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Hotels in De Soto

Choose from 316 De Soto Hotel Deals

Gundersen Hotel & Suites

Gundersen Hotel & Suites

2.5 out of 5
1520 Clinic Court La Crosse WI
  • 12 hours drive from Mississippi River
Book a stay at this business-friendly hotel in La Crosse. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,000 reviews)
The hotel was spotlessly clean. Check-in desk staff were polite and professional. Room was huge. Bed was comfortable--not too hard or too soft but just wonderfully right. Breakfast options included hot items and cold breakfast item. Parking lot was well lit. No complaints from me!

Reviewed on Jan 14, 2026

Gundersen Hotel & Suites
Boarders Inn & Suites by Cobblestone Hotels – Waukon

Boarders Inn & Suites by Cobblestone Hotels – Waukon

3.5 out of 5
407 Rossville Rd Waukon IA
  • 10 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Waukon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8/10 Very Good! (452 reviews)
Yes, everything was satisfactory. Thank you.

Reviewed on Jan 1, 2026

Boarders Inn & Suites by Cobblestone Hotels – Waukon
AmericInn by Wyndham Viroqua

AmericInn by Wyndham Viroqua

2.5 out of 5
1325 N Main St Viroqua WI
  • 11 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Viroqua. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Viroqua Country Club and Sidie ...
8/10 Very Good! (341 reviews)
staff

Reviewed on Dec 26, 2025

AmericInn by Wyndham Viroqua
Old Towne Motel

Old Towne Motel

2 out of 5
Hwy. 14, 61 & 27 South Westby WI
  • 11 hours drive from Mississippi River
Stay at this motel in Westby. Enjoy free WiFi, free parking, and room service. Popular attractions Dregne's Scandinavian Gifts and Branches Winery are located ...
7.8/10 Good! (243 reviews)
Clean and comfortable

Reviewed on Jan 20, 2026

Old Towne Motel
Welch Motel

Welch Motel

2.5 out of 5
3643 Mormon Coulee Rd. La Crosse WI
  • 12 hours drive from Mississippi River
Stay at this motel in La Crosse. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
7/10 Good! (289 reviews)
Fun Retro motel They kept the 1960's vibe and the rooms, shower, water, heater etc were all great. The only complaint I had (and it would be a minor fix) is that there was no security chain on our door inside. We put a chair under the door knob but for a few bucks the hotel could fix that.

Reviewed on Jan 15, 2026

Welch Motel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in De Soto

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Frequently Asked Questions About De Soto hotels

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How many hotels are there in De Soto?

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