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Seneca

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Seneca Flights as Low as $152

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Breeze Airways
Fri, Oct 9 - Mon, Oct 12
FLL
Fort Lauderdale - Hollywood Intl.
GSP
Greenville-Spartanburg Intl.
$152 Roundtrip, found 6 days ago
$152
Roundtrip
found 6 days ago
Select Breeze Airways flight, departing Fri, Oct 9 from Fort Lauderdale - Hollywood Intl. to Greenville-Spartanburg Intl., returning Mon, Oct 12, priced at $152 found 6 days ago
Breeze Airways
Fri, Oct 9 - Mon, Oct 12
FLL
Fort Lauderdale - Hollywood Intl.
GSP
Greenville-Spartanburg Intl.
$157 Roundtrip, found 6 days ago
$157
Roundtrip
found 6 days ago
Select Breeze Airways flight, departing Fri, Oct 9 from Fort Lauderdale - Hollywood Intl. to Greenville-Spartanburg Intl., returning Mon, Oct 12, priced at $157 found 6 days ago
Breeze Airways
Fri, Oct 9 - Mon, Oct 12
FLL
Fort Lauderdale - Hollywood Intl.
GSP
Greenville-Spartanburg Intl.
$162 Roundtrip, found 6 days ago
$162
Roundtrip
found 6 days ago
Select Breeze Airways flight, departing Fri, Oct 9 from Fort Lauderdale - Hollywood Intl. to Greenville-Spartanburg Intl., returning Mon, Oct 12, priced at $162 found 6 days ago
Breeze Airways
Fri, Oct 9 - Mon, Oct 12
FLL
Fort Lauderdale - Hollywood Intl.
GSP
Greenville-Spartanburg Intl.
$196 Roundtrip, found 6 days ago
$196
Roundtrip
found 6 days ago
Select Breeze Airways flight, departing Fri, Oct 9 from Fort Lauderdale - Hollywood Intl. to Greenville-Spartanburg Intl., returning Mon, Oct 12, priced at $196 found 6 days ago
Breeze Airways
Fri, Oct 9 - Mon, Oct 12
FLL
Fort Lauderdale - Hollywood Intl.
GSP
Greenville-Spartanburg Intl.
$201 Roundtrip, found 6 days ago
$201
Roundtrip
found 6 days ago
Select Breeze Airways flight, departing Fri, Oct 9 from Fort Lauderdale - Hollywood Intl. to Greenville-Spartanburg Intl., returning Mon, Oct 12, priced at $201 found 6 days ago
Breeze Airways
Tue, Jul 14 - Wed, Jul 29
FLL
Fort Lauderdale - Hollywood Intl.
GSP
Greenville-Spartanburg Intl.
$202 Roundtrip, found 6 days ago
$202
Roundtrip
found 6 days ago
Select Breeze Airways flight, departing Tue, Jul 14 from Fort Lauderdale - Hollywood Intl. to Greenville-Spartanburg Intl., returning Wed, Jul 29, priced at $202 found 6 days ago
Breeze Airways
Fri, Oct 9 - Mon, Oct 12
FLL
Fort Lauderdale - Hollywood Intl.
GSP
Greenville-Spartanburg Intl.
$206 Roundtrip, found 6 days ago
$206
Roundtrip
found 6 days ago
Select Breeze Airways flight, departing Fri, Oct 9 from Fort Lauderdale - Hollywood Intl. to Greenville-Spartanburg Intl., returning Mon, Oct 12, priced at $206 found 6 days ago
Delta
Tue, Oct 6 - Tue, Oct 13
FLL
Fort Lauderdale - Hollywood Intl.
GSP
Greenville-Spartanburg Intl.
$213 Roundtrip, found 6 days ago
$213
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Oct 6 from Fort Lauderdale - Hollywood Intl. to Greenville-Spartanburg Intl., returning Tue, Oct 13, priced at $213 found 6 days ago
Bargain Flight
Wed, Aug 12 - Wed, Aug 19
BOS
Logan Intl.
GSP
Greenville-Spartanburg Intl.
$228 Roundtrip, found 1 day ago
$228
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Wed, Aug 12 from Logan Intl. to Greenville-Spartanburg Intl., returning Wed, Aug 19, priced at $228 found 1 day ago
American Airlines
Wed, Aug 12 - Wed, Aug 19
BOS
Logan Intl.
GSP
Greenville-Spartanburg Intl.
$273 Roundtrip, found 1 day ago
$273
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Aug 12 from Logan Intl. to Greenville-Spartanburg Intl., returning Wed, Aug 19, priced at $273 found 1 day ago
Delta
Wed, Aug 26 - Tue, Sep 15
BDL
Bradley Intl.
GSP
Greenville-Spartanburg Intl.
$285 Roundtrip, found 1 day ago
$285
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Aug 26 from Bradley Intl. to Greenville-Spartanburg Intl., returning Tue, Sep 15, priced at $285 found 1 day ago
Delta
Wed, Jun 10 - Wed, Jun 24
IAD
Washington Dulles Intl.
GSP
Greenville-Spartanburg Intl.
$384 Roundtrip, found 20 hours ago
$384
Roundtrip
found 20 hours ago
Select Delta flight, departing Wed, Jun 10 from Washington Dulles Intl. to Greenville-Spartanburg Intl., returning Wed, Jun 24, priced at $384 found 20 hours ago
American Airlines
Wed, Jun 24 - Tue, Jun 30
AUS
Austin-Bergstrom Intl.
GSP
Greenville-Spartanburg Intl.
$414 Roundtrip, found 18 hours ago
$414
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Wed, Jun 24 from Austin-Bergstrom Intl. to Greenville-Spartanburg Intl., returning Tue, Jun 30, priced at $414 found 18 hours ago
United
Tue, Jun 9 - Sat, Jun 13
MLI
Quad City Intl.
GSP
Greenville-Spartanburg Intl.
$422 Roundtrip, found 1 day ago
$422
Roundtrip
found 1 day ago
Select United flight, departing Tue, Jun 9 from Quad City Intl. to Greenville-Spartanburg Intl., returning Sat, Jun 13, priced at $422 found 1 day ago
Delta
Mon, Jun 22 - Mon, Jun 22
BUF
Buffalo Niagara Intl.
GSP
Greenville-Spartanburg Intl.
$478 Roundtrip, found 1 day ago
$478
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Jun 22 from Buffalo Niagara Intl. to Greenville-Spartanburg Intl., returning Mon, Jun 22, priced at $478 found 1 day ago
Delta
Wed, Jun 10 - Wed, Jun 17
MOB
Mobile Regional
GSP
Greenville-Spartanburg Intl.
$486 Roundtrip, found 12 hours ago
$486
Roundtrip
found 12 hours ago
Select Delta flight, departing Wed, Jun 10 from Mobile Regional to Greenville-Spartanburg Intl., returning Wed, Jun 17, priced at $486 found 12 hours ago

