Search Cheap Flights to
Defiance

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Defiance Flights as Low as $153

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Wed, May 21 - Sun, May 25
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$153 Roundtrip, found 5 days ago
$153
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, May 21 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Sun, May 25, priced at $153 found 5 days ago
Frontier Airlines
Wed, May 7 - Tue, May 20
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$160 Roundtrip, found 3 hours ago
$160
Roundtrip
found 3 hours ago
Select Frontier Airlines flight, departing Wed, May 7 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Tue, May 20, priced at $160 found 3 hours ago
Frontier Airlines
Tue, Mar 25 - Wed, Apr 2
PHX
Sky Harbor Intl.
STL
Lambert-St. Louis Intl.
$160 Roundtrip, found 1 day ago
$160
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Tue, Mar 25 from Sky Harbor Intl. to Lambert-St. Louis Intl., returning Wed, Apr 2, priced at $160 found 1 day ago
Frontier Airlines
Wed, Mar 26 - Wed, Apr 2
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$161 Roundtrip, found 9 hours ago
$161
Roundtrip
found 9 hours ago
Select Frontier Airlines flight, departing Wed, Mar 26 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Wed, Apr 2, priced at $161 found 9 hours ago
Delta
Wed, Mar 26 - Mon, Mar 31
LGA
LaGuardia
STL
Lambert-St. Louis Intl.
$178 Roundtrip, found 22 hours ago
$178
Roundtrip
found 22 hours ago
Select Delta flight, departing Wed, Mar 26 from LaGuardia to Lambert-St. Louis Intl., returning Mon, Mar 31, priced at $178 found 22 hours ago
Frontier Airlines
Thu, Mar 20 - Mon, Mar 24
BWI
Baltimore Washington Intl. Thurgood Marshall
STL
Lambert-St. Louis Intl.
$182 Roundtrip, found 6 hours ago
$182
Roundtrip
found 6 hours ago
Select Frontier Airlines flight, departing Thu, Mar 20 from Baltimore Washington Intl. Thurgood Marshall to Lambert-St. Louis Intl., returning Mon, Mar 24, priced at $182 found 6 hours ago
Spirit Airlines
Sat, May 10 - Tue, May 13
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$186 Roundtrip, found 3 hours ago
$186
Roundtrip
found 3 hours ago
Select Spirit Airlines flight, departing Sat, May 10 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Tue, May 13, priced at $186 found 3 hours ago
Southern Airways Express
Fri, Jul 18 - Sun, Jul 20
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$207 Roundtrip, found 5 hours ago
$207
Roundtrip
found 5 hours ago
Select Southern Airways Express flight, departing Fri, Jul 18 from O'Hare Intl. to Lambert-St. Louis Intl., returning Sun, Jul 20, priced at $207 found 5 hours ago
American Airlines
Wed, May 21 - Sun, May 25
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$230 Roundtrip, found 5 days ago
$230
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, May 21 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Sun, May 25, priced at $230 found 5 days ago
American Airlines
Tue, Apr 1 - Tue, Apr 8
COS
Colorado Springs
STL
Lambert-St. Louis Intl.
$239 Roundtrip, found 6 days ago
$239
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Apr 1 from Colorado Springs to Lambert-St. Louis Intl., returning Tue, Apr 8, priced at $239 found 6 days ago
Delta
Wed, May 21 - Sun, May 25
DAL
Love Field
STL
Lambert-St. Louis Intl.
$250 Roundtrip, found 5 days ago
$250
Roundtrip
found 5 days ago
Select Delta flight, departing Wed, May 21 from Love Field to Lambert-St. Louis Intl., returning Sun, May 25, priced at $250 found 5 days ago
United
Wed, May 21 - Sun, May 25
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$250 Roundtrip, found 5 days ago
$250
Roundtrip
found 5 days ago
Select United flight, departing Wed, May 21 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Sun, May 25, priced at $250 found 5 days ago
Delta
Tue, May 6 - Tue, May 13
OAK
Oakland Intl.
STL
Lambert-St. Louis Intl.
$297 Roundtrip, found 6 hours ago
$297
Roundtrip
found 6 hours ago
Select Delta flight, departing Tue, May 6 from Oakland Intl. to Lambert-St. Louis Intl., returning Tue, May 13, priced at $297 found 6 hours ago
Frontier Airlines
Mon, Mar 10 - Fri, Mar 14
TTN
Mercer
STL
Lambert-St. Louis Intl.
$382 Roundtrip, found 6 days ago
$382
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Mon, Mar 10 from Mercer to Lambert-St. Louis Intl., returning Fri, Mar 14, priced at $382 found 6 days ago
Hawaiian Airlines
Mon, Mar 17 - Thu, Mar 20
PHX
Sky Harbor Intl.
STL
Lambert-St. Louis Intl.
$947 Roundtrip, found 21 hours ago
$947
Roundtrip
found 21 hours ago
Select Hawaiian Airlines flight, departing Mon, Mar 17 from Sky Harbor Intl. to Lambert-St. Louis Intl., returning Thu, Mar 20, priced at $947 found 21 hours ago
Alaska Airlines
Mon, Mar 17 - Thu, Mar 20
PHX
Sky Harbor Intl.
STL
Lambert-St. Louis Intl.
$947 Roundtrip, found 21 hours ago
$947
Roundtrip
found 21 hours ago
Select Alaska Airlines flight, departing Mon, Mar 17 from Sky Harbor Intl. to Lambert-St. Louis Intl., returning Thu, Mar 20, priced at $947 found 21 hours ago

