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Muscatine

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Muscatine Flights as Low as $255

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Bargain Flight
Thu, Aug 6 - Mon, Aug 10
SAV
Savannah - Hilton Head Intl.
MLI
Quad City Intl.
$255 Roundtrip, found 1 day ago
$255
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Thu, Aug 6 from Savannah - Hilton Head Intl. to Quad City Intl., returning Mon, Aug 10, priced at $255 found 1 day ago
Delta
Tue, Sep 22 - Sat, Sep 26
MSY
Louis Armstrong New Orleans Intl.
MLI
Quad City Intl.
$261 Roundtrip, found 5 days ago
$261
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Sep 22 from Louis Armstrong New Orleans Intl. to Quad City Intl., returning Sat, Sep 26, priced at $261 found 5 days ago
American Airlines
Tue, Sep 22 - Sat, Sep 26
MSY
Louis Armstrong New Orleans Intl.
MLI
Quad City Intl.
$261 Roundtrip, found 5 days ago
$261
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Sep 22 from Louis Armstrong New Orleans Intl. to Quad City Intl., returning Sat, Sep 26, priced at $261 found 5 days ago
Bargain Flight
Tue, Jul 14 - Sat, Jul 18
MSY
Louis Armstrong New Orleans Intl.
MLI
Quad City Intl.
$274 Roundtrip, found 1 day ago
$274
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Tue, Jul 14 from Louis Armstrong New Orleans Intl. to Quad City Intl., returning Sat, Jul 18, priced at $274 found 1 day ago
Bargain Flight
Wed, Jul 15 - Mon, Jul 20
MSY
Louis Armstrong New Orleans Intl.
MLI
Quad City Intl.
$276 Roundtrip, found 2 days ago
$276
Roundtrip
found 2 days ago
Select Bargain Flight flight, departing Wed, Jul 15 from Louis Armstrong New Orleans Intl. to Quad City Intl., returning Mon, Jul 20, priced at $276 found 2 days ago
American Airlines
Tue, Sep 22 - Sat, Sep 26
MSY
Louis Armstrong New Orleans Intl.
MLI
Quad City Intl.
$285 Roundtrip, found 5 days ago
$285
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Sep 22 from Louis Armstrong New Orleans Intl. to Quad City Intl., returning Sat, Sep 26, priced at $285 found 5 days ago
Delta
Tue, Aug 4 - Tue, Aug 11
SAV
Savannah - Hilton Head Intl.
MLI
Quad City Intl.
$298 Roundtrip, found 5 days ago
$298
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Aug 4 from Savannah - Hilton Head Intl. to Quad City Intl., returning Tue, Aug 11, priced at $298 found 5 days ago
Delta
Mon, Aug 3 - Tue, Aug 11
SAV
Savannah - Hilton Head Intl.
MLI
Quad City Intl.
$300 Roundtrip, found 5 days ago
$300
Roundtrip
found 5 days ago
Select Delta flight, departing Mon, Aug 3 from Savannah - Hilton Head Intl. to Quad City Intl., returning Tue, Aug 11, priced at $300 found 5 days ago
Delta
Tue, Aug 4 - Mon, Aug 10
SAV
Savannah - Hilton Head Intl.
MLI
Quad City Intl.
$307 Roundtrip, found 5 days ago
$307
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Aug 4 from Savannah - Hilton Head Intl. to Quad City Intl., returning Mon, Aug 10, priced at $307 found 5 days ago
Delta
Mon, Aug 3 - Mon, Aug 10
SAV
Savannah - Hilton Head Intl.
MLI
Quad City Intl.
$309 Roundtrip, found 5 days ago
$309
Roundtrip
found 5 days ago
Select Delta flight, departing Mon, Aug 3 from Savannah - Hilton Head Intl. to Quad City Intl., returning Mon, Aug 10, priced at $309 found 5 days ago
American Airlines
Thu, Aug 6 - Mon, Aug 10
SAV
Savannah - Hilton Head Intl.
MLI
Quad City Intl.
$316 Roundtrip, found 1 day ago
$316
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Aug 6 from Savannah - Hilton Head Intl. to Quad City Intl., returning Mon, Aug 10, priced at $316 found 1 day ago
Delta
Thu, Aug 6 - Tue, Aug 11
SAV
Savannah - Hilton Head Intl.
MLI
Quad City Intl.
$322 Roundtrip, found 5 days ago
$322
Roundtrip
found 5 days ago
Select Delta flight, departing Thu, Aug 6 from Savannah - Hilton Head Intl. to Quad City Intl., returning Tue, Aug 11, priced at $322 found 5 days ago
Delta
Thu, Aug 6 - Mon, Aug 10
SAV
Savannah - Hilton Head Intl.
MLI
Quad City Intl.
$331 Roundtrip, found 1 day ago
$331
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Aug 6 from Savannah - Hilton Head Intl. to Quad City Intl., returning Mon, Aug 10, priced at $331 found 1 day ago
Delta
Tue, Sep 22 - Sat, Sep 26
MSY
Louis Armstrong New Orleans Intl.
MLI
Quad City Intl.
$340 Roundtrip, found 5 days ago
$340
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Sep 22 from Louis Armstrong New Orleans Intl. to Quad City Intl., returning Sat, Sep 26, priced at $340 found 5 days ago
Delta
Tue, Jul 21 - Wed, Jul 29
RSW
Southwest Florida Intl.
MLI
Quad City Intl.
$355 Roundtrip, found 19 hours ago
$355
Roundtrip
found 19 hours ago
Select Delta flight, departing Tue, Jul 21 from Southwest Florida Intl. to Quad City Intl., returning Wed, Jul 29, priced at $355 found 19 hours ago
Delta
Sat, Aug 1 - Sat, Aug 1
PNS
Pensacola Intl.
MLI
Quad City Intl.
$668 Roundtrip, found 18 hours ago
$668
Roundtrip
found 18 hours ago
Select Delta flight, departing Sat, Aug 1 from Pensacola Intl. to Quad City Intl., returning Sat, Aug 1, priced at $668 found 18 hours ago

Cheap Flights to Muscatine

Fall in love at first flight with your vacation to Muscatine by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Muscatine on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Muscatine, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Muscatine

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Muscatine with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the MLI airport.

