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Santa Isabel Vacation Packages

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A tropical island with a beach, clear turquoise waters, and lush greenery.

Santa Isabel
Colón
Panama
Mexico and Central America
Hotwire.com

Santa Isabel Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.

Hotel Riazor

3 out of 5

Price was $882, price is now $611 per person

$611

per person

Oct 25 - Oct 29

found 15 hours ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this hotel in Panama City. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Megapolis Hotel Panamá

4.5 out of 5

Price was $1,493, price is now $802 per person

$802

per person

Dec 3 - Dec 6

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Deben mejorar el servicio de atención de parte de su personal de recepción y desayuno

Reviewed on Sep 21, 2026

Central Hotel Panama Casco Viejo

4 out of 5

Price was $1,466, price is now $921 per person

$921

per person

Oct 30 - Nov 3

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Such a great experience! I’d recommend it to anyone and love to stay again.

Reviewed on Sep 20, 2026

Salomon Urban Hub by Wynwood

3.5 out of 5

Price was $1,076, price is now $715 per person

$715

per person

Oct 25 - Oct 29

found 15 hours ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this apartment in Panama City. Enjoy free WiFi, free parking, and rainfall showerheads. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Sofia's B&B Hostal Boutique

3 out of 5

Price was $948, price is now $657 per person

$657

per person

Oct 25 - Oct 29

found 15 hours ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this B&B in Panama City. Enjoy free WiFi, breakfast (surcharge), and an airport shuttle (surcharge). Popular attractions Albrook Shopping Mall and Multiplaza Pacific Mall are located nearby.

Luxury Oasis in Panama's Casco Viejo

2 out of 5

Price was $1,093, price is now $764 per person

$764

per person

Oct 25 - Oct 29

found 15 hours ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this apartment in Panama City. Enjoy free parking. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Perfect location

Reviewed on Feb 9, 2026

Casa Mallet by Wynwood House

4 out of 5

Price was $1,973, price is now $1,388 per person

$1,388

per person

Dec 4 - Dec 11

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

Stay at this apartment in Panama City. Enjoy free WiFi, parking (surcharge), and premium bedding. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

I would highly recommend, the service I received was impeccable and just a wonderful experience! I was a bit hesitant regarding the location but once I got there, it turned out to be perfect. The concierge staff was such a pleasure to work with especially ‘Jerry’, who provided recommendations and information. This was such a blessing to us. I would stay here again in a heart beat. It’s a must stay!

Reviewed on Sep 16, 2026

Riande Aeropuerto Hotel & Casino

4 out of 5

Price was $1,019, price is now $725 per person

$725

per person

Dec 3 - Dec 6

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Metromall Panama and Los Pueblos Commercial Center are located nearby.

Santa Isabel Vacation Packages 3-4 Night Stays

Price found within the past 48 hours. Click for updated prices.

Salomon Urban Hub by Wynwood

3.5 out of 5

Bella Vista

Price was $1,076, price is now $715 per person

$715

per person

Oct 25 - Oct 29

found 15 hours ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)