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Defiance

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Defiance Flights as Low as $56

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Tue, Jul 28 - Sat, Aug 8
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$56 Roundtrip, found 3 hours ago
$56
Roundtrip
found 3 hours ago
Select Frontier Airlines flight, departing Tue, Jul 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 8, priced at $56 found 3 hours ago
Frontier Airlines
Wed, Aug 12 - Thu, Aug 20
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$58 Roundtrip, found 18 hours ago
$58
Roundtrip
found 18 hours ago
Select Frontier Airlines flight, departing Wed, Aug 12 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Thu, Aug 20, priced at $58 found 18 hours ago
Frontier Airlines
Tue, Jul 28 - Wed, Aug 5
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$66 Roundtrip, found 14 hours ago
$66
Roundtrip
found 14 hours ago
Select Frontier Airlines flight, departing Tue, Jul 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Aug 5, priced at $66 found 14 hours ago
Frontier Airlines
Sat, Aug 8 - Tue, Aug 25
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$106 Roundtrip, found 20 hours ago
$106
Roundtrip
found 20 hours ago
Select Frontier Airlines flight, departing Sat, Aug 8 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Tue, Aug 25, priced at $106 found 20 hours ago
Delta
Tue, Aug 25 - Tue, Aug 25
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$114 Roundtrip, found 20 hours ago
$114
Roundtrip
found 20 hours ago
Select Delta flight, departing Tue, Aug 25 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Aug 25, priced at $114 found 20 hours ago
Delta
Tue, Aug 4 - Tue, Aug 11
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$170 Roundtrip, found 13 hours ago
$170
Roundtrip
found 13 hours ago
Select Delta flight, departing Tue, Aug 4 from Denver Intl. to Lambert-St. Louis Intl., returning Tue, Aug 11, priced at $170 found 13 hours ago
United
Tue, Jul 28 - Sat, Aug 8
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 3 hours ago
$197
Roundtrip
found 3 hours ago
Select United flight, departing Tue, Jul 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 8, priced at $197 found 3 hours ago
American Airlines
Tue, Jul 28 - Sat, Aug 8
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 3 hours ago
$197
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Tue, Jul 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 8, priced at $197 found 3 hours ago
Bargain Flight
Mon, Aug 24 - Tue, Sep 1
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$212 Roundtrip, found 2 days ago
$212
Roundtrip
found 2 days ago
Select Bargain Flight flight, departing Mon, Aug 24 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Tue, Sep 1, priced at $212 found 2 days ago
Frontier Airlines
Tue, Aug 4 - Tue, Aug 18
CVG
Cincinnati - Northern Kentucky Intl.
STL
Lambert-St. Louis Intl.
$220 Roundtrip, found 12 hours ago
$220
Roundtrip
found 12 hours ago
Select Frontier Airlines flight, departing Tue, Aug 4 from Cincinnati - Northern Kentucky Intl. to Lambert-St. Louis Intl., returning Tue, Aug 18, priced at $220 found 12 hours ago
Delta
Sat, Aug 8 - Tue, Aug 25
DAL
Love Field
STL
Lambert-St. Louis Intl.
$222 Roundtrip, found 14 hours ago
$222
Roundtrip
found 14 hours ago
Select Delta flight, departing Sat, Aug 8 from Love Field to Lambert-St. Louis Intl., returning Tue, Aug 25, priced at $222 found 14 hours ago
Bargain Flight
Wed, Jul 29 - Sat, Aug 1
BWI
Baltimore Washington Intl. Thurgood Marshall
STL
Lambert-St. Louis Intl.
$230 Roundtrip, found 13 hours ago
$230
Roundtrip
found 13 hours ago
Select Bargain Flight flight, departing Wed, Jul 29 from Baltimore Washington Intl. Thurgood Marshall to Lambert-St. Louis Intl., returning Sat, Aug 1, priced at $230 found 13 hours ago
Delta
Wed, Jul 29 - Wed, Aug 5
DCA
Ronald Reagan Washington National
STL
Lambert-St. Louis Intl.
$257 Roundtrip, found 19 hours ago
$257
Roundtrip
found 19 hours ago
Select Delta flight, departing Wed, Jul 29 from Ronald Reagan Washington National to Lambert-St. Louis Intl., returning Wed, Aug 5, priced at $257 found 19 hours ago
Bargain Flight
Tue, Aug 18 - Wed, Aug 19
BOS
Logan Intl.
STL
Lambert-St. Louis Intl.
$267 Roundtrip, found 3 hours ago
$267
Roundtrip
found 3 hours ago
Select Bargain Flight flight, departing Tue, Aug 18 from Logan Intl. to Lambert-St. Louis Intl., returning Wed, Aug 19, priced at $267 found 3 hours ago
Frontier Airlines
Mon, Aug 3 - Wed, Aug 5
IAD
Washington Dulles Intl.
STL
Lambert-St. Louis Intl.
$269 Roundtrip, found 14 hours ago
$269
Roundtrip
found 14 hours ago
Select Frontier Airlines flight, departing Mon, Aug 3 from Washington Dulles Intl. to Lambert-St. Louis Intl., returning Wed, Aug 5, priced at $269 found 14 hours ago
Alaska Airlines
Wed, Jul 22 - Sat, Aug 8
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$638 Roundtrip, found 14 hours ago
$638
Roundtrip
found 14 hours ago
Select Alaska Airlines flight, departing Wed, Jul 22 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Aug 8, priced at $638 found 14 hours ago

