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Seneca

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Seneca Flights as Low as $117

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Breeze Airways
Fri, Jan 8 - Mon, Jan 11
MCO
Orlando Intl.
GSP
Greenville-Spartanburg Intl.
$117 Roundtrip, found 12 hours ago
$117
Roundtrip
found 12 hours ago
Select Breeze Airways flight, departing Fri, Jan 8 from Orlando Intl. to Greenville-Spartanburg Intl., returning Mon, Jan 11, priced at $117 found 12 hours ago
Breeze Airways
Sat, Oct 10 - Tue, Oct 27
FLL
Fort Lauderdale - Hollywood Intl.
GSP
Greenville-Spartanburg Intl.
$157 Roundtrip, found 3 days ago
$157
Roundtrip
found 3 days ago
Select Breeze Airways flight, departing Sat, Oct 10 from Fort Lauderdale - Hollywood Intl. to Greenville-Spartanburg Intl., returning Tue, Oct 27, priced at $157 found 3 days ago
Breeze Airways
Thu, Sep 24 - Wed, Sep 30
TPA
Tampa Intl.
GSP
Greenville-Spartanburg Intl.
$161 Roundtrip, found 4 days ago
$161
Roundtrip
found 4 days ago
Select Breeze Airways flight, departing Thu, Sep 24 from Tampa Intl. to Greenville-Spartanburg Intl., returning Wed, Sep 30, priced at $161 found 4 days ago
American Airlines
Mon, Nov 9 - Sat, Nov 14
DCA
Ronald Reagan Washington National
GSP
Greenville-Spartanburg Intl.
$180 Roundtrip, found 16 hours ago
$180
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Mon, Nov 9 from Ronald Reagan Washington National to Greenville-Spartanburg Intl., returning Sat, Nov 14, priced at $180 found 16 hours ago
Delta
Mon, Nov 23 - Wed, Dec 9
BWI
Baltimore Washington Intl. Thurgood Marshall
GSP
Greenville-Spartanburg Intl.
$187 Roundtrip, found 1 day ago
$187
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Nov 23 from Baltimore Washington Intl. Thurgood Marshall to Greenville-Spartanburg Intl., returning Wed, Dec 9, priced at $187 found 1 day ago
Bargain Flight
Mon, Nov 9 - Wed, Nov 18
MSP
Minneapolis - St. Paul Intl.
GSP
Greenville-Spartanburg Intl.
$246 Roundtrip, found 1 day ago
$246
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Mon, Nov 9 from Minneapolis - St. Paul Intl. to Greenville-Spartanburg Intl., returning Wed, Nov 18, priced at $246 found 1 day ago
Bargain Flight
Tue, Oct 6 - Wed, Oct 14
BOS
Logan Intl.
GSP
Greenville-Spartanburg Intl.
$257 Roundtrip, found 16 hours ago
$257
Roundtrip
found 16 hours ago
Select Bargain Flight flight, departing Tue, Oct 6 from Logan Intl. to Greenville-Spartanburg Intl., returning Wed, Oct 14, priced at $257 found 16 hours ago
Bargain Flight
Tue, Mar 2 - Tue, Mar 9
LAS
Harry Reid Intl.
GSP
Greenville-Spartanburg Intl.
$295 Roundtrip, found 4 days ago
$295
Roundtrip
found 4 days ago
Select Bargain Flight flight, departing Tue, Mar 2 from Harry Reid Intl. to Greenville-Spartanburg Intl., returning Tue, Mar 9, priced at $295 found 4 days ago
Southwest Airlines
Wed, Oct 14 - Fri, Oct 23
DJT
President Donald J. Trump Intl. Airport
GSP
Greenville-Spartanburg Intl.
$297 Roundtrip, found 5 days ago
$297
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Wed, Oct 14 from President Donald J. Trump Intl. Airport to Greenville-Spartanburg Intl., returning Fri, Oct 23, priced at $297 found 5 days ago
Bargain Flight
Tue, Oct 6 - Sat, Oct 10
DFW
Dallas-Fort Worth Intl.
GSP
Greenville-Spartanburg Intl.
$301 Roundtrip, found 1 hour ago
$301
Roundtrip
found 1 hour ago
Select Bargain Flight flight, departing Tue, Oct 6 from Dallas-Fort Worth Intl. to Greenville-Spartanburg Intl., returning Sat, Oct 10, priced at $301 found 1 hour ago
Delta
Sat, Oct 10 - Tue, Oct 13
GRR
Gerald R. Ford Intl.
GSP
Greenville-Spartanburg Intl.
$313 Roundtrip, found 8 hours ago
$313
Roundtrip
found 8 hours ago
Select Delta flight, departing Sat, Oct 10 from Gerald R. Ford Intl. to Greenville-Spartanburg Intl., returning Tue, Oct 13, priced at $313 found 8 hours ago
Delta
Sun, Sep 27 - Tue, Oct 6
ATL
Hartsfield-Jackson Atlanta Intl.
GSP
Greenville-Spartanburg Intl.
$319 Roundtrip, found 3 days ago
$319
Roundtrip
found 3 days ago
Select Delta flight, departing Sun, Sep 27 from Hartsfield-Jackson Atlanta Intl. to Greenville-Spartanburg Intl., returning Tue, Oct 6, priced at $319 found 3 days ago
United
Thu, Nov 19 - Fri, Dec 4
EWR
Newark Liberty Intl. Airport
GSP
Greenville-Spartanburg Intl.
$329 Roundtrip, found 20 hours ago
$329
Roundtrip
found 20 hours ago
Select United flight, departing Thu, Nov 19 from Newark Liberty Intl. Airport to Greenville-Spartanburg Intl., returning Fri, Dec 4, priced at $329 found 20 hours ago
Bargain Flight
Wed, Oct 7 - Sat, Oct 10
DTW
Detroit Metropolitan Wayne County
GSP
Greenville-Spartanburg Intl.
$363 Roundtrip, found 6 hours ago
$363
Roundtrip
found 6 hours ago
Select Bargain Flight flight, departing Wed, Oct 7 from Detroit Metropolitan Wayne County to Greenville-Spartanburg Intl., returning Sat, Oct 10, priced at $363 found 6 hours ago
American Airlines
Tue, Sep 29 - Tue, Oct 6
BGR
Bangor Intl.
GSP
Greenville-Spartanburg Intl.
$397 Roundtrip, found 22 hours ago
$397
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Tue, Sep 29 from Bangor Intl. to Greenville-Spartanburg Intl., returning Tue, Oct 6, priced at $397 found 22 hours ago
Southwest Airlines
Fri, Oct 30 - Sun, Nov 1
DAL
Love Field
GSP
Greenville-Spartanburg Intl.
$442 Roundtrip, found 15 hours ago
$442
Roundtrip
found 15 hours ago
Select Southwest Airlines flight, departing Fri, Oct 30 from Love Field to Greenville-Spartanburg Intl., returning Sun, Nov 1, priced at $442 found 15 hours ago

