Search Cheap Flights to
Defiance

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Defiance Flights as Low as $38

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, Oct 28 - Wed, Nov 4
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$38 Roundtrip, found 6 hours ago
$38
Roundtrip
found 6 hours ago
Select Frontier Airlines flight, departing Wed, Oct 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Nov 4, priced at $38 found 6 hours ago
Frontier Airlines
Mon, Nov 16 - Wed, Dec 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$43 Roundtrip, found 17 hours ago
$43
Roundtrip
found 17 hours ago
Select Frontier Airlines flight, departing Mon, Nov 16 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Dec 2, priced at $43 found 17 hours ago
Frontier Airlines
Wed, Oct 21 - Fri, Oct 30
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$48 Roundtrip, found 15 hours ago
$48
Roundtrip
found 15 hours ago
Select Frontier Airlines flight, departing Wed, Oct 21 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Fri, Oct 30, priced at $48 found 15 hours ago
Frontier Airlines
Wed, Oct 28 - Wed, Nov 4
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$88 Roundtrip, found 3 hours ago
$88
Roundtrip
found 3 hours ago
Select Frontier Airlines flight, departing Wed, Oct 28 from Denver Intl. to Lambert-St. Louis Intl., returning Wed, Nov 4, priced at $88 found 3 hours ago
Frontier Airlines
Wed, Oct 21 - Wed, Oct 28
MCO
Orlando Intl.
STL
Lambert-St. Louis Intl.
$111 Roundtrip, found 14 hours ago
$111
Roundtrip
found 14 hours ago
Select Frontier Airlines flight, departing Wed, Oct 21 from Orlando Intl. to Lambert-St. Louis Intl., returning Wed, Oct 28, priced at $111 found 14 hours ago
Delta
Tue, Jan 5 - Tue, Jan 5
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$112 Roundtrip, found 2 hours ago
$112
Roundtrip
found 2 hours ago
Select Delta flight, departing Tue, Jan 5 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jan 5, priced at $112 found 2 hours ago
American Airlines
Wed, Oct 21 - Wed, Oct 28
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$117 Roundtrip, found 5 hours ago
$117
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Wed, Oct 21 from O'Hare Intl. to Lambert-St. Louis Intl., returning Wed, Oct 28, priced at $117 found 5 hours ago
Southwest Airlines
Wed, Oct 14 - Wed, Oct 28
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$117 Roundtrip, found 9 hours ago
$117
Roundtrip
found 9 hours ago
Select Southwest Airlines flight, departing Wed, Oct 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Oct 28, priced at $117 found 9 hours ago
United
Wed, Oct 21 - Wed, Oct 28
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$117 Roundtrip, found 5 hours ago
$117
Roundtrip
found 5 hours ago
Select United flight, departing Wed, Oct 21 from O'Hare Intl. to Lambert-St. Louis Intl., returning Wed, Oct 28, priced at $117 found 5 hours ago
Frontier Airlines
Fri, Oct 16 - Mon, Nov 2
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$148 Roundtrip, found 5 days ago
$148
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Fri, Oct 16 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Mon, Nov 2, priced at $148 found 5 days ago
Frontier Airlines
Wed, Nov 4 - Mon, Nov 9
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$173 Roundtrip, found 21 hours ago
$173
Roundtrip
found 21 hours ago
Select Frontier Airlines flight, departing Wed, Nov 4 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Mon, Nov 9, priced at $173 found 21 hours ago
Frontier Airlines
Wed, Oct 21 - Sat, Oct 24
EWR
Newark Liberty Intl. Airport
STL
Lambert-St. Louis Intl.
$215 Roundtrip, found 9 hours ago
$215
Roundtrip
found 9 hours ago
Select Frontier Airlines flight, departing Wed, Oct 21 from Newark Liberty Intl. Airport to Lambert-St. Louis Intl., returning Sat, Oct 24, priced at $215 found 9 hours ago
Frontier Airlines
Wed, Oct 28 - Sat, Nov 14
LGA
LaGuardia
STL
Lambert-St. Louis Intl.
$224 Roundtrip, found 1 hour ago
$224
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Wed, Oct 28 from LaGuardia to Lambert-St. Louis Intl., returning Sat, Nov 14, priced at $224 found 1 hour ago
Frontier Airlines
Sat, Oct 10 - Wed, Oct 14
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$241 Roundtrip, found 22 hours ago
$241
Roundtrip
found 22 hours ago
Select Frontier Airlines flight, departing Sat, Oct 10 from San Francisco Intl. to Lambert-St. Louis Intl., returning Wed, Oct 14, priced at $241 found 22 hours ago
Southwest Airlines
Mon, Oct 12 - Thu, Oct 29
DAL
Love Field
STL
Lambert-St. Louis Intl.
$252 Roundtrip, found 6 days ago
$252
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Mon, Oct 12 from Love Field to Lambert-St. Louis Intl., returning Thu, Oct 29, priced at $252 found 6 days ago
Alaska Airlines
Tue, Oct 13 - Sat, Oct 24
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$301 Roundtrip, found 2 hours ago
$301
Roundtrip
found 2 hours ago
Select Alaska Airlines flight, departing Tue, Oct 13 from San Francisco Intl. to Lambert-St. Louis Intl., returning Sat, Oct 24, priced at $301 found 2 hours ago

