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Hotels in Seneca

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Check Last Minute Seneca Hotel Deals

Tonight Dec 29 - Dec 30Next weekend Jan 3 - Jan 5

Choose from 1499 Seneca Hotel Deals

Lakeside Lodge Clemson
Lakeside Lodge Clemson
2.5 out of 5
13500 Clemson Blvd, Seneca, SC
  • 11 min drive from Keowee Reservoir
The price is $134 per night from Dec 30 to Dec 31
$134
includes taxes & fees
Dec 30 - Dec 31
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.8/10 Excellent! (762 reviews)
Beautiful lakeside resort near Greenville
"We enjoyed our two-night stay at Lakeside Lodge during a family trip to SC for a graduation. Loved the view of the lake from our room! Although NO BREAKFAST is offered, the restaurant does serve outstanding dinner entrees."

Reviewed on Dec 18, 2024

Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson
Tru by Hilton Seneca Clemson
2.5 out of 5
13050 Clemson Blvd, Seneca, SC
  • 11 min drive from Keowee Reservoir
The price is $120 per night from Jan 18 to Jan 19
$120
includes taxes & fees
Jan 18 - Jan 19, 2025
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (655 reviews)
"Very clean and modern hotel."

Reviewed on Dec 22, 2024

Tru by Hilton Seneca Clemson
Hampton Inn & Suites Seneca-Clemson Area
Hampton Inn & Suites Seneca-Clemson Area
2.5 out of 5
1011 East North 1st Street, Seneca, SC
  • 7 min drive from Keowee Reservoir
The price is $128 per night from Jan 1 to Jan 2
$128
includes taxes & fees
Jan 1 - Jan 2, 2025
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (569 reviews)
"Staff was very friendly. Quiet and clean hotel."

Reviewed on Dec 23, 2024

Hampton Inn & Suites Seneca-Clemson Area
Days Inn by Wyndham Seneca / Clemson Area
Days Inn by Wyndham Seneca / Clemson Area
2 out of 5
11015 N Radio Station Rd, Seneca, SC
  • 14 min drive from Keowee Reservoir
The price is $79 per night from Jan 19 to Jan 20
$79
includes taxes & fees
Jan 19 - Jan 20, 2025
Book a stay at this business-friendly motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
6.8/10 (653 reviews)
"Rooms need new carpet & painting. Pricing reflects the physical condition of the rooms. Front desk staff were exceptionally nice & courteous."

Reviewed on Dec 20, 2024

Days Inn by Wyndham Seneca / Clemson Area
Quality Inn Seneca US-123
Quality Inn Seneca US-123
2.5 out of 5
226 Hi Tech Rd, Seneca, SC
  • 10 min drive from Keowee Reservoir
The price is $107 per night from Jan 19 to Jan 20
$107
includes taxes & fees
Jan 19 - Jan 20, 2025
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (557 reviews)
Great stay!
"Very good stay! The front desk service is fantastic!"

Reviewed on Dec 21, 2024

Quality Inn Seneca US-123
The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown Clemson
4 out of 5
110 Sloan St, Clemson, SC
  • 15 min drive from Keowee Reservoir
The price is $176 per night from Jan 1 to Jan 2
$176
includes taxes & fees
Jan 1 - Jan 2, 2025
Stay at this 4-star hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and valet parking (surcharge). Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (448 reviews)
"Very warm beautiful upscale property. Very comfortable and luxurious rooms. Great location. Very friendly and attentive staff."

Reviewed on Dec 27, 2024

The Shepherd Hotel Downtown Clemson
Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference Center
2.5 out of 5
1310 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
The price is $103 per night from Dec 31 to Jan 1
$103
includes taxes & fees
Dec 31 - Jan 1, 2025
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (966 reviews)
"Huge clean rooms, very nice and polite staff."

Reviewed on Dec 17, 2024

Best Western Plus Clemson Hotel & Conference Center
Inn @ Clemson
Inn @ Clemson
2.5 out of 5
1303 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
The price is $99 per night from Dec 30 to Dec 31
$99
includes taxes & fees
Dec 30 - Dec 31
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,000 reviews)
"Clemson themed, nice clean property"

Reviewed on Dec 21, 2024

Inn @ Clemson
Microtel Inn & Suites by Wyndham Anderson/Clemson
Microtel Inn & Suites by Wyndham Anderson/Clemson
2 out of 5
102 Electric City Blvd, Anderson, SC
  • 42 min drive from Keowee Reservoir
The price is $103 per night from Jan 7 to Jan 8
$103
includes taxes & fees
Jan 7 - Jan 8, 2025
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,000 reviews)
"The service was friendly and prompt. The room was clean and comfortable."

Reviewed on Dec 20, 2024

Microtel Inn & Suites by Wyndham Anderson/Clemson
Comfort Inn & Suites Clemson - University Area
Comfort Inn & Suites Clemson - University Area
2.5 out of 5
1305 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
The price is $103 per night from Jan 4 to Jan 5
$103
includes taxes & fees
Jan 4 - Jan 5, 2025
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,003 reviews)
"It’s clean"

Reviewed on Dec 25, 2024

Comfort Inn & Suites Clemson - University Area
Holiday Inn Express & Suites Clemson, an IHG Hotel
Holiday Inn Express & Suites Clemson, an IHG Hotel
2.5 out of 5
1381 Tiger Blvd, Clemson, SC
  • 17 min drive from Keowee Reservoir
The price is $125 per night from Jan 4 to Jan 5
$125
includes taxes & fees
Jan 4 - Jan 5, 2025
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (846 reviews)
"Very easy check in and nice place to stay at a reasonable rate."

Reviewed on Dec 7, 2024

Holiday Inn Express & Suites Clemson, an IHG Hotel
The Abernathy of Clemson
The Abernathy of Clemson
4 out of 5
157 Old Greenville Hwy, Clemson, SC
  • 14 min drive from Keowee Reservoir
The price is $165 per night from Dec 30 to Dec 31
$165
includes taxes & fees
Dec 30 - Dec 31
Stay at this 4-star business-friendly hotel in Clemson. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
9.6/10 Exceptional! (478 reviews)
"Very clean and comfortable. We had a great stay"

Reviewed on Dec 22, 2024

The Abernathy of Clemson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Seneca

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If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $79. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Seneca hotel deals at the last minute.

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Frequently Asked Questions About Seneca hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Seneca?

With over 1,499 hotels in Seneca, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $79.

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Finding a cheap car rental deal in Seneca is as easy as scoring cheap hotels in Seneca. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.