Search Cheap Flights to
Murphysboro

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Murphysboro Flights as Low as $144

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Contour Airlines
Sun, Apr 12 - Mon, Apr 27
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$144 Roundtrip, found 5 days ago
$144
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Sun, Apr 12 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Mon, Apr 27, priced at $144 found 5 days ago
Contour Airlines
Sun, Apr 19 - Tue, May 5
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$148 Roundtrip, found 18 hours ago
$148
Roundtrip
found 18 hours ago
Select Contour Airlines flight, departing Sun, Apr 19 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Tue, May 5, priced at $148 found 18 hours ago
Contour Airlines
Mon, Apr 20 - Fri, May 8
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$151 Roundtrip, found 2 hours ago
$151
Roundtrip
found 2 hours ago
Select Contour Airlines flight, departing Mon, Apr 20 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Fri, May 8, priced at $151 found 2 hours ago
Contour Airlines
Fri, May 1 - Wed, May 13
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$161 Roundtrip, found 18 hours ago
$161
Roundtrip
found 18 hours ago
Select Contour Airlines flight, departing Fri, May 1 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Wed, May 13, priced at $161 found 18 hours ago
Contour Airlines
Mon, Apr 27 - Mon, May 11
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$202 Roundtrip, found 3 hours ago
$202
Roundtrip
found 3 hours ago
Select Contour Airlines flight, departing Mon, Apr 27 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Mon, May 11, priced at $202 found 3 hours ago
Contour Airlines
Mon, Apr 27 - Fri, May 8
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$212 Roundtrip, found 1 day ago
$212
Roundtrip
found 1 day ago
Select Contour Airlines flight, departing Mon, Apr 27 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Fri, May 8, priced at $212 found 1 day ago
Contour Airlines
Mon, Apr 13 - Mon, Apr 27
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$218 Roundtrip, found 2 days ago
$218
Roundtrip
found 2 days ago
Select Contour Airlines flight, departing Mon, Apr 13 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Mon, Apr 27, priced at $218 found 2 days ago
Contour Airlines
Mon, Apr 27 - Mon, May 11
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$223 Roundtrip, found 1 day ago
$223
Roundtrip
found 1 day ago
Select Contour Airlines flight, departing Mon, Apr 27 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Mon, May 11, priced at $223 found 1 day ago
Contour Airlines
Mon, Apr 13 - Fri, Apr 24
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$228 Roundtrip, found 2 days ago
$228
Roundtrip
found 2 days ago
Select Contour Airlines flight, departing Mon, Apr 13 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Fri, Apr 24, priced at $228 found 2 days ago
Contour Airlines
Fri, Apr 10 - Wed, Apr 22
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$233 Roundtrip, found 18 hours ago
$233
Roundtrip
found 18 hours ago
Select Contour Airlines flight, departing Fri, Apr 10 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Wed, Apr 22, priced at $233 found 18 hours ago
Contour Airlines
Sat, Apr 11 - Wed, Apr 22
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$233 Roundtrip, found 18 hours ago
$233
Roundtrip
found 18 hours ago
Select Contour Airlines flight, departing Sat, Apr 11 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Wed, Apr 22, priced at $233 found 18 hours ago
Contour Airlines
Sat, Apr 25 - Tue, May 19
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$243 Roundtrip, found 18 hours ago
$243
Roundtrip
found 18 hours ago
Select Contour Airlines flight, departing Sat, Apr 25 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Tue, May 19, priced at $243 found 18 hours ago
Contour Airlines
Sun, Apr 26 - Tue, May 19
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$253 Roundtrip, found 18 hours ago
$253
Roundtrip
found 18 hours ago
Select Contour Airlines flight, departing Sun, Apr 26 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Tue, May 19, priced at $253 found 18 hours ago
Contour Airlines
Mon, Apr 20 - Fri, May 8
ORD
O'Hare Intl.
MWA
Veterans Airport of Southern Illinois
$259 Roundtrip, found 3 days ago
$259
Roundtrip
found 3 days ago
Select Contour Airlines flight, departing Mon, Apr 20 from O'Hare Intl. to Veterans Airport of Southern Illinois, returning Fri, May 8, priced at $259 found 3 days ago
American Airlines
Wed, May 20 - Wed, May 27
STL
Lambert-St. Louis Intl.
MWA
Veterans Airport of Southern Illinois
$324 Roundtrip, found 12 hours ago
$324
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Wed, May 20 from Lambert-St. Louis Intl. to Veterans Airport of Southern Illinois, returning Wed, May 27, priced at $324 found 12 hours ago
American Airlines
Thu, Apr 9 - Mon, Apr 13
AUS
Austin-Bergstrom Intl.
MWA
Veterans Airport of Southern Illinois
$610 Roundtrip, found 4 days ago
$610
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Apr 9 from Austin-Bergstrom Intl. to Veterans Airport of Southern Illinois, returning Mon, Apr 13, priced at $610 found 4 days ago

Cheap Flights to Murphysboro

Fall in love at first flight with your vacation to Murphysboro by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Murphysboro on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Murphysboro, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Murphysboro

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Murphysboro with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the MDH airport.

