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Hotels in Seneca

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Choose from 1516 Seneca Hotel Deals

Lakeside Lodge Clemson
Lakeside Lodge Clemson
2.5 out of 5
13500 Clemson Blvd, Seneca, SC
  • 11 min drive from Keowee Reservoir
The price is $134 per night from Nov 28 to Nov 29
$134
includes taxes & fees
Nov 28 - Nov 29
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.8/10 Excellent! (751 reviews)
"Beautiful property!"

Reviewed on Nov 21, 2024

Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson
Tru by Hilton Seneca Clemson
2.5 out of 5
13050 Clemson Blvd, Seneca, SC
  • 11 min drive from Keowee Reservoir
The price is $118 per night from Dec 27 to Dec 28
$118
includes taxes & fees
Dec 27 - Dec 28
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (642 reviews)
"Nice friendly, clean"

Reviewed on Nov 19, 2024

Tru by Hilton Seneca Clemson
Quality Inn Seneca US-123
Quality Inn Seneca US-123
2.5 out of 5
226 Hi Tech Rd, Seneca, SC
  • 10 min drive from Keowee Reservoir
The price is $88 per night from Dec 16 to Dec 17
$88
includes taxes & fees
Dec 16 - Dec 17
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (553 reviews)
"Nice stay"

Reviewed on Nov 5, 2024

Quality Inn Seneca US-123
Hampton Inn & Suites Seneca-Clemson Area
Hampton Inn & Suites Seneca-Clemson Area
2.5 out of 5
1011 East North 1st Street, Seneca, SC
  • 7 min drive from Keowee Reservoir
The price is $133 per night from Dec 15 to Dec 16
$133
includes taxes & fees
Dec 15 - Dec 16
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (566 reviews)
"As advertised."

Reviewed on Nov 24, 2024

Hampton Inn & Suites Seneca-Clemson Area
Fairfield Inn & Suites Seneca Clemson Univ Area
Fairfield Inn & Suites Seneca Clemson Univ Area
2.5 out of 5
800 BYPASS 123, Seneca, SC
  • 10 min drive from Keowee Reservoir
The price is $142 per night from Nov 28 to Nov 29
$142
includes taxes & fees
Nov 28 - Nov 29
Book a stay at this business-friendly hotel in Seneca. Enjoy free parking, a fitness center, and a 24-hour front desk. Our guests praise the helpful staff in ...
9.4/10 Exceptional! (126 reviews)
"Clean, quiet, and nice staff! I would stay here again when I’m in town."

Reviewed on Nov 23, 2024

Fairfield Inn & Suites Seneca Clemson Univ Area
Days Inn by Wyndham Seneca / Clemson Area
Days Inn by Wyndham Seneca / Clemson Area
2 out of 5
11015 N Radio Station Rd, Seneca, SC
  • 14 min drive from Keowee Reservoir
The price is $77 per night from Dec 12 to Dec 13
$77
includes taxes & fees
Dec 12 - Dec 13
Book a stay at this business-friendly motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
6.8/10 (647 reviews)
"My stay was very nice. The only thing was the tv was broken in rm 121. No worries, tough, as i was busy with family"

Reviewed on Nov 11, 2024

Days Inn by Wyndham Seneca / Clemson Area
Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference Center
2.5 out of 5
1310 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
The price is $93 per night from Dec 6 to Dec 7
$93
includes taxes & fees
Dec 6 - Dec 7
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (942 reviews)
"Great staff, clean rooms , good location"

Reviewed on Nov 22, 2024

Best Western Plus Clemson Hotel & Conference Center
The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown Clemson
4 out of 5
110 Sloan St, Clemson, SC
  • 15 min drive from Keowee Reservoir
The price is $188 per night from Dec 22 to Dec 23
$188
includes taxes & fees
Dec 22 - Dec 23
Stay at this 4-star hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and valet parking (surcharge). Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (428 reviews)
"Beautiful hotel and the staff couldn’t have been nicer. Rooms were really nice as well"

Reviewed on Nov 21, 2024

The Shepherd Hotel Downtown Clemson
Inn @ Clemson
Inn @ Clemson
2.5 out of 5
1303 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
The price is $99 per night from Dec 1 to Dec 2
$99
includes taxes & fees
Dec 1 - Dec 2
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,002 reviews)
"Nice staff."

Reviewed on Nov 23, 2024

Inn @ Clemson
Comfort Inn & Suites Clemson - University Area
Comfort Inn & Suites Clemson - University Area
2.5 out of 5
1305 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
The price is $92 per night from Dec 26 to Dec 27
$92
includes taxes & fees
Dec 26 - Dec 27
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,004 reviews)
Clemson
"Great location and very reasonable price for the area"

Reviewed on Nov 22, 2024

Comfort Inn & Suites Clemson - University Area
Microtel Inn & Suites by Wyndham Anderson/Clemson
Microtel Inn & Suites by Wyndham Anderson/Clemson
2 out of 5
102 Electric City Blvd, Anderson, SC
  • 42 min drive from Keowee Reservoir
The price is $73 per night from Dec 25 to Dec 26
$73
includes taxes & fees
Dec 25 - Dec 26
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,004 reviews)
"had plenty of parking, felt safe and in a well lit area. staff was also nice and helpful!"

Reviewed on Nov 23, 2024

Microtel Inn & Suites by Wyndham Anderson/Clemson
The Inn at Patrick Square
The Inn at Patrick Square
3.5 out of 5
115 Market Street, Clemson, SC
  • 22 min drive from Keowee Reservoir
The price is $165 per night from Nov 28 to Nov 29
$165
includes taxes & fees
Nov 28 - Nov 29
Stay at this 3.5-star hotel in Clemson. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
9.8/10 Exceptional! (667 reviews)
"Great Inn and always super clean with a friendly warm welcoming staff. Great dining options within walking distance. Highly recommend. If you want a relaxing, convenient, southern experience stay here."

Reviewed on Nov 7, 2024

The Inn at Patrick Square
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Seneca

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Seneca hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Seneca.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Seneca’s 1,516 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $73. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Seneca hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Seneca. No matter your reason for visiting Seneca, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Seneca hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Seneca for as low as $73.

How many hotels are there in Seneca?

With over 1,516 hotels in Seneca, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $73.

How to find cheap car rentals in Seneca?

Finding a cheap car rental deal in Seneca is as easy as scoring cheap hotels in Seneca. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Seneca now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Seneca right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.