Search for Cheap Deals on
Independent in Defiance

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking, and you save up to 60%!


Featured Defiance Independent

The Wildwood Hotel
The Wildwood Hotel
3.5 out of 5
2801 Fountain Pl, Wildwood, MO
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
The Wildwood Hotel
Relax Inn Saint Charles
Relax Inn Saint Charles
2 out of 5
3800 Harry S Truman Blvd, St. Charles, MO
Fully refundable
Stay at this motel in St. Charles. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the clean rooms in our reviews. Popular attractions ...
Relax Inn Saint Charles
Economy Inn Wentzville
Economy Inn Wentzville
2 out of 5
1390 Continental Dr, Wentzville, MO
Stay at this hotel in Wentzville. Enjoy free parking, a 24-hour front desk, and laundry facilities. Popular attractions Quail Ridge Park and Vietnam Veterans ...
Economy Inn Wentzville
Research Park Inn St Louis West – Chesterfield
Research Park Inn St Louis West – Chesterfield
3 out of 5
32 Research Park Circle, St. Charles, MO
Stay at this 3-star business-friendly hotel in St. Charles. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Research Park Inn St Louis West – Chesterfield
The Lodge Hotel and Banquets
The Lodge Hotel and Banquets
2 out of 5
3551 Pennridge Drive, 3551, Bridgeton, MO
Book a stay at this business-friendly hotel in Bridgeton. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our ...
The Lodge Hotel and Banquets
River Sirens Hotel
River Sirens Hotel
2.5 out of 5
4 E Main St, Washington, MO
Stay at this hotel in Washington. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Blumenhof Vineyards and Fort Charrette Historic Village ...
River Sirens Hotel
The Inn at Elijah McLeans
The Inn at Elijah McLeans
4 out of 5
602 W Front St, Washington, MO
Stay at this 4-star inn in Washington. Enjoy free WiFi, free parking, and cable TV channels. Popular attractions Blumenhof Vineyards and Fort Charrette Historic ...
The Inn at Elijah McLeans
Craigshire Suites
Craigshire Suites
3 out of 5
1881 Craigshire Rd, Maryland Heights, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly aparthotel in Maryland Heights. Enjoy free parking, a business center, and laundry facilities. Popular attractions Westport ...
Craigshire Suites
Central Hotel
Central Hotel
3.5 out of 5
1017 Maupin, New Haven, MO
Fully refundable
Stay at this 3.5-star business-friendly B&B in New Haven. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Astral Glass Studio and Gallery ...
Central Hotel
Cedar Creek
Cedar Creek
3 out of 5
1401 Olive Road, New Haven, MO
Fully refundableReserve now, pay when you stay
Stay at this 3-star golf lodge in New Haven. Enjoy a golf course, a 24-hour fitness center, and a 24-hour business center. Our guests praise the helpful staff ...
Cedar Creek
Extended Stay Warrenton Inn
Extended Stay Warrenton Inn
2 out of 5
220 Arlington Way, Warrenton, MO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Warrenton. Enjoy free WiFi, free parking, and cable TV channels. Popular attractions Truesdale Park and Dyer Park are located nearby.
Extended Stay Warrenton Inn
Pinckney Bend Bed & Breakfast
Pinckney Bend Bed & Breakfast
3 out of 5
449 Vine St, New Haven, MO
Stay at this 3-star B&B in New Haven. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Astral Glass Studio and Gallery and Pinckney Bend ...
Pinckney Bend Bed & Breakfast
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Independent hotels in Defiance

You’ve already taken the guesswork out of your next vacation. You know you want a Independent hotel in Defiance. What can you say? You like their style, they’re in a good part of Defiance, and they never let you down. New bar in town? You’re the first one to check it out. Spiciest item on the menu? You can take the heat. But even the best gamblers hedge their bets. No matter how crazy good your trip is, you want something familiar waiting for you at the end of the day.

All in a name

We all have favorites. There’s nothing wrong with knowing what you like. You like to stay at Independent near , Defiance to do the tourist thing (because sometimes it is fun) and then hit up the places that aren’t on the map. And no matter what fun you get into, you have Independent hotels with their comfy beds and thoughtful amenities waiting to tuck you in.

As you like it

Have a price you want to stick to, so you can paint the town red? Maybe, it’s all about the hotel features. Who couldn’t use a hot tub? Pick your pleasure by:

  • Hotwire Hot Rate: Grab the Independent hotel in Defiance at an absolute steal. After you book it, we’ll tell you the hotel name. You might nab that 4-star hotel for a 2-star price.
  • Price: How low can we go? Quite low in fact. Check out our prices per night, starting at $68.
  • Amenities: Grab a cocktail at the lounge and maybe wander upstairs to the rooftop terrace—all the stuff that makes a great vacay.

You’ve already done the hard part—figuring out where you want to stay. Now it’s time to use the money you saved to let the real fun begin. Underground shows? Off-beat attractions? Rooftop escapes? The choice is yours. The only thing wonderfully predictable about this trip is the Independent room you’ll be staying in.