Search Cheap Flights to
Hartsville

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

Hartsville Flights as Low as $388

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Wed, Oct 28 - Wed, Nov 4
LGA
LaGuardia
FLO
Florence Regional
$388 Roundtrip, found 1 day ago
$388
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Oct 28 from LaGuardia to Florence Regional, returning Wed, Nov 4, priced at $388 found 1 day ago
American Airlines
Thu, Oct 29 - Sat, Oct 31
LGA
LaGuardia
FLO
Florence Regional
$446 Roundtrip, found 1 day ago
$446
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Oct 29 from LaGuardia to Florence Regional, returning Sat, Oct 31, priced at $446 found 1 day ago
American Airlines
Mon, Oct 26 - Fri, Nov 6
LGA
LaGuardia
FLO
Florence Regional
$504 Roundtrip, found 1 day ago
$504
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Oct 26 from LaGuardia to Florence Regional, returning Fri, Nov 6, priced at $504 found 1 day ago
American Airlines
Tue, Dec 22 - Wed, Jan 6
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$537 Roundtrip, found 2 days ago
$537
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Dec 22 from John F. Kennedy Intl. to Florence Regional, returning Wed, Jan 6, priced at $537 found 2 days ago
American Airlines
Fri, Dec 25 - Tue, Jan 5
LGA
LaGuardia
FLO
Florence Regional
$540 Roundtrip, found 2 days ago
$540
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Dec 25 from LaGuardia to Florence Regional, returning Tue, Jan 5, priced at $540 found 2 days ago
American Airlines
Tue, Dec 22 - Tue, Jan 5
LGA
LaGuardia
FLO
Florence Regional
$548 Roundtrip, found 2 days ago
$548
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Dec 22 from LaGuardia to Florence Regional, returning Tue, Jan 5, priced at $548 found 2 days ago
American Airlines
Sat, Oct 24 - Sun, Oct 25
BOS
Logan Intl.
FLO
Florence Regional
$555 Roundtrip, found 4 days ago
$555
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Oct 24 from Logan Intl. to Florence Regional, returning Sun, Oct 25, priced at $555 found 4 days ago
American Airlines
Tue, Oct 20 - Sat, Oct 24
BWI
Baltimore Washington Intl. Thurgood Marshall
FLO
Florence Regional
$559 Roundtrip, found 4 days ago
$559
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Oct 20 from Baltimore Washington Intl. Thurgood Marshall to Florence Regional, returning Sat, Oct 24, priced at $559 found 4 days ago
American Airlines
Thu, Dec 24 - Tue, Jan 5
LGA
LaGuardia
FLO
Florence Regional
$562 Roundtrip, found 2 days ago
$562
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Dec 24 from LaGuardia to Florence Regional, returning Tue, Jan 5, priced at $562 found 2 days ago
American Airlines
Sat, Oct 17 - Mon, Nov 16
PWM
Portland Intl. Jetport
FLO
Florence Regional
$583 Roundtrip, found 20 hours ago
$583
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Sat, Oct 17 from Portland Intl. Jetport to Florence Regional, returning Mon, Nov 16, priced at $583 found 20 hours ago
American Airlines
Sat, Oct 3 - Wed, Oct 7
BWI
Baltimore Washington Intl. Thurgood Marshall
FLO
Florence Regional
$586 Roundtrip, found 2 days ago
$586
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Oct 3 from Baltimore Washington Intl. Thurgood Marshall to Florence Regional, returning Wed, Oct 7, priced at $586 found 2 days ago
American Airlines
Sun, Dec 27 - Tue, Jan 5
LGA
LaGuardia
FLO
Florence Regional
$590 Roundtrip, found 2 days ago
$590
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sun, Dec 27 from LaGuardia to Florence Regional, returning Tue, Jan 5, priced at $590 found 2 days ago
American Airlines
Thu, Oct 22 - Tue, Nov 17
PWM
Portland Intl. Jetport
FLO
Florence Regional
$591 Roundtrip, found 2 hours ago
$591
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Thu, Oct 22 from Portland Intl. Jetport to Florence Regional, returning Tue, Nov 17, priced at $591 found 2 hours ago
American Airlines
Tue, Dec 22 - Thu, Dec 31
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$594 Roundtrip, found 2 days ago
$594
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Dec 22 from John F. Kennedy Intl. to Florence Regional, returning Thu, Dec 31, priced at $594 found 2 days ago
American Airlines
Tue, Dec 15 - Tue, Dec 22
TUL
Tulsa Intl.
FLO
Florence Regional
$595 Roundtrip, found 1 day ago
$595
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Dec 15 from Tulsa Intl. to Florence Regional, returning Tue, Dec 22, priced at $595 found 1 day ago
American Airlines
Wed, Dec 23 - Tue, Jan 5
LGA
LaGuardia
FLO
Florence Regional
$596 Roundtrip, found 2 days ago
$596
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Dec 23 from LaGuardia to Florence Regional, returning Tue, Jan 5, priced at $596 found 2 days ago
Hartsville Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$388

Last Minute Hotel Deals in Hartsville

Fairfield Inn by Marriott Hartsville

Fairfield Inn by Marriott Hartsville

3 out of 5
200 S 4th St Hartsville SC
Book a stay at this business-friendly hotel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (800 reviews)
"n/a"

Reviewed on Sep 25, 2026

Get rates
Fairfield Inn by Marriott Hartsville
The Landmark Inn

The Landmark Inn

2.5 out of 5
1301 South 4th Street Hartsville SC
Book a stay at this business-friendly motel in Hartsville. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. ...
Get rates
The Landmark Inn
The Mantissa Hotel

The Mantissa Hotel

3 out of 5
130 East Carolina Ave Hartsville SC
Stay at this hotel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
Get rates
The Mantissa Hotel
Hampton Inn & Suites Hartsville

Hampton Inn & Suites Hartsville

2.5 out of 5
203 East Carolina Ave. Hartsville SC
Stay at this hotel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.2/10 Wonderful! (522 reviews)
"Always love staying here when visiting my daughter at Coker. Such kind staff. They were booked full and seemed under staffed for cleaning so all staff was pitching in to help out."

Reviewed on Sep 22, 2026

Get rates
Hampton Inn & Suites Hartsville
Quality Inn Hartsville

Quality Inn Hartsville

2.5 out of 5
903 S 5th Street Hartsville SC
Stay at this hotel in Hartsville. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Hartsville Museum and Hartsville Memorial Library are ...
6/10 (353 reviews)
"When arriving it looked like a normal quality inn. The gentleman at the front desk was pleasantly talkative and helpful. After checking into the two king size bedrooms, we noticed a strong smell of marijuana and cigarettes. One of the lamps did not work, which then the front desk replaced. There ..."

Reviewed on Sep 22, 2026

Get rates
Quality Inn Hartsville
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,454 reviews)
"The front desk person was amazing!"

Reviewed on Sep 25, 2026

Get rates
Park Inn by Radisson Florence, SC
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Get rates
Howard Johnson by Wyndham Florence
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Get rates
Quality Inn & Suites Florence Civic Center
See all 201 properties in Hartsville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.