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Seneca

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Seneca Flights as Low as $199

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Tue, Oct 21 - Tue, Oct 28
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$199 Roundtrip, found 8 hours ago
$199
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Tue, Oct 21 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Tue, Oct 28, priced at $199 found 8 hours ago
Delta
Sat, Oct 18 - Tue, Oct 21
BDL
Bradley Intl.
GSP
Greenville-Spartanburg Intl.
$199 Roundtrip, found 8 hours ago
$199
Roundtrip
found 8 hours ago
Select Delta flight, departing Sat, Oct 18 from Bradley Intl. to Greenville-Spartanburg Intl., returning Tue, Oct 21, priced at $199 found 8 hours ago
Delta
Tue, Oct 21 - Tue, Oct 28
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$199 Roundtrip, found 8 hours ago
$199
Roundtrip
found 8 hours ago
Select Delta flight, departing Tue, Oct 21 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Tue, Oct 28, priced at $199 found 8 hours ago
United
Wed, Oct 15 - Mon, Oct 20
EWR
Newark Liberty Intl. Airport
GSP
Greenville-Spartanburg Intl.
$209 Roundtrip, found 23 hours ago
$209
Roundtrip
found 23 hours ago
Select United flight, departing Wed, Oct 15 from Newark Liberty Intl. Airport to Greenville-Spartanburg Intl., returning Mon, Oct 20, priced at $209 found 23 hours ago
United
Tue, Oct 21 - Tue, Oct 28
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$213 Roundtrip, found 8 hours ago
$213
Roundtrip
found 8 hours ago
Select United flight, departing Tue, Oct 21 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Tue, Oct 28, priced at $213 found 8 hours ago
Delta
Wed, Oct 15 - Tue, Oct 21
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$220 Roundtrip, found 8 hours ago
$220
Roundtrip
found 8 hours ago
Select Delta flight, departing Wed, Oct 15 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Tue, Oct 21, priced at $220 found 8 hours ago
American Airlines
Tue, Oct 21 - Tue, Oct 28
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$223 Roundtrip, found 8 hours ago
$223
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Tue, Oct 21 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Tue, Oct 28, priced at $223 found 8 hours ago
American Airlines
Tue, Nov 4 - Sat, Nov 8
EWR
Newark Liberty Intl. Airport
GSP
Greenville-Spartanburg Intl.
$232 Roundtrip, found 8 hours ago
$232
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Tue, Nov 4 from Newark Liberty Intl. Airport to Greenville-Spartanburg Intl., returning Sat, Nov 8, priced at $232 found 8 hours ago
Delta
Wed, Oct 15 - Tue, Oct 21
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$235 Roundtrip, found 8 hours ago
$235
Roundtrip
found 8 hours ago
Select Delta flight, departing Wed, Oct 15 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Tue, Oct 21, priced at $235 found 8 hours ago
American Airlines
Wed, Nov 19 - Wed, Nov 26
FLL
Fort Lauderdale - Hollywood Intl.
GSP
Greenville-Spartanburg Intl.
$287 Roundtrip, found 8 hours ago
$287
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Wed, Nov 19 from Fort Lauderdale - Hollywood Intl. to Greenville-Spartanburg Intl., returning Wed, Nov 26, priced at $287 found 8 hours ago
Breeze Airways
Mon, Oct 20 - Mon, Oct 20
BDL
Bradley Intl.
GSP
Greenville-Spartanburg Intl.
$292 Roundtrip, found 2 days ago
$292
Roundtrip
found 2 days ago
Select Breeze Airways flight, departing Mon, Oct 20 from Bradley Intl. to Greenville-Spartanburg Intl., returning Mon, Oct 20, priced at $292 found 2 days ago
Bargain Flight
Sat, Sep 20 - Tue, Sep 23
LAX
Los Angeles Intl.
GSP
Greenville-Spartanburg Intl.
$321 Roundtrip, found 8 hours ago
$321
Roundtrip
found 8 hours ago
Select Bargain Flight flight, departing Sat, Sep 20 from Los Angeles Intl. to Greenville-Spartanburg Intl., returning Tue, Sep 23, priced at $321 found 8 hours ago
American Airlines
Wed, Oct 15 - Sat, Oct 18
TTN
Mercer
GSP
Greenville-Spartanburg Intl.
$376 Roundtrip, found 8 hours ago
$376
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Wed, Oct 15 from Mercer to Greenville-Spartanburg Intl., returning Sat, Oct 18, priced at $376 found 8 hours ago
American Airlines
Wed, Oct 15 - Sat, Oct 18
PHL
Philadelphia Intl.
GSP
Greenville-Spartanburg Intl.
$377 Roundtrip, found 8 hours ago
$377
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Wed, Oct 15 from Philadelphia Intl. to Greenville-Spartanburg Intl., returning Sat, Oct 18, priced at $377 found 8 hours ago
American Airlines
Sat, Sep 27 - Tue, Sep 30
FSM
Fort Smith Regional
GSP
Greenville-Spartanburg Intl.
$438 Roundtrip, found 8 hours ago
$438
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Sat, Sep 27 from Fort Smith Regional to Greenville-Spartanburg Intl., returning Tue, Sep 30, priced at $438 found 8 hours ago
Delta
Tue, Sep 16 - Wed, Sep 24
MKE
General Mitchell Intl.
GSP
Greenville-Spartanburg Intl.
$451 Roundtrip, found 8 hours ago
$451
Roundtrip
found 8 hours ago
Select Delta flight, departing Tue, Sep 16 from General Mitchell Intl. to Greenville-Spartanburg Intl., returning Wed, Sep 24, priced at $451 found 8 hours ago