Cheap Flights to Defiance

Fall in love at first flight with your vacation to Defiance by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Defiance on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Defiance, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Defiance

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Defiance with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Defiance?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Defiance are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Defiance?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Defiance.

What airport is best to fly into Defiance?

When you’re planning your trip to Defiance, convenience is the name of the game. Luckily, Defiance Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your Defiance must-do list.

How much are flights to Defiance?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Defiance on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $153, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Defiance?

The trick to saving a stack of cash on your flight to Defiance? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $153 right now, why wait?

Defiance Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$152

Last Minute Hotel Deals in Defiance

Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. Louis
3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
The price is $133 per night from Mar 9 to Mar 10
$133
includes taxes & fees
Mar 9 - Mar 10
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,834 reviews)
"My only issue was the parking lot and area around the property. It was dirty and had trash scattered around. It was a bit noisy but im not sure what it was. Some boom or bang that happened periodically. Other than that it was great abd id stay again."

Reviewed on Mar 4, 2025

Hollywood Casino & Hotel St. Louis
Sonesta ES Suites St. Louis - Chesterfield
Sonesta ES Suites St. Louis - Chesterfield
3 out of 5
15431 Conway Rd, Chesterfield, MO
The price is $108 per night from Mar 13 to Mar 14
$108
includes taxes & fees
Mar 13 - Mar 14
Stay at this hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,011 reviews)
Quiet
"Everything was clean and quiet."

Reviewed on Mar 6, 2025

Sonesta ES Suites St. Louis - Chesterfield
The Wildwood Hotel
The Wildwood Hotel
3.5 out of 5
2801 Fountain Pl, Wildwood, MO
The price is $107 per night from Mar 9 to Mar 10
$107
includes taxes & fees
Mar 9 - Mar 10
Stay at this 3.5-star business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
9/10 Wonderful! (1,465 reviews)
"Good place to visit again next trip"

Reviewed on Mar 5, 2025

The Wildwood Hotel
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3 out of 5
1088 South Highway Drive, Fenton, MO
The price is $103 per night from Mar 9 to Mar 10
$103
includes taxes & fees
Mar 9 - Mar 10
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9/10 Wonderful! (1,011 reviews)
"Staff was very helpful"

Reviewed on Mar 4, 2025

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Ameristar Casino Resort and Spa
Ameristar Casino Resort and Spa
4.5 out of 5
1 Ameristar Blvd, St. Charles, MO
The price is $214 per night from Mar 9 to Mar 10
$214
includes taxes & fees
Mar 9 - Mar 10
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms and the property ...
8.2/10 Very Good! (1,005 reviews)
"Nice"

Reviewed on Mar 2, 2025

Ameristar Casino Resort and Spa
Wingate by Wyndham St. Louis/Fenton Route 66
Wingate by Wyndham St. Louis/Fenton Route 66
2.5 out of 5
1100 S Highway Dr, Fenton, MO
The price is $91 per night from Mar 9 to Mar 10
$91
includes taxes & fees
Mar 9 - Mar 10
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (1,006 reviews)
"."

Reviewed on Mar 1, 2025

Wingate by Wyndham St. Louis/Fenton Route 66
Crowne Plaza St. Louis Airport by IHG
Crowne Plaza St. Louis Airport by IHG
3.5 out of 5
11228 Lone Eagle Dr, Bridgeton, MO
The price is $167 per night from Mar 9 to Mar 10
$167
includes taxes & fees
Mar 9 - Mar 10
Stay at this 3.5-star business-friendly hotel in Bridgeton. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
8/10 Very Good! (1,006 reviews)
"Open glass concept, bar area"

Reviewed on Mar 5, 2025

Crowne Plaza St. Louis Airport by IHG
Best Western Plus St. Louis West-Westport
Best Western Plus St. Louis West-Westport
2.5 out of 5
12220 Dorsett Rd, Maryland Heights, MO
The price is $103 per night from Mar 9 to Mar 10
$103
includes taxes & fees
Mar 9 - Mar 10
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,011 reviews)
"Thanks you for your good service"

Reviewed on Mar 5, 2025

Best Western Plus St. Louis West-Westport
See all 805 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.