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Defiance

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Defiance Flights as Low as $119

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Sat, Jul 26 - Sat, Aug 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$119 Roundtrip, found 5 hours ago
$119
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Sat, Jul 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 2, priced at $119 found 5 hours ago
Spirit Airlines
Sun, May 11 - Sat, May 17
FLL
Fort Lauderdale - Hollywood Intl.
STL
Lambert-St. Louis Intl.
$132 Roundtrip, found 10 hours ago
$132
Roundtrip
found 10 hours ago
Select Spirit Airlines flight, departing Sun, May 11 from Fort Lauderdale - Hollywood Intl. to Lambert-St. Louis Intl., returning Sat, May 17, priced at $132 found 10 hours ago
Spirit Airlines
Thu, Jun 5 - Sat, Jun 7
FLL
Fort Lauderdale - Hollywood Intl.
STL
Lambert-St. Louis Intl.
$132 Roundtrip, found 6 days ago
$132
Roundtrip
found 6 days ago
Select Spirit Airlines flight, departing Thu, Jun 5 from Fort Lauderdale - Hollywood Intl. to Lambert-St. Louis Intl., returning Sat, Jun 7, priced at $132 found 6 days ago
Frontier Airlines
Sat, Jun 14 - Sun, Jun 22
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$136 Roundtrip, found 22 hours ago
$136
Roundtrip
found 22 hours ago
Select Frontier Airlines flight, departing Sat, Jun 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sun, Jun 22, priced at $136 found 22 hours ago
Frontier Airlines
Sat, Jul 19 - Sun, Jul 20
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$139 Roundtrip, found 2 days ago
$139
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Sat, Jul 19 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sun, Jul 20, priced at $139 found 2 days ago
Frontier Airlines
Sat, May 17 - Mon, May 19
CVG
Cincinnati - Northern Kentucky Intl.
STL
Lambert-St. Louis Intl.
$173 Roundtrip, found 1 day ago
$173
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, May 17 from Cincinnati - Northern Kentucky Intl. to Lambert-St. Louis Intl., returning Mon, May 19, priced at $173 found 1 day ago
Delta
Sat, May 24 - Sat, May 24
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$177 Roundtrip, found 4 days ago
$177
Roundtrip
found 4 days ago
Select Delta flight, departing Sat, May 24 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, May 24, priced at $177 found 4 days ago
Frontier Airlines
Tue, Apr 29 - Wed, Apr 30
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$188 Roundtrip, found 5 days ago
$188
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Tue, Apr 29 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Wed, Apr 30, priced at $188 found 5 days ago
Bargain Flight
Fri, May 23 - Mon, May 26
CVG
Cincinnati - Northern Kentucky Intl.
STL
Lambert-St. Louis Intl.
$194 Roundtrip, found 17 hours ago
$194
Roundtrip
found 17 hours ago
Select Bargain Flight flight, departing Fri, May 23 from Cincinnati - Northern Kentucky Intl. to Lambert-St. Louis Intl., returning Mon, May 26, priced at $194 found 17 hours ago
Frontier Airlines
Sat, May 17 - Wed, May 21
BUF
Buffalo Niagara Intl.
STL
Lambert-St. Louis Intl.
$212 Roundtrip, found 1 day ago
$212
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, May 17 from Buffalo Niagara Intl. to Lambert-St. Louis Intl., returning Wed, May 21, priced at $212 found 1 day ago
Bargain Flight
Mon, May 26 - Tue, May 27
TUL
Tulsa Intl.
STL
Lambert-St. Louis Intl.
$215 Roundtrip, found 15 hours ago
$215
Roundtrip
found 15 hours ago
Select Bargain Flight flight, departing Mon, May 26 from Tulsa Intl. to Lambert-St. Louis Intl., returning Tue, May 27, priced at $215 found 15 hours ago
American Airlines
Sat, Jul 26 - Sat, Aug 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$217 Roundtrip, found 5 hours ago
$217
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Sat, Jul 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 2, priced at $217 found 5 hours ago
American Airlines
Tue, Jun 3 - Thu, Jun 12
ABE
Lehigh Valley Intl.
STL
Lambert-St. Louis Intl.
$233 Roundtrip, found 12 hours ago
$233
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Tue, Jun 3 from Lehigh Valley Intl. to Lambert-St. Louis Intl., returning Thu, Jun 12, priced at $233 found 12 hours ago
Delta
Sat, May 31 - Tue, Jun 10
MDT
Harrisburg Intl.
STL
Lambert-St. Louis Intl.
$237 Roundtrip, found 12 hours ago
$237
Roundtrip
found 12 hours ago
Select Delta flight, departing Sat, May 31 from Harrisburg Intl. to Lambert-St. Louis Intl., returning Tue, Jun 10, priced at $237 found 12 hours ago
Bargain Flight
Wed, Jul 16 - Wed, Jul 23
BOS
Logan Intl.
STL
Lambert-St. Louis Intl.
$245 Roundtrip, found 18 hours ago
$245
Roundtrip
found 18 hours ago
Select Bargain Flight flight, departing Wed, Jul 16 from Logan Intl. to Lambert-St. Louis Intl., returning Wed, Jul 23, priced at $245 found 18 hours ago
United
Wed, May 28 - Tue, Jun 3
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$277 Roundtrip, found 8 hours ago
$277
Roundtrip
found 8 hours ago
Select United flight, departing Wed, May 28 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Tue, Jun 3, priced at $277 found 8 hours ago

