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Choose from 924 O'Fallon Hotel Deals

Comfort Inn & Suites St. Louis - O'Fallon
Reviewed on Jul 14, 2025

Holiday Inn Express St. Louis West - O'Fallon by IHG
Reviewed on Jul 6, 2025

Sleep Inn & Suites O'Fallon MO - Technology Drive
Reviewed on Jul 15, 2025

Staybridge Suites O'Fallon Chesterfield by IHG
Reviewed on Jul 12, 2025

Residence Inn by Marriott O'Fallon
Reviewed on Jun 22, 2025

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Reviewed on Jul 14, 2025

Hollywood Casino & Hotel St. Louis
Reviewed on Jul 14, 2025

Best Western St. Louis-Kirkwood Route 66
Reviewed on Jul 14, 2025

Renaissance St. Louis Airport Hotel
Reviewed on Jul 13, 2025

Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Reviewed on Jul 9, 2025

Wingate by Wyndham St. Louis/Fenton Route 66
Reviewed on Jul 14, 2025

Pear Tree Inn St. Louis Airport
Reviewed on Jul 14, 2025
Find cheap hotels in O'Fallon
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For you, intrepid voyager, Hotwire has a large selection of the best hotels in O'Fallon.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of O'Fallon’s 924 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $79. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great O'Fallon hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in O'Fallon. No matter your reason for visiting O'Fallon, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About O'Fallon hotels
Where can I find the best last-minute travel deals?
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How many hotels are there in O'Fallon?
With over 924 hotels in O'Fallon, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $79.
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Top Booked Hotels in O'Fallon
- Comfort Inn & Suites St. Louis - O'Fallon
- Holiday Inn Express St. Louis West - O'Fallon by IHG
- Sleep Inn & Suites O'Fallon MO - Technology Drive
- Staybridge Suites O'Fallon Chesterfield by IHG
- Residence Inn by Marriott O'Fallon
- Hollywood Casino & Hotel St. Louis
- Best Western St. Louis-Kirkwood Route 66
- Renaissance St. Louis Airport Hotel
- Days Inn and Suites by Wyndham St. Louis/Westport Plaza
- Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
- Ameristar Casino Resort and Spa
- The Wildwood Hotel
- DoubleTree by Hilton St. Louis Airport
- Hotels near CarShield Field
- Hotels near 9-11 Memorial
- Hotels near Alligator Creek Aquatic Center
- Hotels near Six Flags St. Louis
- Hotels near Hollywood Casino Amphitheatre
- Hotels near Mississippi River
- Hotels near Westport Plaza
- Hotels near Ameristar Casino St. Charles
- Hotels near Hollywood Casino
- Hotels near Historic Main Street
- Hotels near St Charles Convention Center
- Hotels near Magic House - St. Louis Children's Museum
- Hotels near Route 66 State Park
- Hotels near Lindenwood University
- Hotels near Missouri River
- Hotels near Purina Farms
- Hotels near Raging Rivers Waterpark
- Hotels near St. Louis Premium Outlets
- Hotels near Hidden Valley Ski Resort
- Hotels near The Factory
- Hotels with a Pool in O'Fallon
- Family Hotels in O'Fallon
- Hotels with Free Parking in O'Fallon
- Hotels with an Indoor Pool in O'Fallon
- Pet-friendly Hotels in O'Fallon
- Hotel Wedding Venues in O'Fallon
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- Apartment Hotel in O'Fallon
- Resorts & Hotels with Spas in O'Fallon
- Winery Hotels in O'Fallon
- Luxury Hotels in O'Fallon
- St. Charles Hotels
- Maryland Heights Hotels
- Chesterfield Hotels
- Innsbrook Hotels
- Hazelwood Hotels
- Grafton Hotels
- Fenton Hotels
- St. Peters Hotels
- Ozarks Hotels
- Eureka Hotels
- Wentzville Hotels
- Bridgeton Hotels
- Washington Hotels
- Richmond Heights Hotels
- Kirkwood Hotels
- Wildwood Hotels
- Florissant Hotels
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