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Myrtle

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Myrtle Flights as Low as $445

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Tue, Nov 25 - Wed, Dec 3
CVG
Cincinnati - Northern Kentucky Intl.
TUP
Tupelo Regional
$445 Roundtrip, found 4 days ago
$445
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Nov 25 from Cincinnati - Northern Kentucky Intl. to Tupelo Regional, returning Wed, Dec 3, priced at $445 found 4 days ago
American Airlines
Thu, Nov 27 - Wed, Dec 3
CVG
Cincinnati - Northern Kentucky Intl.
TUP
Tupelo Regional
$460 Roundtrip, found 20 hours ago
$460
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Thu, Nov 27 from Cincinnati - Northern Kentucky Intl. to Tupelo Regional, returning Wed, Dec 3, priced at $460 found 20 hours ago
American Airlines
Tue, Nov 25 - Wed, Dec 3
CVG
Cincinnati - Northern Kentucky Intl.
TUP
Tupelo Regional
$476 Roundtrip, found 4 days ago
$476
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Nov 25 from Cincinnati - Northern Kentucky Intl. to Tupelo Regional, returning Wed, Dec 3, priced at $476 found 4 days ago
American Airlines
Thu, Nov 27 - Wed, Dec 3
CVG
Cincinnati - Northern Kentucky Intl.
TUP
Tupelo Regional
$481 Roundtrip, found 20 hours ago
$481
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Thu, Nov 27 from Cincinnati - Northern Kentucky Intl. to Tupelo Regional, returning Wed, Dec 3, priced at $481 found 20 hours ago
American Airlines
Thu, Nov 27 - Wed, Dec 3
CVG
Cincinnati - Northern Kentucky Intl.
TUP
Tupelo Regional
$506 Roundtrip, found 20 hours ago
$506
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Thu, Nov 27 from Cincinnati - Northern Kentucky Intl. to Tupelo Regional, returning Wed, Dec 3, priced at $506 found 20 hours ago
American Airlines
Thu, Nov 27 - Wed, Dec 3
CVG
Cincinnati - Northern Kentucky Intl.
TUP
Tupelo Regional
$514 Roundtrip, found 20 hours ago
$514
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Thu, Nov 27 from Cincinnati - Northern Kentucky Intl. to Tupelo Regional, returning Wed, Dec 3, priced at $514 found 20 hours ago
American Airlines
Tue, Nov 25 - Wed, Dec 3
CVG
Cincinnati - Northern Kentucky Intl.
TUP
Tupelo Regional
$515 Roundtrip, found 4 days ago
$515
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Nov 25 from Cincinnati - Northern Kentucky Intl. to Tupelo Regional, returning Wed, Dec 3, priced at $515 found 4 days ago
American Airlines
Tue, Nov 25 - Wed, Dec 3
CVG
Cincinnati - Northern Kentucky Intl.
TUP
Tupelo Regional
$540 Roundtrip, found 1 day ago
$540
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Nov 25 from Cincinnati - Northern Kentucky Intl. to Tupelo Regional, returning Wed, Dec 3, priced at $540 found 1 day ago
American Airlines
Tue, Nov 25 - Wed, Dec 3
CVG
Cincinnati - Northern Kentucky Intl.
TUP
Tupelo Regional
$546 Roundtrip, found 4 days ago
$546
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Nov 25 from Cincinnati - Northern Kentucky Intl. to Tupelo Regional, returning Wed, Dec 3, priced at $546 found 4 days ago
American Airlines
Tue, Nov 25 - Wed, Dec 3
CVG
Cincinnati - Northern Kentucky Intl.
TUP
Tupelo Regional
$551 Roundtrip, found 1 day ago
$551
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Nov 25 from Cincinnati - Northern Kentucky Intl. to Tupelo Regional, returning Wed, Dec 3, priced at $551 found 1 day ago
United
Thu, Nov 27 - Wed, Dec 3
CVG
Cincinnati - Northern Kentucky Intl.
TUP
Tupelo Regional
$574 Roundtrip, found 20 hours ago
$574
Roundtrip
found 20 hours ago
Select United flight, departing Thu, Nov 27 from Cincinnati - Northern Kentucky Intl. to Tupelo Regional, returning Wed, Dec 3, priced at $574 found 20 hours ago
American Airlines
Tue, Nov 25 - Wed, Dec 3
CVG
Cincinnati - Northern Kentucky Intl.
TUP
Tupelo Regional
$581 Roundtrip, found 1 day ago
$581
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Nov 25 from Cincinnati - Northern Kentucky Intl. to Tupelo Regional, returning Wed, Dec 3, priced at $581 found 1 day ago
United
Thu, Nov 27 - Wed, Dec 3
CVG
Cincinnati - Northern Kentucky Intl.
TUP
Tupelo Regional
$587 Roundtrip, found 20 hours ago
$587
Roundtrip
found 20 hours ago
Select United flight, departing Thu, Nov 27 from Cincinnati - Northern Kentucky Intl. to Tupelo Regional, returning Wed, Dec 3, priced at $587 found 20 hours ago
American Airlines
Tue, Nov 25 - Wed, Dec 3
CVG
Cincinnati - Northern Kentucky Intl.
TUP
Tupelo Regional
$591 Roundtrip, found 1 day ago
$591
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Nov 25 from Cincinnati - Northern Kentucky Intl. to Tupelo Regional, returning Wed, Dec 3, priced at $591 found 1 day ago
American Airlines
Tue, Nov 25 - Wed, Dec 3
CVG
Cincinnati - Northern Kentucky Intl.
TUP
Tupelo Regional
$595 Roundtrip, found 1 day ago
$595
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Nov 25 from Cincinnati - Northern Kentucky Intl. to Tupelo Regional, returning Wed, Dec 3, priced at $595 found 1 day ago
American Airlines
Tue, Nov 25 - Wed, Dec 3
CVG
Cincinnati - Northern Kentucky Intl.
TUP
Tupelo Regional
$605 Roundtrip, found 1 day ago
$605
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Nov 25 from Cincinnati - Northern Kentucky Intl. to Tupelo Regional, returning Wed, Dec 3, priced at $605 found 1 day ago

