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Choose from 419 Florence Hotel Deals
Park Inn by Radisson Florence, SC
Howard Johnson by Wyndham Florence
"Rooms need upgrades. Things are worn out"
Reviewed on Nov 4, 2026
Comfort Inn & Suites Florence Center Area
"This our go to place to stay when we drive to NJ. Stayed here 3 times already this year. The staff here is the very definition of southern hospitality. This is the primary reason why we keep coming back. The hotel is also always clean and the rooms are well maintained. Breakfast has different varieties ..."
Reviewed on Nov 3, 2026
Hyatt Place Florence Downtown
"Rooms were clean, the staff were really kind, the breakfast had some variety. Would stay again if I needed to go to Florence, South Carolina. Very walkable, in the downtown area."
Reviewed on Nov 3, 2026
Spark by Hilton Florence North I-95, SC
"We had a nice stay at this property, and we were happy about its cleanliness, good service and location."
Reviewed on Nov 3, 2026
SpringHill Suites by Marriott Florence
"The hotel pool amd rooms were nice, and there was a big variety for breakfast. Our toilet didn't work well, and the tub slanted inward to the middle but otherwise enjoyable."
Reviewed on Nov 3, 2026
Days Inn by Wyndham Florence Near Civic Center
"Clean"
Reviewed on Nov 2, 2026
TownePlace Suites by Marriott Florence
"My stay was awesome! The entire staff was friendly and extremely helpful on all the small things that can make travel stressful. From the moment I walked in they provided gold star service. Jenine, Kamesha (sp?), Hanna, and the rest of the staff were spectacular. I opening the spellings correct, ..."
Reviewed on Oct 31, 2026
Quality Inn & Suites Florence Civic Center
Hampton Inn & Suites Florence Center
La Quinta Inn & Suites by Wyndham Florence
Tru by Hilton Florence I-95
Find cheap hotels in Florence
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Florence hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in Florence.
Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Florence’s 419 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $68. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Florence hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Florence. No matter your reason for visiting Florence, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Florence hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Florence for as low as $68.
How many hotels are there in Florence?
With over 419 hotels in Florence, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $68.
How to find cheap car rentals in Florence?
Finding a cheap car rental deal in Florence is as easy as scoring cheap hotels in Florence. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
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