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Florence

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Florence Flights as Low as $414

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Wed, Aug 27 - Sat, Aug 30
TPA
Tampa Intl.
FLO
Florence Regional
$414 Roundtrip, found 1 day ago
$414
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Aug 27 from Tampa Intl. to Florence Regional, returning Sat, Aug 30, priced at $414 found 1 day ago
American Airlines
Wed, Oct 8 - Mon, Oct 13
TTN
Mercer
FLO
Florence Regional
$418 Roundtrip, found 5 days ago
$418
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Oct 8 from Mercer to Florence Regional, returning Mon, Oct 13, priced at $418 found 5 days ago
American Airlines
Sat, Aug 30 - Sun, Aug 31
TPA
Tampa Intl.
FLO
Florence Regional
$447 Roundtrip, found 1 day ago
$447
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Aug 30 from Tampa Intl. to Florence Regional, returning Sun, Aug 31, priced at $447 found 1 day ago
American Airlines
Sat, Aug 30 - Tue, Sep 2
TPA
Tampa Intl.
FLO
Florence Regional
$457 Roundtrip, found 1 day ago
$457
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Aug 30 from Tampa Intl. to Florence Regional, returning Tue, Sep 2, priced at $457 found 1 day ago
American Airlines
Sat, Oct 11 - Tue, Oct 14
PHL
Philadelphia Intl.
FLO
Florence Regional
$459 Roundtrip, found 5 days ago
$459
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sat, Oct 11 from Philadelphia Intl. to Florence Regional, returning Tue, Oct 14, priced at $459 found 5 days ago
American Airlines
Sat, Aug 30 - Mon, Sep 1
TPA
Tampa Intl.
FLO
Florence Regional
$462 Roundtrip, found 1 day ago
$462
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Aug 30 from Tampa Intl. to Florence Regional, returning Mon, Sep 1, priced at $462 found 1 day ago
American Airlines
Tue, Oct 7 - Sat, Oct 11
PHL
Philadelphia Intl.
FLO
Florence Regional
$469 Roundtrip, found 5 days ago
$469
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Oct 7 from Philadelphia Intl. to Florence Regional, returning Sat, Oct 11, priced at $469 found 5 days ago
American Airlines
Fri, Aug 29 - Sat, Aug 30
TPA
Tampa Intl.
FLO
Florence Regional
$472 Roundtrip, found 1 day ago
$472
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Aug 29 from Tampa Intl. to Florence Regional, returning Sat, Aug 30, priced at $472 found 1 day ago
American Airlines
Wed, Oct 8 - Mon, Oct 13
TTN
Mercer
FLO
Florence Regional
$474 Roundtrip, found 5 days ago
$474
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Oct 8 from Mercer to Florence Regional, returning Mon, Oct 13, priced at $474 found 5 days ago
American Airlines
Tue, Aug 19 - Sat, Aug 23
TPA
Tampa Intl.
FLO
Florence Regional
$475 Roundtrip, found 4 days ago
$475
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Aug 19 from Tampa Intl. to Florence Regional, returning Sat, Aug 23, priced at $475 found 4 days ago
American Airlines
Fri, Aug 29 - Sun, Aug 31
TPA
Tampa Intl.
FLO
Florence Regional
$477 Roundtrip, found 1 day ago
$477
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Aug 29 from Tampa Intl. to Florence Regional, returning Sun, Aug 31, priced at $477 found 1 day ago
American Airlines
Mon, Oct 6 - Sun, Oct 12
PHL
Philadelphia Intl.
FLO
Florence Regional
$479 Roundtrip, found 1 day ago
$479
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Oct 6 from Philadelphia Intl. to Florence Regional, returning Sun, Oct 12, priced at $479 found 1 day ago
American Airlines
Thu, Aug 28 - Sat, Aug 30
TPA
Tampa Intl.
FLO
Florence Regional
$480 Roundtrip, found 1 day ago
$480
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Aug 28 from Tampa Intl. to Florence Regional, returning Sat, Aug 30, priced at $480 found 1 day ago
American Airlines
Thu, Aug 28 - Sun, Aug 31
TPA
Tampa Intl.
FLO
Florence Regional
$485 Roundtrip, found 1 day ago
$485
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Aug 28 from Tampa Intl. to Florence Regional, returning Sun, Aug 31, priced at $485 found 1 day ago
American Airlines
Fri, Oct 10 - Sun, Oct 12
PHL
Philadelphia Intl.
FLO
Florence Regional
$489 Roundtrip, found 5 days ago
$489
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Oct 10 from Philadelphia Intl. to Florence Regional, returning Sun, Oct 12, priced at $489 found 5 days ago
American Airlines
Wed, Oct 8 - Mon, Oct 13
PHL
Philadelphia Intl.
FLO
Florence Regional
$497 Roundtrip, found 1 day ago
$497
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Oct 8 from Philadelphia Intl. to Florence Regional, returning Mon, Oct 13, priced at $497 found 1 day ago

