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Florence

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Florence Flights as Low as $311

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Tue, Jan 19 - Sat, Jan 30
DFW
Dallas-Fort Worth Intl.
FLO
Florence Regional
$311 Roundtrip, found 12 hours ago
$311
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Tue, Jan 19 from Dallas-Fort Worth Intl. to Florence Regional, returning Sat, Jan 30, priced at $311 found 12 hours ago
American Airlines
Thu, Jan 21 - Thu, Jan 28
DFW
Dallas-Fort Worth Intl.
FLO
Florence Regional
$361 Roundtrip, found 17 hours ago
$361
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Thu, Jan 21 from Dallas-Fort Worth Intl. to Florence Regional, returning Thu, Jan 28, priced at $361 found 17 hours ago
American Airlines
Sat, Jan 16 - Sat, Jan 30
DFW
Dallas-Fort Worth Intl.
FLO
Florence Regional
$421 Roundtrip, found 2 days ago
$421
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Jan 16 from Dallas-Fort Worth Intl. to Florence Regional, returning Sat, Jan 30, priced at $421 found 2 days ago
American Airlines
Wed, Nov 25 - Mon, Nov 30
STL
Lambert-St. Louis Intl.
FLO
Florence Regional
$427 Roundtrip, found 3 days ago
$427
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Nov 25 from Lambert-St. Louis Intl. to Florence Regional, returning Mon, Nov 30, priced at $427 found 3 days ago
American Airlines
Tue, Jan 19 - Sat, Jan 30
DFW
Dallas-Fort Worth Intl.
FLO
Florence Regional
$433 Roundtrip, found 5 days ago
$433
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Jan 19 from Dallas-Fort Worth Intl. to Florence Regional, returning Sat, Jan 30, priced at $433 found 5 days ago
American Airlines
Wed, Nov 25 - Mon, Nov 30
STL
Lambert-St. Louis Intl.
FLO
Florence Regional
$437 Roundtrip, found 17 hours ago
$437
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Wed, Nov 25 from Lambert-St. Louis Intl. to Florence Regional, returning Mon, Nov 30, priced at $437 found 17 hours ago
American Airlines
Tue, Jan 26 - Sat, Feb 13
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$451 Roundtrip, found 17 hours ago
$451
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Tue, Jan 26 from Minneapolis - St. Paul Intl. to Florence Regional, returning Sat, Feb 13, priced at $451 found 17 hours ago
American Airlines
Thu, Jan 21 - Thu, Jan 28
DFW
Dallas-Fort Worth Intl.
FLO
Florence Regional
$451 Roundtrip, found 17 hours ago
$451
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Thu, Jan 21 from Dallas-Fort Worth Intl. to Florence Regional, returning Thu, Jan 28, priced at $451 found 17 hours ago
American Airlines
Thu, Jan 21 - Thu, Jan 28
DFW
Dallas-Fort Worth Intl.
FLO
Florence Regional
$461 Roundtrip, found 2 days ago
$461
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Jan 21 from Dallas-Fort Worth Intl. to Florence Regional, returning Thu, Jan 28, priced at $461 found 2 days ago
American Airlines
Wed, Nov 25 - Mon, Nov 30
STL
Lambert-St. Louis Intl.
FLO
Florence Regional
$461 Roundtrip, found 17 hours ago
$461
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Wed, Nov 25 from Lambert-St. Louis Intl. to Florence Regional, returning Mon, Nov 30, priced at $461 found 17 hours ago
American Airlines
Wed, Nov 25 - Mon, Nov 30
STL
Lambert-St. Louis Intl.
FLO
Florence Regional
$462 Roundtrip, found 3 days ago
$462
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Nov 25 from Lambert-St. Louis Intl. to Florence Regional, returning Mon, Nov 30, priced at $462 found 3 days ago
American Airlines
Wed, Nov 25 - Mon, Nov 30
STL
Lambert-St. Louis Intl.
FLO
Florence Regional
$467 Roundtrip, found 17 hours ago
$467
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Wed, Nov 25 from Lambert-St. Louis Intl. to Florence Regional, returning Mon, Nov 30, priced at $467 found 17 hours ago
American Airlines
Mon, Jan 4 - Wed, Jan 20
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$473 Roundtrip, found 17 hours ago
$473
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Mon, Jan 4 from Minneapolis - St. Paul Intl. to Florence Regional, returning Wed, Jan 20, priced at $473 found 17 hours ago
American Airlines
Tue, Dec 22 - Wed, Jan 6
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$475 Roundtrip, found 17 hours ago
$475
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Tue, Dec 22 from John F. Kennedy Intl. to Florence Regional, returning Wed, Jan 6, priced at $475 found 17 hours ago
American Airlines
Tue, Jan 26 - Sat, Feb 13
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$479 Roundtrip, found 17 hours ago
$479
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Tue, Jan 26 from Minneapolis - St. Paul Intl. to Florence Regional, returning Sat, Feb 13, priced at $479 found 17 hours ago
American Airlines
Wed, Nov 11 - Sat, Nov 14
PIA
Greater Peoria Regional
FLO
Florence Regional
$501 Roundtrip, found 17 hours ago
$501
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Wed, Nov 11 from Greater Peoria Regional to Florence Regional, returning Sat, Nov 14, priced at $501 found 17 hours ago

