
$648
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Sat, Nov 8 from Albuquerque Intl. Sunport to Florence Regional, returning Sun, Nov 9, priced at $648 found 8 hours ago
American Airlines
Fri, May 2 - Sun, May 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$655 Roundtrip, found 1 day ago
$655
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, May 2 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, May 4, priced at $655 found 1 day ago
American Airlines
Wed, Nov 5 - Thu, Nov 13
ABQ
Albuquerque Intl. Sunport
FLO
Florence Regional
$658 Roundtrip, found 8 hours ago
$658
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Wed, Nov 5 from Albuquerque Intl. Sunport to Florence Regional, returning Thu, Nov 13, priced at $658 found 8 hours ago
American Airlines
Thu, Nov 6 - Mon, Nov 10
ABQ
Albuquerque Intl. Sunport
FLO
Florence Regional
$661 Roundtrip, found 8 hours ago
$661
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Thu, Nov 6 from Albuquerque Intl. Sunport to Florence Regional, returning Mon, Nov 10, priced at $661 found 8 hours ago
American Airlines
Fri, May 2 - Sun, May 4
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$663 Roundtrip, found 1 day ago
$663
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, May 2 from John F. Kennedy Intl. to Florence Regional, returning Sun, May 4, priced at $663 found 1 day ago
American Airlines
Thu, Nov 6 - Mon, Nov 10
ABQ
Albuquerque Intl. Sunport
FLO
Florence Regional
$664 Roundtrip, found 8 hours ago
$664
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Thu, Nov 6 from Albuquerque Intl. Sunport to Florence Regional, returning Mon, Nov 10, priced at $664 found 8 hours ago
American Airlines
Fri, May 2 - Sun, May 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$667 Roundtrip, found 1 day ago
$667
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, May 2 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, May 4, priced at $667 found 1 day ago

Cheap Flights to Lake City

Fall in love at first flight with your vacation to Lake City by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Lake City on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Lake City, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Lake City

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Lake City with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the ADR airport.

What is the cheapest month to fly to Lake City?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Lake City are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Lake City?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Lake City.

What airport is best to fly into Lake City?

When you’re planning your trip to Lake City, convenience is the name of the game. Luckily, Lake City Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Lake City must-do list.

How much are flights to Lake City?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Lake City on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $481, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Lake City?

The trick to saving a stack of cash on your flight to Lake City? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $481 right now, why wait?

Lake City Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$480

Last Minute Hotel Deals in Lake City

The Inn at the Crossroads
The Inn at the Crossroads
2 out of 5
128 West Main Street, Lake City, SC
The price is $200 per night from May 4 to May 5
$200
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (701 reviews)
"awesome excellent service"

Reviewed on Apr 29, 2025

The Inn at the Crossroads
Quality Inn & Suites
Quality Inn & Suites
2.5 out of 5
202 N Ron Mcnair Blvd, Lake City, SC
The price is $132 per night from May 25 to May 26
$132
includes taxes & fees
May 25 - May 26
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7/10 Good! (150 reviews)
"Stayed here only because all hotels in Florence SC, our intended destination were booked. Checked in after 11PM, didn't even enter in lobby, but passed my ID through to the employee on duty, who, in turn, passed me the keys. Room was clean, and provided a place to sleep for 7 hours before leaving ..."

Reviewed on Feb 27, 2025

Quality Inn & Suites
Days Inn by Wyndham Lake City
Days Inn by Wyndham Lake City
2 out of 5
170 S Ron Mcnair Blvd, Lake City, SC
The price is $119 per night from May 4 to May 5
$119
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly motel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Lynches Lake Historical Society ...
6.4/10 (229 reviews)
"I had a great experience."

Reviewed on Apr 26, 2025

Days Inn by Wyndham Lake City
Security inn & suites
Security inn & suites
2 out of 5
319 Sumter St, Lake City, SC
Stay at this hotel in Lake City. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Lynches Lake Historical Society and The Bean Market ...
Get rates
Security inn & suites
Quality Inn & Suites Florence Civic Center
Quality Inn & Suites Florence Civic Center
2.5 out of 5
150 Dunbarton Dr, Florence, SC
The price is $93 per night from Jun 1 to Jun 2
$93
includes taxes & fees
Jun 1 - Jun 2
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,197 reviews)
"Very comfortable bed"

Reviewed on Apr 22, 2025

Quality Inn & Suites Florence Civic Center
Comfort Inn & Suites
Comfort Inn & Suites
2.5 out of 5
527 Woody Jones Blvd, Florence, SC
The price is $117 per night from May 18 to May 19
$117
includes taxes & fees
May 18 - May 19
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,002 reviews)
"Staff very friendly and eager to help you"

Reviewed on Apr 22, 2025

Comfort Inn & Suites
Days Inn by Wyndham Florence Near Civic Center
Days Inn by Wyndham Florence Near Civic Center
2.5 out of 5
140 Dunbarton Dr, Florence, SC
The price is $71 per night from May 4 to May 5
$71
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,000 reviews)
"Clean amd quiet. The breakfast was not so good"

Reviewed on Apr 11, 2025

Days Inn by Wyndham Florence Near Civic Center
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
2.5 out of 5
3440 W Radio Dr, Florence, SC
The price is $129 per night from May 4 to May 5
$129
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9/10 Wonderful! (1,004 reviews)
"We read here twice. The first time was pleasant, and the staff were efficient and friendly. The second time we stayed, the staff were slow but still friendly. Both stays were on a Thursday night."

Reviewed on Apr 26, 2025

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
See all 79 properties in Lake City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.