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Defiance

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Defiance Flights as Low as $88

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, Apr 22 - Wed, Apr 22
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$88 Roundtrip, just found
$88
Roundtrip
just found
Select Frontier Airlines flight, departing Wed, Apr 22 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Apr 22, priced at $88 just found
Frontier Airlines
Sat, Apr 4 - Sat, Apr 25
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$102 Roundtrip, just found
$102
Roundtrip
just found
Select Frontier Airlines flight, departing Sat, Apr 4 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Apr 25, priced at $102 just found
Frontier Airlines
Tue, Apr 7 - Wed, Apr 22
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$115 Roundtrip, found 6 days ago
$115
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Tue, Apr 7 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Apr 22, priced at $115 found 6 days ago
Frontier Airlines
Wed, May 13 - Tue, Jun 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$116 Roundtrip, just found
$116
Roundtrip
just found
Select Frontier Airlines flight, departing Wed, May 13 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jun 2, priced at $116 just found
Frontier Airlines
Fri, Apr 17 - Mon, May 4
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$173 Roundtrip, just found
$173
Roundtrip
just found
Select Frontier Airlines flight, departing Fri, Apr 17 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Mon, May 4, priced at $173 just found
Frontier Airlines
Thu, Apr 9 - Mon, Apr 13
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$184 Roundtrip, just found
$184
Roundtrip
just found
Select Frontier Airlines flight, departing Thu, Apr 9 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Mon, Apr 13, priced at $184 just found
Frontier Airlines
Sun, Apr 12 - Mon, Apr 27
TTN
Mercer
STL
Lambert-St. Louis Intl.
$184 Roundtrip, just found
$184
Roundtrip
just found
Select Frontier Airlines flight, departing Sun, Apr 12 from Mercer to Lambert-St. Louis Intl., returning Mon, Apr 27, priced at $184 just found
Frontier Airlines
Thu, Apr 9 - Wed, Apr 15
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$184 Roundtrip, just found
$184
Roundtrip
just found
Select Frontier Airlines flight, departing Thu, Apr 9 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Wed, Apr 15, priced at $184 just found
American Airlines
Mon, May 11 - Mon, May 18
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$191 Roundtrip, just found
$191
Roundtrip
just found
Select American Airlines flight, departing Mon, May 11 from O'Hare Intl. to Lambert-St. Louis Intl., returning Mon, May 18, priced at $191 just found
Bargain Flight
Sat, Apr 11 - Tue, Apr 14
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$199 Roundtrip, just found
$199
Roundtrip
just found
Select Bargain Flight flight, departing Sat, Apr 11 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Tue, Apr 14, priced at $199 just found
Frontier Airlines
Tue, Apr 14 - Thu, Apr 23
LGA
LaGuardia
STL
Lambert-St. Louis Intl.
$201 Roundtrip, found 1 day ago
$201
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Tue, Apr 14 from LaGuardia to Lambert-St. Louis Intl., returning Thu, Apr 23, priced at $201 found 1 day ago
Bargain Flight
Tue, Apr 21 - Tue, Apr 28
MSP
Minneapolis - St. Paul Intl.
STL
Lambert-St. Louis Intl.
$204 Roundtrip, just found
$204
Roundtrip
just found
Select Bargain Flight flight, departing Tue, Apr 21 from Minneapolis - St. Paul Intl. to Lambert-St. Louis Intl., returning Tue, Apr 28, priced at $204 just found
Frontier Airlines
Thu, Apr 9 - Mon, Apr 27
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$210 Roundtrip, just found
$210
Roundtrip
just found
Select Frontier Airlines flight, departing Thu, Apr 9 from San Francisco Intl. to Lambert-St. Louis Intl., returning Mon, Apr 27, priced at $210 just found
Delta
Wed, Apr 29 - Tue, May 5
MSP
Minneapolis - St. Paul Intl.
STL
Lambert-St. Louis Intl.
$211 Roundtrip, just found
$211
Roundtrip
just found
Select Delta flight, departing Wed, Apr 29 from Minneapolis - St. Paul Intl. to Lambert-St. Louis Intl., returning Tue, May 5, priced at $211 just found
Delta
Sat, May 23 - Wed, May 27
DAL
Love Field
STL
Lambert-St. Louis Intl.
$317 Roundtrip, just found
$317
Roundtrip
just found
Select Delta flight, departing Sat, May 23 from Love Field to Lambert-St. Louis Intl., returning Wed, May 27, priced at $317 just found
Alaska Airlines
Tue, Apr 7 - Tue, Apr 21
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$343 Roundtrip, just found
$343
Roundtrip
just found
Select Alaska Airlines flight, departing Tue, Apr 7 from San Francisco Intl. to Lambert-St. Louis Intl., returning Tue, Apr 21, priced at $343 just found

