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Seneca

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Seneca Flights as Low as $122

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Allegiant Air
Thu, Feb 11 - Thu, Feb 18
FLL
Fort Lauderdale - Hollywood Intl.
GSP
Greenville-Spartanburg Intl.
$122 Roundtrip, found 8 hours ago
$122
Roundtrip
found 8 hours ago
Select Allegiant Air flight, departing Thu, Feb 11 from Fort Lauderdale - Hollywood Intl. to Greenville-Spartanburg Intl., returning Thu, Feb 18, priced at $122 found 8 hours ago
Allegiant Air
Fri, Nov 6 - Mon, Nov 9
PIE
St. Petersburg-Clearwater Intl.
GSP
Greenville-Spartanburg Intl.
$154 Roundtrip, found 1 day ago
$154
Roundtrip
found 1 day ago
Select Allegiant Air flight, departing Fri, Nov 6 from St. Petersburg-Clearwater Intl. to Greenville-Spartanburg Intl., returning Mon, Nov 9, priced at $154 found 1 day ago
Breeze Airways
Tue, Nov 17 - Tue, Dec 8
PVD
T.F. Green
GSP
Greenville-Spartanburg Intl.
$173 Roundtrip, found 6 hours ago
$173
Roundtrip
found 6 hours ago
Select Breeze Airways flight, departing Tue, Nov 17 from T.F. Green to Greenville-Spartanburg Intl., returning Tue, Dec 8, priced at $173 found 6 hours ago
American Airlines
Thu, Jan 21 - Thu, Feb 4
DCA
Ronald Reagan Washington National
GSP
Greenville-Spartanburg Intl.
$177 Roundtrip, found 5 hours ago
$177
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Thu, Jan 21 from Ronald Reagan Washington National to Greenville-Spartanburg Intl., returning Thu, Feb 4, priced at $177 found 5 hours ago
Breeze Airways
Fri, Nov 6 - Mon, Nov 9
TPA
Tampa Intl.
GSP
Greenville-Spartanburg Intl.
$188 Roundtrip, found 5 hours ago
$188
Roundtrip
found 5 hours ago
Select Breeze Airways flight, departing Fri, Nov 6 from Tampa Intl. to Greenville-Spartanburg Intl., returning Mon, Nov 9, priced at $188 found 5 hours ago
Breeze Airways
Fri, Dec 4 - Mon, Dec 7
BDL
Bradley Intl.
GSP
Greenville-Spartanburg Intl.
$225 Roundtrip, found 18 hours ago
$225
Roundtrip
found 18 hours ago
Select Breeze Airways flight, departing Fri, Dec 4 from Bradley Intl. to Greenville-Spartanburg Intl., returning Mon, Dec 7, priced at $225 found 18 hours ago
Bargain Flight
Wed, Feb 17 - Wed, Feb 24
ROC
Greater Rochester Intl.
GSP
Greenville-Spartanburg Intl.
$233 Roundtrip, found 7 hours ago
$233
Roundtrip
found 7 hours ago
Select Bargain Flight flight, departing Wed, Feb 17 from Greater Rochester Intl. to Greenville-Spartanburg Intl., returning Wed, Feb 24, priced at $233 found 7 hours ago
Southwest Airlines
Sun, Nov 22 - Wed, Dec 2
BWI
Baltimore Washington Intl. Thurgood Marshall
GSP
Greenville-Spartanburg Intl.
$236 Roundtrip, found 12 hours ago
$236
Roundtrip
found 12 hours ago
Select Southwest Airlines flight, departing Sun, Nov 22 from Baltimore Washington Intl. Thurgood Marshall to Greenville-Spartanburg Intl., returning Wed, Dec 2, priced at $236 found 12 hours ago
Delta
Mon, Dec 14 - Thu, Dec 24
ATL
Hartsfield-Jackson Atlanta Intl.
GSP
Greenville-Spartanburg Intl.
$239 Roundtrip, found 4 hours ago
$239
Roundtrip
found 4 hours ago
Select Delta flight, departing Mon, Dec 14 from Hartsfield-Jackson Atlanta Intl. to Greenville-Spartanburg Intl., returning Thu, Dec 24, priced at $239 found 4 hours ago
Bargain Flight
Mon, Dec 14 - Thu, Dec 17
BOS
Logan Intl.
GSP
Greenville-Spartanburg Intl.
$243 Roundtrip, found 1 hour ago
$243
Roundtrip
found 1 hour ago
Select Bargain Flight flight, departing Mon, Dec 14 from Logan Intl. to Greenville-Spartanburg Intl., returning Thu, Dec 17, priced at $243 found 1 hour ago
Bargain Flight
Tue, Nov 24 - Thu, Nov 26
DTW
Detroit Metropolitan Wayne County
GSP
Greenville-Spartanburg Intl.
$281 Roundtrip, found 6 hours ago
$281
Roundtrip
found 6 hours ago
Select Bargain Flight flight, departing Tue, Nov 24 from Detroit Metropolitan Wayne County to Greenville-Spartanburg Intl., returning Thu, Nov 26, priced at $281 found 6 hours ago
Delta
Tue, Jan 26 - Tue, Feb 2
ATW
Appleton Intl.
GSP
Greenville-Spartanburg Intl.
$321 Roundtrip, found 2 hours ago
$321
Roundtrip
found 2 hours ago
Select Delta flight, departing Tue, Jan 26 from Appleton Intl. to Greenville-Spartanburg Intl., returning Tue, Feb 2, priced at $321 found 2 hours ago
Bargain Flight
Mon, Nov 23 - Tue, Dec 8
SEA
Seattle - Tacoma Intl.
GSP
Greenville-Spartanburg Intl.
$329 Roundtrip, found 7 hours ago
$329
Roundtrip
found 7 hours ago
Select Bargain Flight flight, departing Mon, Nov 23 from Seattle - Tacoma Intl. to Greenville-Spartanburg Intl., returning Tue, Dec 8, priced at $329 found 7 hours ago
American Airlines
Thu, Dec 10 - Thu, Apr 8
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$335 Roundtrip, found 11 hours ago
$335
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Thu, Dec 10 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Thu, Apr 8, priced at $335 found 11 hours ago
American Airlines
Fri, Jan 29 - Wed, Feb 17
SMF
Sacramento Intl.
GSP
Greenville-Spartanburg Intl.
$337 Roundtrip, found 10 hours ago
$337
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Fri, Jan 29 from Sacramento Intl. to Greenville-Spartanburg Intl., returning Wed, Feb 17, priced at $337 found 10 hours ago
United
Thu, Feb 4 - Tue, Feb 9
FNT
Bishop Intl.
GSP
Greenville-Spartanburg Intl.
$339 Roundtrip, found 15 hours ago
$339
Roundtrip
found 15 hours ago
Select United flight, departing Thu, Feb 4 from Bishop Intl. to Greenville-Spartanburg Intl., returning Tue, Feb 9, priced at $339 found 15 hours ago

