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Hotels in Seneca

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Choose from 1550 Seneca Hotel Deals

Lakeside Lodge Clemson
Lakeside Lodge Clemson
2.5 out of 5
13500 Clemson Blvd, Seneca, SC
  • 11 min drive from Keowee Reservoir
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.8/10 Excellent! (868 reviews)
Loved it!
"Beautiful accommodations, extremely clean, and very friendly people"

Reviewed on May 14, 2025

Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson
Tru by Hilton Seneca Clemson
2.5 out of 5
13050 Clemson Blvd, Seneca, SC
  • 11 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (714 reviews)
"We love this hotel when visiting family in the area. Good location, fun atmosphere, excellent staff."

Reviewed on May 9, 2025

Tru by Hilton Seneca Clemson
Postcard Cabins Lake Hartwell
Postcard Cabins Lake Hartwell
2 out of 5
299 Outpost Rd, Seneca, SC
  • 20 min drive from Keowee Reservoir
Stay at this cabin in Seneca. Enjoy free parking, patios, and climate control. Popular attractions Friendship Recreaction Area and Cross Creek Plantation Golf ...
10/10 Exceptional! (6 reviews)
"The view of the woods out of the large window as you lay in bed is relaxing and surprising even at night."

Reviewed on May 9, 2025

Postcard Cabins Lake Hartwell
Quality Inn Seneca US-123
Quality Inn Seneca US-123
2.5 out of 5
226 Hi Tech Rd, Seneca, SC
  • 10 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (589 reviews)
"breakfast"

Reviewed on May 10, 2025

Quality Inn Seneca US-123
Fairfield Inn & Suites Seneca Clemson Univ Area
Fairfield Inn & Suites Seneca Clemson Univ Area
2.5 out of 5
800 BYPASS 123, Seneca, SC
  • 10 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (148 reviews)
"Me and my mom stayed here for my friend’s graduation from Clemson university. We had a wonderful time. The hotel was clean and the staff we very helpful."

Reviewed on May 12, 2025

Fairfield Inn & Suites Seneca Clemson Univ Area
Hampton Inn & Suites Seneca-Clemson Area
Hampton Inn & Suites Seneca-Clemson Area
2.5 out of 5
1011 East North 1st Street, Seneca, SC
  • 7 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (595 reviews)
"Location"

Reviewed on May 11, 2025

Hampton Inn & Suites Seneca-Clemson Area
Best Western Seneca-Clemson
Best Western Seneca-Clemson
2.5 out of 5
511 Bypass Highway 123, Seneca, SC
  • 8 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (587 reviews)
"Very good breakfast for a free buffet. Not within walking distance of many restaurants or shops. Fitness facility is about a 10 minute drive. Very nice staff. Good location for exploring the lakes region of South Carolina."

Reviewed on May 15, 2025

Best Western Seneca-Clemson
Days Inn by Wyndham Seneca / Clemson Area
Days Inn by Wyndham Seneca / Clemson Area
2 out of 5
11015 N Radio Station Rd, Seneca, SC
  • 14 min drive from Keowee Reservoir
Stay at this motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Applewood ...
6.8/10 (678 reviews)
"Clean and comfortable. Good location. Close to Clemson University"

Reviewed on May 9, 2025

Days Inn by Wyndham Seneca / Clemson Area
Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference Center
2.5 out of 5
1310 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,003 reviews)
"Clemson graduation..pricey but so were all the other hotels."

Reviewed on May 15, 2025

Best Western Plus Clemson Hotel & Conference Center
The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown Clemson
4 out of 5
110 Sloan St, Clemson, SC
  • 15 min drive from Keowee Reservoir
Stay at this 4-star hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and valet parking (surcharge). Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (576 reviews)
"Beautiful hotel."

Reviewed on May 17, 2025

The Shepherd Hotel Downtown Clemson
Inn @ Clemson
Inn @ Clemson
2.5 out of 5
1303 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,009 reviews)
Inn @ Clemson was a great place to stay!!
"Beautiful place to stay. Bed was comfortable, room very clean, stand up shower stall was large. Very enjoyable stay, will book again!!"

Reviewed on May 12, 2025

Inn @ Clemson
Wooded Cottage - 3 Mi to Clemson University
Wooded Cottage - 3 Mi to Clemson University
3 out of 5
Clemson
  • 16 min drive from Keowee Reservoir
Stay at this 3-star cottage in Clemson. Enjoy free parking and air conditioning. Popular attractions Clemson Area African American Museum and Larry W. Abernathy ...
Wooded Cottage - 3 Mi to Clemson University
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Seneca

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Seneca.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Seneca’s 1,550 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as . In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Seneca hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Seneca. No matter your reason for visiting Seneca, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Seneca hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Seneca?

With over 1,550 hotels in Seneca, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as .

How to find cheap car rentals in Seneca?

Finding a cheap car rental deal in Seneca is as easy as scoring cheap hotels in Seneca. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.