Cheap Flights to Defiance

Fall in love at first flight with your vacation to Defiance by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Defiance on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Defiance, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Defiance

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Defiance with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Defiance?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Defiance are in July, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Defiance?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 13 to choose from for your flight to Defiance.

What airport is best to fly into Defiance?

When you’re planning your trip to Defiance, convenience is the name of the game. Luckily, Defiance Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your Defiance must-do list.

How much are flights to Defiance?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Defiance on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $56, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Defiance?

The trick to saving a stack of cash on your flight to Defiance? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $56 right now, why wait?

Defiance Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$56

Last Minute Hotel Deals in Defiance

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,401 reviews)
"The floors in our room weren't thoroughly cleaned prior to our arrival. When we entered upon arrival there was no soap in the bathroom. There were also contacts on the floor under the bathroom sink/counter. In the main portion of our room, I found a cookie on the floor by the bed and chips under ..."

Reviewed on Jul 1, 2026

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Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.6/10 Excellent! (2,209 reviews)
"Good price"

Reviewed on Jul 1, 2026

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Hollywood Casino & Hotel St. Louis
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
Book a stay at this business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
9.2/10 Wonderful! (1,663 reviews)
"The employees were nice, friendly and helpful. The room was roomy, clean and the bed was nice and comfortable. I really like that the B&B Theater was right across the street to walk to. We enjoyed a movie at the Theater."

Reviewed on Jul 1, 2026

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The Wildwood Hotel
Hilton St. Louis Frontenac

Hilton St. Louis Frontenac

4 out of 5
1335 S Lindbergh Blvd Frontenac MO
Book a stay at this business-friendly hotel in Frontenac. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (1,000 reviews)
"It's a classic hotel in a great location. The front desk staff aren't the most enthusiastic—they do their job, but don't really go the extra mile to help guests. The hotel is a bit dated, but it's clean, and that's what matters most. I don't think the breakfast is worth the price, as it's very basic. ..."

Reviewed on Jun 30, 2026

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Hilton St. Louis Frontenac
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
Book a stay at this luxury hotel in St. Charles. Enjoy a full-service spa, 6 restaurants, and a casino. Our guests praise the clean rooms in our reviews. Popular ...
8.6/10 Excellent! (1,002 reviews)
"Property is well maintained, inside and out. Beds are comfortable and the bathroom is large with a great walk in shower. Loved the step-down into the separate room which overlooks the river or city. There is a TV in there as well as a large sofa. Not too long of a walk from the garage or the casino. ..."

Reviewed on Jul 1, 2026

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Ameristar Casino Resort and Spa
Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

2.5 out of 5
1970 Craig Rd Maryland Heights MO
Stay at this hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
4.4/10 (1,009 reviews)
"Poorly lit from the outside. Inside was dingey and the entire premises from the lobby all the way through the hallways and into the rooms smelled like marijuana and cigarette smoke. The carpet and wallpaper were peeling. The hallways were uninviting and dingey. The marijuana order was pungent. Door ..."

Reviewed on Jul 1, 2026

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Days Inn and Suites by Wyndham St. Louis/Westport Plaza
La Quinta Inn & Suites by Wyndham St. Louis Westport

La Quinta Inn & Suites by Wyndham St. Louis Westport

3 out of 5
11805 Lackland Rd Maryland Heights MO
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free WiFi, free parking, and a free airport shuttle. Our guests praise the helpful staff ...
7.2/10 Good! (1,132 reviews)
"Non communication abt breakfast time n check out"

Reviewed on Jul 1, 2026

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La Quinta Inn & Suites by Wyndham St. Louis Westport
WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon

2.5 out of 5
7850 Veterans Memorial Parkway St. Peters MO
Stay at this hotel in St. Peters. Enjoy free WiFi, free parking, and a fitness center. Popular attractions Bowlero St. Peters and CarShield Field are located ...
8.4/10 Very Good! (185 reviews)
"No frills hotel is very good. Worth staying for the cost. We were there 6 nights and very satisfied. Room was clean, the staff friendly bed comfortable and it was quiet."

Reviewed on Jun 29, 2026

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WoodSpring Suites St Peters-OFallon
See all 875 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.