Search for Cheap Deals on
Hotels in Greenville

Check Last Minute Greenville Hotel Deals

Tonight Jan 24 - Jan 25Next weekend Jan 30 - Feb 1

Choose from 329 Greenville Hotel Deals

Cobblestone Hotel & Suites - Greenville

Cobblestone Hotel & Suites - Greenville

3.5 out of 5
81 Hadley Road Greenville PA
  • 4 min drive from Greenville Medical Center UPMC
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (638 reviews)
Clean room and adequate breakfast.

Reviewed on Jan 8, 2026

Cobblestone Hotel & Suites - Greenville
Cianci's Motel and Suites

Cianci's Motel and Suites

2 out of 5
399 Mercer Road Greenville PA
  • 5 min drive from Greenville Medical Center UPMC
Stay at this motel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attraction Greenville ...
9.4/10 Exceptional! (597 reviews)
Staff was friendly and accommodating. Room was well maintained and clean.

Reviewed on Jan 7, 2026

Cianci's Motel and Suites
The Grand Resort

The Grand Resort

4 out of 5
9519 East Market Street Warren OH
  • 57 min drive from Greenville Medical Center UPMC
Book a stay at this golf hotel in Warren. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.2/10 Wonderful! (757 reviews)
Our stay was top notch start to finish. We had never stayed here before. I came with a friend and it has amenities for any age or group or for a simple get away with someone. Food, parking, rooms, the roman bath, cigar lounge, sitting areas. All absolutely amazing! Staff was very pleasnt as ...

Reviewed on Jan 23, 2026

The Grand Resort
Wingate by Wyndham Grove City

Wingate by Wyndham Grove City

2.5 out of 5
118 Garrett Dr Grove City PA
  • 56 min drive from Greenville Medical Center UPMC
Book a stay at this business-friendly hotel in Grove City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,001 reviews)
👍

Reviewed on Jan 5, 2026

Wingate by Wyndham Grove City
Comfort Suites Youngstown North

Comfort Suites Youngstown North

2.5 out of 5
201 Perni Ln Youngstown OH
  • 59 min drive from Greenville Medical Center UPMC
Book a stay at this business-friendly hotel in Youngstown. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,006 reviews)
Everything was great.

Reviewed on Jan 11, 2026

Comfort Suites Youngstown North
Park Inn by Radisson Sharon

Park Inn by Radisson Sharon

3.5 out of 5
3377 New Castle Road West Middlesex PA
  • 39 min drive from Greenville Medical Center UPMC
Book a stay at this golf hotel in West Middlesex. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
6/10 (1,001 reviews)
This property is beautiful! It seems that amenities such as hot tub and sauna are closed ‘indefinitely.’ Perhaps those would be worth investing in.

Reviewed on Jan 10, 2026

Park Inn by Radisson Sharon
Park Inn by Radisson

Park Inn by Radisson

2.5 out of 5
1924 Leesburg Grove City Road Grove City PA
  • 55 min drive from Greenville Medical Center UPMC
Book a stay at this business-friendly hotel in Grove City. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
7.2/10 Good! (1,000 reviews)
Rooms were very clean, staff was very courteous, price & location can't be beat!!

Reviewed on Dec 29, 2025

Park Inn by Radisson
Super 8 by Wyndham Grove City

Super 8 by Wyndham Grove City

2 out of 5
2001 Leesburg Grove City Rd Mercer PA
  • 55 min drive from Greenville Medical Center UPMC
Book a stay at this business-friendly motel in Mercer. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8/10 Very Good! (984 reviews)
Courteous and efficient staff. Clean, quiet, safe lodging.

Reviewed on Jan 19, 2026

Super 8 by Wyndham Grove City
Hampton Inn & Suites Niles/Warren

Hampton Inn & Suites Niles/Warren

2.5 out of 5
5581 Youngstown Warren Road Niles OH
  • 1 hour drive from Greenville Medical Center UPMC
Stay at this hotel in Niles. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Eastwood ...
9/10 Wonderful! (803 reviews)
The room was cleaned when we got there but only once did the housekeeping cleaned. We had to ask to get the garbage out or take it out ourselves. The fridge did not work and they didnt changed it out until 1day before we left. I know there is a lot of working going on at the hotel and i didn't mind ...

Reviewed on Jan 14, 2026

Hampton Inn & Suites Niles/Warren
Residence Inn Youngstown Warren/Niles

Residence Inn Youngstown Warren/Niles

3 out of 5
5555 Youngstown-Warren Rd Niles OH
  • 1 hour drive from Greenville Medical Center UPMC
Book a stay at this business-friendly hotel in Niles. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Eastwood Mall and Eastwood Field ...
9.2/10 Wonderful! (291 reviews)
Room was very clean! Bed very comfortable and staff very helpful when we needed to stay longer due to the weather. We will be back to stay!

Reviewed on Jan 21, 2026

Residence Inn Youngstown Warren/Niles
Days Inn by Wyndham Niles

Days Inn by Wyndham Niles

2 out of 5
1300 Youngstown Warren Rd Niles OH
  • 1 hour drive from Greenville Medical Center UPMC
Book a stay at this business-friendly hotel in Niles. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.2/10 Good! (712 reviews)
Yes

Reviewed on Jan 1, 2026

Days Inn by Wyndham Niles
Quality Inn & Suites Grove City - Outlet Mall

Quality Inn & Suites Grove City - Outlet Mall

2.5 out of 5
2049 Leesburg-Grove City Road Mercer PA
  • 55 min drive from Greenville Medical Center UPMC
Book a stay at this business-friendly hotel in Mercer. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.2/10 Good! (902 reviews)
Friendly staff. Clean room, but several areas needed repaired in the room. Great location.

Reviewed on Jan 1, 2026

Quality Inn & Suites Grove City - Outlet Mall
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Greenville

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Greenville hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Greenville.

Choosing the right hotel in Pennsylvania has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Greenville’s 329 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $59. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Greenville hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Greenville. No matter your reason for visiting Greenville, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Greenville hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Greenville for as low as $59.

How many hotels are there in Greenville?

With over 329 hotels in Greenville, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $59.

How to find cheap car rentals in Greenville?

Finding a cheap car rental deal in Greenville is as easy as scoring cheap hotels in Greenville. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.