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Tonight Jun 26 - Jun 27This weekend Jun 26 - Jun 28

Choose from 405 Florence Hotel Deals

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
  • 9 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,315 reviews)
"Clean room ,good breakfast"

Reviewed on Jun 26, 2026

Park Inn by Radisson Florence, SC
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
  • 9 min drive from Florence Civic Center
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,682 reviews)
"The property is older and a little outdated. The design looks like military barracks with green grass in the middle. The was furnished alright, however there was hair on 3 of the 4 pillows on the bed, along with red nail polish on obe one of the pillows, and a red dot on the toilet paper that looked ..."

Reviewed on Jun 26, 2026

Howard Johnson by Wyndham Florence
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
  • 7 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,304 reviews)
"Clean room, staffs were nice, breakfast was so-so. No cream cheese for bagels. Overall I would stay again"

Reviewed on Jun 26, 2026

Comfort Inn & Suites Florence Center Area
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
  • 9 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (208 reviews)
"This was the second time staying at this hotel (Quality Inn) on our way back from Florida to Delaware. The hotel is clean and there are a lot of food choices in the area."

Reviewed on Jun 25, 2026

Quality Inn & Suites Florence Civic Center
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
  • 9 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (183 reviews)
"Hotel was clean and well maintained. Staff was helpful, but spent a great deal of time talking to friends and was constantly telling customers "to wait a few minutes". Breakfast was very bad, no eggs in the egg container, "enhanced water' was really water downed juice instead of real juice, meat ..."

Reviewed on Jun 25, 2026

Spark by Hilton Florence North I-95, SC
Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
  • 12 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
9/10 Wonderful! (1,002 reviews)
"The Hotel is pretty good. The pool is a little small. The room was nice and clean. The bed was nice and comfortable.We will come back"

Reviewed on Jun 26, 2026

Hyatt Place Florence Downtown
La Quinta Inn & Suites by Wyndham Florence

La Quinta Inn & Suites by Wyndham Florence

3 out of 5
2123 W Lucas St Florence SC
  • 10 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
La Quinta Inn & Suites by Wyndham Florence
Comfort Suites Florence I-95

Comfort Suites Florence I-95

2.5 out of 5
2120 West Lucas Street Florence SC
  • 10 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.2/10 Very Good! (1,002 reviews)
"Great area and nice hotel!"

Reviewed on Jun 26, 2026

Comfort Suites Florence I-95
Super 8 by Wyndham Florence

Super 8 by Wyndham Florence

2 out of 5
1832 1/2 Lucas Street, I95 Exit 164 Florence SC
  • 10 min drive from Florence Civic Center
Stay at this motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7/10 Good! (1,000 reviews)
"When I checked in the desk clerk said breakfast was between 6am to 8am I was there at 6:45 and the door was locked so I checked out by putting key through night window at 7am The place was good except there was no breakfast so don't advertise it"

Reviewed on Jun 26, 2026

Super 8 by Wyndham Florence
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
  • 8 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,001 reviews)
"Clean and great staff. Would definitely return"

Reviewed on Jun 25, 2026

Days Inn by Wyndham Florence Near Civic Center
Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG

Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG

2.5 out of 5
2101 Florence Harllee Blvd Florence SC
  • 25 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,004 reviews)
"The stay was one of the best experiences I have had in long time."

Reviewed on Jun 25, 2026

Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG
Hampton Inn & Suites Florence-North-I-95

Hampton Inn & Suites Florence-North-I-95

2.5 out of 5
1735 Stokes Road Florence SC
  • 9 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (940 reviews)
"Great hotel"

Reviewed on Jun 24, 2026

Hampton Inn & Suites Florence-North-I-95
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Florence

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If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $62. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Florence hotel deals at the last minute.

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Frequently Asked Questions About Florence hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Florence?

With over 405 hotels in Florence, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $62.

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Finding a cheap car rental deal in Florence is as easy as scoring cheap hotels in Florence. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.