Search Cheap Flights to
Seneca

Photo by Cindy Keese

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Seneca Flights as Low as $107

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Breeze Airways
Mon, Sep 15 - Fri, Sep 19
BDL
Bradley Intl.
GSP
Greenville-Spartanburg Intl.
$107 Roundtrip, found 22 hours ago
$107
Roundtrip
found 22 hours ago
Select Breeze Airways flight, departing Mon, Sep 15 from Bradley Intl. to Greenville-Spartanburg Intl., returning Fri, Sep 19, priced at $107 found 22 hours ago
Bargain Flight
Wed, Sep 10 - Sat, Sep 13
DCA
Ronald Reagan Washington National
GSP
Greenville-Spartanburg Intl.
$180 Roundtrip, found 1 day ago
$180
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Wed, Sep 10 from Ronald Reagan Washington National to Greenville-Spartanburg Intl., returning Sat, Sep 13, priced at $180 found 1 day ago
Delta
Sat, Aug 30 - Sun, Aug 31
TPA
Tampa Intl.
GSP
Greenville-Spartanburg Intl.
$202 Roundtrip, found 1 day ago
$202
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Aug 30 from Tampa Intl. to Greenville-Spartanburg Intl., returning Sun, Aug 31, priced at $202 found 1 day ago
Delta
Thu, Sep 4 - Sat, Sep 13
PIT
Pittsburgh Intl.
GSP
Greenville-Spartanburg Intl.
$207 Roundtrip, found 2 days ago
$207
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Sep 4 from Pittsburgh Intl. to Greenville-Spartanburg Intl., returning Sat, Sep 13, priced at $207 found 2 days ago
Delta
Tue, Sep 16 - Wed, Sep 17
BWI
Baltimore Washington Intl. Thurgood Marshall
GSP
Greenville-Spartanburg Intl.
$211 Roundtrip, found 6 days ago
$211
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Sep 16 from Baltimore Washington Intl. Thurgood Marshall to Greenville-Spartanburg Intl., returning Wed, Sep 17, priced at $211 found 6 days ago
Delta
Sat, Sep 20 - Tue, Sep 30
HPN
Westchester County
GSP
Greenville-Spartanburg Intl.
$233 Roundtrip, found 1 day ago
$233
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Sep 20 from Westchester County to Greenville-Spartanburg Intl., returning Tue, Sep 30, priced at $233 found 1 day ago
Bargain Flight
Tue, Sep 23 - Tue, Sep 30
BOS
Logan Intl.
GSP
Greenville-Spartanburg Intl.
$238 Roundtrip, found 3 days ago
$238
Roundtrip
found 3 days ago
Select Bargain Flight flight, departing Tue, Sep 23 from Logan Intl. to Greenville-Spartanburg Intl., returning Tue, Sep 30, priced at $238 found 3 days ago
Delta
Sun, Aug 31 - Sat, Sep 6
CLE
Hopkins Intl.
GSP
Greenville-Spartanburg Intl.
$241 Roundtrip, found 1 day ago
$241
Roundtrip
found 1 day ago
Select Delta flight, departing Sun, Aug 31 from Hopkins Intl. to Greenville-Spartanburg Intl., returning Sat, Sep 6, priced at $241 found 1 day ago
Delta
Tue, Oct 14 - Wed, Oct 22
FLL
Fort Lauderdale - Hollywood Intl.
GSP
Greenville-Spartanburg Intl.
$257 Roundtrip, found 1 day ago
$257
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Oct 14 from Fort Lauderdale - Hollywood Intl. to Greenville-Spartanburg Intl., returning Wed, Oct 22, priced at $257 found 1 day ago
Delta
Tue, Oct 14 - Tue, Oct 21
PBI
Palm Beach Intl.
GSP
Greenville-Spartanburg Intl.
$262 Roundtrip, found 3 days ago
$262
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Oct 14 from Palm Beach Intl. to Greenville-Spartanburg Intl., returning Tue, Oct 21, priced at $262 found 3 days ago
United
Tue, Oct 21 - Wed, Oct 22
IAH
George Bush Intercontinental
GSP
Greenville-Spartanburg Intl.
$265 Roundtrip, found 15 hours ago
$265
Roundtrip
found 15 hours ago
Select United flight, departing Tue, Oct 21 from George Bush Intercontinental to Greenville-Spartanburg Intl., returning Wed, Oct 22, priced at $265 found 15 hours ago
Delta
Sat, Nov 8 - Tue, Nov 11
BUF
Buffalo Niagara Intl.
GSP
Greenville-Spartanburg Intl.
$267 Roundtrip, found 1 day ago
$267
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Nov 8 from Buffalo Niagara Intl. to Greenville-Spartanburg Intl., returning Tue, Nov 11, priced at $267 found 1 day ago
Bargain Flight
Sat, Sep 20 - Tue, Sep 23
LAX
Los Angeles Intl.
GSP
Greenville-Spartanburg Intl.
$269 Roundtrip, found 1 day ago
$269
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Sat, Sep 20 from Los Angeles Intl. to Greenville-Spartanburg Intl., returning Tue, Sep 23, priced at $269 found 1 day ago
Delta
Mon, Sep 29 - Mon, Oct 6
ALB
Albany Intl.
GSP
Greenville-Spartanburg Intl.
$277 Roundtrip, found 1 day ago
$277
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Sep 29 from Albany Intl. to Greenville-Spartanburg Intl., returning Mon, Oct 6, priced at $277 found 1 day ago
United
Sat, Oct 18 - Tue, Oct 21
MSP
Minneapolis - St. Paul Intl.
GSP
Greenville-Spartanburg Intl.
$284 Roundtrip, found 6 days ago
$284
Roundtrip
found 6 days ago
Select United flight, departing Sat, Oct 18 from Minneapolis - St. Paul Intl. to Greenville-Spartanburg Intl., returning Tue, Oct 21, priced at $284 found 6 days ago
Delta
Tue, Nov 18 - Tue, Nov 25
GNV
Gainesville Regional
GSP
Greenville-Spartanburg Intl.
$287 Roundtrip, found 1 day ago
$287
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Nov 18 from Gainesville Regional to Greenville-Spartanburg Intl., returning Tue, Nov 25, priced at $287 found 1 day ago

