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Defiance

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Defiance Flights as Low as $110

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Sat, Feb 1 - Wed, Feb 5
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$110 Roundtrip, found 2 days ago
$110
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Sat, Feb 1 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Feb 5, priced at $110 found 2 days ago
Frontier Airlines
Mon, Jan 13 - Sat, Jan 25
MSY
Louis Armstrong New Orleans Intl.
STL
Lambert-St. Louis Intl.
$114 Roundtrip, found 1 day ago
$114
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Mon, Jan 13 from Louis Armstrong New Orleans Intl. to Lambert-St. Louis Intl., returning Sat, Jan 25, priced at $114 found 1 day ago
Frontier Airlines
Sat, Jan 18 - Wed, Jan 22
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$117 Roundtrip, found 4 days ago
$117
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Sat, Jan 18 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Wed, Jan 22, priced at $117 found 4 days ago
Frontier Airlines
Tue, Jan 14 - Sat, Jan 25
LAX
Los Angeles Intl.
STL
Lambert-St. Louis Intl.
$118 Roundtrip, found 1 day ago
$118
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Tue, Jan 14 from Los Angeles Intl. to Lambert-St. Louis Intl., returning Sat, Jan 25, priced at $118 found 1 day ago
Frontier Airlines
Thu, Jan 23 - Wed, Jan 29
SMF
Sacramento Intl.
STL
Lambert-St. Louis Intl.
$118 Roundtrip, found 18 hours ago
$118
Roundtrip
found 18 hours ago
Select Frontier Airlines flight, departing Thu, Jan 23 from Sacramento Intl. to Lambert-St. Louis Intl., returning Wed, Jan 29, priced at $118 found 18 hours ago
Frontier Airlines
Thu, Jan 16 - Sat, Jan 18
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$118 Roundtrip, found 18 hours ago
$118
Roundtrip
found 18 hours ago
Select Frontier Airlines flight, departing Thu, Jan 16 from O'Hare Intl. to Lambert-St. Louis Intl., returning Sat, Jan 18, priced at $118 found 18 hours ago
American Airlines
Tue, Jan 14 - Wed, Jan 15
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$157 Roundtrip, found 18 hours ago
$157
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Tue, Jan 14 from O'Hare Intl. to Lambert-St. Louis Intl., returning Wed, Jan 15, priced at $157 found 18 hours ago
Southern Airways Express
Fri, Jan 17 - Tue, Jan 21
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$165 Roundtrip, found 18 hours ago
$165
Roundtrip
found 18 hours ago
Select Southern Airways Express flight, departing Fri, Jan 17 from O'Hare Intl. to Lambert-St. Louis Intl., returning Tue, Jan 21, priced at $165 found 18 hours ago
Delta
Sat, Jan 18 - Mon, Jan 20
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$176 Roundtrip, found 18 hours ago
$176
Roundtrip
found 18 hours ago
Select Delta flight, departing Sat, Jan 18 from O'Hare Intl. to Lambert-St. Louis Intl., returning Mon, Jan 20, priced at $176 found 18 hours ago
Southern Airways Express
Sun, Jan 5 - Mon, Jan 6
BNA
Nashville Intl.
STL
Lambert-St. Louis Intl.
$193 Roundtrip, found 1 day ago
$193
Roundtrip
found 1 day ago
Select Southern Airways Express flight, departing Sun, Jan 5 from Nashville Intl. to Lambert-St. Louis Intl., returning Mon, Jan 6, priced at $193 found 1 day ago
Spirit Airlines
Tue, Jan 14 - Tue, Jan 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$193 Roundtrip, found 4 days ago
$193
Roundtrip
found 4 days ago
Select Spirit Airlines flight, departing Tue, Jan 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jan 21, priced at $193 found 4 days ago
United
Thu, Jan 23 - Tue, Jan 28
SMF
Sacramento Intl.
STL
Lambert-St. Louis Intl.
$216 Roundtrip, found 18 hours ago
$216
Roundtrip
found 18 hours ago
Select United flight, departing Thu, Jan 23 from Sacramento Intl. to Lambert-St. Louis Intl., returning Tue, Jan 28, priced at $216 found 18 hours ago
Delta
Tue, Jan 21 - Sun, Jan 26
ATW
Appleton Intl.
STL
Lambert-St. Louis Intl.
$228 Roundtrip, found 1 day ago
$228
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Jan 21 from Appleton Intl. to Lambert-St. Louis Intl., returning Sun, Jan 26, priced at $228 found 1 day ago
Alaska Airlines
Thu, May 8 - Tue, May 13
SMF
Sacramento Intl.
STL
Lambert-St. Louis Intl.
$246 Roundtrip, found 4 days ago
$246
Roundtrip
found 4 days ago
Select Alaska Airlines flight, departing Thu, May 8 from Sacramento Intl. to Lambert-St. Louis Intl., returning Tue, May 13, priced at $246 found 4 days ago
United
Tue, Feb 25 - Tue, Feb 25
AUS
Austin-Bergstrom Intl.
STL
Lambert-St. Louis Intl.
$250 Roundtrip, found 1 day ago
$250
Roundtrip
found 1 day ago
Select United flight, departing Tue, Feb 25 from Austin-Bergstrom Intl. to Lambert-St. Louis Intl., returning Tue, Feb 25, priced at $250 found 1 day ago
Delta
Tue, Feb 11 - Wed, Feb 19
ABQ
Albuquerque Intl. Sunport
STL
Lambert-St. Louis Intl.
$296 Roundtrip, found 4 days ago
$296
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Feb 11 from Albuquerque Intl. Sunport to Lambert-St. Louis Intl., returning Wed, Feb 19, priced at $296 found 4 days ago

Cheap Flights to Defiance

Fall in love at first flight with your vacation to Defiance by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Defiance on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Defiance, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Defiance

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Defiance with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Defiance?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Defiance are in February, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Defiance?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Defiance.