Cheap Flights to Seneca

Fall in love at first flight with your vacation to Seneca by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Seneca on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Seneca, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Seneca

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Seneca with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the GSP airport.

What is the cheapest month to fly to Seneca?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Seneca are in January, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Seneca?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 11 to choose from for your flight to Seneca.

What airport is best to fly into Seneca?

When you’re planning your trip to Seneca, convenience is the name of the game. Luckily, Seneca Greenville-Spartanburg Intl. Airport is nearby so you can deplane and get going on checking off everything on your Seneca must-do list.

How much are flights to Seneca?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Seneca on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $117, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Seneca?

The trick to saving a stack of cash on your flight to Seneca? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $117 right now, why wait?

Seneca Flight Information
Destination airport
Greenville-Spartanburg Intl.
Destination airport IATA code
GSP
Roundtrip price
$116

Last Minute Hotel Deals in Seneca

Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd Seneca SC
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
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Lakeside Lodge Clemson
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

2 out of 5
299 Outpost Rd Seneca SC
Stay at this cabin in Seneca. Enjoy free parking, patios, and climate control. Popular attractions Friendship Recreation Area and Cross Creek Plantation Golf ...
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Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Quality Inn Seneca US-123

Quality Inn Seneca US-123

2.5 out of 5
226 Hi Tech Rd Seneca SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8/10 Very Good! (751 reviews)
"Old pretty clean but needs remodeling ! Breakfast and coffee were good, staff was nice ! Except one on midnight shift ! Had yelling and banging on a person room went to office at 3 am she must have been sleeping ! Said next day she was busy checking people in & didnot hear the banging"

Reviewed on Sep 16, 2026

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Quality Inn Seneca US-123
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

2.5 out of 5
1011 East North 1st Street Seneca SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Get rates
Hampton Inn & Suites Seneca-Clemson Area
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

2.5 out of 5
13050 Clemson Blvd Seneca SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
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Tru by Hilton Seneca Clemson
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

3 out of 5
800 BYPASS 123 Seneca SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (274 reviews)
"Awesome hotel! The staff was so nice and the hotel was so clean. Our room was great! And the breakfast was really good as well."

Reviewed on Sep 15, 2026

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Fairfield Inn & Suites Seneca Clemson Univ Area
Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

2 out of 5
11015 N Radio Station Rd Seneca SC
Stay at this motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Applewood ...
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Days Inn by Wyndham Seneca / Clemson Area
Best Western Seneca-Clemson

Best Western Seneca-Clemson

2.5 out of 5
511 Bypass Highway 123 Seneca SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (688 reviews)
"Na"

Reviewed on Sep 14, 2026

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Best Western Seneca-Clemson
See all 1,699 properties in Seneca
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.