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Hotels in Seneca

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Choose from 1547 Seneca Hotel Deals

Lakeside Lodge Clemson
Lakeside Lodge Clemson
2.5 out of 5
13500 Clemson Blvd, Seneca, SC
  • 11 min drive from Keowee Reservoir
The price is $134 per night from Apr 8 to Apr 9
$134
includes taxes & fees
Apr 8 - Apr 9
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.8/10 Excellent! (826 reviews)
"Closest, Best resort style hotel near Clemson University!"

Reviewed on Apr 2, 2025

Lakeside Lodge Clemson
Quality Inn Seneca US-123
Quality Inn Seneca US-123
2.5 out of 5
226 Hi Tech Rd, Seneca, SC
  • 10 min drive from Keowee Reservoir
The price is $101 per night from Apr 21 to Apr 22
$101
includes taxes & fees
Apr 21 - Apr 22
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (576 reviews)
"Clean and efficient somewhat dated"

Reviewed on Mar 6, 2025

Quality Inn Seneca US-123
Tru by Hilton Seneca Clemson
Tru by Hilton Seneca Clemson
2.5 out of 5
13050 Clemson Blvd, Seneca, SC
  • 11 min drive from Keowee Reservoir
The price is $128 per night from Apr 13 to Apr 14
$128
includes taxes & fees
Apr 13 - Apr 14
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (693 reviews)
"Rooms are so small, and does not have any closets."

Reviewed on Apr 1, 2025

Tru by Hilton Seneca Clemson
Postcard Cabins Lake Hartwell
Postcard Cabins Lake Hartwell
2 out of 5
299 Outpost Rd, Seneca, SC
  • 20 min drive from Keowee Reservoir
The price is $110 per night from Apr 15 to Apr 16
$110
includes taxes & fees
Apr 15 - Apr 16
Stay at this cabin in Seneca. Enjoy free parking, patios, and climate control. Popular attractions Friendship Recreaction Area and Cross Creek Plantation Golf ...
10/10 Exceptional! (4 reviews)
"This is a fantastic place to stay and get away. Good for quiet work or true relaxation. Internet was blazing fast too. Can I stay forever?"

Reviewed on Feb 16, 2025

Postcard Cabins Lake Hartwell
Best Western Seneca-Clemson
Best Western Seneca-Clemson
2.5 out of 5
511 Bypass Highway 123, Seneca, SC
  • 8 min drive from Keowee Reservoir
The price is $98 per night from Apr 14 to Apr 15
$98
includes taxes & fees
Apr 14 - Apr 15
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (579 reviews)
"Very clean rooms, and nice staff."

Reviewed on Mar 28, 2025

Best Western Seneca-Clemson
Hampton Inn & Suites Seneca-Clemson Area
Hampton Inn & Suites Seneca-Clemson Area
2.5 out of 5
1011 East North 1st Street, Seneca, SC
  • 7 min drive from Keowee Reservoir
The price is $133 per night from Apr 27 to Apr 28
$133
includes taxes & fees
Apr 27 - Apr 28
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (587 reviews)
"Very clean and the staff is very helpful"

Reviewed on Mar 12, 2025

Hampton Inn & Suites Seneca-Clemson Area
Fairfield Inn & Suites Seneca Clemson Univ Area
Fairfield Inn & Suites Seneca Clemson Univ Area
2.5 out of 5
800 BYPASS 123, Seneca, SC
  • 10 min drive from Keowee Reservoir
The price is $142 per night from Apr 8 to Apr 9
$142
includes taxes & fees
Apr 8 - Apr 9
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (137 reviews)
"Nice Room , friendly staff , nice and clean breakfast bar!"

Reviewed on Mar 31, 2025

Fairfield Inn & Suites Seneca Clemson Univ Area
Days Inn by Wyndham Seneca / Clemson Area
Days Inn by Wyndham Seneca / Clemson Area
2 out of 5
11015 N Radio Station Rd, Seneca, SC
  • 14 min drive from Keowee Reservoir
The price is $90 per night from May 4 to May 5
$90
includes taxes & fees
May 4 - May 5
Stay at this motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Applewood ...
6.8/10 (664 reviews)
"Good"

Reviewed on Apr 1, 2025

Days Inn by Wyndham Seneca / Clemson Area
The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown Clemson
4 out of 5
110 Sloan St, Clemson, SC
  • 15 min drive from Keowee Reservoir
The price is $199 per night from May 4 to May 5
$199
includes taxes & fees
May 4 - May 5
Stay at this 4-star hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and valet parking (surcharge). Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (528 reviews)
"Wonderful hotel in the heart of Clemson. Staff are all friendly and helpful. Clean and comfortable rooms."

Reviewed on Apr 2, 2025

The Shepherd Hotel Downtown Clemson
Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference Center
2.5 out of 5
1310 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
The price is $103 per night from Apr 13 to Apr 14
$103
includes taxes & fees
Apr 13 - Apr 14
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,007 reviews)
"Our room was 79 degrees with no air on when we entered. Most hotels turn the air on for you when you’re about to arrive. It was too hot to stay in the room. Once the AC was turned on it cooled down after 30 minutes. Someone came up to help us as soon as we called."

Reviewed on Apr 6, 2025

Best Western Plus Clemson Hotel & Conference Center
Inn @ Clemson
Inn @ Clemson
2.5 out of 5
1303 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
The price is $110 per night from Apr 15 to Apr 16
$110
includes taxes & fees
Apr 15 - Apr 16
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,002 reviews)
"Stayed here for a quick weekend trip for a gymnastics meet. It was great. Great room rates and easy access to food and the location we needed to go. Would book again."

Reviewed on Apr 3, 2025

Inn @ Clemson
Comfort Inn & Suites Clemson - University Area
Comfort Inn & Suites Clemson - University Area
2.5 out of 5
1305 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
The price is $103 per night from Apr 15 to Apr 16
$103
includes taxes & fees
Apr 15 - Apr 16
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,005 reviews)
"All good - as expected"

Reviewed on Apr 3, 2025

Comfort Inn & Suites Clemson - University Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Seneca

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If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $90. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Seneca hotel deals at the last minute.

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Frequently Asked Questions About Seneca hotels

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How many hotels are there in Seneca?

With over 1,547 hotels in Seneca, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $90.

How to find cheap car rentals in Seneca?

Finding a cheap car rental deal in Seneca is as easy as scoring cheap hotels in Seneca. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.