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Defiance

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Defiance Flights as Low as $114

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

United
Tue, Sep 9 - Mon, Sep 15
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$114 Roundtrip, found 1 day ago
$114
Roundtrip
found 1 day ago
Select United flight, departing Tue, Sep 9 from O'Hare Intl. to Lambert-St. Louis Intl., returning Mon, Sep 15, priced at $114 found 1 day ago
American Airlines
Tue, Sep 9 - Mon, Sep 15
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$121 Roundtrip, found 1 day ago
$121
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 9 from O'Hare Intl. to Lambert-St. Louis Intl., returning Mon, Sep 15, priced at $121 found 1 day ago
Frontier Airlines
Thu, Jul 10 - Sat, Jul 12
SLC
Salt Lake City Intl.
STL
Lambert-St. Louis Intl.
$169 Roundtrip, found 3 days ago
$169
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Thu, Jul 10 from Salt Lake City Intl. to Lambert-St. Louis Intl., returning Sat, Jul 12, priced at $169 found 3 days ago
Frontier Airlines
Sat, May 24 - Tue, May 27
LAS
Harry Reid Intl.
STL
Lambert-St. Louis Intl.
$170 Roundtrip, found 4 days ago
$170
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Sat, May 24 from Harry Reid Intl. to Lambert-St. Louis Intl., returning Tue, May 27, priced at $170 found 4 days ago
Delta
Sat, Sep 6 - Sat, Sep 13
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$177 Roundtrip, found 1 day ago
$177
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Sep 6 from O'Hare Intl. to Lambert-St. Louis Intl., returning Sat, Sep 13, priced at $177 found 1 day ago
United
Wed, Aug 27 - Thu, Sep 4
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$180 Roundtrip, found 1 day ago
$180
Roundtrip
found 1 day ago
Select United flight, departing Wed, Aug 27 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Thu, Sep 4, priced at $180 found 1 day ago
Bargain Flight
Sun, Sep 7 - Tue, Sep 16
MSP
Minneapolis - St. Paul Intl.
STL
Lambert-St. Louis Intl.
$188 Roundtrip, found 13 hours ago
$188
Roundtrip
found 13 hours ago
Select Bargain Flight flight, departing Sun, Sep 7 from Minneapolis - St. Paul Intl. to Lambert-St. Louis Intl., returning Tue, Sep 16, priced at $188 found 13 hours ago
Southern Airways Express
Tue, Sep 9 - Mon, Sep 15
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$207 Roundtrip, found 1 day ago
$207
Roundtrip
found 1 day ago
Select Southern Airways Express flight, departing Tue, Sep 9 from O'Hare Intl. to Lambert-St. Louis Intl., returning Mon, Sep 15, priced at $207 found 1 day ago
Bargain Flight
Mon, Jun 2 - Fri, Jun 6
CMH
John Glenn Columbus Intl.
STL
Lambert-St. Louis Intl.
$227 Roundtrip, found 19 hours ago
$227
Roundtrip
found 19 hours ago
Select Bargain Flight flight, departing Mon, Jun 2 from John Glenn Columbus Intl. to Lambert-St. Louis Intl., returning Fri, Jun 6, priced at $227 found 19 hours ago
United
Wed, Jun 4 - Mon, Jun 9
FCA
Glacier Park Intl.
STL
Lambert-St. Louis Intl.
$236 Roundtrip, found 16 hours ago
$236
Roundtrip
found 16 hours ago
Select United flight, departing Wed, Jun 4 from Glacier Park Intl. to Lambert-St. Louis Intl., returning Mon, Jun 9, priced at $236 found 16 hours ago
Frontier Airlines
Tue, Jul 1 - Thu, Jul 3
CLT
Charlotte-Douglas Intl.
STL
Lambert-St. Louis Intl.
$237 Roundtrip, found 1 day ago
$237
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Tue, Jul 1 from Charlotte-Douglas Intl. to Lambert-St. Louis Intl., returning Thu, Jul 3, priced at $237 found 1 day ago
Alaska Airlines
Wed, Aug 27 - Thu, Sep 4
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$249 Roundtrip, found 1 day ago
$249
Roundtrip
found 1 day ago
Select Alaska Airlines flight, departing Wed, Aug 27 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Thu, Sep 4, priced at $249 found 1 day ago
Bargain Flight
Sat, May 24 - Sun, May 25
DSM
Des Moines Intl.
STL
Lambert-St. Louis Intl.
$252 Roundtrip, found 1 day ago
$252
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Sat, May 24 from Des Moines Intl. to Lambert-St. Louis Intl., returning Sun, May 25, priced at $252 found 1 day ago
Spirit Airlines
Thu, Jun 19 - Sun, Jun 22
MSP
Minneapolis - St. Paul Intl.
STL
Lambert-St. Louis Intl.
$258 Roundtrip, found 23 hours ago
$258
Roundtrip
found 23 hours ago
Select Spirit Airlines flight, departing Thu, Jun 19 from Minneapolis - St. Paul Intl. to Lambert-St. Louis Intl., returning Sun, Jun 22, priced at $258 found 23 hours ago
Hawaiian Airlines
Fri, May 30 - Tue, Jun 10
FCA
Glacier Park Intl.
STL
Lambert-St. Louis Intl.
$291 Roundtrip, found 2 days ago
$291
Roundtrip
found 2 days ago
Select Hawaiian Airlines flight, departing Fri, May 30 from Glacier Park Intl. to Lambert-St. Louis Intl., returning Tue, Jun 10, priced at $291 found 2 days ago
Bargain Flight
Tue, May 20 - Tue, May 20
SAT
San Antonio Intl.
STL
Lambert-St. Louis Intl.
$323 Roundtrip, found 23 hours ago
$323
Roundtrip
found 23 hours ago
Select Bargain Flight flight, departing Tue, May 20 from San Antonio Intl. to Lambert-St. Louis Intl., returning Tue, May 20, priced at $323 found 23 hours ago

