Search for Cheap Deals on
Hotels in De Soto

Choose from 319 De Soto Hotel Deals

Gundersen Hotel & Suites

Gundersen Hotel & Suites

2.5 out of 5
1520 Clinic Court La Crosse WI
  • 12 hours drive from Mississippi River
Book a stay at this business-friendly hotel in La Crosse. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,004 reviews)
place is set up for older guests, anticipating elders needs. While we don't yet require that, we can appreciate their forward looking approach to serving older people.

Reviewed on Nov 27, 2025

Gundersen Hotel & Suites
Boarders Inn & Suites by Cobblestone Hotels – Waukon

Boarders Inn & Suites by Cobblestone Hotels – Waukon

3.5 out of 5
407 Rossville Rd Waukon IA
  • 10 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Waukon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8/10 Very Good! (447 reviews)
The staff is super friendly and helpful. They act like they are really glad that you are staying with them. The room was clean and cozy.

Reviewed on Nov 26, 2025

Boarders Inn & Suites by Cobblestone Hotels – Waukon
AmericInn by Wyndham Viroqua

AmericInn by Wyndham Viroqua

2.5 out of 5
1325 N Main St Viroqua WI
  • 11 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Viroqua. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Viroqua Country Club and Sidie ...
8/10 Very Good! (331 reviews)
every thing was good as thru provided shelter from the storm

Reviewed on Dec 1, 2025

AmericInn by Wyndham Viroqua
Welch Motel

Welch Motel

2.5 out of 5
3643 Mormon Coulee Rd. La Crosse WI
  • 12 hours drive from Mississippi River
Stay at this motel in La Crosse. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
7/10 Good! (282 reviews)
Yes

Reviewed on Dec 1, 2025

Welch Motel
Scenic Valley Motel

Scenic Valley Motel

2 out of 5
1608 Main St Lansing IA
  • 11 hours drive from Mississippi River
Stay at this motel in Lansing. Enjoy free WiFi, free parking, and housekeeping. Popular attractions Mount Hosmer Park and Lansing City Library are located ...
8.2/10 Very Good! (114 reviews)
Super clean. Love it.

Reviewed on Nov 6, 2025

Scenic Valley Motel
MIDWAY MOTEL

MIDWAY MOTEL

2.5 out of 5
850 N Main St Viroqua WI
  • 11 hours drive from Mississippi River
Stay at this hotel in Viroqua. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Viroqua Country Club and Sidie Hollow Park are located ...
8.4/10 Very Good! (42 reviews)
Room was cleang

Reviewed on Nov 10, 2025

MIDWAY MOTEL
Old Towne Motel

Old Towne Motel

2 out of 5
Hwy. 14, 61 & 27 South Westby WI
  • 11 hours drive from Mississippi River
Stay at this motel in Westby. Enjoy free WiFi, free parking, and room service. Popular attractions Dregne's Scandinavian Gifts and Branches Winery are located ...
7.8/10 Good! (238 reviews)
Booked 3 hrs before stay. Was efficient check in. The property was older but very clean. Liked having the availability of a patio door to put my belongings in the room from the car. Note to make reservation at supper club next door if planning to eat there (not associated with hotel).

Reviewed on Oct 21, 2025

Old Towne Motel
Adriatic

Adriatic

2 out of 5
3438 Mormon Coulee Rd La Crosse WI
  • 12 hours drive from Mississippi River
Stay at this hotel in La Crosse. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions La Crosse Center and St. Rose of Viterbo Convent ...
7/10 Good! (23 reviews)
The room could have been cleaner but overall it was a good stay.

Reviewed on Nov 11, 2025

Adriatic
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in De Soto

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your De Soto hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in De Soto.

Choosing the right hotel in Wisconsin has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of De Soto’s 319 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $67. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great De Soto hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in De Soto. No matter your reason for visiting De Soto, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About De Soto hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in De Soto for as low as $67.

How many hotels are there in De Soto?

With over 319 hotels in De Soto, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $67.

How to find cheap car rentals in De Soto?

Finding a cheap car rental deal in De Soto is as easy as scoring cheap hotels in De Soto. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.