Hotels Near
Downtown

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Featured Downtown Hotels

Quality Inn Seneca US-123
Quality Inn Seneca US-123
2.5 out of 5
226 Hi Tech Rd, Seneca, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (579 reviews)
Family trip
"First room smelled of stale cigarette smoke, otherwise i would've rated them higher. Staff was EXTREMELY friendly and helpful. Front desk clerk moved us immediately to a different room. That room was very nice and comfortable. Would stay there again."

Reviewed on Apr 8, 2025

Quality Inn Seneca US-123
The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown Clemson
4 out of 5
110 Sloan St, Clemson, SC
Stay at this 4-star hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and valet parking (surcharge). Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (535 reviews)
"Beautiful hotel in the heart of downtown Clemson. Lovely rooftop balcony for viewing campus. Highly recommend!"

Reviewed on Apr 11, 2025

The Shepherd Hotel Downtown Clemson
Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference Center
2.5 out of 5
1310 Tiger Blvd, Clemson, SC
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,000 reviews)
"Nice hotel, consistently great."

Reviewed on Apr 14, 2025

Best Western Plus Clemson Hotel & Conference Center
Lakeside Lodge Clemson
Lakeside Lodge Clemson
2.5 out of 5
13500 Clemson Blvd, Seneca, SC
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.8/10 Excellent! (835 reviews)
"Great place"

Reviewed on Apr 5, 2025

Lakeside Lodge Clemson
Inn @ Clemson
Inn @ Clemson
2.5 out of 5
1303 Tiger Blvd, Clemson, SC
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,002 reviews)
"Check in was easy and all staff at check in and check out were great. Room and facility were all very clean and nice. Would definitely stay here again."

Reviewed on Apr 13, 2025

Inn @ Clemson
Comfort Inn & Suites Clemson - University Area
Comfort Inn & Suites Clemson - University Area
2.5 out of 5
1305 Tiger Blvd, Clemson, SC
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,006 reviews)
"Super clean"

Reviewed on Apr 13, 2025

Comfort Inn & Suites Clemson - University Area
Days Inn by Wyndham Anderson
Days Inn by Wyndham Anderson
2 out of 5
1007 George Smith Mill Rd, Anderson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly motel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (917 reviews)
"great"

Reviewed on Apr 12, 2025

Days Inn by Wyndham Anderson
Wooded Cottage - 3 Mi to Clemson University
Wooded Cottage - 3 Mi to Clemson University
3 out of 5
Clemson
Stay at this 3-star cottage in Clemson. Enjoy free parking and air conditioning. Popular attractions Clemson Area African American Museum and Larry W. Abernathy ...
Wooded Cottage - 3 Mi to Clemson University
Holiday Inn Express & Suites Clemson by IHG
Holiday Inn Express & Suites Clemson by IHG
2.5 out of 5
1381 Tiger Blvd, Clemson, SC
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (875 reviews)
I would recommend this hotel.
"Easy and quick check in. The room was clean and beautiful. The breakfast food was fresh, however, i think they should've had waffles. One moemre thing, the hotel was convenient and out of heavy traffice which i value a lot."

Reviewed on Apr 13, 2025

Holiday Inn Express & Suites Clemson by IHG
Microtel Inn & Suites by Wyndham Anderson/Clemson
Microtel Inn & Suites by Wyndham Anderson/Clemson
2 out of 5
102 Electric City Blvd, Anderson, SC
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,000 reviews)
Good stay
"Clean room with easy check in. We took our pet and had a room in the first floor near the exit so it was easy to take her in and out"

Reviewed on Apr 7, 2025

Microtel Inn & Suites by Wyndham Anderson/Clemson
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
2.5 out of 5
107 Interstate Blvd, Anderson, SC
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (532 reviews)
"Enjoyed the stay"

Reviewed on Apr 6, 2025

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
Tru by Hilton Seneca Clemson
Tru by Hilton Seneca Clemson
2.5 out of 5
13050 Clemson Blvd, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (696 reviews)
Great front desk host
"Have stayed here multiple times as daughter attends Clemson University. Had a problem with the a/c unit and unfortunately had to change rooms but Hannah, the front desk host, was absolutely wonderful in dealing with the situation. So friendly, compassionate and professional. She deserves a raise ..."

Reviewed on Apr 10, 2025

Tru by Hilton Seneca Clemson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Downtown

Seneca is a city that has a lot going on, but you have your sights set on Downtown. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Downtown has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Downtown hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Seneca so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Downtown underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Downtown city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Downtown cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Downtown at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $65
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Downtown hotel you want, book it, and never look back. Because your great escape is ahead of you.