Cheap Flights to Myrtle

Fall in love at first flight with your vacation to Myrtle by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Myrtle on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Myrtle, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Myrtle

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Myrtle with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the TUP airport.

What is the cheapest month to fly to Myrtle?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Myrtle are in November, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Myrtle?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Myrtle.

What airport is best to fly into Myrtle?

When you’re planning your trip to Myrtle, convenience is the name of the game. Luckily, Myrtle University - Oxford Airport is nearby so you can deplane and get going on checking off everything on your Myrtle must-do list.

How much are flights to Myrtle?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Myrtle on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $445, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Myrtle?

The trick to saving a stack of cash on your flight to Myrtle? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $445 right now, why wait?

Myrtle Flight Information
Destination airport
Tupelo Regional
Destination airport IATA code
TUP
Roundtrip price
$445

Last Minute Hotel Deals in Myrtle

La Quinta Inn & Suites by Wyndham Oxford

La Quinta Inn & Suites by Wyndham Oxford

3 out of 5
1171 Frontage Road, Oxford, MS
Stay at this 3-star business-friendly hotel in Oxford. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9/10 Wonderful! (876 reviews)
Great

Reviewed on Oct 20, 2025

Get rates
La Quinta Inn & Suites by Wyndham Oxford
The Inn at Ole Miss

The Inn at Ole Miss

3 out of 5
120 Alumni Drive, University, MS
Stay at this 3-star business-friendly hotel in University. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (1,008 reviews)
The staff was very friendly and the lobby was clean and inviting. The room provided plenty of room and basic amenities; however, it is very dated. No

Reviewed on Oct 23, 2025

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The Inn at Ole Miss
Tru by Hilton Oxford

Tru by Hilton Oxford

2.5 out of 5
97 Ed Perry Blvd, Oxford, MS
Book a stay at this business-friendly hotel in Oxford. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9/10 Wonderful! (843 reviews)
Very nice property. Very clean and the staff was very nice. I had a little trouble keeping the room cool enough. There were no cups in my bathroom. Not even plastic ones and that would’ve been nice. Also would’ve been nice to have a coffee maker in the room. I know that’s a luxury and there are coffee ...

Reviewed on Oct 19, 2025

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Tru by Hilton Oxford
Graduate by Hilton Oxford

Graduate by Hilton Oxford

4 out of 5
400 North Lamar Boulevard, Oxford, MS
Stay at this 4-star business-friendly hotel in Oxford. Enjoy free WiFi, 2 restaurants, and a rooftop terrace. Our guests praise the bar and the helpful staff ...
8.8/10 Excellent! (1,001 reviews)
Awesome location and the service was great!!!

Reviewed on Oct 21, 2025

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Graduate by Hilton Oxford
Best Western New Albany

Best Western New Albany

2.5 out of 5
400 State Highway 30 W, New Albany, MS
Book a stay at this business-friendly hotel in New Albany. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,011 reviews)
Very nice place. Enjoyed our stay. Bed was very comfortable

Reviewed on Oct 21, 2025

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Best Western New Albany
Hampton Inn New Albany

Hampton Inn New Albany

2.5 out of 5
320 Coulter Cv, New Albany, MS
Book a stay at this business-friendly hotel in New Albany. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the property ...
8.4/10 Very Good! (715 reviews)
Great place to stay!

Reviewed on Oct 14, 2025

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Hampton Inn New Albany
American Inn - Pontotoc

American Inn - Pontotoc

2 out of 5
217 Highway 15 N, Pontotoc, MS
Stay at this hotel in Pontotoc. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the clean rooms in our reviews. Popular attraction ...
7.8/10 Good! (302 reviews)
Clean room

Reviewed on Oct 18, 2025

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American Inn - Pontotoc
Holiday Inn Express New Albany by IHG

Holiday Inn Express New Albany by IHG

2.5 out of 5
300 Highway 30, New Albany, MS
Book a stay at this business-friendly hotel in New Albany. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (535 reviews)
Our check-in clerk was excellent. She was very professional and well-dressed. However, our check-out clerk was the opposite. He didn’t stand to greet me, his off color died hair was a distraction and the shirt he had on looked like he’d slept in it and was a crazy print that basically matched his ...

Reviewed on Oct 21, 2025

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Holiday Inn Express New Albany by IHG
See all 600 properties in Myrtle
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.