Cheap Flights to Seneca

Fall in love at first flight with your vacation to Seneca by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Seneca on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Seneca, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Seneca

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Seneca with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the GSP airport.

What is the cheapest month to fly to Seneca?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Seneca are in February, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Seneca?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 12 to choose from for your flight to Seneca.

What airport is best to fly into Seneca?

When you’re planning your trip to Seneca, convenience is the name of the game. Luckily, Seneca Greenville-Spartanburg Intl. Airport is nearby so you can deplane and get going on checking off everything on your Seneca must-do list.

How much are flights to Seneca?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Seneca on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $122, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Seneca?

The trick to saving a stack of cash on your flight to Seneca? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $122 right now, why wait?

Seneca Flight Information
Destination airport
Greenville-Spartanburg Intl.
Destination airport IATA code
GSP
Roundtrip price
$122

Last Minute Hotel Deals in Seneca

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

2 out of 5
299 Outpost Rd Seneca SC
Stay at this cabin in Seneca. Enjoy free parking, patios, and climate control. Popular attractions Friendship Recreation Area and Cross Creek Plantation Golf ...
9.8/10 Exceptional! (117 reviews)
"This is a very interesting camping/glamping experience. It's off the beaten path to some degree. We were familiar with area already.The cabins/tiny homes are very clean inside. And well put together. Very quiet area/ property grounds. We enjoyed the stay. Thought that it was closer to the lake but ..."

Reviewed on Oct 30, 2026

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Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd Seneca SC
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
9/10 Wonderful! (1,000 reviews)
"The photos make the property seem much more luxurious and big. It was a nice hotel. But I wouldn’t go thinking I’m having an amazing vacation."

Reviewed on Oct 28, 2026

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Lakeside Lodge Clemson
Quality Inn Seneca US-123

Quality Inn Seneca US-123

2.5 out of 5
226 Hi Tech Rd Seneca SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8/10 Very Good! (766 reviews)
"For the most part, it was a good stay. I had some issues with the Internet and the Breakfast was a little slack."

Reviewed on Oct 27, 2026

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Quality Inn Seneca US-123
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

2.5 out of 5
13050 Clemson Blvd Seneca SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
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Tru by Hilton Seneca Clemson
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

2.5 out of 5
1011 East North 1st Street Seneca SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (764 reviews)
"Bit of a damp smell in our room which was on the first floor. Room was clean though. Staff were nice and very helpful. Further from Clemson than we imagined unfortunately."

Reviewed on Oct 26, 2026

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Hampton Inn & Suites Seneca-Clemson Area
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

3 out of 5
800 BYPASS 123 Seneca SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
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Fairfield Inn & Suites Seneca Clemson Univ Area
Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

2 out of 5
11015 N Radio Station Rd Seneca SC
Stay at this motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Applewood ...
6.8/10 (792 reviews)
"Very clean room, recently renovated. Comfy bed!"

Reviewed on Oct 28, 2026

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Days Inn by Wyndham Seneca / Clemson Area
Best Western Seneca-Clemson

Best Western Seneca-Clemson

2.5 out of 5
511 Bypass Highway 123 Seneca SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
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Best Western Seneca-Clemson
See all 1,689 properties in Seneca
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.