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Murphysboro

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Murphysboro Flights as Low as $156

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Contour Airlines
Wed, May 6 - Wed, May 6
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$156 Roundtrip, found 5 days ago
$156
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Wed, May 6 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Wed, May 6, priced at $156 found 5 days ago
Contour Airlines
Sun, May 3 - Wed, May 6
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$158 Roundtrip, found 5 days ago
$158
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Sun, May 3 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Wed, May 6, priced at $158 found 5 days ago
Contour Airlines
Wed, May 6 - Thu, May 7
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$162 Roundtrip, found 5 days ago
$162
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Wed, May 6 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Thu, May 7, priced at $162 found 5 days ago
Contour Airlines
Sun, May 3 - Mon, May 11
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$218 Roundtrip, found 4 days ago
$218
Roundtrip
found 4 days ago
Select Contour Airlines flight, departing Sun, May 3 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Mon, May 11, priced at $218 found 4 days ago
Contour Airlines
Wed, Apr 29 - Wed, May 13
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$223 Roundtrip, found 2 days ago
$223
Roundtrip
found 2 days ago
Select Contour Airlines flight, departing Wed, Apr 29 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Wed, May 13, priced at $223 found 2 days ago
Contour Airlines
Fri, May 1 - Wed, May 13
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$224 Roundtrip, found 2 days ago
$224
Roundtrip
found 2 days ago
Select Contour Airlines flight, departing Fri, May 1 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Wed, May 13, priced at $224 found 2 days ago
Contour Airlines
Sun, May 3 - Fri, May 8
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$228 Roundtrip, found 1 day ago
$228
Roundtrip
found 1 day ago
Select Contour Airlines flight, departing Sun, May 3 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Fri, May 8, priced at $228 found 1 day ago
Contour Airlines
Fri, May 1 - Fri, May 8
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$233 Roundtrip, found 1 day ago
$233
Roundtrip
found 1 day ago
Select Contour Airlines flight, departing Fri, May 1 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Fri, May 8, priced at $233 found 1 day ago
Contour Airlines
Sun, May 3 - Sun, May 3
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$243 Roundtrip, found 6 days ago
$243
Roundtrip
found 6 days ago
Select Contour Airlines flight, departing Sun, May 3 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Sun, May 3, priced at $243 found 6 days ago
Contour Airlines
Sun, May 3 - Tue, May 5
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$258 Roundtrip, found 1 day ago
$258
Roundtrip
found 1 day ago
Select Contour Airlines flight, departing Sun, May 3 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Tue, May 5, priced at $258 found 1 day ago
Contour Airlines
Fri, May 1 - Tue, May 5
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$264 Roundtrip, found 1 day ago
$264
Roundtrip
found 1 day ago
Select Contour Airlines flight, departing Fri, May 1 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Tue, May 5, priced at $264 found 1 day ago
Contour Airlines
Sat, May 2 - Tue, May 5
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$265 Roundtrip, found 1 day ago
$265
Roundtrip
found 1 day ago
Select Contour Airlines flight, departing Sat, May 2 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Tue, May 5, priced at $265 found 1 day ago
Contour Airlines
Sun, May 3 - Sat, May 9
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$268 Roundtrip, found 5 days ago
$268
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Sun, May 3 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Sat, May 9, priced at $268 found 5 days ago
Contour Airlines
Thu, Apr 30 - Fri, May 8
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$274 Roundtrip, found 1 day ago
$274
Roundtrip
found 1 day ago
Select Contour Airlines flight, departing Thu, Apr 30 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Fri, May 8, priced at $274 found 1 day ago
Contour Airlines
Wed, May 6 - Sat, May 9
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$275 Roundtrip, found 5 days ago
$275
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Wed, May 6 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Sat, May 9, priced at $275 found 5 days ago
American Airlines
Wed, May 20 - Wed, May 27
STL
Lambert-St. Louis Intl.
MWA
Veterans Airport of Southern Illinois
$305 Roundtrip, found 10 hours ago
$305
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Wed, May 20 from Lambert-St. Louis Intl. to Veterans Airport of Southern Illinois, returning Wed, May 27, priced at $305 found 10 hours ago

Cheap Flights to Murphysboro

Fall in love at first flight with your vacation to Murphysboro by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Murphysboro on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Murphysboro, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Murphysboro

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Murphysboro with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the MDH airport.

