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Hotels in Florence

Choose from 370 Florence Hotel Deals

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
  • 9 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
8.8/10 Excellent! (2,233 reviews)
I slept well. TV was good. Shower and bathroom were nice. Hot food at breakfast was cold.

Reviewed on Jan 17, 2026

Park Inn by Radisson Florence, SC
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
  • 7 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,183 reviews)
The room was clean and comfortable. The location was excellent and a perfect stop midway to Florida for some weary travelers.

Reviewed on Jan 15, 2026

Comfort Inn & Suites Florence Center Area
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
  • 9 min drive from Florence Civic Center
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,543 reviews)
Yes. Everyone and everything was great

Reviewed on Jan 17, 2026

Howard Johnson by Wyndham Florence
Days Inn by Wyndham Florence/I-95 North

Days Inn by Wyndham Florence/I-95 North

2 out of 5
2111 West Lucas St/I-95 Florence SC
  • 10 min drive from Florence Civic Center
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,011 reviews)
Good room, great price

Reviewed on Jan 17, 2026

Days Inn by Wyndham Florence/I-95 North
Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
  • 11 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,002 reviews)
Friendly staff

Reviewed on Jan 15, 2026

Hyatt Place Florence Downtown
La Quinta Inn & Suites by Wyndham Florence

La Quinta Inn & Suites by Wyndham Florence

3 out of 5
2123 W Lucas St Florence SC
  • 10 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,667 reviews)
Extremely clean room very friendly staff breakfast had a great variety

Reviewed on Jan 13, 2026

La Quinta Inn & Suites by Wyndham Florence
Residence Inn Marriott Florence

Residence Inn Marriott Florence

3 out of 5
2660 Hospitality Blvd Florence SC
  • 4 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (498 reviews)
I gave it four stars because they was a five dollar parking fee that’s charged on the credit card you leave for incidentals I was not aware of the parking fee. We only stayed one night so I guess it’s five dollars per night for parking. Other than that. Everything was great. Rooms were clean. Breakfast ...

Reviewed on Jan 5, 2026

Residence Inn Marriott Florence
Hampton Inn & Suites Florence Center

Hampton Inn & Suites Florence Center

2.5 out of 5
3000 W Radio Dr Florence SC
  • 8 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9/10 Wonderful! (839 reviews)
Breakfast was far could use more options that are healthy . Rooms were very nice and super clean.

Reviewed on Jan 17, 2026

Hampton Inn & Suites Florence Center
TownePlace Suites by Marriott Florence

TownePlace Suites by Marriott Florence

3 out of 5
2650 Hospitality Boulevard Florence SC
  • 7 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free parking, and a 24-hour fitness center. Our guests praise the helpful staff ...
8.8/10 Excellent! (729 reviews)
Room is clean. Great coffee. Staff great. Will definitely be back

Reviewed on Jan 16, 2026

TownePlace Suites by Marriott Florence
Tru by Hilton Florence I-95

Tru by Hilton Florence I-95

2.5 out of 5
2140 West Lucas Street Florence SC
  • 10 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (1,002 reviews)
A clean room is a priority, but check in staff was perfect. I appreciate the breakfast counter but I lived the temperature control in our room just as much. Looking forward to our next stay.

Reviewed on Jan 16, 2026

Tru by Hilton Florence I-95
Microtel Inn & Suites by Wyndham Florence

Microtel Inn & Suites by Wyndham Florence

2 out of 5
1912 Enterprise Dr Florence SC
  • 10 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
6.6/10 (1,002 reviews)
Friendly staff, clean rooms, nice location

Reviewed on Dec 29, 2025

Microtel Inn & Suites by Wyndham Florence
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
  • 9 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,251 reviews)
The room was as described. It was neat, clean and spotless with 1 kimg size bed, and 1 sofa bed.

Reviewed on Jan 17, 2026

Quality Inn & Suites Florence Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Florence

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Frequently Asked Questions About Florence hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Florence?

With over 370 hotels in Florence, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $59.

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