Hotels Near
Downtown

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Featured Downtown Hotels

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd Seneca SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (664 reviews)
Property, room, and front desk were all very nice. Safety strips in the bathtub would be my only suggestion.

Reviewed on Nov 28, 2025

Quality Inn Seneca Clemson Area US-123
Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

2 out of 5
1007 George Smith Mill Rd Anderson SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly motel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (1,028 reviews)
Great

Reviewed on Dec 2, 2025

Days Inn by Wyndham Anderson
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,001 reviews)
Everything was good except the bacon. Please make crispier

Reviewed on Dec 2, 2025

Best Western Plus Clemson Hotel & Conference Center
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

2.5 out of 5
1305 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,000 reviews)
Everything about the hotel was perfect location, price, amenities, & staff.

Reviewed on Nov 29, 2025

Comfort Inn & Suites Clemson - University Area
Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
Clemson SC
Stay at this cottage in Clemson. Enjoy air conditioning. Popular attractions Clemson Area African American Museum and Larry W. Abernathy Waterfront Park are ...
10/10 Exceptional! (1 review)
Wooded Cottage - 3 Mi to Clemson University
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St Clemson SC
Stay at this hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean rooms in our reviews. ...
9.8/10 Exceptional! (736 reviews)
Clean room, friendly staff 2nd floor a bit loud with the bar upstairs and chairs moving across the floor (ceiling of room)

Reviewed on Dec 2, 2025

The Shepherd Hotel Downtown Clemson
Baymont by Wyndham Anderson Clemson

Baymont by Wyndham Anderson Clemson

2.5 out of 5
128 Interstate Blvd Anderson SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (840 reviews)
The staff were awesome

Reviewed on Nov 22, 2025

Baymont by Wyndham Anderson Clemson
Quality Inn Clemson near University

Quality Inn Clemson near University

2.5 out of 5
3430 Clemson Blvd Anderson SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
6.8/10 (888 reviews)
Shopping is good nears around

Reviewed on Sep 27, 2025

Quality Inn Clemson near University
Inn @ Clemson

Inn @ Clemson

2.5 out of 5
1303 Tiger Blvd Clemson SC
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,018 reviews)
Staff was helpful. Check-in was easy and a very convenient location. Room was clean and in good condition

Reviewed on Dec 2, 2025

Inn @ Clemson
Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd Seneca SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.8/10 Excellent! (1,001 reviews)
Clean room, outdoor fire pit but restaurant closed was hoping for a good meal

Reviewed on Dec 4, 2025

Lakeside Lodge Clemson
Hilton Garden Inn Anderson

Hilton Garden Inn Anderson

3 out of 5
115 Destination Blvd Anderson SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Anderson. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.8/10 Excellent! (672 reviews)
Bed was hard to me.

Reviewed on Dec 2, 2025

Hilton Garden Inn Anderson
Microtel Inn & Suites by Wyndham Anderson/Clemson

Microtel Inn & Suites by Wyndham Anderson/Clemson

2 out of 5
102 Electric City Blvd Anderson SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,000 reviews)
The carpet in the room was stained and looked like it had water stains. The TV remote had dead batteries and I had to call the front desk. The bed was comfortable and the staff was responsive.

Reviewed on Dec 2, 2025

Microtel Inn & Suites by Wyndham Anderson/Clemson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Downtown

Seneca is a city that has a lot going on, but you have your sights set on Downtown. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Downtown has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Downtown hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Seneca so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Downtown underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Downtown city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Downtown cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Downtown at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $52
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Downtown hotel you want, book it, and never look back. Because your great escape is ahead of you.