Cheap Flights to Seneca

Fall in love at first flight with your vacation to Seneca by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Seneca on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Seneca, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Seneca

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Seneca with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the GSP airport.

What is the cheapest month to fly to Seneca?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Seneca are in October, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Seneca?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to Seneca.

What airport is best to fly into Seneca?

When you’re planning your trip to Seneca, convenience is the name of the game. Luckily, Seneca Greenville-Spartanburg Intl. Airport is nearby so you can deplane and get going on checking off everything on your Seneca must-do list.

How much are flights to Seneca?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Seneca on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $152, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Seneca?

The trick to saving a stack of cash on your flight to Seneca? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $152 right now, why wait?

Seneca Flight Information
Destination airport
Greenville-Spartanburg Intl.
Destination airport IATA code
GSP
Roundtrip price
$152

Last Minute Hotel Deals in Seneca

Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd Seneca SC
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
9/10 Wonderful! (1,005 reviews)
"A beautiful and large room with a king size bed! The lake was beautiful, even though I didn't have a lake facing room. I could still enjoy it from the other spots on the property. The bed was very comfortable and the property was very quiet. Loved the stay. The only thing that I could say was the ..."

Reviewed on Jun 3, 2026

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Lakeside Lodge Clemson
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

2 out of 5
299 Outpost Rd Seneca SC
Stay at this cabin in Seneca. Enjoy free parking, patios, and climate control. Popular attractions Friendship Recreaction Area and Cross Creek Plantation Golf ...
9.8/10 Exceptional! (76 reviews)
"Cutest little cabin!!!!!!!!! We loved everything! The view was amazing, The bed was cozy, etc!!! I can’t wait to return!"

Reviewed on Jun 2, 2026

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Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

3 out of 5
800 BYPASS 123 Seneca SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (234 reviews)
"A little maintenance was needed on the shower door in our bathroom and the bed was just ok. The room was very clean, thank you housekeeping. The breakfast area was super clean and the offerings were plentiful and well stocked."

Reviewed on May 29, 2026

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Fairfield Inn & Suites Seneca Clemson Univ Area
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd Seneca SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8/10 Very Good! (708 reviews)
"Breakfast needs more items to choose from."

Reviewed on May 24, 2026

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Quality Inn Seneca Clemson Area US-123
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

2.5 out of 5
1011 East North 1st Street Seneca SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (718 reviews)
"There was no hot water for tea in the lobby. First time that ever happened."

Reviewed on Jun 2, 2026

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Hampton Inn & Suites Seneca-Clemson Area
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

2.5 out of 5
13050 Clemson Blvd Seneca SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (845 reviews)
"Everything about this hotel was great the staff was very friendly rooms was very clean great location I highly suggest staying here"

Reviewed on May 27, 2026

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Tru by Hilton Seneca Clemson
Best Western Seneca-Clemson

Best Western Seneca-Clemson

2.5 out of 5
511 Bypass Highway 123 Seneca SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (663 reviews)
"Friendly staff, comfortable bed"

Reviewed on May 28, 2026

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Best Western Seneca-Clemson
Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

2 out of 5
11015 N Radio Station Rd Seneca SC
Stay at this motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Applewood ...
6.8/10 (752 reviews)
"Clean and comfortable"

Reviewed on May 20, 2026

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Days Inn by Wyndham Seneca / Clemson Area
See all 1,641 properties in Seneca
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.