Cheap Flights to Defiance

Fall in love at first flight with your vacation to Defiance by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Defiance on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Defiance, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Defiance

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Defiance with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Defiance?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Defiance are in September, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Defiance?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 12 to choose from for your flight to Defiance.

What airport is best to fly into Defiance?

When you’re planning your trip to Defiance, convenience is the name of the game. Luckily, Defiance Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your Defiance must-do list.

How much are flights to Defiance?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Defiance on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $114, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Defiance?

The trick to saving a stack of cash on your flight to Defiance? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $114 right now, why wait?

Defiance Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$114

Last Minute Hotel Deals in Defiance

Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. Louis
3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,910 reviews)
It was better than average.
"The room was nice, comfortable and clean. The bed was comfortable. The barn door for the bathroom was a bit odd. Dinner for 4 in their Smokehoue BBQ Restaurant we very mediocre and took far too long to serve. With a bill of over $150 and us all agreeing that the mac and cheese on the side was the ..."

Reviewed on May 14, 2025

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Hollywood Casino & Hotel St. Louis
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3 out of 5
1088 South Highway Drive, Fenton, MO
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,020 reviews)
pretty good, indoor pool closed with no notice
"It was a pretty nice place but one of the main reasons I got a room there is because it had a indoor pool and hot tub that ended up not being open and there was nothing about that online."

Reviewed on May 16, 2025

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Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Ameristar Casino Resort and Spa
Ameristar Casino Resort and Spa
4.5 out of 5
1 Ameristar Blvd, St. Charles, MO
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms and the property ...
8.2/10 Very Good! (1,014 reviews)
Great for a quick stay
"Overnight stay was just right! If it were a longer stay, as I've done before, not a having a microwave readily available is an inconvenience. We stayed in one of the updated rooms and it was exactly as pictured! We received a river view room, love that sunrise! Water pressure in the bathroom does ..."

Reviewed on May 12, 2025

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Ameristar Casino Resort and Spa
Wingate by Wyndham St. Louis/Fenton Route 66
Wingate by Wyndham St. Louis/Fenton Route 66
3 out of 5
1100 S Highway Dr, Fenton, MO
Stay at this 3-star business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,021 reviews)
"Great Staff/Good Hot Water/Decent breakfast. Stay here regularly."

Reviewed on May 15, 2025

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Wingate by Wyndham St. Louis/Fenton Route 66
The Wildwood Hotel
The Wildwood Hotel
3.5 out of 5
2801 Fountain Pl, Wildwood, MO
Stay at this 3.5-star business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
9/10 Wonderful! (1,511 reviews)
"Everyone was nice and it was a great stay"

Reviewed on May 16, 2025

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The Wildwood Hotel
La Quinta Inn & Suites by Wyndham St. Louis Westport
La Quinta Inn & Suites by Wyndham St. Louis Westport
2.5 out of 5
11805 Lackland Rd, Maryland Heights, MO
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.2/10 Good! (1,020 reviews)
"We were trying to stay"

Reviewed on May 14, 2025

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La Quinta Inn & Suites by Wyndham St. Louis Westport
Sonesta ES Suites St. Louis - Chesterfield
Sonesta ES Suites St. Louis - Chesterfield
3 out of 5
15431 Conway Rd, Chesterfield, MO
Stay at this hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,017 reviews)
"Beds were comfortable property was clean I definitely will visit again"

Reviewed on May 16, 2025

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Sonesta ES Suites St. Louis - Chesterfield
Crowne Plaza St. Louis Airport by IHG
Crowne Plaza St. Louis Airport by IHG
3.5 out of 5
11228 Lone Eagle Dr, Bridgeton, MO
Stay at this 3.5-star business-friendly hotel in Bridgeton. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
8/10 Very Good! (1,006 reviews)
"Good"

Reviewed on May 11, 2025

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Crowne Plaza St. Louis Airport by IHG
See all 832 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.