Hotels Near
Downtown

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!


Featured Downtown Hotels

Quality Inn Seneca Clemson Area US-123
Quality Inn Seneca Clemson Area US-123
2.5 out of 5
226 Hi Tech Rd, Seneca, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (598 reviews)
"Really good place"

Reviewed on Jun 13, 2025

Quality Inn Seneca Clemson Area US-123
The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown Clemson
4 out of 5
110 Sloan St, Clemson, SC
Fully refundableReserve now, pay when you stay
Stay at this 4-star hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and valet parking (surcharge). Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (599 reviews)
"Beautiful hotel!"

Reviewed on Jun 16, 2025

The Shepherd Hotel Downtown Clemson
Days Inn by Wyndham Anderson
Days Inn by Wyndham Anderson
2 out of 5
1007 George Smith Mill Rd, Anderson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly motel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (995 reviews)
"Clean"

Reviewed on Jun 15, 2025

Days Inn by Wyndham Anderson
Lakeside Lodge Clemson
Lakeside Lodge Clemson
2.5 out of 5
13500 Clemson Blvd, Seneca, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
9/10 Wonderful! (901 reviews)
"Very nice place! We will be back for sure!"

Reviewed on Jun 16, 2025

Lakeside Lodge Clemson
Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference Center
2.5 out of 5
1310 Tiger Blvd, Clemson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Clemson. Enjoy free parking, an outdoor pool, and a 24-hour fitness center. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,001 reviews)
"The hotel was safe, clean, and peaceful. That’s all I ask for."

Reviewed on Jun 8, 2025

Best Western Plus Clemson Hotel & Conference Center
Comfort Inn & Suites Clemson - University Area
Comfort Inn & Suites Clemson - University Area
2.5 out of 5
1305 Tiger Blvd, Clemson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,005 reviews)
"For a quick trip this hotel offered everything we needed. One of the elevators was out but a minor inconvenience."

Reviewed on Jun 10, 2025

Comfort Inn & Suites Clemson - University Area
Wooded Cottage - 3 Mi to Clemson University
Wooded Cottage - 3 Mi to Clemson University
3 out of 5
Clemson
Stay at this 3-star cottage in Clemson. Enjoy free parking and air conditioning. Popular attractions Clemson Area African American Museum and Larry W. Abernathy ...
Wooded Cottage - 3 Mi to Clemson University
Inn @ Clemson
Inn @ Clemson
2.5 out of 5
1303 Tiger Blvd, Clemson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,000 reviews)
"Construction Liked the area, but had to drive everywhere"

Reviewed on Jun 8, 2025

Inn @ Clemson
Microtel Inn & Suites by Wyndham Anderson/Clemson
Microtel Inn & Suites by Wyndham Anderson/Clemson
2 out of 5
102 Electric City Blvd, Anderson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,005 reviews)
"First time staying here and I had a great experience. The only con is I wish they had a hot breakfast. But everything else, the service, comfort, and location was good."

Reviewed on Jun 13, 2025

Microtel Inn & Suites by Wyndham Anderson/Clemson
Clemson University's James F. Martin Inn
Clemson University's James F. Martin Inn
3 out of 5
240 Madren Center Drive, Clemson, SC
Fully refundableReserve now, pay when you stay
Stay at this 3-star golf hotel in Clemson. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our ...
9.4/10 Exceptional! (882 reviews)
"A wonderful place to stay in Clemson. They have such a friendly staff and have the benefit of a cafe and restaurant at the Madren Center."

Reviewed on Jun 15, 2025

Clemson University's James F. Martin Inn
Hampton Inn & Suites Seneca-Clemson Area
Hampton Inn & Suites Seneca-Clemson Area
2.5 out of 5
1011 East North 1st Street, Seneca, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (602 reviews)
"Clean rooms. Afordable rates. Staff all very friendly. Carpet was old."

Reviewed on Jun 16, 2025

Hampton Inn & Suites Seneca-Clemson Area
Holiday Inn Express & Suites Clemson by IHG
Holiday Inn Express & Suites Clemson by IHG
2.5 out of 5
1381 Tiger Blvd, Clemson, SC
Fully refundable
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (896 reviews)
Two nights no problems
"The hotel was remodeling but I never heard anything. Very nice, my second stay here and I like it. It’s in a safe area, I used to work in the city so I’m family with area."

Reviewed on Jun 12, 2025

Holiday Inn Express & Suites Clemson by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Downtown

Seneca is a city that has a lot going on, but you have your sights set on Downtown. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Downtown has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Downtown hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Seneca so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Downtown underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Downtown city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Downtown cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Downtown at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Downtown hotel you want, book it, and never look back. Because your great escape is ahead of you.