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Choose from 361 Odessa Hotel Deals

MCM Grande Hotel FunDome Odessa
MCM Grande Hotel FunDome Odessa
3 out of 5
6201 E Business I-20, Odessa, TX
  • 10 min drive from Odessa Regional Medical Center
Stay at this 3-star business-friendly hotel in Odessa. Enjoy free breakfast, free parking, and room service. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (1,062 reviews)
"The pool, free drinks and the food"

Reviewed on Jun 19, 2025

MCM Grande Hotel FunDome Odessa
Baymont by Wyndham Odessa
Baymont by Wyndham Odessa
2.5 out of 5
4101 Parks Legado Rd, Odessa, TX
  • 14 min drive from Odessa Regional Medical Center
Book a stay at this business-friendly hotel in Odessa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.2/10 Very Good! (1,150 reviews)
"What we didn't like was the pepper on the eggs. Some people can't eat pepper. It would have been better to let people put their own pepper on their eggs."

Reviewed on Jun 14, 2025

Baymont by Wyndham Odessa
MCM Elegante Hotel and Conference Center Odessa
MCM Elegante Hotel and Conference Center Odessa
3.5 out of 5
5200 E. University Blvd., Odessa, TX
  • 10 min drive from Odessa Regional Medical Center
Stay at this 3.5-star spa hotel in Odessa. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our ...
8.8/10 Excellent! (1,013 reviews)
"Great hotel. Rooms were comfortable and clean. Loved how updated everything was. Great shower!"

Reviewed on Jun 19, 2025

MCM Elegante Hotel and Conference Center Odessa
Odessa Marriott Hotel & Conference Center
Odessa Marriott Hotel & Conference Center
4 out of 5
305 East 5th Street, Odessa, TX
  • 3 min walk from Odessa Regional Medical Center
Stay at this 4-star business-friendly hotel in Odessa. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (405 reviews)
"Everything was great. Only minor discomfort was the bath towels. They were quite rough and scratchy."

Reviewed on Jun 15, 2025

Odessa Marriott Hotel & Conference Center
Ramada by Wyndham Odessa Near University of Texas Permian
Ramada by Wyndham Odessa Near University of Texas Permian
2.5 out of 5
3001 E Business Loop 20, Odessa, TX
  • 8 min drive from Odessa Regional Medical Center
Book a stay at this business-friendly hotel in Odessa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
6.6/10 (1,001 reviews)
"Nice to relax."

Reviewed on Jun 20, 2025

Ramada by Wyndham Odessa Near University of Texas Permian
Best Western Plus North Odessa Inn & Suites
Best Western Plus North Odessa Inn & Suites
2.5 out of 5
7001 Tres Hermanas Boulevard, Odessa, TX
  • 13 min drive from Odessa Regional Medical Center
Book a stay at this business-friendly hotel in Odessa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (527 reviews)
"Not too shabby."

Reviewed on Jun 19, 2025

Best Western Plus North Odessa Inn & Suites
La Quinta Inn & Suites by Wyndham Odessa North
La Quinta Inn & Suites by Wyndham Odessa North
3 out of 5
4122 Faudree Rd, Odessa, TX
  • 16 min drive from Odessa Regional Medical Center
Stay at this 3-star business-friendly hotel in Odessa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8/10 Very Good! (462 reviews)
"stopped just for a night, could tell not new, bathtub/shower needs updating - shower wall cracked, and needs re-caulking"

Reviewed on Jun 2, 2025

La Quinta Inn & Suites by Wyndham Odessa North
Howard Johnson by Wyndham Odessa TX
Howard Johnson by Wyndham Odessa TX
2 out of 5
2925 E. Business Loop 20, Odessa, TX
  • 7 min drive from Odessa Regional Medical Center
Stay at this motel in Odessa. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Ellen Noel Art Museum and Presidential Museum and Leadership ...
6/10 (1,002 reviews)
"The front dest were rude and stared at you the while time while you get your contential breakfast. Night and day shift were rude and no ice machine"

Reviewed on Jun 13, 2025

Howard Johnson by Wyndham Odessa TX
Holiday Inn Express & Suites Odessa I-20 by IHG
Holiday Inn Express & Suites Odessa I-20 by IHG
2.5 out of 5
1800 S HWY 385, Odessa, TX
  • 5 min drive from Odessa Regional Medical Center
Book a stay at this business-friendly hotel in Odessa. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff in ...
8.6/10 Excellent! (412 reviews)
"Very comfortable and good location"

Reviewed on Jun 3, 2025

Holiday Inn Express & Suites Odessa I-20 by IHG
Super 8 by Wyndham Odessa TX
Super 8 by Wyndham Odessa TX
2 out of 5
2833 E I 20, Odessa, TX
  • 7 min drive from Odessa Regional Medical Center
Book a stay at this business-friendly hotel in Odessa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.6/10 Good! (678 reviews)
"Two night stay everything was great but I thought the floors could of been a little cleaner (swept and vacuumed) it wasn’t bad but you could tell it wasn’t done once we walked into the room our first night and throughout our stay…"

Reviewed on Jun 18, 2025

Super 8 by Wyndham Odessa TX
Holiday Inn Odessa by IHG
Holiday Inn Odessa by IHG
3 out of 5
5275 E 42nd Street, Odessa, TX
  • 10 min drive from Odessa Regional Medical Center
Stay at this 3-star business-friendly hotel in Odessa. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
8.6/10 Excellent! (399 reviews)
"Good stay"

Reviewed on Jun 8, 2025

Holiday Inn Odessa by IHG
avid hotel Odessa Northwest by IHG
avid hotel Odessa Northwest by IHG
2.5 out of 5
8200 DR EMMITT HEADLEE ST, Odessa, TX
  • 17 min drive from Odessa Regional Medical Center
Stay at this hotel in Odessa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Cinemark ...
8.4/10 Very Good! (118 reviews)
"We enjoyed this hotel nice rooms and comfortable bed."

Reviewed on May 20, 2025

avid hotel Odessa Northwest by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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