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Defiance

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Defiance Flights as Low as $46

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Mon, Sep 28 - Mon, Oct 12
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$46 Roundtrip, found 5 days ago
$46
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Mon, Sep 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, Oct 12, priced at $46 found 5 days ago
Frontier Airlines
Fri, Oct 30 - Fri, Nov 13
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$76 Roundtrip, found 5 hours ago
$76
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Fri, Oct 30 from Denver Intl. to Lambert-St. Louis Intl., returning Fri, Nov 13, priced at $76 found 5 hours ago
Frontier Airlines
Fri, Oct 30 - Thu, Nov 19
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$80 Roundtrip, found 5 hours ago
$80
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Fri, Oct 30 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Thu, Nov 19, priced at $80 found 5 hours ago
Southwest Airlines
Tue, Oct 6 - Tue, Oct 6
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$101 Roundtrip, found 5 hours ago
$101
Roundtrip
found 5 hours ago
Select Southwest Airlines flight, departing Tue, Oct 6 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Oct 6, priced at $101 found 5 hours ago
Delta
Tue, Oct 6 - Tue, Oct 6
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$113 Roundtrip, found 5 hours ago
$113
Roundtrip
found 5 hours ago
Select Delta flight, departing Tue, Oct 6 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Oct 6, priced at $113 found 5 hours ago
Frontier Airlines
Mon, Oct 19 - Sat, Oct 31
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$159 Roundtrip, found 4 hours ago
$159
Roundtrip
found 4 hours ago
Select Frontier Airlines flight, departing Mon, Oct 19 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Sat, Oct 31, priced at $159 found 4 hours ago
Southwest Airlines
Fri, Oct 30 - Thu, Nov 19
DAL
Love Field
STL
Lambert-St. Louis Intl.
$171 Roundtrip, found 5 hours ago
$171
Roundtrip
found 5 hours ago
Select Southwest Airlines flight, departing Fri, Oct 30 from Love Field to Lambert-St. Louis Intl., returning Thu, Nov 19, priced at $171 found 5 hours ago
Delta
Sat, Sep 5 - Sat, Sep 5
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$177 Roundtrip, found 1 hour ago
$177
Roundtrip
found 1 hour ago
Select Delta flight, departing Sat, Sep 5 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Sat, Sep 5, priced at $177 found 1 hour ago
Bargain Flight
Tue, Nov 3 - Mon, Nov 9
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$199 Roundtrip, found 3 days ago
$199
Roundtrip
found 3 days ago
Select Bargain Flight flight, departing Tue, Nov 3 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Mon, Nov 9, priced at $199 found 3 days ago
Frontier Airlines
Mon, Oct 12 - Wed, Oct 14
EWR
Newark Liberty Intl. Airport
STL
Lambert-St. Louis Intl.
$199 Roundtrip, found 5 hours ago
$199
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Mon, Oct 12 from Newark Liberty Intl. Airport to Lambert-St. Louis Intl., returning Wed, Oct 14, priced at $199 found 5 hours ago
American Airlines
Fri, Sep 11 - Wed, Sep 23
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$204 Roundtrip, found 14 hours ago
$204
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Fri, Sep 11 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Sep 23, priced at $204 found 14 hours ago
American Airlines
Mon, Oct 12 - Wed, Oct 14
LGA
LaGuardia
STL
Lambert-St. Louis Intl.
$217 Roundtrip, found 6 hours ago
$217
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Mon, Oct 12 from LaGuardia to Lambert-St. Louis Intl., returning Wed, Oct 14, priced at $217 found 6 hours ago
Alaska Airlines
Sat, Sep 5 - Sat, Sep 5
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$263 Roundtrip, found 1 hour ago
$263
Roundtrip
found 1 hour ago
Select Alaska Airlines flight, departing Sat, Sep 5 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Sat, Sep 5, priced at $263 found 1 hour ago
Southwest Airlines
Fri, Oct 30 - Tue, Nov 3
ORF
Norfolk Intl.
STL
Lambert-St. Louis Intl.
$281 Roundtrip, found 8 hours ago
$281
Roundtrip
found 8 hours ago
Select Southwest Airlines flight, departing Fri, Oct 30 from Norfolk Intl. to Lambert-St. Louis Intl., returning Tue, Nov 3, priced at $281 found 8 hours ago
Delta
Fri, Sep 11 - Sat, Sep 26
TLH
Tallahassee Intl.
STL
Lambert-St. Louis Intl.
$374 Roundtrip, found 9 hours ago
$374
Roundtrip
found 9 hours ago
Select Delta flight, departing Fri, Sep 11 from Tallahassee Intl. to Lambert-St. Louis Intl., returning Sat, Sep 26, priced at $374 found 9 hours ago
Alaska Airlines
Fri, Aug 28 - Sun, Aug 30
PAE
Seattle Paine Field Intl. Airport
STL
Lambert-St. Louis Intl.
$453 Roundtrip, found 4 days ago
$453
Roundtrip
found 4 days ago
Select Alaska Airlines flight, departing Fri, Aug 28 from Seattle Paine Field Intl. Airport to Lambert-St. Louis Intl., returning Sun, Aug 30, priced at $453 found 4 days ago

Cheap Flights to Defiance

Fall in love at first flight with your vacation to Defiance by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Defiance on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Defiance, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Defiance

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Defiance with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Defiance?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Defiance are in September, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Defiance?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to Defiance.

What airport is best to fly into Defiance?

When you’re planning your trip to Defiance, convenience is the name of the game. Luckily, Defiance Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your Defiance must-do list.

How much are flights to Defiance?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Defiance on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $46, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Defiance?

The trick to saving a stack of cash on your flight to Defiance? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $46 right now, why wait?

Defiance Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$56

Last Minute Hotel Deals in Defiance

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
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Hollywood Casino & Hotel St. Louis
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,523 reviews)
"An old drury needs to be updated or is in the process"

Reviewed on Aug 11, 2026

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Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
Book a stay at this business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
9.2/10 Wonderful! (1,653 reviews)
"Very nice and clean! LOVED the breakfast options! Warm up breakfast sandwiches, nutella, healthy oatmeal that passes the Yuka app, we were thrilled! The fair price of 150 per night for a king suite is what drew us to the property but we were happy with our stay!"

Reviewed on Aug 12, 2026

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The Wildwood Hotel
Hilton St. Louis Frontenac

Hilton St. Louis Frontenac

4 out of 5
1335 S Lindbergh Blvd Frontenac MO
Book a stay at this business-friendly hotel in Frontenac. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. ...
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Hilton St. Louis Frontenac
Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

2.5 out of 5
1970 Craig Rd Maryland Heights MO
Stay at this hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
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Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield

3 out of 5
355 Chesterfield Ctr Chesterfield MO
Book a stay at this business-friendly hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
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Drury Plaza Hotel St. Louis Chesterfield
Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66

3 out of 5
1100 S Highway Dr Fenton MO
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
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Wingate by Wyndham St. Louis/Fenton Route 66
Drury Plaza Hotel St. Louis Creve Coeur

Drury Plaza Hotel St. Louis Creve Coeur

3 out of 5
11980 Olive Blvd St. Louis MO
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,020 reviews)
"Loved loved loved this hotel the staff were very inviting and helpful. I loved the 530 kickback and the free hot breakfast. The location was very convenient with many other restaurants and stores close. Overall I’ll stay here again and again 100/100!"

Reviewed on Aug 9, 2026

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Drury Plaza Hotel St. Louis Creve Coeur
See all 879 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.