Hotels NearDowntown
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Featured Downtown Hotels

Quality Inn Seneca Clemson Area US-123
Property, room, and front desk were all very nice. Safety strips in the bathtub would be my only suggestion.
Reviewed on Nov 28, 2025

Days Inn by Wyndham Anderson
Great
Reviewed on Dec 2, 2025

Best Western Plus Clemson Hotel & Conference Center
Everything was good except the bacon. Please make crispier
Reviewed on Dec 2, 2025

Comfort Inn & Suites Clemson - University Area
Everything about the hotel was perfect location, price, amenities, & staff.
Reviewed on Nov 29, 2025

Wooded Cottage - 3 Mi to Clemson University

The Shepherd Hotel Downtown Clemson
Clean room, friendly staff 2nd floor a bit loud with the bar upstairs and chairs moving across the floor (ceiling of room)
Reviewed on Dec 2, 2025

Baymont by Wyndham Anderson Clemson
The staff were awesome
Reviewed on Nov 22, 2025

Quality Inn Clemson near University
Shopping is good nears around
Reviewed on Sep 27, 2025

Inn @ Clemson
Staff was helpful. Check-in was easy and a very convenient location. Room was clean and in good condition
Reviewed on Dec 2, 2025

Lakeside Lodge Clemson
Clean room, outdoor fire pit but restaurant closed was hoping for a good meal
Reviewed on Dec 4, 2025

Hilton Garden Inn Anderson
Bed was hard to me.
Reviewed on Dec 2, 2025

Microtel Inn & Suites by Wyndham Anderson/Clemson
The carpet in the room was stained and looked like it had water stains. The TV remote had dead batteries and I had to call the front desk. The bed was comfortable and the staff was responsive.
Reviewed on Dec 2, 2025
Hotels in Downtown
Seneca is a city that has a lot going on, but you have your sights set on Downtown. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Downtown has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Downtown hotels that will do the trick.
A beautiful day in the neighborhood
As much as you like getting out there, it’s also good to know a part of Seneca so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Downtown underground. What’s a journey without a good story to go with it?
Beyond the block
We’re not talking about the Downtown city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Downtown cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:
- Hotwire Hot Rate: Snag some of the best hotels in Downtown at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
- Price: You have a price in mind, and we have solutions. Hotels start as low as $52
- Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.
Find the Downtown hotel you want, book it, and never look back. Because your great escape is ahead of you.
Hotels by Star Rating
Top Attractions in Downtown
- Hotels near Clemson University (6.72 mi)
- Hotels near Memorial Stadium (6.35 mi)
- Hotels near Lake Jocassee (20.72 mi)
- Hotels near Chattahoochee National Forest (67.29 mi)
- Hotels near Devils Fork State Park (18.7 mi)
- Hotels near T. Ed Garrison Arena (8.54 mi)
- Hotels near Lake Hartwell State Park (13.82 mi)
- Hotels near Oconee State Park (15.46 mi)
- Hotels near Keowee Key Golf Course (10.52 mi)
- Hotels near Anderson Mall (18.85 mi)
- Hotels near Littlejohn Coliseum (6.09 mi)
- Hotels near Southern Wesleyan University (11.36 mi)
- Hotels near Fort Hill (6.55 mi)
- Hotels near Tugaloo State Park (14.44 mi)
- Hotels near Tri-County Technical College (9.63 mi)
Cities near Downtown
- Clemson Hotels (6.61 mi)
- Blue Ridge Mountains Hotels (84.23 mi)
- Anderson Hotels (21.21 mi)
- Seneca Hotels (0.24 mi)
- Easley Hotels (22.34 mi)
- Toccoa Hotels (22.69 mi)
- Appalachian Mountains Hotels (502.03 mi)
- Hartwell Hotels (22.77 mi)
- Walhalla Hotels (8.46 mi)
- Pickens Hotels (19.71 mi)
- Salem Hotels (14.39 mi)
- Lavonia Hotels (19.1 mi)
- Pendleton Hotels (9.89 mi)
- Central Hotels (10.22 mi)
- Mountain Rest Hotels (17.22 mi)
- Townville Hotels (8.77 mi)
- Sunset Hotels (22.2 mi)
- Westminster Hotels (8.19 mi)
- Northeast Georgia Hotels (46.43 mi)
- Southeastern United States Hotels (143.99 mi)