Cheap Flights to Florence

Fall in love at first flight with your vacation to Florence by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Florence on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Florence, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Florence

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Florence with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the DLL airport.

What is the cheapest month to fly to Florence?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Florence are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Florence?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Florence.

What airport is best to fly into Florence?

When you’re planning your trip to Florence, convenience is the name of the game. Luckily, Florence Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Florence must-do list.

How much are flights to Florence?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Florence on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $414, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Florence?

The trick to saving a stack of cash on your flight to Florence? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $414 right now, why wait?

Florence Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$435

Last Minute Hotel Deals in Florence

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,114 reviews)
"Perfect for overnight while traveling, plenty of food options and right off I-95"

Reviewed on Aug 14, 2025

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Park Inn by Radisson Florence, SC
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street, I-95 Exit 164, Florence, SC
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,329 reviews)
Great comfort and quality.
"The hotel was comfortable and clean. Check-in was easy and I enjoyed a comfortable night's sleep for a great price!"

Reviewed on Aug 11, 2025

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Howard Johnson by Wyndham Florence
Comfort Inn & Suites

Comfort Inn & Suites

2.5 out of 5
527 Woody Jones Blvd, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,050 reviews)
"Great for price"

Reviewed on Aug 13, 2025

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Comfort Inn & Suites
Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence, Florence, SC
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,000 reviews)
"Bed not comfy, very soft."

Reviewed on Aug 7, 2025

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Hyatt Place Florence Downtown
La Quinta Inn & Suites by Wyndham Florence

La Quinta Inn & Suites by Wyndham Florence

3 out of 5
2123 W Lucas St, Florence, SC
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,672 reviews)
Superb!
"I was pleasantly surprised at just how nice it was here at the Laquinta. The rooms were superb abd the beds were comfortable."

Reviewed on Aug 14, 2025

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La Quinta Inn & Suites by Wyndham Florence
Days Inn by Wyndham Florence/I-95 North

Days Inn by Wyndham Florence/I-95 North

2 out of 5
2111 West Lucas St/I-95, I-95 & Hwy 52 Exit 164, Florence, SC
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,001 reviews)
"Easy access to everything needed. Staff and house keeping are exceptional. Sheets, pillows are awesome, Quiet and safe feeling."

Reviewed on Aug 11, 2025

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Days Inn by Wyndham Florence/I-95 North
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,002 reviews)
"For an overnight on a road trip, it was fine. The A/C was deafening and the floor needed mopping, but otherwise adequate."

Reviewed on Aug 13, 2025

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Days Inn by Wyndham Florence Near Civic Center
Microtel Inn & Suites by Wyndham Florence

Microtel Inn & Suites by Wyndham Florence

2 out of 5
1912 Enterprise Dr, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
6.6/10 (1,001 reviews)
One night stay
"It was a nice place but i didn't like you had to do $100 deposit just for one night. Just because of other people actions"

Reviewed on Jul 26, 2025

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Microtel Inn & Suites by Wyndham Florence
See all 340 properties in Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.