Hotels Near
Downtown

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Featured Downtown Hotels

Quality Inn Seneca US-123
Quality Inn Seneca US-123
2.5 out of 5
226 Hi Tech Rd, Seneca, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (585 reviews)
"Nice place for the price. I would stay here again. Looks newly renovated and was clean. Very comfy bed, pillows. Breakfast was basic but delicious. Staff was excellent. Very pleasant and professional. We enjoyed our short stay."

Reviewed on Apr 27, 2025

Quality Inn Seneca US-123
Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference Center
2.5 out of 5
1310 Tiger Blvd, Clemson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,001 reviews)
"Great hotel for the price! Clean, great breakfast, great location!"

Reviewed on May 6, 2025

Best Western Plus Clemson Hotel & Conference Center
Lakeside Lodge Clemson
Lakeside Lodge Clemson
2.5 out of 5
13500 Clemson Blvd, Seneca, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.8/10 Excellent! (855 reviews)
"The staff was very helpful. Great room and loved the location"

Reviewed on May 5, 2025

Lakeside Lodge Clemson
The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown Clemson
4 out of 5
110 Sloan St, Clemson, SC
Fully refundableReserve now, pay when you stay
Stay at this 4-star hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and valet parking (surcharge). Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (564 reviews)
"The staff was very attentive and polite during my stay."

Reviewed on May 5, 2025

The Shepherd Hotel Downtown Clemson
Inn @ Clemson
Inn @ Clemson
2.5 out of 5
1303 Tiger Blvd, Clemson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,004 reviews)
"One odd thing was that the hotel did not have soap for the rooms. I noticed we didn’t have any in our room and went to housekeeping. They told me they were out of soap and we would have to use shower gel. It seemed strange that they would run out of soap right before the weekend."

Reviewed on May 3, 2025

Inn @ Clemson
Comfort Inn & Suites Clemson - University Area
Comfort Inn & Suites Clemson - University Area
2.5 out of 5
1305 Tiger Blvd, Clemson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
"Nice place"

Reviewed on May 4, 2025

Comfort Inn & Suites Clemson - University Area
Days Inn by Wyndham Anderson
Days Inn by Wyndham Anderson
2 out of 5
1007 George Smith Mill Rd, Anderson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly motel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (939 reviews)
"Convenient drive to the hospital for work. Nice stay. Will be back again!!"

Reviewed on May 3, 2025

Days Inn by Wyndham Anderson
Wooded Cottage - 3 Mi to Clemson University
Wooded Cottage - 3 Mi to Clemson University
3 out of 5
Clemson
Stay at this 3-star cottage in Clemson. Enjoy free parking and air conditioning. Popular attractions Clemson Area African American Museum and Larry W. Abernathy ...
10/10 Exceptional! (1 review)
Wooded Cottage - 3 Mi to Clemson University
Postcard Cabins Lake Hartwell
Postcard Cabins Lake Hartwell
2 out of 5
299 Outpost Rd, Seneca, SC
Stay at this cabin in Seneca. Enjoy free parking, patios, and climate control. Popular attractions Friendship Recreaction Area and Cross Creek Plantation Golf ...
10/10 Exceptional! (5 reviews)
"This is a fantastic place to stay and get away. Good for quiet work or true relaxation. Internet was blazing fast too. Can I stay forever?"

Reviewed on Feb 16, 2025

Postcard Cabins Lake Hartwell
Holiday Inn Express & Suites Clemson by IHG
Holiday Inn Express & Suites Clemson by IHG
2.5 out of 5
1381 Tiger Blvd, Clemson, SC
Fully refundable
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (880 reviews)
"Great hotel"

Reviewed on May 2, 2025

Holiday Inn Express & Suites Clemson by IHG
Microtel Inn & Suites by Wyndham Anderson/Clemson
Microtel Inn & Suites by Wyndham Anderson/Clemson
2 out of 5
102 Electric City Blvd, Anderson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,000 reviews)
"Property was clean. Staff was super friendly. Close to multiple dining places."

Reviewed on Apr 28, 2025

Microtel Inn & Suites by Wyndham Anderson/Clemson
The Inn at Patrick Square
The Inn at Patrick Square
3.5 out of 5
115 Market Street, Clemson, SC
Stay at this 3.5-star hotel in Clemson. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
9.8/10 Exceptional! (712 reviews)
"Beautiful hotel just 9 minutes from Clemson campus, and appreciated the 24 hour staff when had a late check in."

Reviewed on May 7, 2025

The Inn at Patrick Square
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Downtown

Seneca is a city that has a lot going on, but you have your sights set on Downtown. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Downtown has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Downtown hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Seneca so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Downtown underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Downtown city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Downtown cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Downtown at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $65
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Downtown hotel you want, book it, and never look back. Because your great escape is ahead of you.