Cheap Flights to Defiance

Fall in love at first flight with your vacation to Defiance by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Defiance on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Defiance, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Defiance

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Defiance with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Defiance?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Defiance are in October, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Defiance?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Defiance.

What airport is best to fly into Defiance?

When you’re planning your trip to Defiance, convenience is the name of the game. Luckily, Defiance Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your Defiance must-do list.

How much are flights to Defiance?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Defiance on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $38, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Defiance?

The trick to saving a stack of cash on your flight to Defiance? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $38 right now, why wait?

Defiance Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$38

Last Minute Hotel Deals in Defiance

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.6/10 Excellent! (2,229 reviews)
"The check in slow and I was the only one. We had requested a king size bed through Expedia and we get to the room and it’s two queens and a tub. We went back down and told them the room was unexceptable They said they were full but did fine us a room with a king and walk in shower Expedia needs to ..."

Reviewed on Sep 22, 2026

Get rates
Hollywood Casino & Hotel St. Louis
Sonesta ES Suites St. Louis - Chesterfield

Sonesta ES Suites St. Louis - Chesterfield

3 out of 5
15431 Conway Rd Chesterfield MO
Stay at this hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Get rates
Sonesta ES Suites St. Louis - Chesterfield
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,571 reviews)
"The hotel was very clean, the check in was pretty easy , and the staff was friendly, if you’re in St. Louis for a night and need a nice clean place to stay they’re great !!"

Reviewed on Sep 21, 2026

Get rates
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
Book a stay at this luxury hotel in St. Charles. Enjoy a full-service spa, 6 restaurants, and a casino. Our guests praise the clean rooms in our reviews. Popular ...
8.6/10 Excellent! (1,061 reviews)
"The smell was so bad, it made me sick. I had a terrible headache from it. It smelled like stale cigarettes. I will never star there again. So disappointed!!"

Reviewed on Sep 20, 2026

Get rates
Ameristar Casino Resort and Spa
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
Book a stay at this business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
Get rates
The Wildwood Hotel
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

3 out of 5
13639 Riverport Dr Maryland Heights MO
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
7.6/10 Good! (1,011 reviews)
"Had a good stay and friendly staff"

Reviewed on Sep 21, 2026

Get rates
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield

3 out of 5
355 Chesterfield Ctr Chesterfield MO
Book a stay at this business-friendly hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,268 reviews)
"Very clean and helpful staff"

Reviewed on Sep 21, 2026

Get rates
Drury Plaza Hotel St. Louis Chesterfield
Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 out of 5
1147 Technology Drive O'Fallon MO
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Get rates
Sleep Inn & Suites O'Fallon MO - Technology Drive
See all 898 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.