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Featured Seneca Family Hotels
Best Western Seneca-Clemson
511 Bypass Highway 123, Seneca, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Quality Inn Seneca US-123
226 Hi Tech Rd, Seneca, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Hampton Inn & Suites Seneca-Clemson Area
1011 East North 1st Street, Seneca, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Days Inn by Wyndham Seneca / Clemson Area
11015 N Radio Station Rd, Seneca, SC
Fully refundableReserve now, pay when you stay
Stay at this motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Applewood ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels with Pools in Seneca
Hampton Inn & Suites Seneca-Clemson Area
1011 East North 1st Street, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (590 reviews)
"Mostly liked the location. It is in the part of town where we spent most of our time."
Reviewed on Apr 23, 2025
Best Western Seneca-Clemson
511 Bypass Highway 123, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (581 reviews)
"Always great service"
Reviewed on Apr 22, 2025
Days Inn by Wyndham Seneca / Clemson Area
11015 N Radio Station Rd, Seneca, SC
Stay at this motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Applewood ...
"The staff was very polite, helpful and accomadating. Room was very clean. Grounds were manicured."
Reviewed on Apr 19, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels With Connecting Rooms in Seneca
Days Inn by Wyndham Seneca / Clemson Area
11015 N Radio Station Rd, Seneca, SC
Stay at this motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Applewood ...
Quality Inn Seneca US-123
226 Hi Tech Rd, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options
- Hotels with a Pool in Seneca
- Apartment Hotel in Seneca
- Romantic Hotels in Seneca
- Hotels with Free Parking in Seneca
- Pet-friendly Hotels in Seneca
- Hotels with Hot Tubs in Seneca
- Hotel Wedding Venues in Seneca
- Historic Hotels in Seneca
- Resorts & Hotels with Spas in Seneca
- Hotels with smoking rooms in Seneca
Seneca Neighborhoods
Cities near Seneca
- Highlands Hotels (28.85 mi)
- Clemson Hotels (6.58 mi)
- Brevard Hotels (39.8 mi)
- Anderson Hotels (21.32 mi)
- North Carolina Mountains Hotels (75.4 mi)
- Blue Ridge Mountains Hotels (84.01 mi)
- Cashiers Hotels (30.58 mi)
- Clayton Hotels (28.66 mi)
- Sapphire Hotels (29.23 mi)
- Clarkesville Hotels (32.86 mi)
- Salem Hotels (14.16 mi)
- Lake Toxaway Hotels (30.86 mi)
- Central Hotels (10.12 mi)
- Easley Hotels (22.2 mi)
- Toccoa Hotels (22.8 mi)
- Hartwell Hotels (23.01 mi)
- Dillard Hotels (31.47 mi)
- Mountain Rest Hotels (17.07 mi)
- Lavonia Hotels (19.33 mi)
- Tiger Hotels (29.4 mi)
Car Rentals Near Seneca
- Car rentals in Highlands
- Car rentals in Clemson
- Car rentals in Brevard
- Car rentals in Anderson
- Car rentals in North Carolina Mountains
- Car rentals in Blue Ridge Mountains
- Car rentals in Cashiers
- Car rentals in Clayton
- Car rentals in Sapphire
- Car rentals in Clarkesville
- Car rentals in Salem
- Car rentals in Lake Toxaway
- Car rentals in Central
- Car rentals in Easley
- Car rentals in Toccoa
- Car rentals in Hartwell
Top Family Hotel Destinations
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- Fort Walton Beach Family Hotels
- Pensacola Beach Family Hotels
- Tampa Family Hotels
- Myrtle Beach Family Hotels
- Miami Beach Family Hotels
- Birmingham Family Hotels
Top Booked Hotels in Seneca
- Quality Inn Seneca US-123
- Tru by Hilton Seneca Clemson
- Best Western Seneca-Clemson
- Hampton Inn & Suites Seneca-Clemson Area
- Days Inn by Wyndham Seneca / Clemson Area
- Best Western Plus Clemson Hotel & Conference Center
- Inn @ Clemson
- Days Inn by Wyndham Anderson
- Comfort Inn & Suites Clemson - University Area
- Horizon Inn & Suites
- Microtel Inn & Suites by Wyndham Anderson/Clemson