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Defiance

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Defiance Flights as Low as $47

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, Dec 2 - Mon, Dec 7
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$47 Roundtrip, found 1 hour ago
$47
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Wed, Dec 2 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, Dec 7, priced at $47 found 1 hour ago
Frontier Airlines
Mon, Dec 14 - Mon, Jan 4
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$48 Roundtrip, found 2 hours ago
$48
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Mon, Dec 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, Jan 4, priced at $48 found 2 hours ago
Frontier Airlines
Wed, Nov 18 - Wed, Dec 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$52 Roundtrip, found 2 hours ago
$52
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Wed, Nov 18 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Dec 2, priced at $52 found 2 hours ago
Frontier Airlines
Fri, Dec 18 - Mon, Jan 4
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$53 Roundtrip, found 2 hours ago
$53
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Fri, Dec 18 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, Jan 4, priced at $53 found 2 hours ago
Frontier Airlines
Fri, Dec 4 - Fri, Dec 11
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$80 Roundtrip, found 16 hours ago
$80
Roundtrip
found 16 hours ago
Select Frontier Airlines flight, departing Fri, Dec 4 from Denver Intl. to Lambert-St. Louis Intl., returning Fri, Dec 11, priced at $80 found 16 hours ago
Delta
Mon, Nov 23 - Mon, Nov 23
MSP
Minneapolis - St. Paul Intl.
STL
Lambert-St. Louis Intl.
$112 Roundtrip, found 4 hours ago
$112
Roundtrip
found 4 hours ago
Select Delta flight, departing Mon, Nov 23 from Minneapolis - St. Paul Intl. to Lambert-St. Louis Intl., returning Mon, Nov 23, priced at $112 found 4 hours ago
American Airlines
Thu, Jan 21 - Fri, Jan 22
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$117 Roundtrip, just found
$117
Roundtrip
just found
Select American Airlines flight, departing Thu, Jan 21 from O'Hare Intl. to Lambert-St. Louis Intl., returning Fri, Jan 22, priced at $117 just found
Southwest Airlines
Tue, Feb 9 - Fri, Feb 19
MSP
Minneapolis - St. Paul Intl.
STL
Lambert-St. Louis Intl.
$117 Roundtrip, found 1 hour ago
$117
Roundtrip
found 1 hour ago
Select Southwest Airlines flight, departing Tue, Feb 9 from Minneapolis - St. Paul Intl. to Lambert-St. Louis Intl., returning Fri, Feb 19, priced at $117 found 1 hour ago
United
Thu, Jan 21 - Fri, Jan 22
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$117 Roundtrip, just found
$117
Roundtrip
just found
Select United flight, departing Thu, Jan 21 from O'Hare Intl. to Lambert-St. Louis Intl., returning Fri, Jan 22, priced at $117 just found
Frontier Airlines
Wed, Dec 2 - Wed, Dec 9
BWI
Baltimore Washington Intl. Thurgood Marshall
STL
Lambert-St. Louis Intl.
$120 Roundtrip, found 1 hour ago
$120
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Wed, Dec 2 from Baltimore Washington Intl. Thurgood Marshall to Lambert-St. Louis Intl., returning Wed, Dec 9, priced at $120 found 1 hour ago
Frontier Airlines
Tue, Dec 8 - Wed, Jan 6
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$165 Roundtrip, found 1 hour ago
$165
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Tue, Dec 8 from San Francisco Intl. to Lambert-St. Louis Intl., returning Wed, Jan 6, priced at $165 found 1 hour ago
Frontier Airlines
Tue, Nov 24 - Wed, Dec 9
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$165 Roundtrip, found 1 hour ago
$165
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Tue, Nov 24 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Wed, Dec 9, priced at $165 found 1 hour ago
Frontier Airlines
Wed, Nov 18 - Wed, Dec 2
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$176 Roundtrip, found 2 hours ago
$176
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Wed, Nov 18 from Tampa Intl. to Lambert-St. Louis Intl., returning Wed, Dec 2, priced at $176 found 2 hours ago
Frontier Airlines
Wed, Nov 25 - Fri, Dec 4
FLL
Fort Lauderdale - Hollywood Intl.
STL
Lambert-St. Louis Intl.
$199 Roundtrip, found 1 day ago
$199
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, Nov 25 from Fort Lauderdale - Hollywood Intl. to Lambert-St. Louis Intl., returning Fri, Dec 4, priced at $199 found 1 day ago
Southwest Airlines
Tue, Nov 24 - Wed, Dec 9
DAL
Love Field
STL
Lambert-St. Louis Intl.
$299 Roundtrip, found 1 hour ago
$299
Roundtrip
found 1 hour ago
Select Southwest Airlines flight, departing Tue, Nov 24 from Love Field to Lambert-St. Louis Intl., returning Wed, Dec 9, priced at $299 found 1 hour ago
Alaska Airlines
Thu, Dec 31 - Tue, Jan 12
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$338 Roundtrip, found 2 hours ago
$338
Roundtrip
found 2 hours ago
Select Alaska Airlines flight, departing Thu, Dec 31 from San Francisco Intl. to Lambert-St. Louis Intl., returning Tue, Jan 12, priced at $338 found 2 hours ago

Cheap Flights to Defiance

Fall in love at first flight with your vacation to Defiance by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Defiance on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Defiance, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Defiance

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Defiance with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Defiance?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Defiance are in December, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Defiance?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Defiance.

What airport is best to fly into Defiance?

When you’re planning your trip to Defiance, convenience is the name of the game. Luckily, Defiance Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your Defiance must-do list.

How much are flights to Defiance?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Defiance on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $47, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Defiance?

The trick to saving a stack of cash on your flight to Defiance? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $47 right now, why wait?

Defiance Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$47

Last Minute Hotel Deals in Defiance

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.6/10 Excellent! (2,238 reviews)
"Always love staying here! Rooms are so spacious and comfy"

Reviewed on Nov 1, 2026

Get rates
Hollywood Casino & Hotel St. Louis
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
Book a stay at this luxury hotel in St. Charles. Enjoy a full-service spa, 6 restaurants, and a casino. Our guests praise the clean rooms in our reviews. Popular ...
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Ameristar Casino Resort and Spa
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

3 out of 5
13639 Riverport Dr Maryland Heights MO
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
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Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
Book a stay at this business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
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The Wildwood Hotel
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,625 reviews)
"Definitely feel like I got ripped off . I will not stay here again"

Reviewed on Nov 1, 2026

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Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Sonesta ES Suites St. Louis - Chesterfield

Sonesta ES Suites St. Louis - Chesterfield

3 out of 5
15431 Conway Rd Chesterfield MO
Stay at this hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
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Sonesta ES Suites St. Louis - Chesterfield
Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters

3 out of 5
170 Mid Rivers Mall Circle St. Peters MO
Book a stay at this business-friendly hotel in St. Peters. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,005 reviews)
"We thoroughly enjoyed our stay at Drury, but we were a bit disappointed by a couple of things that were not in the management's ability to help before we came to the hotel. Their evening meal with the room was good, they are friendly as usual. But the sofa in our suite (of the sofa bed) was pretty ..."

Reviewed on Nov 2, 2026

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Drury Inn & Suites St. Louis St. Peters
Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

2.5 out of 5
1970 Craig Rd Maryland Heights MO
Stay at this hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
4.4/10 (1,003 reviews)
"Absolutely horrible"

Reviewed on Nov 1, 2026

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Days Inn and Suites by Wyndham St. Louis/Westport Plaza
See all 897 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.