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Defiance

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Defiance Flights as Low as $60

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Spirit Airlines
Thu, Aug 14 - Fri, Aug 15
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$60 Roundtrip, found 3 hours ago
$60
Roundtrip
found 3 hours ago
Select Spirit Airlines flight, departing Thu, Aug 14 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Fri, Aug 15, priced at $60 found 3 hours ago
Spirit Airlines
Fri, Aug 8 - Thu, Aug 14
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$71 Roundtrip, found 3 hours ago
$71
Roundtrip
found 3 hours ago
Select Spirit Airlines flight, departing Fri, Aug 8 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Thu, Aug 14, priced at $71 found 3 hours ago
Frontier Airlines
Thu, Aug 7 - Thu, Aug 14
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$92 Roundtrip, found 19 hours ago
$92
Roundtrip
found 19 hours ago
Select Frontier Airlines flight, departing Thu, Aug 7 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Thu, Aug 14, priced at $92 found 19 hours ago
Spirit Airlines
Sat, Aug 2 - Sat, Aug 9
FLL
Fort Lauderdale - Hollywood Intl.
STL
Lambert-St. Louis Intl.
$110 Roundtrip, found 21 hours ago
$110
Roundtrip
found 21 hours ago
Select Spirit Airlines flight, departing Sat, Aug 2 from Fort Lauderdale - Hollywood Intl. to Lambert-St. Louis Intl., returning Sat, Aug 9, priced at $110 found 21 hours ago
Delta
Thu, Aug 14 - Fri, Aug 15
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$123 Roundtrip, found 3 hours ago
$123
Roundtrip
found 3 hours ago
Select Delta flight, departing Thu, Aug 14 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Fri, Aug 15, priced at $123 found 3 hours ago
Frontier Airlines
Sat, Oct 4 - Sat, Oct 11
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$129 Roundtrip, found 3 hours ago
$129
Roundtrip
found 3 hours ago
Select Frontier Airlines flight, departing Sat, Oct 4 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Oct 11, priced at $129 found 3 hours ago
Frontier Airlines
Wed, Jul 16 - Sat, Jul 19
MCO
Orlando Intl.
STL
Lambert-St. Louis Intl.
$133 Roundtrip, found 4 days ago
$133
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Wed, Jul 16 from Orlando Intl. to Lambert-St. Louis Intl., returning Sat, Jul 19, priced at $133 found 4 days ago
United
Sat, Oct 4 - Sat, Oct 11
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$157 Roundtrip, found 3 hours ago
$157
Roundtrip
found 3 hours ago
Select United flight, departing Sat, Oct 4 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Oct 11, priced at $157 found 3 hours ago
American Airlines
Thu, Nov 27 - Wed, Dec 3
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$159 Roundtrip, found 3 hours ago
$159
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Thu, Nov 27 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Dec 3, priced at $159 found 3 hours ago
United
Sat, Aug 30 - Sat, Sep 6
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$196 Roundtrip, found 1 day ago
$196
Roundtrip
found 1 day ago
Select United flight, departing Sat, Aug 30 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Sat, Sep 6, priced at $196 found 1 day ago
Delta
Wed, Aug 6 - Wed, Aug 6
BHM
Birmingham Intl.
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 22 hours ago
$197
Roundtrip
found 22 hours ago
Select Delta flight, departing Wed, Aug 6 from Birmingham Intl. to Lambert-St. Louis Intl., returning Wed, Aug 6, priced at $197 found 22 hours ago
United
Tue, Nov 18 - Mon, Nov 24
SAT
San Antonio Intl.
STL
Lambert-St. Louis Intl.
$202 Roundtrip, found 12 hours ago
$202
Roundtrip
found 12 hours ago
Select United flight, departing Tue, Nov 18 from San Antonio Intl. to Lambert-St. Louis Intl., returning Mon, Nov 24, priced at $202 found 12 hours ago
Delta
Tue, Sep 2 - Wed, Sep 3
MSY
Louis Armstrong New Orleans Intl.
STL
Lambert-St. Louis Intl.
$210 Roundtrip, found 11 hours ago
$210
Roundtrip
found 11 hours ago
Select Delta flight, departing Tue, Sep 2 from Louis Armstrong New Orleans Intl. to Lambert-St. Louis Intl., returning Wed, Sep 3, priced at $210 found 11 hours ago
Alaska Airlines
Wed, Aug 27 - Thu, Sep 4
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$254 Roundtrip, found 18 hours ago
$254
Roundtrip
found 18 hours ago
Select Alaska Airlines flight, departing Wed, Aug 27 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Thu, Sep 4, priced at $254 found 18 hours ago
American Airlines
Tue, Sep 23 - Wed, Sep 24
CLD
McClellan-Palomar
STL
Lambert-St. Louis Intl.
$268 Roundtrip, found 19 hours ago
$268
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Tue, Sep 23 from McClellan-Palomar to Lambert-St. Louis Intl., returning Wed, Sep 24, priced at $268 found 19 hours ago
Hawaiian Airlines
Wed, Jul 30 - Sat, Aug 2
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$309 Roundtrip, found 6 hours ago
$309
Roundtrip
found 6 hours ago
Select Hawaiian Airlines flight, departing Wed, Jul 30 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Sat, Aug 2, priced at $309 found 6 hours ago