What is the cheapest month to fly to Murphysboro?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Murphysboro are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Murphysboro?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Murphysboro.

What airport is best to fly into Murphysboro?

When you’re planning your trip to Murphysboro, convenience is the name of the game. Luckily, Murphysboro Veterans Airport of Southern Illinois Airport is nearby so you can deplane and get going on checking off everything on your Murphysboro must-do list.

How much are flights to Murphysboro?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Murphysboro on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $156, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Murphysboro?

The trick to saving a stack of cash on your flight to Murphysboro? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $156 right now, why wait?

Murphysboro Flight Information
Destination airport
Veterans Airport of Southern Illinois
Destination airport IATA code
MWA
Roundtrip price
$156

Last Minute Hotel Deals in Murphysboro

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

2.5 out of 5
120 MUDDY MONSTER ROAD Murphysboro IL
Book a stay at this business-friendly hotel in Murphysboro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (537 reviews)
Great stat

Reviewed on Apr 17, 2026

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Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Drury Inn & Suites Marion

Drury Inn & Suites Marion

3 out of 5
2706 W DeYoung St Marion IL
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,001 reviews)
Breakfast and eating area was excellent

Reviewed on Apr 20, 2026

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Drury Inn & Suites Marion
Walker's Bluff Casino Resort

Walker's Bluff Casino Resort

4.5 out of 5
777 Walkers Bluff Way Carterville IL
Book a stay at this luxury resort in Carterville. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms ...
9.4/10 Exceptional! (436 reviews)
Excellent pool and hot tub, indoors and outdoors Very clean property indoors, and outdoors Restaurants OK Staff vary accommodating

Reviewed on Apr 23, 2026

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Walker's Bluff Casino Resort
Baymont by Wyndham Marion

Baymont by Wyndham Marion

2.5 out of 5
2608 W Main St Marion IL
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,072 reviews)
Room was clean, bed were comfortable, air conditioning took a long time to kick in, breakfast was mainly carbs not much protein especially protein small children would eat.

Reviewed on Apr 21, 2026

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Baymont by Wyndham Marion
Super 8 by Wyndham Marion

Super 8 by Wyndham Marion

2 out of 5
2601 Vernell Rd Marion IL
Book a stay at this business-friendly motel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.6/10 Good! (1,002 reviews)
There was mold in the AC unit and the Shower exhaust fan did not function properly. Also in room 105 One of the beds had a noticeable indentation. Next, I had to summon the male receptionist to literally turn the TV on because it’s a two step process. First you press the Aux button and secondly, ...

Reviewed on Apr 22, 2026

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Super 8 by Wyndham Marion
Super 8 by Wyndham Carbondale

Super 8 by Wyndham Carbondale

2 out of 5
1180 E Main St Carbondale IL
Book a stay at this business-friendly motel in Carbondale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,002 reviews)
Clean room. People in the lobby very friendly.

Reviewed on Apr 25, 2026

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Super 8 by Wyndham Carbondale
Country Inn & Suites by Radisson, Marion, IL

Country Inn & Suites by Radisson, Marion, IL

2.5 out of 5
1306 Halfway Road Marion IL
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (1,002 reviews)
Hotel was very clean and staff were very friendly and very helpful!

Reviewed on Apr 24, 2026

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Country Inn & Suites by Radisson, Marion, IL
Quality Inn & Suites Marion

Quality Inn & Suites Marion

2.5 out of 5
2600 W Main St Marion IL
Stay at this hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the comfy beds in our reviews. Popular ...
7.4/10 Good! (1,000 reviews)
No hot water in sink or tub. Another customer complaint about not having hot water while I was getting breakfast and was given credit for the inconvenience . Upon checking out I complained about also not having hot water. I was told there was nothing they could because I had paid thru Expedia .

Reviewed on Apr 5, 2026

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Quality Inn & Suites Marion
See all 338 properties in Murphysboro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.