Search for Cheap Deals on
Hotels in Hartsville

Check Last Minute Hartsville Hotel Deals

Tonight May 17 - May 18Next weekend May 22 - May 24

Choose from 188 Hartsville Hotel Deals

Fairfield Inn by Marriott Hartsville

Fairfield Inn by Marriott Hartsville

3 out of 5
200 S 4th St Hartsville SC
  • 5 min drive from Neptune Island Waterpark
Book a stay at this business-friendly hotel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.6/10 Excellent! (730 reviews)
Room was clean. Easy check in

Reviewed on May 12, 2026

Fairfield Inn by Marriott Hartsville
The Landmark Inn

The Landmark Inn

2.5 out of 5
1301 South 4th Street Hartsville SC
  • 6 min drive from Neptune Island Waterpark
Book a stay at this business-friendly motel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
The Landmark Inn
Hampton Inn & Suites Hartsville

Hampton Inn & Suites Hartsville

2.5 out of 5
203 East Carolina Ave. Hartsville SC
  • 5 min drive from Neptune Island Waterpark
Stay at this hotel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.2/10 Wonderful! (501 reviews)
Room was clean. Quiet. Nearby restaurants were delicious!

Reviewed on Apr 27, 2026

Hampton Inn & Suites Hartsville
The Mantissa Hotel

The Mantissa Hotel

3 out of 5
130 East Carolina Ave Hartsville SC
  • 5 min drive from Neptune Island Waterpark
Stay at this hotel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.2/10 Wonderful! (288 reviews)
Adorable hotel. Great location in Hartsville

Reviewed on May 8, 2026

The Mantissa Hotel
Quality Inn Hartsville

Quality Inn Hartsville

2.5 out of 5
903 S 5th Street Hartsville SC
  • 5 min drive from Neptune Island Waterpark
Stay at this hotel in Hartsville. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Hartsville Museum and Hartsville Memorial Library are ...
Quality Inn Hartsville
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
  • 51 min drive from Neptune Island Waterpark
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,658 reviews)
Clean comfortable and convenient. The staff was friendly, I could walk to the Starbucks and restaurants. The room was very clean. The bed was very comfortable. Great for this weary traveler.

Reviewed on May 14, 2026

Howard Johnson by Wyndham Florence
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
  • 48 min drive from Neptune Island Waterpark
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (145 reviews)
Good overall. Outside entrance was my only problem.

Reviewed on May 17, 2026

Quality Inn & Suites Florence Civic Center
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
  • 51 min drive from Neptune Island Waterpark
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,260 reviews)
Variety of breakfast items both hot and cold. Very friendly and helpful staff; clean rooms a plus. Pet friendly rooms are well kept.

Reviewed on May 17, 2026

Park Inn by Radisson Florence, SC
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
  • 50 min drive from Neptune Island Waterpark
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,279 reviews)
The property was very nice and in a quiet location while being close to many restaurants and amenities. There is a nice walking trail across from the property. The front desk employee who checked us in was very sweet. The young lady that checked us out was less than friendly and didn't even say thank ...

Reviewed on May 16, 2026

Comfort Inn & Suites Florence Center Area
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
  • 51 min drive from Neptune Island Waterpark
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (114 reviews)
Bed was comfortable and place quiet for our one night stay. The quality of breakfast not so great. Coffee could have been better

Reviewed on May 16, 2026

Spark by Hilton Florence North I-95, SC
Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
  • 58 min drive from Neptune Island Waterpark
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
9/10 Wonderful! (1,004 reviews)
.

Reviewed on May 15, 2026

Hyatt Place Florence Downtown
Hampton Inn & Suites Florence-North-I-95

Hampton Inn & Suites Florence-North-I-95

2.5 out of 5
1735 Stokes Road Florence SC
  • 50 min drive from Neptune Island Waterpark
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (909 reviews)
Good basic Hampton Inn. Front desk was very attentive and helpful. The breakfast area and food was the best I’ve had at a Hampton Inn.

Reviewed on May 15, 2026

Hampton Inn & Suites Florence-North-I-95
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Hartsville

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Hartsville hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Hartsville.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Hartsville’s 188 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $76. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Hartsville hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Hartsville. No matter your reason for visiting Hartsville, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Hartsville hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Hartsville for as low as $76.

How many hotels are there in Hartsville?

With over 188 hotels in Hartsville, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $76.

How to find cheap car rentals in Hartsville?

Finding a cheap car rental deal in Hartsville is as easy as scoring cheap hotels in Hartsville. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.