What is the cheapest month to fly to Murphysboro?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Murphysboro are in April, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Murphysboro?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Murphysboro.

What airport is best to fly into Murphysboro?

When you’re planning your trip to Murphysboro, convenience is the name of the game. Luckily, Murphysboro Veterans Airport of Southern Illinois Airport is nearby so you can deplane and get going on checking off everything on your Murphysboro must-do list.

How much are flights to Murphysboro?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Murphysboro on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $144, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Murphysboro?

The trick to saving a stack of cash on your flight to Murphysboro? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $144 right now, why wait?

Murphysboro Flight Information
Destination airport
Veterans Airport of Southern Illinois
Destination airport IATA code
MWA
Roundtrip price
$144

Last Minute Hotel Deals in Murphysboro

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

2.5 out of 5
120 MUDDY MONSTER ROAD Murphysboro IL
Book a stay at this business-friendly hotel in Murphysboro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (533 reviews)
Staff are super nice, helpful, and friendly! Breakfast was always great, good selection to choose from. Its clean and quiet, a perfect home away from home couldn't be happer!

Reviewed on Mar 15, 2026

Get rates
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Best Western Marion Hotel

Best Western Marion Hotel

2.5 out of 5
400 Comfort Dr Marion IL
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.2/10 Very Good! (1,002 reviews)
Clean and quiet room. Excellent breakfast with eggs, sausage, waffles, yogurt, fruit, etc. Helpful and friendly staff. Convenient location.

Reviewed on Mar 31, 2026

Get rates
Best Western Marion Hotel
Drury Inn & Suites Marion

Drury Inn & Suites Marion

3 out of 5
2706 W DeYoung St Marion IL
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,001 reviews)
Friendly Staff, even with a late evening arrival. The room was clean and fresh and the linens smelled of fresh laundering. The breakfast was tasty. Perfect for our overnight stay!

Reviewed on Mar 20, 2026

Get rates
Drury Inn & Suites Marion
Quality Inn & Suites Marion

Quality Inn & Suites Marion

2.5 out of 5
2600 W Main St Marion IL
Stay at this hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the comfy beds in our reviews. Popular ...
7.4/10 Good! (1,004 reviews)
No stairs for 1st floor, very confusing to get around. It smelled like a nursing home on the bottom floor, the top floor smelled as if someone had been cooking fish in it. The bed was comfy, the shower was hot. Didn't try the breakfast because it isn't celiac friendly

Reviewed on Apr 3, 2026

Get rates
Quality Inn & Suites Marion
Holiday Inn Express & Suites Carbondale - University Area by IHG

Holiday Inn Express & Suites Carbondale - University Area by IHG

3 out of 5
2300 Reed Station Parkway Carbondale IL
Book a stay at this business-friendly hotel in Carbondale. Enjoy free WiFi, free parking, and a 24-hour fitness center. Our guests praise the helpful staff in ...
8.8/10 Excellent! (667 reviews)
I was thrilled to have a walk in shower. Our main concerns were the mattress could be softer, the toilet should be taller + the level of noise with a toilet flush does not allow people to sleep through it - it is way too loud. We did feel the condition went downhill a bit from the previous year. ...

Reviewed on Apr 3, 2026

Get rates
Holiday Inn Express & Suites Carbondale - University Area by IHG
Comfort Inn & Suites Marion I-57

Comfort Inn & Suites Marion I-57

2.5 out of 5
2403 Black Diamond Dr Marion IL
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,001 reviews)
The breakfast was hot and fresh with a nice selection of items which included over medium eggs!!! We loved it!

Reviewed on Apr 2, 2026

Get rates
Comfort Inn & Suites Marion I-57
Country Inn & Suites by Radisson, Marion, IL

Country Inn & Suites by Radisson, Marion, IL

2.5 out of 5
1306 Halfway Road Marion IL
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (1,001 reviews)
Everything was great for my stay.

Reviewed on Apr 1, 2026

Get rates
Country Inn & Suites by Radisson, Marion, IL
Best Western Saluki Inn

Best Western Saluki Inn

2.5 out of 5
801 N Giant City Rd Carbondale IL
Book a stay at this business-friendly hotel in Carbondale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8/10 Very Good! (1,002 reviews)
Breakfast bar was super good and well organized

Reviewed on Apr 3, 2026

Get rates
Best Western Saluki Inn
See all 337 properties in Murphysboro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.