Cheap Flights to Seneca

Fall in love at first flight with your vacation to Seneca by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Seneca on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Seneca, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Seneca

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Seneca with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the GSP airport.

What is the cheapest month to fly to Seneca?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Seneca are in October, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Seneca?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to Seneca.

What airport is best to fly into Seneca?

When you’re planning your trip to Seneca, convenience is the name of the game. Luckily, Seneca Greenville-Spartanburg Intl. Airport is nearby so you can deplane and get going on checking off everything on your Seneca must-do list.

How much are flights to Seneca?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Seneca on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $199, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Seneca?

The trick to saving a stack of cash on your flight to Seneca? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $199 right now, why wait?

Seneca Flight Information
Destination airport
Seneca
Destination airport IATA code
GSP

Last Minute Hotel Deals in Seneca

Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd, Seneca, SC
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.8/10 Excellent! (1,000 reviews)
"Very pleasant stay!"

Reviewed on Sep 9, 2025

Get rates
Lakeside Lodge Clemson
Best Western Seneca-Clemson

Best Western Seneca-Clemson

2.5 out of 5
511 Bypass Highway 123, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (609 reviews)
"The staff were great in answering questions. Room was clean. Appreciated having the microwave and refrigerator in the room. There were enough towels for every member of our party. The free breakfast was excellent. Loved the variety. It may have been in small print in the reservation, but was surprised ..."

Reviewed on Sep 8, 2025

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Best Western Seneca-Clemson
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

2.5 out of 5
1011 East North 1st Street, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (633 reviews)
"Everything was good"

Reviewed on Aug 29, 2025

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Hampton Inn & Suites Seneca-Clemson Area
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

2.5 out of 5
800 BYPASS 123, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (190 reviews)
"Good"

Reviewed on Aug 30, 2025

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Fairfield Inn & Suites Seneca Clemson Univ Area
Postcard Cabins Lake Hartwell

Postcard Cabins Lake Hartwell

2 out of 5
299 Outpost Rd, Seneca, SC
Stay at this cabin in Seneca. Enjoy free parking, patios, and climate control. Popular attractions Friendship Recreaction Area and Cross Creek Plantation Golf ...
9.8/10 Exceptional! (30 reviews)
"Amazing stay! Nice decent size for just couples, amazing view! They have everything we needed nothing else we can think of something missing! Only thing I wish bigger mirror."

Reviewed on Sep 7, 2025

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Postcard Cabins Lake Hartwell
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

2.5 out of 5
13050 Clemson Blvd, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (766 reviews)
"What I liked was the customer service Alexa gave me. Had me sign up for Hilton Rewards program too since she mentioned it. No extra blankets in the room. The stay was excellent. Definitely recommend if in the Clemson area."

Reviewed on Sep 3, 2025

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Tru by Hilton Seneca Clemson
Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

2 out of 5
1007 George Smith Mill Rd, Anderson, SC
Book a stay at this business-friendly motel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,000 reviews)
"Super nice place -nice people"

Reviewed on Sep 8, 2025

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Days Inn by Wyndham Anderson
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd, Clemson, SC
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,001 reviews)
"I was there three hours before check in time and was not offered complementary check i. or even an option to pay for it. The place looks very empty so hard to see why."

Reviewed on Sep 7, 2025

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Best Western Plus Clemson Hotel & Conference Center
See all 1,631 properties in Seneca
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.