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Hotels in Seneca

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Last Minute Hot Rate® Hotel Deals in Seneca

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Choose from 1481 Seneca Hotel Deals

Days Inn by Wyndham Anderson
Days Inn by Wyndham Anderson
2 out of 5
1007 George Smith Mill Rd, Anderson, SC
  • 43 min drive from Keowee Reservoir
The price is $59 per night from Jun 30 to Jul 1
$59
per night
Jun 30 - Jul 1
Book a stay at this business-friendly motel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (750 reviews)
"This hotel was lovely, and the complimentary upgrade to the new section of rooms was a welcome treat. The facility was modern and comfortable, and all systems (bathroom, WiFi, TV) worked as they should."

Reviewed on Jun 20, 2024

Days Inn by Wyndham Anderson
Lakeside Lodge Clemson
Lakeside Lodge Clemson
2.5 out of 5
13500 Clemson Blvd, Seneca, SC
  • 11 min drive from Keowee Reservoir
The price is $109 per night from Jun 24 to Jun 25
$109
per night
Jun 24 - Jun 25
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
8.8/10 Excellent! (632 reviews)
"Beautiful property and we greatly enjoyed our stay. Walked to dinner & shopping, hung out out by the awesome pool... a very nice getaway!"

Reviewed on Jun 17, 2024

Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson
Tru by Hilton Seneca Clemson
2.5 out of 5
13050 Clemson Blvd, Seneca, SC
  • 11 min drive from Keowee Reservoir
The price is $116 per night from Jun 29 to Jun 30
$116
per night
Jun 29 - Jun 30
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (584 reviews)
Business Trip
"Check was smooth with no issues. Room was clean and comfortable. I would stay here again."

Reviewed on Jun 14, 2024

Tru by Hilton Seneca Clemson
Hampton Inn & Suites Seneca-Clemson Area
Hampton Inn & Suites Seneca-Clemson Area
2.5 out of 5
1011 East North 1st Street, Seneca, SC
  • 7 min drive from Keowee Reservoir
The price is $114 per night from Jul 18 to Jul 19
$114
per night
Jul 18 - Jul 19
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (525 reviews)
Wonderful family place to vacay
"Enjoyed everything from the breakfast to the pool."

Reviewed on Jun 16, 2024

Hampton Inn & Suites Seneca-Clemson Area
Quality Inn Seneca US-123
Quality Inn Seneca US-123
2.5 out of 5
226 Hi Tech Rd, Seneca, SC
  • 10 min drive from Keowee Reservoir
The price is $80 per night from Jun 30 to Jul 1
$80
per night
Jun 30 - Jul 1
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. Popular ...
7.8/10 Good! (491 reviews)
"All was good!"

Reviewed on Jun 8, 2024

Quality Inn Seneca US-123
Days Inn by Wyndham Seneca / Clemson Area
Days Inn by Wyndham Seneca / Clemson Area
2 out of 5
11015 N Radio Station Rd, Seneca, SC
  • 14 min drive from Keowee Reservoir
The price is $69 per night from Jul 14 to Jul 15
$69
per night
Jul 14 - Jul 15
Book a stay at this business-friendly motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
6.8/10 (611 reviews)
"Basic & Reasonable"

Reviewed on Jun 16, 2024

Days Inn by Wyndham Seneca / Clemson Area
Best Western Seneca-Clemson
Best Western Seneca-Clemson
2.5 out of 5
511 Bypass Highway 123, Seneca, SC
  • 8 min drive from Keowee Reservoir
The price is $98 per night from Jul 7 to Jul 8
$98
per night
Jul 7 - Jul 8
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (524 reviews)
"Amanda was so sweet at check in.."

Reviewed on Jun 20, 2024

Best Western Seneca-Clemson
Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference Center
2.5 out of 5
1310 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
The price is $101 per night from Jun 25 to Jun 26
$101
per night
Jun 25 - Jun 26
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (801 reviews)
"Great stay! The bed was a little hard for my taste, but I still slept well."

Reviewed on Jun 17, 2024

Best Western Plus Clemson Hotel & Conference Center
Inn @ Clemson
Inn @ Clemson
2.5 out of 5
1303 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
The price is $99 per night from Jun 24 to Jun 25
$99
per night
Jun 24 - Jun 25
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,003 reviews)
"What a fun and modern boutique hotel"

Reviewed on Jun 19, 2024

Inn @ Clemson
The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown Clemson
4 out of 5
110 Sloan St, Clemson, SC
  • 15 min drive from Keowee Reservoir
The price is $169 per night from Jun 25 to Jun 26
$169
per night
Jun 25 - Jun 26
Stay at this 4-star hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and valet parking (surcharge). Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (304 reviews)
"Beautiful hotel and friendly staff. Rooftop view of Clemson was the best part!"

Reviewed on Jun 21, 2024

The Shepherd Hotel Downtown Clemson
Comfort Inn & Suites Clemson - University Area
Comfort Inn & Suites Clemson - University Area
2.5 out of 5
1305 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
The price is $93 per night from Jun 30 to Jul 1
$93
per night
Jun 30 - Jul 1
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,001 reviews)
"The rooms were large and clean. The staff were wonderful. We even had a change in our schedule and wanted to add another night. They were able to keep us in the same room and add the extra with no trouble. Definitely would stay here again."

Reviewed on Jun 8, 2024

Comfort Inn & Suites Clemson - University Area
Holiday Inn Express & Suites Clemson, an IHG Hotel
Holiday Inn Express & Suites Clemson, an IHG Hotel
2.5 out of 5
1381 Tiger Blvd, Clemson, SC
  • 17 min drive from Keowee Reservoir
The price is $111 per night from Jun 30 to Jul 1
$111
per night
Jun 30 - Jul 1
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (786 reviews)
"I like the hospitality and easy parking. There was nothing I didn’t like"

Reviewed on Jun 19, 2024

Holiday Inn Express & Suites Clemson, an IHG Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in Seneca

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Seneca hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Seneca.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Seneca’s 1,481 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $59. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Seneca hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Seneca. No matter your reason for visiting Seneca, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Seneca hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Seneca for as low as $59.

How many hotels are there in Seneca?

With over 1,481 hotels in Seneca, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $59.

How to find cheap car rentals in Seneca?

Finding a cheap car rental deal in Seneca is as easy as scoring cheap hotels in Seneca. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Seneca now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Seneca right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.