Cheap Flights to Florence

Fall in love at first flight with your vacation to Florence by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Florence on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Florence, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Florence

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Florence with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the DLL airport.

What is the cheapest month to fly to Florence?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Florence are in January, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Florence?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Florence.

What airport is best to fly into Florence?

When you’re planning your trip to Florence, convenience is the name of the game. Luckily, Florence Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Florence must-do list.

How much are flights to Florence?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Florence on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $311, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Florence?

The trick to saving a stack of cash on your flight to Florence? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $311 right now, why wait?

Florence Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$310

Last Minute Hotel Deals in Florence

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,500 reviews)
"Le personnel très aimable et le décor de l'entrée très agréable"

Reviewed on Nov 4, 2026

Get rates
Park Inn by Radisson Florence, SC
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,749 reviews)
"Clean room, breakfast could have been more extensive"

Reviewed on Nov 4, 2026

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Howard Johnson by Wyndham Florence
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,388 reviews)
"Clean rooms, very friendly and helpful staff. Good breakfast"

Reviewed on Nov 4, 2026

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Comfort Inn & Suites Florence Center Area
Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
9/10 Wonderful! (1,000 reviews)
"Rooms were clean, the staff were really kind, the breakfast had some variety. Would stay again if I needed to go to Florence, South Carolina. Very walkable, in the downtown area."

Reviewed on Nov 3, 2026

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Hyatt Place Florence Downtown
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (350 reviews)
"Couldn’t check in. Had to book a second hotel at 3am"

Reviewed on Nov 4, 2026

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Spark by Hilton Florence North I-95, SC
SpringHill Suites by Marriott Florence

SpringHill Suites by Marriott Florence

3 out of 5
2670 Hospitality Blvd Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,002 reviews)
"The hotel pool amd rooms were nice, and there was a big variety for breakfast. Our toilet didn't work well, and the tub slanted inward to the middle but otherwise enjoyable."

Reviewed on Nov 3, 2026

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SpringHill Suites by Marriott Florence
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,001 reviews)
"Room was very clean and comfortable. The free breakfast was muffins, bagels, yogurt, juice, and dry cereal with milk or soy milk., An apple we took to have after lunch while hiking in Shenandoah National Park was bad, probably should have taken 2 at breakfast. Staff was friendly and helpful. The ..."

Reviewed on Nov 4, 2026

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Days Inn by Wyndham Florence Near Civic Center
TownePlace Suites by Marriott Florence

TownePlace Suites by Marriott Florence

3 out of 5
2650 Hospitality Boulevard Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, a 24-hour fitness center, and parking (surcharge). Our guests praise the helpful ...
9/10 Wonderful! (923 reviews)
"My stay was awesome! The entire staff was friendly and extremely helpful on all the small things that can make travel stressful. From the moment I walked in they provided gold star service. Jenine, Kamesha (sp?), Hanna, and the rest of the staff were spectacular. I opening the spellings correct, ..."

Reviewed on Oct 31, 2026

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TownePlace Suites by Marriott Florence
See all 419 properties in Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.