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Featured Downtown Hotels

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd Seneca SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (656 reviews)
Everything has been very good with staff, the room and the property. Would ask that on the days there is no housekeeping service that the trash and fresh towels would be addressed.

Reviewed on Nov 1, 2025

Quality Inn Seneca Clemson Area US-123
Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

2 out of 5
1007 George Smith Mill Rd Anderson SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly motel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (1,000 reviews)
Didn't Eat

Reviewed on Nov 5, 2025

Days Inn by Wyndham Anderson
Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
Clemson SC
Stay at this 3-star cottage in Clemson. Enjoy air conditioning. Popular attractions Clemson Area African American Museum and Larry W. Abernathy Waterfront Park ...
10/10 Exceptional! (1 review)
Wooded Cottage - 3 Mi to Clemson University
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,005 reviews)
Restaurant connected to hotel

Reviewed on Nov 4, 2025

Best Western Plus Clemson Hotel & Conference Center
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

2.5 out of 5
1305 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,006 reviews)
The hotel was amazing with the exception of the front desk clerk. She was rude.

Reviewed on Nov 5, 2025

Comfort Inn & Suites Clemson - University Area
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St Clemson SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean rooms in our reviews. ...
9.6/10 Exceptional! (720 reviews)
First, but definitely not last stay
Our room, although small, was lovely and spotless. Bed linens were soft and cozy.

Reviewed on Oct 25, 2025

The Shepherd Hotel Downtown Clemson
Quality Inn Clemson near University

Quality Inn Clemson near University

2.5 out of 5
3430 Clemson Blvd Anderson SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
6.8/10 (884 reviews)
Shopping is good nears around

Reviewed on Sep 27, 2025

Quality Inn Clemson near University
Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd Seneca SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
9/10 Wonderful! (1,002 reviews)
Clean room! The staff was great! Beautiful views!

Reviewed on Nov 4, 2025

Lakeside Lodge Clemson
Microtel Inn & Suites by Wyndham Anderson/Clemson

Microtel Inn & Suites by Wyndham Anderson/Clemson

2 out of 5
102 Electric City Blvd Anderson SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,003 reviews)
Clean room, attentive staff.

Reviewed on Nov 8, 2025

Microtel Inn & Suites by Wyndham Anderson/Clemson
Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

2 out of 5
11015 N Radio Station Rd Seneca SC
Stay at this motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Applewood ...
6.8/10 (713 reviews)
Clean, friendly.. great service and lots to do

Reviewed on Oct 28, 2025

Days Inn by Wyndham Seneca / Clemson Area
Baymont by Wyndham Anderson Clemson

Baymont by Wyndham Anderson Clemson

2.5 out of 5
128 Interstate Blvd Anderson SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (831 reviews)
Clean attractive room and friendly staff.

Reviewed on Nov 11, 2025

Baymont by Wyndham Anderson Clemson
Hilton Garden Inn Anderson

Hilton Garden Inn Anderson

3 out of 5
115 Destination Blvd Anderson SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Anderson. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.8/10 Excellent! (661 reviews)
The room was very clean & spacious. Our dinner was very good. The breakfasr was exceptional. We were extra time to keep our room as our vehicle was in the shop unexpectedly. We were not charged for the extra time. The only negative was the tub was incredibly slippery.

Reviewed on Oct 16, 2025

Hilton Garden Inn Anderson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Downtown

Seneca is a city that has a lot going on, but you have your sights set on Downtown. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Downtown has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Downtown hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Seneca so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Downtown underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Downtown city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Downtown cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Downtown at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $65
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Downtown hotel you want, book it, and never look back. Because your great escape is ahead of you.