What is the cheapest month to fly to Muscatine?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Muscatine are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Muscatine?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 13 to choose from for your flight to Muscatine.

What airport is best to fly into Muscatine?

When you’re planning your trip to Muscatine, convenience is the name of the game. Luckily, Muscatine Quad City Intl. Airport is nearby so you can deplane and get going on checking off everything on your Muscatine must-do list.

How much are flights to Muscatine?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Muscatine on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $255, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Muscatine?

The trick to saving a stack of cash on your flight to Muscatine? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $255 right now, why wait?

Muscatine Flight Information
Destination airport
Quad City Intl.
Destination airport IATA code
MLI
Roundtrip price
$254

Last Minute Hotel Deals in Muscatine

AmericInn by Wyndham Muscatine

AmericInn by Wyndham Muscatine

3 out of 5
3115 Hwy 61 North Muscatine IA
Book a stay at this business-friendly hotel in Muscatine. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Muscatine Aquatic Center and ...
7.6/10 Good! (459 reviews)
"I booked a king bed with signed for 2 adults and 1 child. The room did not have a safe bed for my teenage son. I went to the front desk and they told me they did not have another room and weren’t sure if they had cots available. If they could locate a cot, it would be an additional $25/night. We ..."

Reviewed on Jul 2, 2026

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AmericInn by Wyndham Muscatine
Best Western Muscatine / Pearl City Hotel

Best Western Muscatine / Pearl City Hotel

2.5 out of 5
305 Cleveland St Muscatine IA
Book a stay at this business-friendly hotel in Muscatine. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (532 reviews)
"Nice property. Clean and modern rooms"

Reviewed on Jul 8, 2026

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Best Western Muscatine / Pearl City Hotel
The Merrill Hotel, Muscatine, a Tribute Portfolio Hotel

The Merrill Hotel, Muscatine, a Tribute Portfolio Hotel

4 out of 5
119 Mississippi Drive West Muscatine IA
Book a stay at this business-friendly hotel in Muscatine. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions Riverside Park and Muscatine ...
9.6/10 Exceptional! (294 reviews)
"Overall, nice place to stay on the riverfront. Plenty of places to walk to as far as bars, restaurants and riverfront walking path. Restaurant at the hotel was very pleasant."

Reviewed on Jun 19, 2026

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The Merrill Hotel, Muscatine, a Tribute Portfolio Hotel
The Sage Hotel

The Sage Hotel

2 out of 5
2402 Park Ave Muscatine IA
Stay at this hotel in Muscatine. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Muscatine Aquatic Center and Geneva Golf and Country ...
6.8/10 (77 reviews)
"This hotel is nice and reasonably priced. Especially since we booked last minute on the 4th of July. It is a bit outdated and older, but our room was clean and comfy. Everything worked and the room was a great size that gave us space to move around. Would definitely stay again."

Reviewed on Jul 6, 2026

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The Sage Hotel
Comfort Inn Muscatine near Hwy 61

Comfort Inn Muscatine near Hwy 61

2.5 out of 5
115 Cleveland St Muscatine IA
Stay at this hotel in Muscatine. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Muscatine Aquatic Center and Geneva Golf and Country ...
7.8/10 Good! (238 reviews)
"Breakfast nothing great"

Reviewed on Jun 22, 2026

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Comfort Inn Muscatine near Hwy 61
Super 8 by Wyndham Muscatine

Super 8 by Wyndham Muscatine

2 out of 5
2900 N Highway 61 Muscatine IA
Stay at this hotel in Muscatine. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Muscatine Aquatic Center and Geneva Golf and Country ...
6.4/10 (287 reviews)
"Staff was helpful and friendly. Place was clean and quiet."

Reviewed on Jul 6, 2026

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Super 8 by Wyndham Muscatine
Hampton Inn Muscatine

Hampton Inn Muscatine

2.5 out of 5
3303 N Port Drive Muscatine IA
Stay at this hotel in Muscatine. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Muscatine Aquatic Center and Muscatine Municipal Golf ...
8.4/10 Very Good! (485 reviews)
"At a hotel, you shouldn't have a sign on the front desk that states "I'm away from the desk". The hotel looks as if it's going through some renovations but next time, I'll spend a little more and stay at the Merrill downtown Muscatine. Not impressed at all. Okay to sleep at but that's it."

Reviewed on Jun 25, 2026

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Hampton Inn Muscatine
Strawberry Farm Bed & Breakfast

Strawberry Farm Bed & Breakfast

3 out of 5
3402 Tipton Rd Muscatine IA
Stay at this B&B in Muscatine. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Geneva Golf and Country Club and Muscatine Arboretum are ...
9.4/10 Exceptional! (31 reviews)
"This is a beautiful house and the hosts are delightful"

Reviewed on Jul 3, 2026

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Strawberry Farm Bed & Breakfast
See all 305 properties in Muscatine
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.