Cheap Flights to Defiance

Fall in love at first flight with your vacation to Defiance by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Defiance on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Defiance, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Defiance

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Defiance with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Defiance?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Defiance are in July, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Defiance?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 13 to choose from for your flight to Defiance.

What airport is best to fly into Defiance?

When you’re planning your trip to Defiance, convenience is the name of the game. Luckily, Defiance Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your Defiance must-do list.

How much are flights to Defiance?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Defiance on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $119, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Defiance?

The trick to saving a stack of cash on your flight to Defiance? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $119 right now, why wait?

Defiance Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$119

Last Minute Hotel Deals in Defiance

Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. Louis
3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
The price is $143 per night from May 1 to May 2
$143
includes taxes & fees
May 1 - May 2
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,877 reviews)
"We enjoyed everything but they need to upgrade their beds and cable system."

Reviewed on Apr 27, 2025

Hollywood Casino & Hotel St. Louis
Ameristar Casino Resort and Spa
Ameristar Casino Resort and Spa
4.5 out of 5
1 Ameristar Blvd, St. Charles, MO
The price is $214 per night from Apr 30 to May 1
$214
includes taxes & fees
Apr 30 - May 1
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms and the property ...
8.2/10 Very Good! (1,009 reviews)
"Everything was very clean, restaurants were good, and staff was awesome."

Reviewed on Apr 22, 2025

Ameristar Casino Resort and Spa
The Wildwood Hotel
The Wildwood Hotel
3.5 out of 5
2801 Fountain Pl, Wildwood, MO
The price is $118 per night from May 5 to May 6
$118
includes taxes & fees
May 5 - May 6
Stay at this 3.5-star business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
9/10 Wonderful! (1,480 reviews)
"We have etayed there before and love the hotel."

Reviewed on Apr 21, 2025

The Wildwood Hotel
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3 out of 5
1088 South Highway Drive, Fenton, MO
The price is $103 per night from Apr 29 to Apr 30
$103
includes taxes & fees
Apr 29 - Apr 30
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,001 reviews)
"The outside of the building appeared very run down, and the landscaping needed lots of attention. However, the hallways, carpet, room interior, shower/bath, etc were all very clean, fresh smelling, and the bed was very comfortable. Overall, I was very pleased with my stay."

Reviewed on Apr 15, 2025

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
La Quinta Inn & Suites by Wyndham St. Louis Westport
La Quinta Inn & Suites by Wyndham St. Louis Westport
2.5 out of 5
11805 Lackland Rd, Maryland Heights, MO
The price is $103 per night from May 18 to May 19
$103
includes taxes & fees
May 18 - May 19
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.2/10 Good! (1,005 reviews)
"property room relatively clean although vinyl floor was really dirty had not been mopped. Front desk very nice."

Reviewed on Apr 26, 2025

La Quinta Inn & Suites by Wyndham St. Louis Westport
Wingate by Wyndham St. Louis/Fenton Route 66
Wingate by Wyndham St. Louis/Fenton Route 66
3 out of 5
1100 S Highway Dr, Fenton, MO
The price is $98 per night from Apr 29 to Apr 30
$98
includes taxes & fees
Apr 29 - Apr 30
Stay at this 3-star business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (1,005 reviews)
"I love the colors"

Reviewed on Apr 25, 2025

Wingate by Wyndham St. Louis/Fenton Route 66
Drury Plaza Hotel St. Louis St. Charles
Drury Plaza Hotel St. Louis St. Charles
3 out of 5
380 Mulholland Drive, St. Charles, MO
The price is $128 per night from May 4 to May 5
$128
includes taxes & fees
May 4 - May 5
Stay at this 3-star business-friendly hotel in St. Charles. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,002 reviews)
"Everything was great."

Reviewed on Apr 23, 2025

Drury Plaza Hotel St. Louis St. Charles
Hyatt Place St. Louis/Chesterfield
Hyatt Place St. Louis/Chesterfield
3 out of 5
333 Chesterfield Center East, Chesterfield, MO
The price is $147 per night from May 11 to May 12
$147
includes taxes & fees
May 11 - May 12
Stay at this 3-star business-friendly hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,000 reviews)
"Stay was quiet and clean. Breakfast was great."

Reviewed on Apr 21, 2025

Hyatt Place St. Louis/Chesterfield
See all 820 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.