Hotels NearDowntown
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Featured Downtown Hotels

Quality Inn Seneca Clemson Area US-123
Good available parking. Room clean. Breakfast was minimal, but good. The tub was slippery and needed a mat. I almost fell a couple of times. I would stay here again.
Reviewed on Dec 29, 2025

Best Western Plus Clemson Hotel & Conference Center
The hotel staff were efficient and friendly.
Reviewed on Dec 26, 2025

Days Inn by Wyndham Anderson
Love it
Reviewed on Dec 26, 2025

Wooded Cottage - 3 Mi to Clemson University

The Shepherd Hotel Downtown Clemson
.
Reviewed on Dec 17, 2025

Microtel Inn & Suites by Wyndham Anderson/Clemson
Clean, convenient location
Reviewed on Dec 27, 2025

Comfort Inn & Suites Clemson - University Area
The room was immaculate and very comfortable.
Reviewed on Dec 27, 2025

Hilton Garden Inn Anderson
Home when in Anderson
Reviewed on Dec 28, 2025

Lakeside Lodge Clemson
Enjoyed our stay.
Reviewed on Dec 15, 2025

Quality Inn Clemson near University
Yes very
Reviewed on Dec 6, 2025

Tru by Hilton Seneca Clemson
Breakfast was typical but the staff was very friendly and helpful. Nice clean room, safe area close to Clemson University.
Reviewed on Dec 28, 2025

Baymont by Wyndham Anderson Clemson
I reported a issue with the shower curtain and due to curtain needing repairs, it was difficult to shower - seniors having to bathe instead; not acceptable for me. They said they would repair after we checked out. Room 301.
Reviewed on Dec 26, 2025
Hotels in Downtown
Seneca is a city that has a lot going on, but you have your sights set on Downtown. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Downtown has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Downtown hotels that will do the trick.
A beautiful day in the neighborhood
As much as you like getting out there, it’s also good to know a part of Seneca so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Downtown underground. What’s a journey without a good story to go with it?
Beyond the block
We’re not talking about the Downtown city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Downtown cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:
- Hotwire Hot Rate: Snag some of the best hotels in Downtown at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
- Price: You have a price in mind, and we have solutions. Hotels start as low as $55
- Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.
Find the Downtown hotel you want, book it, and never look back. Because your great escape is ahead of you.
Hotels by Star Rating
Top Attractions in Downtown
- Hotels near Clemson University (6.72 mi)
- Hotels near Lake Jocassee (20.72 mi)
- Hotels near Memorial Stadium (6.35 mi)
- Hotels near Chattahoochee National Forest (67.29 mi)
- Hotels near Devils Fork State Park (18.7 mi)
- Hotels near T. Ed Garrison Arena (8.54 mi)
- Hotels near Lake Hartwell State Park (13.82 mi)
- Hotels near Oconee State Park (15.46 mi)
- Hotels near Keowee Key Golf Course (10.52 mi)
- Hotels near Littlejohn Coliseum (6.09 mi)
- Hotels near Fort Hill (6.55 mi)
- Hotels near Anderson Mall (18.85 mi)
- Hotels near Tugaloo State Park (14.44 mi)
- Hotels near Southern Wesleyan University (11.36 mi)
- Hotels near Tri-County Technical College (9.63 mi)
Cities near Downtown
- Clemson Hotels (6.61 mi)
- Blue Ridge Mountains Hotels (84.23 mi)
- Anderson Hotels (21.21 mi)
- Seneca Hotels (0.24 mi)
- Easley Hotels (22.34 mi)
- Toccoa Hotels (22.69 mi)
- Appalachian Mountains Hotels (502.03 mi)
- Salem Hotels (14.39 mi)
- Hartwell Hotels (22.77 mi)
- Lavonia Hotels (19.1 mi)
- Pickens Hotels (19.71 mi)
- Walhalla Hotels (8.46 mi)
- Southeastern United States Hotels (143.99 mi)
- The Carolinas Hotels (181.23 mi)
- Sunset Hotels (22.2 mi)
- Mountain Rest Hotels (17.22 mi)
- Fair Play Hotels (11.94 mi)
- Westminster Hotels (8.19 mi)
- Pendleton Hotels (9.89 mi)
- Townville Hotels (8.77 mi)
