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Florence

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Florence Flights as Low as $370

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Wed, Jul 16 - Sat, Jul 19
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$370 Roundtrip, found 14 hours ago
$370
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Wed, Jul 16 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 19, priced at $370 found 14 hours ago
American Airlines
Tue, Oct 7 - Sat, Oct 11
PHL
Philadelphia Intl.
FLO
Florence Regional
$403 Roundtrip, found 13 hours ago
$403
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Tue, Oct 7 from Philadelphia Intl. to Florence Regional, returning Sat, Oct 11, priced at $403 found 13 hours ago
American Airlines
Tue, Oct 7 - Sat, Oct 11
PHL
Philadelphia Intl.
FLO
Florence Regional
$414 Roundtrip, found 3 days ago
$414
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Oct 7 from Philadelphia Intl. to Florence Regional, returning Sat, Oct 11, priced at $414 found 3 days ago
American Airlines
Wed, Jul 16 - Sat, Jul 19
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$433 Roundtrip, found 14 hours ago
$433
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Wed, Jul 16 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 19, priced at $433 found 14 hours ago
American Airlines
Wed, Jul 16 - Sun, Jul 20
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$437 Roundtrip, found 3 days ago
$437
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jul 16 from John F. Kennedy Intl. to Florence Regional, returning Sun, Jul 20, priced at $437 found 3 days ago
American Airlines
Wed, Jul 16 - Sat, Jul 19
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$441 Roundtrip, found 14 hours ago
$441
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Wed, Jul 16 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 19, priced at $441 found 14 hours ago
American Airlines
Wed, Jul 16 - Sat, Jul 19
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$442 Roundtrip, found 14 hours ago
$442
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Wed, Jul 16 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 19, priced at $442 found 14 hours ago
American Airlines
Tue, Oct 7 - Sat, Oct 11
PHL
Philadelphia Intl.
FLO
Florence Regional
$459 Roundtrip, found 13 hours ago
$459
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Tue, Oct 7 from Philadelphia Intl. to Florence Regional, returning Sat, Oct 11, priced at $459 found 13 hours ago
American Airlines
Wed, Oct 8 - Mon, Oct 13
PHL
Philadelphia Intl.
FLO
Florence Regional
$469 Roundtrip, found 1 day ago
$469
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Oct 8 from Philadelphia Intl. to Florence Regional, returning Mon, Oct 13, priced at $469 found 1 day ago
American Airlines
Wed, Jul 16 - Sat, Jul 19
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$488 Roundtrip, found 3 days ago
$488
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jul 16 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 19, priced at $488 found 3 days ago
American Airlines
Wed, Jul 16 - Sat, Jul 19
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$496 Roundtrip, found 14 hours ago
$496
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Wed, Jul 16 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 19, priced at $496 found 14 hours ago
American Airlines
Wed, Jul 16 - Sat, Jul 19
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$504 Roundtrip, found 14 hours ago
$504
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Wed, Jul 16 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 19, priced at $504 found 14 hours ago
American Airlines
Wed, Jul 16 - Sat, Jul 19
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$505 Roundtrip, found 14 hours ago
$505
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Wed, Jul 16 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 19, priced at $505 found 14 hours ago
American Airlines
Tue, Oct 7 - Sat, Oct 11
PHL
Philadelphia Intl.
FLO
Florence Regional
$506 Roundtrip, found 13 hours ago
$506
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Tue, Oct 7 from Philadelphia Intl. to Florence Regional, returning Sat, Oct 11, priced at $506 found 13 hours ago
American Airlines
Wed, Jul 16 - Sun, Jul 20
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$509 Roundtrip, found 3 days ago
$509
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jul 16 from John F. Kennedy Intl. to Florence Regional, returning Sun, Jul 20, priced at $509 found 3 days ago
American Airlines
Wed, Jul 16 - Sat, Jul 19
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$544 Roundtrip, found 14 hours ago
$544
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Wed, Jul 16 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 19, priced at $544 found 14 hours ago

Cheap Flights to Florence

Fall in love at first flight with your vacation to Florence by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Florence on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Florence, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Florence

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Florence with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the DLL airport.

What is the cheapest month to fly to Florence?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Florence are in July, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Florence?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Florence.

What airport is best to fly into Florence?

When you’re planning your trip to Florence, convenience is the name of the game. Luckily, Florence Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Florence must-do list.

How much are flights to Florence?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Florence on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $370, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Florence?

The trick to saving a stack of cash on your flight to Florence? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $370 right now, why wait?

Florence Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$370

Last Minute Hotel Deals in Florence

Howard Johnson by Wyndham Florence
Howard Johnson by Wyndham Florence
2 out of 5
2038 W Lucas Street, I-95 Exit 164, Florence, SC
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,268 reviews)
"Better than expected, great location, just needs minor repairs from renovation i.e. old headboard mounting holes. Free WiFi."

Reviewed on Jul 5, 2025

Get rates
Howard Johnson by Wyndham Florence
Comfort Inn & Suites
Comfort Inn & Suites
2.5 out of 5
527 Woody Jones Blvd, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,014 reviews)
"Nice property"

Reviewed on Jul 1, 2025

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Comfort Inn & Suites
Park Inn by Radisson Florence, SC
Park Inn by Radisson Florence, SC
2.5 out of 5
1729 Mandeville Road, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,075 reviews)
"Super clean, nice hotel. Newer building, easy stay."

Reviewed on Jul 4, 2025

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Park Inn by Radisson Florence, SC
Quality Inn & Suites Florence Civic Center
Quality Inn & Suites Florence Civic Center
2.5 out of 5
150 Dunbarton Dr, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,221 reviews)
"Always stay here on mybway to Orlando for business"

Reviewed on Jul 1, 2025

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Quality Inn & Suites Florence Civic Center
Hyatt Place Florence Downtown
Hyatt Place Florence Downtown
3 out of 5
100 East Evans Street Florence, Florence, SC
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,005 reviews)
"Nice and friendly faces 👌"

Reviewed on Jul 5, 2025

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Hyatt Place Florence Downtown
La Quinta Inn & Suites by Wyndham Florence
La Quinta Inn & Suites by Wyndham Florence
3 out of 5
2123 W Lucas St, Florence, SC
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,648 reviews)
"Nicely updated. Bathroom has some mold around tub. Very quiet. Very helpful and friendly staff. Easy access from an to 95."

Reviewed on Jul 3, 2025

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La Quinta Inn & Suites by Wyndham Florence
TownePlace Suites by Marriott Florence
TownePlace Suites by Marriott Florence
3 out of 5
2650 Hospitality Boulevard, Florence, SC
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free parking, and a 24-hour fitness center. Our guests praise the helpful staff ...
8.8/10 Excellent! (603 reviews)
"The front desk was wonderful! The breakfast was good!"

Reviewed on Jun 30, 2025

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TownePlace Suites by Marriott Florence
Days Inn by Wyndham Florence/I-95 North
Days Inn by Wyndham Florence/I-95 North
2 out of 5
2111 West Lucas St/I-95, I-95 & Hwy 52 Exit 164, Florence, SC
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,000 reviews)
"LOVE THE STAFF"

Reviewed on Jun 27, 2025

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Days Inn by Wyndham Florence/I-95 North
See all 331 properties in Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.