Hotels Near
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Featured Downtown Hotels

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd, Seneca, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (651 reviews)
Ok

Reviewed on Oct 20, 2025

Quality Inn Seneca Clemson Area US-123
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd, Clemson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,002 reviews)
Room was clean Common spaces were clean Great location to walk to downtown Clemson and football stadium

Reviewed on Oct 21, 2025

Best Western Plus Clemson Hotel & Conference Center
Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

2 out of 5
1007 George Smith Mill Rd, Anderson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly motel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (1,033 reviews)
Clean and great value .

Reviewed on Oct 20, 2025

Days Inn by Wyndham Anderson
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St, Clemson, SC
Fully refundableReserve now, pay when you stay
Stay at this 4-star hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean rooms in our ...
9.6/10 Exceptional! (713 reviews)
World-class Everything! Friendly well-trained staff, great food, super hangout on the roof. We’re coming back!

Reviewed on Oct 22, 2025

The Shepherd Hotel Downtown Clemson
Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd, Seneca, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
9/10 Wonderful! (1,001 reviews)
Overall a great place to stay. Too bad it's always sold out on a game weekend.

Reviewed on Oct 21, 2025

Lakeside Lodge Clemson
Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
Clemson
Stay at this 3-star cottage in Clemson. Enjoy free parking and air conditioning. Popular attractions Clemson Area African American Museum and Larry W. Abernathy ...
10/10 Exceptional! (1 review)
Wooded Cottage - 3 Mi to Clemson University
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

2.5 out of 5
1305 Tiger Blvd, Clemson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,003 reviews)
It was good

Reviewed on Oct 20, 2025

Comfort Inn & Suites Clemson - University Area
Inn @ Clemson

Inn @ Clemson

2.5 out of 5
1303 Tiger Blvd, Clemson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,008 reviews)
Excellent

Reviewed on Oct 11, 2025

Inn @ Clemson
Hilton Garden Inn Anderson

Hilton Garden Inn Anderson

3 out of 5
115 Destination Blvd, Anderson, SC
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Anderson. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.8/10 Excellent! (656 reviews)
The room was very clean & spacious. Our dinner was very good. The breakfasr was exceptional. We were extra time to keep our room as our vehicle was in the shop unexpectedly. We were not charged for the extra time. The only negative was the tub was incredibly slippery.

Reviewed on Oct 16, 2025

Hilton Garden Inn Anderson
Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn

3 out of 5
240 Madren Center Drive, Clemson, SC
Fully refundableReserve now, pay when you stay
Stay at this 3-star golf hotel in Clemson. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our ...
9.4/10 Exceptional! (945 reviews)
This is a beautiful inn on the outskirts of Clemson's campus. The room is spacious, has good lighting and the beds are comfortable!! They seem a little short on outlets/charging stations, but we would definitely stay here again and recommend this location!!!!

Reviewed on Oct 13, 2025

Clemson University's James F. Martin Inn
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

2.5 out of 5
1011 East North 1st Street, Seneca, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (648 reviews)
Property is well kept. Breakfast was fine. Second stay the room did not have usb ports. Otherwise a good stay.

Reviewed on Oct 19, 2025

Hampton Inn & Suites Seneca-Clemson Area
Microtel Inn & Suites by Wyndham Anderson/Clemson

Microtel Inn & Suites by Wyndham Anderson/Clemson

2 out of 5
102 Electric City Blvd, Anderson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,000 reviews)
Quality, clean room with comfortable beds. The staff of this hotel were really fantastic! Friendly and diligent! Excellent place to stay and terrific value.

Reviewed on Oct 20, 2025

Microtel Inn & Suites by Wyndham Anderson/Clemson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Downtown

Seneca is a city that has a lot going on, but you have your sights set on Downtown. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Downtown has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Downtown hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Seneca so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Downtown underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Downtown city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Downtown cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Downtown at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $70
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Downtown hotel you want, book it, and never look back. Because your great escape is ahead of you.