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Hartsville

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Hartsville Flights as Low as $269

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Wed, May 13 - Tue, Jun 2
DCA
Ronald Reagan Washington National
FLO
Florence Regional
$269 Roundtrip, found 1 day ago
$269
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, May 13 from Ronald Reagan Washington National to Florence Regional, returning Tue, Jun 2, priced at $269 found 1 day ago
American Airlines
Tue, Jul 21 - Tue, Jul 28
LGA
LaGuardia
FLO
Florence Regional
$289 Roundtrip, found 4 hours ago
$289
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Tue, Jul 21 from LaGuardia to Florence Regional, returning Tue, Jul 28, priced at $289 found 4 hours ago
American Airlines
Wed, Jun 3 - Wed, Jun 17
LGA
LaGuardia
FLO
Florence Regional
$294 Roundtrip, found 18 hours ago
$294
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Wed, Jun 3 from LaGuardia to Florence Regional, returning Wed, Jun 17, priced at $294 found 18 hours ago
American Airlines
Tue, May 12 - Sat, May 16
BWI
Baltimore Washington Intl. Thurgood Marshall
FLO
Florence Regional
$351 Roundtrip, found 1 day ago
$351
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, May 12 from Baltimore Washington Intl. Thurgood Marshall to Florence Regional, returning Sat, May 16, priced at $351 found 1 day ago
American Airlines
Fri, Jul 17 - Tue, Jul 28
LGA
LaGuardia
FLO
Florence Regional
$368 Roundtrip, found 1 day ago
$368
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Jul 17 from LaGuardia to Florence Regional, returning Tue, Jul 28, priced at $368 found 1 day ago
American Airlines
Wed, Jun 3 - Wed, Jun 17
LGA
LaGuardia
FLO
Florence Regional
$369 Roundtrip, found 4 days ago
$369
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Jun 3 from LaGuardia to Florence Regional, returning Wed, Jun 17, priced at $369 found 4 days ago
American Airlines
Wed, Jun 3 - Wed, Jun 17
LGA
LaGuardia
FLO
Florence Regional
$373 Roundtrip, found 18 hours ago
$373
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Wed, Jun 3 from LaGuardia to Florence Regional, returning Wed, Jun 17, priced at $373 found 18 hours ago
American Airlines
Tue, Jul 14 - Sat, Jul 25
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$375 Roundtrip, found 1 day ago
$375
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jul 14 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 25, priced at $375 found 1 day ago
American Airlines
Tue, Jul 21 - Tue, Jul 28
LGA
LaGuardia
FLO
Florence Regional
$375 Roundtrip, found 4 hours ago
$375
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Tue, Jul 21 from LaGuardia to Florence Regional, returning Tue, Jul 28, priced at $375 found 4 hours ago
American Airlines
Wed, Jun 3 - Wed, Jun 17
LGA
LaGuardia
FLO
Florence Regional
$381 Roundtrip, found 18 hours ago
$381
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Wed, Jun 3 from LaGuardia to Florence Regional, returning Wed, Jun 17, priced at $381 found 18 hours ago
American Airlines
Tue, Jul 21 - Tue, Jul 28
LGA
LaGuardia
FLO
Florence Regional
$397 Roundtrip, found 4 hours ago
$397
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Tue, Jul 21 from LaGuardia to Florence Regional, returning Tue, Jul 28, priced at $397 found 4 hours ago
American Airlines
Wed, Apr 22 - Sat, Apr 25
SAT
San Antonio Intl.
FLO
Florence Regional
$469 Roundtrip, found 4 days ago
$469
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Apr 22 from San Antonio Intl. to Florence Regional, returning Sat, Apr 25, priced at $469 found 4 days ago
American Airlines
Wed, Jul 15 - Sat, Jul 25
BDL
Bradley Intl.
FLO
Florence Regional
$473 Roundtrip, found 1 day ago
$473
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jul 15 from Bradley Intl. to Florence Regional, returning Sat, Jul 25, priced at $473 found 1 day ago
American Airlines
Tue, Mar 31 - Sat, Apr 18
ORF
Norfolk Intl.
FLO
Florence Regional
$529 Roundtrip, found 1 day ago
$529
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Mar 31 from Norfolk Intl. to Florence Regional, returning Sat, Apr 18, priced at $529 found 1 day ago
American Airlines
Tue, Apr 14 - Sun, Apr 19
ATL
Hartsfield-Jackson Atlanta Intl.
FLO
Florence Regional
$577 Roundtrip, found 1 day ago
$577
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Apr 14 from Hartsfield-Jackson Atlanta Intl. to Florence Regional, returning Sun, Apr 19, priced at $577 found 1 day ago
American Airlines
Fri, Apr 17 - Fri, Apr 17
FLL
Fort Lauderdale - Hollywood Intl.
FLO
Florence Regional
$927 Roundtrip, found 11 hours ago
$927
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Fri, Apr 17 from Fort Lauderdale - Hollywood Intl. to Florence Regional, returning Fri, Apr 17, priced at $927 found 11 hours ago