What airport is best to fly into Defiance?

When you’re planning your trip to Defiance, convenience is the name of the game. Luckily, Defiance Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your Defiance must-do list.

How much are flights to Defiance?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Defiance on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $110, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Defiance?

The trick to saving a stack of cash on your flight to Defiance? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $110 right now, why wait?

Defiance Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$110

Last Minute Hotel Deals in Defiance

Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. Louis
3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
The price is $114 per night from Jan 5 to Jan 6
$114
includes taxes & fees
Jan 5 - Jan 6
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,760 reviews)
Great Stay
"Great service and the atmosphere was just great."

Reviewed on Dec 31, 2024

Hollywood Casino & Hotel St. Louis
La Quinta Inn & Suites by Wyndham St. Louis Westport
La Quinta Inn & Suites by Wyndham St. Louis Westport
2.5 out of 5
11805 Lackland Rd, Maryland Heights, MO
The price is $86 per night from Jan 5 to Jan 6
$86
includes taxes & fees
Jan 5 - Jan 6
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.2/10 Good! (1,001 reviews)
Great stay!!
"My husband and I were in town for just a weekend getaway and absolutely loved staying here. The staff was very kind, the room was clean when arriving, and it was in a great location for traveling to and from St. Louis. The only effy things were not a very comfy bed and biscuits at breakfast were ..."

Reviewed on Dec 30, 2024

La Quinta Inn & Suites by Wyndham St. Louis Westport
The Wildwood Hotel
The Wildwood Hotel
3.5 out of 5
2801 Fountain Pl, Wildwood, MO
The price is $118 per night from Jan 2 to Jan 3
$118
includes taxes & fees
Jan 2 - Jan 3
Stay at this 3.5-star business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
9/10 Wonderful! (1,427 reviews)
"Loved staying here"

Reviewed on Dec 27, 2024

The Wildwood Hotel
Sonesta ES Suites St. Louis - Chesterfield
Sonesta ES Suites St. Louis - Chesterfield
3 out of 5
15431 Conway Rd, Chesterfield, MO
The price is $108 per night from Jan 9 to Jan 10
$108
includes taxes & fees
Jan 9 - Jan 10
Stay at this hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,004 reviews)
Nice stay
"Clean comfortable rooms in good condition"

Reviewed on Dec 28, 2024

Sonesta ES Suites St. Louis - Chesterfield
Ameristar Casino Resort and Spa
Ameristar Casino Resort and Spa
4.5 out of 5
1 Ameristar Blvd, St. Charles, MO
The price is $214 per night from Jan 2 to Jan 3
$214
includes taxes & fees
Jan 2 - Jan 3
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms and the property ...
8.2/10 Very Good! (1,005 reviews)
"This is my 1st stay in December. Last year we stayed 1 night during new yrs but did not enjoy our stay because our room was not clean and security wouldn't let my 35yr old married son in the casino gambling area. He left his drivers licenses in his vehicle at home because he road with me and forgot ..."

Reviewed on Dec 28, 2024

Ameristar Casino Resort and Spa
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
2.5 out of 5
1970 Craig Rd, Maryland Heights, MO
The price is $69 per night from Jan 3 to Jan 4
$69
includes taxes & fees
Jan 3 - Jan 4
Stay at this hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
4.6/10 (1,000 reviews)
"As someone who travels by car and loves road trips, I am familiar with the overall quality of affordable motels in the US. My adult son and I stopped at this place on our cross country road trip. If you are on a budget but want clean, safe, convenient--this place is great. The fact that there was ..."

Reviewed on Dec 9, 2024

Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Drury Plaza Hotel St. Louis Chesterfield
Drury Plaza Hotel St. Louis Chesterfield
3 out of 5
355 Chesterfield Ctr, Chesterfield, MO
The price is $146 per night from Jan 6 to Jan 7
$146
includes taxes & fees
Jan 6 - Jan 7
Stay at this 3-star business-friendly hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,005 reviews)
Poor maintenance
"House phone did not work and the drains in both the bathroom and the sink were very slow to clear."

Reviewed on Dec 29, 2024

Drury Plaza Hotel St. Louis Chesterfield
Embassy Suites by Hilton St. Louis St. Charles
Embassy Suites by Hilton St. Louis St. Charles
3.5 out of 5
2 Convention Center Plz, St. Charles, MO
The price is $142 per night from Jan 12 to Jan 13
$142
includes taxes & fees
Jan 12 - Jan 13
Stay at this 3.5-star business-friendly hotel in St. Charles. Enjoy free breakfast, free parking, and a free area shuttle. Our guests praise the breakfast and ...
8.8/10 Excellent! (1,158 reviews)
Best stay
"Ellen at the front desk was so friendly and inviting! Very relaxing, comfortable, and clean place. We will definitely pick this place again!"

Reviewed on Dec 29, 2024

Embassy Suites by Hilton St. Louis St. Charles
See all 836 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.