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Featured Seneca Family Hotels
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Best Western Seneca-Clemson
511 Bypass Highway 123, Seneca, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
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Quality Inn Seneca US-123
226 Hi Tech Rd, Seneca, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
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Hampton Inn & Suites Seneca-Clemson Area
1011 East North 1st Street, Seneca, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
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Days Inn by Wyndham Seneca / Clemson Area
11015 N Radio Station Rd, Seneca, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels with Pools in Seneca
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Hampton Inn & Suites Seneca-Clemson Area
1011 East North 1st Street, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (579 reviews)
"Great hotel breakfast."
Reviewed on Feb 25, 2025
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Best Western Seneca-Clemson
511 Bypass Highway 123, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (573 reviews)
"clean, staff friendly and accommodating, convenient"
Reviewed on Feb 24, 2025
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Days Inn by Wyndham Seneca / Clemson Area
11015 N Radio Station Rd, Seneca, SC
Book a stay at this business-friendly motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
6.8/10 (656 reviews)
"Unfortunately, there is a hundred and fifty dollar deposit that is refundable, but not written anywhere on expedia. My room was only ninety dollars and they wanted a hundred and fifty dollar deposit. Thank GodThe front deskWoman only made me come up with fifty dollars, but I wasn't expecting ..."
Reviewed on Feb 24, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels With Connecting Rooms in Seneca
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Days Inn by Wyndham Seneca / Clemson Area
11015 N Radio Station Rd, Seneca, SC
Book a stay at this business-friendly motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...

Quality Inn Seneca US-123
226 Hi Tech Rd, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options
- Hotels with a Pool in Seneca
- Apartment Hotel in Seneca
- Romantic Hotels in Seneca
- Hotels with Free Parking in Seneca
- Pet-friendly Hotels in Seneca
- Hotels with Hot Tubs in Seneca
- Hotel Wedding Venues in Seneca
- Historic Hotels in Seneca
- Resorts & Hotels with Spas in Seneca
- Hotels with smoking rooms in Seneca
Cities near Seneca
- Highlands Hotels (28.85 mi)
- Clemson Hotels (6.58 mi)
- North Carolina Mountains Hotels (75.4 mi)
- Anderson Hotels (21.32 mi)
- Brevard Hotels (39.8 mi)
- Blue Ridge Mountains Hotels (84.01 mi)
- Cashiers Hotels (30.58 mi)
- Clayton Hotels (28.66 mi)
- Central Hotels (10.12 mi)
- Sapphire Hotels (29.23 mi)
- Southeastern United States Hotels (144.22 mi)
- Lake Toxaway Hotels (30.86 mi)
- Clarkesville Hotels (32.86 mi)
- Easley Hotels (22.2 mi)
- Salem Hotels (14.16 mi)
- Dillard Hotels (31.47 mi)
- Toccoa Hotels (22.8 mi)
- Appalachian Mountains Hotels (355.94 mi)
- Hartwell Hotels (23.01 mi)
- Tiger Hotels (29.4 mi)
Car Rentals Near Seneca
- Car rentals in Highlands
- Car rentals in Clemson
- Car rentals in North Carolina Mountains
- Car rentals in Anderson
- Car rentals in Brevard
- Car rentals in Blue Ridge Mountains
- Car rentals in Cashiers
- Car rentals in Clayton
- Car rentals in Central
- Car rentals in Sapphire
- Car rentals in Southeastern United States
- Car rentals in Lake Toxaway
- Car rentals in Clarkesville
- Car rentals in Easley
- Car rentals in Salem
- Car rentals in Dillard
Top Family Hotel Destinations
- Las Vegas Family Hotels
- Arcade Family Hotels
- Branson Family Hotels
- Biloxi Family Hotels
- Ocean City Family Hotels
- Orlando Family Hotels
- Buffalo Family Hotels
- Reno Family Hotels
- Colorado Springs Family Hotels
- Phoenix Family Hotels
- Niagara Falls Family Hotels
- New York Family Hotels
- Whistler Family Hotels
- Houston Family Hotels
- Fort Walton Beach Family Hotels
- Pensacola Beach Family Hotels
- Tampa Family Hotels
- Myrtle Beach Family Hotels
- Miami Beach Family Hotels
- Birmingham Family Hotels
Top Booked Hotels in Seneca
- Hampton Inn & Suites Seneca-Clemson Area
- Tru by Hilton Seneca Clemson
- Best Western Seneca-Clemson
- Best Western Plus Clemson Hotel & Conference Center
- Inn @ Clemson
- Comfort Inn & Suites Clemson - University Area
- Microtel Inn & Suites by Wyndham Anderson/Clemson
- Holiday Inn Express Hotel & Suites Anderson-I-85, an IHG Hotel
- Holiday Inn Express & Suites Clemson, an IHG Hotel