Search for Cheap Deals on
Hotels in Florence

Check Last Minute Florence Hotel Deals

Tonight Jun 5 - Jun 6This weekend Jun 5 - Jun 7

Choose from 398 Florence Hotel Deals

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
  • 9 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,292 reviews)
"The staff was friendly which made check in easier and check out was a smooth transaction. The room was comfy and clean. However, there are some areas of the hotel are already showing some wear already."

Reviewed on Jun 4, 2026

Park Inn by Radisson Florence, SC
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
  • 9 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (174 reviews)
"N/A"

Reviewed on Jun 4, 2026

Quality Inn & Suites Florence Civic Center
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
  • 9 min drive from Florence Civic Center
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,680 reviews)
"Great staff"

Reviewed on Jun 4, 2026

Howard Johnson by Wyndham Florence
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
  • 9 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (140 reviews)
"Every thing good"

Reviewed on Jun 1, 2026

Spark by Hilton Florence North I-95, SC
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
  • 7 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,298 reviews)
"Clean room and breakfast was great"

Reviewed on Jun 3, 2026

Comfort Inn & Suites Florence Center Area
Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
  • 12 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
9/10 Wonderful! (1,008 reviews)
"Everything was clean, staff was friendly. A few random beggars on the street, but that’s downtown for you."

Reviewed on Jun 3, 2026

Hyatt Place Florence Downtown
Hampton Inn & Suites Florence Center

Hampton Inn & Suites Florence Center

2.5 out of 5
3000 W Radio Dr Florence SC
  • 8 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9/10 Wonderful! (894 reviews)
"Front desk was professional and friendly. Lounge chair in room appeared worm and dirty. All wooden surfaces in the roo9m were sticky, departure staff said it could be the wax they use... For the charge of #133.00 including tax my wife and I were disappointed in the room. Breakfast was OK, nothing ..."

Reviewed on Jun 4, 2026

Hampton Inn & Suites Florence Center
La Quinta Inn & Suites by Wyndham Florence

La Quinta Inn & Suites by Wyndham Florence

3 out of 5
2123 W Lucas St Florence SC
  • 10 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,589 reviews)
"Took 27 minutes to get checked in. I was the 8th person in line. Pool was closed. No hair dryer in the room, called front desk and they did not have any. Breakfast had eggs, biscuits and gravy but no meat."

Reviewed on Jun 2, 2026

La Quinta Inn & Suites by Wyndham Florence
Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG

Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG

2.5 out of 5
2101 Florence Harllee Blvd Florence SC
  • 25 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,005 reviews)
"Great location, friendly staff, clean rooms and breakfast was awesome!!"

Reviewed on Jun 3, 2026

Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG
Staybridge Suites Florence - Civic Center by IHG

Staybridge Suites Florence - Civic Center by IHG

3 out of 5
150 Westpark Drive Florence SC
  • 9 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,003 reviews)
"Staff are outstanding, however we had to move rooms (3) times. First time was due to missed bedsheets that were not changed out, the second time the AC was out in the room. We had to pack up and move (4) kids each time after a 10 hour drive , not fun. And we weren’t given a discount, just an apology. ..."

Reviewed on Jun 4, 2026

Staybridge Suites Florence - Civic Center by IHG
Aloft by Marriott Florence

Aloft by Marriott Florence

3 out of 5
820 WOODY JONES BOULEVARD Florence SC
  • 3 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Popular attractions Regal Swamp ...
8.6/10 Excellent! (340 reviews)
"Never before in my life have I had such a horrible experience at a hotel. Poop in the bed. Just disgusting"

Reviewed on May 30, 2026

Aloft by Marriott Florence
Days Inn by Wyndham Florence/I-95 North

Days Inn by Wyndham Florence/I-95 North

2 out of 5
2111 West Lucas St/I-95 Florence SC
  • 10 min drive from Florence Civic Center
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,002 reviews)
"The mattress’s were filthy. They had stains everywhere on them. The vents had black mold. It’s a shame because days inn used to be exceptionally well maintained. Hopefully they can meet those standards again in the future."

Reviewed on Jun 3, 2026

Days Inn by Wyndham Florence/I-95 North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Florence

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Florence hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Florence.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Florence’s 398 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $63. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Florence hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Florence. No matter your reason for visiting Florence, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Florence hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Florence for as low as $63.

How many hotels are there in Florence?

With over 398 hotels in Florence, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $63.

How to find cheap car rentals in Florence?

Finding a cheap car rental deal in Florence is as easy as scoring cheap hotels in Florence. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.