Cheap Flights to Hartsville

Fall in love at first flight with your vacation to Hartsville by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Hartsville on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Hartsville, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Hartsville

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Hartsville with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the FLO airport.

What is the cheapest month to fly to Hartsville?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Hartsville are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Hartsville?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Hartsville.

What airport is best to fly into Hartsville?

When you’re planning your trip to Hartsville, convenience is the name of the game. Luckily, Hartsville Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Hartsville must-do list.

How much are flights to Hartsville?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Hartsville on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $269, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Hartsville?

The trick to saving a stack of cash on your flight to Hartsville? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $269 right now, why wait?

Hartsville Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$268

Last Minute Hotel Deals in Hartsville

Fairfield Inn by Marriott Hartsville

Fairfield Inn by Marriott Hartsville

3 out of 5
200 S 4th St Hartsville SC
Book a stay at this business-friendly hotel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.6/10 Excellent! (714 reviews)
The room was overall satisfactory however not fully clean when we arrived. There were used bars of soap in the shower, the bed was poorly made (sheets on in the wrong way and came off when sitting on the bed). The WiFi was also not functioning for the entirety of the stay. The breakfast was good ...

Reviewed on Mar 26, 2026

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Fairfield Inn by Marriott Hartsville
The Landmark Inn

The Landmark Inn

2.5 out of 5
1301 South 4th Street Hartsville SC
Book a stay at this business-friendly motel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7/10 Good! (326 reviews)
air conditioning was excellent the bed was comfortable . the check in went smooth and the shower had hot water available. it’s a less expensive room and the amenities are on par for that . quick nights sleep and on to the races

Reviewed on Mar 29, 2026

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The Landmark Inn
The Mantissa Hotel

The Mantissa Hotel

3 out of 5
130 East Carolina Ave Hartsville SC
Stay at this hotel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
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The Mantissa Hotel
Hampton Inn & Suites Hartsville

Hampton Inn & Suites Hartsville

2.5 out of 5
203 East Carolina Ave. Hartsville SC
Stay at this hotel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.2/10 Wonderful! (493 reviews)
C

Reviewed on Mar 7, 2026

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Hampton Inn & Suites Hartsville
Quality Inn Hartsville

Quality Inn Hartsville

2.5 out of 5
903 S 5th Street Hartsville SC
Book a stay at this business-friendly hotel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Hartsville Museum and Hartsville ...
6.2/10 (338 reviews)
Check in was fine. Pool could be used in an "end of the world" movie...chairs, a ladder are in the pool (no water in the pool) looks like fixing the pool has been years in the making. Room had no extra security lock on the door. Mold behind the door and inside the picture frame on the picture on ...

Reviewed on Mar 23, 2026

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Quality Inn Hartsville
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,602 reviews)
Nice person at the reception desk. Breakfast area was well stocked and clean.

Reviewed on Mar 29, 2026

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Howard Johnson by Wyndham Florence
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,240 reviews)
Property was acceptable for our standards.

Reviewed on Mar 26, 2026

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Comfort Inn & Suites Florence Center Area
Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
9/10 Wonderful! (1,004 reviews)
Everything was great except the staff at the bar. The first girl didn’t know how to use a bottle opener to open a beer. I asked the second girl to put in a grilled cheese right away so I can bring it up to my 1 year old baby. It took about an hour to get this grilled cheese and it came out with the ...

Reviewed on Mar 27, 2026

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Hyatt Place Florence Downtown
See all 195 properties in Hartsville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.