Cheap Flights to Defiance

Fall in love at first flight with your vacation to Defiance by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Defiance on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Defiance, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Defiance

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Defiance with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Defiance?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Defiance are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Defiance?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Defiance.

What airport is best to fly into Defiance?

When you’re planning your trip to Defiance, convenience is the name of the game. Luckily, Defiance Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your Defiance must-do list.

How much are flights to Defiance?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Defiance on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $60, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Defiance?

The trick to saving a stack of cash on your flight to Defiance? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $60 right now, why wait?

Defiance Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$60

Last Minute Hotel Deals in Defiance

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3 out of 5
1088 South Highway Drive, Fenton, MO
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,002 reviews)
"It was great breakfast, pool and hot"

Reviewed on Jul 2, 2025

Get rates
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. Louis
3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,945 reviews)
Clean and nice.
"Really great place to stay."

Reviewed on Jul 5, 2025

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Hollywood Casino & Hotel St. Louis
Wingate by Wyndham St. Louis/Fenton Route 66
Wingate by Wyndham St. Louis/Fenton Route 66
3 out of 5
1100 S Highway Dr, Fenton, MO
Stay at this 3-star business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,004 reviews)
"Stayed for the breakfast and the pancake machine was broken"

Reviewed on Jul 4, 2025

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Wingate by Wyndham St. Louis/Fenton Route 66
The Wildwood Hotel
The Wildwood Hotel
3.5 out of 5
2801 Fountain Pl, Wildwood, MO
Stay at this 3.5-star business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
9/10 Wonderful! (1,547 reviews)
"."

Reviewed on Jul 4, 2025

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The Wildwood Hotel
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
3 out of 5
13639 Riverport Dr, Maryland Heights, MO
Stay at this 3-star business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
7.2/10 Good! (1,003 reviews)
One of the Best Hotels in St. Louis
"I Loooooove my room, the size and space of it."

Reviewed on Jul 1, 2025

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Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
La Quinta Inn & Suites by Wyndham St. Louis Westport
La Quinta Inn & Suites by Wyndham St. Louis Westport
3 out of 5
11805 Lackland Rd, Maryland Heights, MO
Stay at this 3-star business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.2/10 Good! (1,002 reviews)
"I read alot of the reviews befor booking my stay over all was good experience but when i went to go take a shower its like someone shaved down the middle of the tub it was very curvy and the plate that shows you the hot and cold sides that was backwards.. but overall it was safe and clean and didnt ..."

Reviewed on Jun 27, 2025

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La Quinta Inn & Suites by Wyndham St. Louis Westport
Ameristar Casino Resort and Spa
Ameristar Casino Resort and Spa
4.5 out of 5
1 Ameristar Blvd, St. Charles, MO
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms and the property ...
8.2/10 Very Good! (1,007 reviews)
Quick family trip
"Great stay! Friendly staff, quick check in, quiet rooms."

Reviewed on Jul 2, 2025

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Ameristar Casino Resort and Spa
Courtyard by Marriott St Louis Westport Plaza
Courtyard by Marriott St Louis Westport Plaza
3 out of 5
11888 Westline Industrial Dr, Maryland Heights, MO
Stay at this 3-star business-friendly hotel in Maryland Heights. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff ...
8.6/10 Excellent! (1,000 reviews)
"The staff were very friendly and helpful. The room was clean and pleasant. The property was very quiet and not crowded and the grounds were very well manicured."

Reviewed on Jun 30, 2025

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Courtyard by Marriott St Louis Westport Plaza
See all 821 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.