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Hotels in Florence

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Tonight Feb 22 - Feb 23Next weekend Feb 28 - Mar 2

Choose from 303 Florence Hotel Deals

Park Inn by Radisson Florence, SC
Park Inn by Radisson Florence, SC
2.5 out of 5
1729 Mandeville Road, Florence, SC
  • 9 min drive from Florence Civic Center
The price is $95 per night from Mar 2 to Mar 3
$95
includes taxes & fees
Mar 2 - Mar 3
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,936 reviews)
"Nice experience!"

Reviewed on Feb 19, 2025

Park Inn by Radisson Florence, SC
Howard Johnson by Wyndham Florence
Howard Johnson by Wyndham Florence
2 out of 5
2038 W Lucas Street, I-95 Exit 164, Florence, SC
  • 9 min drive from Florence Civic Center
The price is $68 per night from Feb 23 to Feb 24
$68
includes taxes & fees
Feb 23 - Feb 24
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,088 reviews)
"I stay there frequently, and it is always pleasant, quiet and the staff are very nice and attentive."

Reviewed on Feb 19, 2025

Howard Johnson by Wyndham Florence
Quality Inn & Suites Florence Civic Center
Quality Inn & Suites Florence Civic Center
2.5 out of 5
150 Dunbarton Dr, Florence, SC
  • 9 min walk from Florence Civic Center
The price is $98 per night from Mar 9 to Mar 10
$98
includes taxes & fees
Mar 9 - Mar 10
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,104 reviews)
"Met our needs"

Reviewed on Feb 19, 2025

Quality Inn & Suites Florence Civic Center
Comfort Inn & Suites
Comfort Inn & Suites
2.5 out of 5
527 Woody Jones Blvd, Florence, SC
  • 3 min walk from Florence Civic Center
The price is $109 per night from Mar 9 to Mar 10
$109
includes taxes & fees
Mar 9 - Mar 10
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,003 reviews)
"I have been doing a lot of traveling lately and this hotel was by far, the most excellent hotel I have stayed in. The breakfast was amazing; the hotel is extremely clean; the staff was friendly and accommodating and caring; the hotel was very pet friendly. Everything about it was wonderful. I can’t ..."

Reviewed on Feb 16, 2025

Comfort Inn & Suites
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr, an IHG Hotel
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr, an IHG Hotel
2.5 out of 5
3440 W Radio Dr, Florence, SC
  • 8 min walk from Florence Civic Center
The price is $111 per night from Mar 9 to Mar 10
$111
includes taxes & fees
Mar 9 - Mar 10
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,003 reviews)
"Totally enjoyed our stay very relaxing, great breakfast,great staff"

Reviewed on Feb 21, 2025

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr, an IHG Hotel
Microtel Inn & Suites by Wyndham Florence
Microtel Inn & Suites by Wyndham Florence
2 out of 5
1912 Enterprise Dr, Florence, SC
  • 10 min drive from Florence Civic Center
The price is $53 per night from Mar 2 to Mar 3
$53
includes taxes & fees
Mar 2 - Mar 3
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
6.6/10 (1,001 reviews)
"Elevator out of order....wake up call ditto breakfast was decent"

Reviewed on Feb 11, 2025

Microtel Inn & Suites by Wyndham Florence
Days Inn by Wyndham Florence/I-95 North
Days Inn by Wyndham Florence/I-95 North
2 out of 5
2111 West Lucas St/I-95, I-95 & Hwy 52 Exit 164, Florence, SC
  • 10 min drive from Florence Civic Center
The price is $68 per night from Mar 23 to Mar 24
$68
includes taxes & fees
Mar 23 - Mar 24
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,000 reviews)
"Smelled like someone 's cigarette smoke lingering in room only negative for me."

Reviewed on Feb 12, 2025

Days Inn by Wyndham Florence/I-95 North
Hyatt Place Florence Downtown
Hyatt Place Florence Downtown
3 out of 5
100 East Evans Street Florence, Florence, SC
  • 11 min drive from Florence Civic Center
The price is $124 per night from Mar 2 to Mar 3
$124
includes taxes & fees
Mar 2 - Mar 3
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (1,000 reviews)
Only one flaw
"Everything about it was very good. Except the parking. It's a minor inconvenience - and I get the limited options downtown - but it was the only negative to our stay. A hike like that could be a challenge to the elderly, infirmed, or even to everybody in extreme weather. Precipitation, sub-freezing ..."

Reviewed on Feb 19, 2025

Hyatt Place Florence Downtown
Staybridge Suites Florence - Civic Center, an IHG Hotel
Staybridge Suites Florence - Civic Center, an IHG Hotel
3 out of 5
150 Westpark Drive, Florence, SC
  • 9 min walk from Florence Civic Center
The price is $151 per night from Mar 2 to Mar 3
$151
includes taxes & fees
Mar 2 - Mar 3
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (806 reviews)
"The staff were friendly and knowledgeable. The Monday-Wednesday reception and light bites were a pleasant bonus. The breakfast buffet was very good. They had plenty of luggage carts."

Reviewed on Feb 18, 2025

Staybridge Suites Florence - Civic Center, an IHG Hotel
Tru by Hilton Florence I-95
Tru by Hilton Florence I-95
2.5 out of 5
2140 West Lucas Street, Florence, SC
  • 10 min drive from Florence Civic Center
The price is $113 per night from Mar 2 to Mar 3
$113
includes taxes & fees
Mar 2 - Mar 3
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,001 reviews)
Only has Tesla Charger
"Should tell Hotels.com that you only offer Tesla charge ports. Good breakfast."

Reviewed on Feb 18, 2025

Tru by Hilton Florence I-95
La Quinta Inn & Suites by Wyndham Florence
La Quinta Inn & Suites by Wyndham Florence
2.5 out of 5
2123 W Lucas St, Florence, SC
  • 10 min drive from Florence Civic Center
The price is $106 per night from Mar 23 to Mar 24
$106
includes taxes & fees
Mar 23 - Mar 24
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,656 reviews)
"Nice hotel"

Reviewed on Feb 20, 2025

La Quinta Inn & Suites by Wyndham Florence
Aloft Florence
Aloft Florence
3 out of 5
820 WOODY JONES BOULEVARD, Florence, SC
  • 3 min walk from Florence Civic Center
The price is $130 per night from Mar 9 to Mar 10
$130
includes taxes & fees
Mar 9 - Mar 10
Stay at this 3-star business-friendly hotel in Florence. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Florence Civic Center ...
8.4/10 Very Good! (107 reviews)
"Was not able to stay due to the pool being closed. Stay was for a special needs child that was looking forward to swimming on school break. Front desk was very kind, will definitely try to book there next time"

Reviewed on Feb 18, 2025

Aloft Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Florence

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Florence.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Florence’s 303 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $53. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Florence hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Florence. No matter your reason for visiting Florence, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Florence hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Florence for as low as $53.

How many hotels are there in Florence?

With over 303 hotels in Florence, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $53.

How to find cheap car rentals in Florence?

Finding a cheap car rental deal in Florence is as easy as scoring cheap hotels in Florence. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.