Search for Cheap Deals on
Spa Resort Hotels in Odessa

Check Last Minute Odessa Hotel Deals

Tonight Mar 21 - Mar 22This weekend Mar 21 - Mar 23

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!

Featured Odessa Resorts & Hotels with Spas

MCM Elegante Hotel and Conference Center Odessa
MCM Elegante Hotel and Conference Center Odessa
3.5 out of 5
5200 E. University Blvd., Odessa, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star spa hotel in Odessa. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our ...
MCM Elegante Hotel and Conference Center Odessa
MCM Grande Hotel FunDome Odessa
MCM Grande Hotel FunDome Odessa
3 out of 5
6201 E Business I-20, Odessa, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Odessa. Enjoy free breakfast, free parking, and room service. Our guests praise the breakfast and the helpful ...
MCM Grande Hotel FunDome Odessa
Best Western Plus North Odessa Inn & Suites
Best Western Plus North Odessa Inn & Suites
2.5 out of 5
7001 Tres Hermanas Boulevard, Odessa, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Odessa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Best Western Plus North Odessa Inn & Suites
Hilton Garden Inn Odessa
Hilton Garden Inn Odessa
3 out of 5
5221 Jbs Pkwy, Odessa, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Odessa. Enjoy free parking, breakfast (surcharge), and room service. Our guests praise the helpful staff in our ...
Hilton Garden Inn Odessa
Holiday Inn Odessa by IHG
Holiday Inn Odessa by IHG
3 out of 5
5275 E 42nd Street, Odessa, TX
Stay at this 3-star business-friendly hotel in Odessa. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
Holiday Inn Odessa by IHG
La Quinta Inn & Suites by Wyndham Odessa North
La Quinta Inn & Suites by Wyndham Odessa North
2.5 out of 5
4122 Faudree Rd, Odessa, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Odessa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
La Quinta Inn & Suites by Wyndham Odessa North
La Quinta Inn & Suites by Wyndham Odessa N. - Sienna Tower
La Quinta Inn & Suites by Wyndham Odessa N. - Sienna Tower
2.5 out of 5
4118 Faudree Rd, Odessa, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Odessa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
La Quinta Inn & Suites by Wyndham Odessa N. - Sienna Tower
Ramada by Wyndham Odessa Near University of Texas Permian
Ramada by Wyndham Odessa Near University of Texas Permian
2.5 out of 5
3001 E Business Loop 20, Odessa, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Odessa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Ramada by Wyndham Odessa Near University of Texas Permian
See all 339 properties in Odessa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.