Cheap Flights to Seneca

Fall in love at first flight with your vacation to Seneca by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Seneca on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Seneca, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Seneca

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Seneca with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the GSP airport.

What is the cheapest month to fly to Seneca?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Seneca are in September, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Seneca?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 13 to choose from for your flight to Seneca.

What airport is best to fly into Seneca?

When you’re planning your trip to Seneca, convenience is the name of the game. Luckily, Seneca Greenville-Spartanburg Intl. Airport is nearby so you can deplane and get going on checking off everything on your Seneca must-do list.

How much are flights to Seneca?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Seneca on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $107, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Seneca?

The trick to saving a stack of cash on your flight to Seneca? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $107 right now, why wait?

Seneca Flight Information
Destination airport
Greenville-Spartanburg Intl.
Destination airport IATA code
GSP
Roundtrip price
$106

Last Minute Hotel Deals in Seneca

Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd, Seneca, SC
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.8/10 Excellent! (998 reviews)
"Stayed in one BR unit with full kitchen which was great! Blender worked perfectly for our daiquiris. It was a hot & sunny weekend. Pool was clean & plenty of chairs. Lobby & outdoor sitting areas nice & comfy during this busy weekend too. Would definitely recommend this resort. Can walk to shopping ..."

Reviewed on Aug 18, 2025

Get rates
Lakeside Lodge Clemson
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (632 reviews)
Nice hotel!
"Nice clean, comfortable stay with a great breakfast."

Reviewed on Aug 19, 2025

Get rates
Quality Inn Seneca Clemson Area US-123
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

2.5 out of 5
1011 East North 1st Street, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (629 reviews)
"The staff were very friendly and helpful. The room was clean and the breakfast was great!"

Reviewed on Aug 19, 2025

Get rates
Hampton Inn & Suites Seneca-Clemson Area
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

2.5 out of 5
800 BYPASS 123, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (184 reviews)
"Beautiful clean hotel. Staff was very welcoming. Breakfast area was very clean with many options. The river view is so beautiful."

Reviewed on Aug 14, 2025

Get rates
Fairfield Inn & Suites Seneca Clemson Univ Area
Best Western Seneca-Clemson

Best Western Seneca-Clemson

2.5 out of 5
511 Bypass Highway 123, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (600 reviews)
"Everything"

Reviewed on Aug 16, 2025

Get rates
Best Western Seneca-Clemson
Postcard Cabins Lake Hartwell

Postcard Cabins Lake Hartwell

2 out of 5
299 Outpost Rd, Seneca, SC
Stay at this cabin in Seneca. Enjoy free parking, patios, and climate control. Popular attractions Friendship Recreaction Area and Cross Creek Plantation Golf ...
9.8/10 Exceptional! (23 reviews)
"It was perfect very clean everything was well thought out using the space very efficiently. Will stay again. It was quiet and a wonderful getaway with beautiful scenery! The big window and amazing bed had the best sleep.."

Reviewed on Aug 18, 2025

Get rates
Postcard Cabins Lake Hartwell
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

2.5 out of 5
13050 Clemson Blvd, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (761 reviews)
"Everything was perfect"

Reviewed on Aug 18, 2025

Get rates
Tru by Hilton Seneca Clemson
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd, Clemson, SC
Book a stay at this business-friendly hotel in Clemson. Enjoy free parking, an outdoor pool, and a 24-hour fitness center. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,003 reviews)
"Air was not on when we entered."

Reviewed on Aug 20, 2025

Get rates
Best Western Plus Clemson Hotel & Conference Center
See all 1,605 properties in Seneca
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.