Hotels NearDowntown
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Featured Downtown Hotels

Quality Inn Seneca Clemson Area US-123
Everything has been very good with staff, the room and the property. Would ask that on the days there is no housekeeping service that the trash and fresh towels would be addressed.
Reviewed on Nov 1, 2025

Days Inn by Wyndham Anderson
Didn't Eat
Reviewed on Nov 5, 2025

Wooded Cottage - 3 Mi to Clemson University

Best Western Plus Clemson Hotel & Conference Center
Restaurant connected to hotel
Reviewed on Nov 4, 2025

Comfort Inn & Suites Clemson - University Area
The hotel was amazing with the exception of the front desk clerk. She was rude.
Reviewed on Nov 5, 2025

The Shepherd Hotel Downtown Clemson
Our room, although small, was lovely and spotless. Bed linens were soft and cozy.
Reviewed on Oct 25, 2025

Quality Inn Clemson near University
Shopping is good nears around
Reviewed on Sep 27, 2025

Lakeside Lodge Clemson
Clean room! The staff was great! Beautiful views!
Reviewed on Nov 4, 2025

Microtel Inn & Suites by Wyndham Anderson/Clemson
Clean room, attentive staff.
Reviewed on Nov 8, 2025

Days Inn by Wyndham Seneca / Clemson Area
Clean, friendly.. great service and lots to do
Reviewed on Oct 28, 2025

Baymont by Wyndham Anderson Clemson
Clean attractive room and friendly staff.
Reviewed on Nov 11, 2025

Hilton Garden Inn Anderson
The room was very clean & spacious. Our dinner was very good. The breakfasr was exceptional. We were extra time to keep our room as our vehicle was in the shop unexpectedly. We were not charged for the extra time. The only negative was the tub was incredibly slippery.
Reviewed on Oct 16, 2025
Hotels in Downtown
Seneca is a city that has a lot going on, but you have your sights set on Downtown. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Downtown has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Downtown hotels that will do the trick.
A beautiful day in the neighborhood
As much as you like getting out there, it’s also good to know a part of Seneca so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Downtown underground. What’s a journey without a good story to go with it?
Beyond the block
We’re not talking about the Downtown city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Downtown cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:
- Hotwire Hot Rate: Snag some of the best hotels in Downtown at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
- Price: You have a price in mind, and we have solutions. Hotels start as low as $65
- Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.
Find the Downtown hotel you want, book it, and never look back. Because your great escape is ahead of you.
Hotels by Star Rating
Top Attractions in Downtown
- Hotels near Clemson University (6.72 mi)
- Hotels near Memorial Stadium (6.35 mi)
- Hotels near Chattahoochee National Forest (67.29 mi)
- Hotels near Lake Jocassee (20.72 mi)
- Hotels near Devils Fork State Park (18.7 mi)
- Hotels near T. Ed Garrison Arena (8.54 mi)
- Hotels near Lake Hartwell State Park (13.82 mi)
- Hotels near Oconee State Park (15.46 mi)
- Hotels near Keowee Key Golf Course (10.52 mi)
- Hotels near Anderson Mall (18.85 mi)
- Hotels near Littlejohn Coliseum (6.09 mi)
- Hotels near Southern Wesleyan University (11.36 mi)
- Hotels near Tugaloo State Park (14.44 mi)
- Hotels near Fort Hill (6.55 mi)
- Hotels near Villas at Foxwood Hills (10.79 mi)
Cities near Downtown
- Clemson Hotels (6.61 mi)
- Blue Ridge Mountains Hotels (84.23 mi)
- Anderson Hotels (21.21 mi)
- Seneca Hotels (0.24 mi)
- Easley Hotels (22.34 mi)
- Toccoa Hotels (22.69 mi)
- Appalachian Mountains Hotels (502.03 mi)
- Salem Hotels (14.39 mi)
- Hartwell Hotels (22.77 mi)
- Pickens Hotels (19.71 mi)
- Walhalla Hotels (8.46 mi)
- Lavonia Hotels (19.1 mi)
- Pendleton Hotels (9.89 mi)
- Central Hotels (10.22 mi)
- Mountain Rest Hotels (17.22 mi)
- Sunset Hotels (22.2 mi)
- Westminster Hotels (8.19 mi)
- Townville Hotels (8.77 mi)
- Fair Play Hotels (11.94 mi)
- Northeast Georgia Hotels (46.43 mi)