Cheap Flights to Defiance

Fall in love at first flight with your vacation to Defiance by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Defiance on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Defiance, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Defiance

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Defiance with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Defiance?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Defiance are in April, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Defiance?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 14 to choose from for your flight to Defiance.

What airport is best to fly into Defiance?

When you’re planning your trip to Defiance, convenience is the name of the game. Luckily, Defiance Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your Defiance must-do list.

How much are flights to Defiance?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Defiance on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $88, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Defiance?

The trick to saving a stack of cash on your flight to Defiance? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $88 right now, why wait?

Defiance Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$88

Last Minute Hotel Deals in Defiance

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.4/10 Very Good! (2,210 reviews)
Hotel itself was fine. Floors in our room were a little gritty to the point where I noticed dirt accumulating in the corners and I needed to clean my feet off before putting my socks on. My biggest complaint was after paying $250 for one night, we were billed another $14 for “amenities” at check ...

Reviewed on Mar 12, 2026

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Hollywood Casino & Hotel St. Louis
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,134 reviews)
Hotel was very dirty. Bed was dirty pull out bed was dirty. No clean towels or wash rags to shower with

Reviewed on Mar 16, 2026

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Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
Book a stay at this business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
9.2/10 Wonderful! (1,631 reviews)
What a pleasant surprise! This area and lovely hotel was wonderful! The room was beautiful. The only negative was the elevator. It was small and it took a while at checkout time.

Reviewed on Mar 16, 2026

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The Wildwood Hotel
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
Book a stay at this luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms in our reviews. ...
8.4/10 Very Good! (1,009 reviews)
Room was clean and very nice! Casino was nice. We didn’t use the spa or weight room.

Reviewed on Mar 16, 2026

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Ameristar Casino Resort and Spa
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

3 out of 5
13639 Riverport Dr Maryland Heights MO
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
7.4/10 Good! (1,009 reviews)
The walls are very thin so we could hear our neighbors yelling all night.

Reviewed on Mar 16, 2026

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Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield

3 out of 5
355 Chesterfield Ctr Chesterfield MO
Book a stay at this business-friendly hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.8/10 Exceptional! (1,101 reviews)
Love this hotel. Everyone is so nice, cheerful and helpful. Always clean and the pool is great

Reviewed on Mar 14, 2026

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Drury Plaza Hotel St. Louis Chesterfield
Crowne Plaza St. Louis Airport by IHG

Crowne Plaza St. Louis Airport by IHG

3.5 out of 5
11228 Lone Eagle Dr Bridgeton MO
Book a stay at this business-friendly hotel in Bridgeton. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8/10 Very Good! (1,007 reviews)
I am writing to share feedback regarding my recent stay. While the property is beautiful and the staff was excellent, I wanted to bring a few concerns to your attention. The cleanliness of the rooms could be improved. It felt as though the cleaning was focused more on initial presentation rather ...

Reviewed on Mar 12, 2026

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Crowne Plaza St. Louis Airport by IHG
Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis

3 out of 5
5 Lambert Drury Place (I-44 & 141) Valley Park MO
Book a stay at this business-friendly hotel in Valley Park. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,003 reviews)
Staff members were all great ! A big shout to the assistant manager on duty while we were there, he is a real go getter. The hospitality of all the staff is perfect. I know we have found a new hotel to stay in

Reviewed on Mar 16, 2026

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Drury Inn & Suites Southwest St. Louis
See all 858 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.