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Defiance

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Defiance Flights as Low as $128

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Fri, Apr 11 - Mon, Apr 21
LAS
Harry Reid Intl.
STL
Lambert-St. Louis Intl.
$128 Roundtrip, found 6 days ago
$128
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Fri, Apr 11 from Harry Reid Intl. to Lambert-St. Louis Intl., returning Mon, Apr 21, priced at $128 found 6 days ago
Frontier Airlines
Sat, Jul 26 - Sat, Aug 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$130 Roundtrip, found 14 hours ago
$130
Roundtrip
found 14 hours ago
Select Frontier Airlines flight, departing Sat, Jul 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 2, priced at $130 found 14 hours ago
Spirit Airlines
Thu, Jun 12 - Mon, Jun 16
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$149 Roundtrip, found 1 day ago
$149
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Thu, Jun 12 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, Jun 16, priced at $149 found 1 day ago
Delta
Wed, May 21 - Wed, May 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$179 Roundtrip, found 14 hours ago
$179
Roundtrip
found 14 hours ago
Select Delta flight, departing Wed, May 21 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, May 21, priced at $179 found 14 hours ago
Delta
Sun, Aug 31 - Sun, Aug 31
DCA
Ronald Reagan Washington National
STL
Lambert-St. Louis Intl.
$199 Roundtrip, found 1 day ago
$199
Roundtrip
found 1 day ago
Select Delta flight, departing Sun, Aug 31 from Ronald Reagan Washington National to Lambert-St. Louis Intl., returning Sun, Aug 31, priced at $199 found 1 day ago
Frontier Airlines
Fri, May 9 - Sun, May 11
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$208 Roundtrip, found 4 days ago
$208
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Fri, May 9 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Sun, May 11, priced at $208 found 4 days ago
American Airlines
Sat, Jul 26 - Sat, Aug 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$217 Roundtrip, found 14 hours ago
$217
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Sat, Jul 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 2, priced at $217 found 14 hours ago
Frontier Airlines
Fri, Apr 18 - Wed, Apr 23
ORF
Norfolk Intl.
STL
Lambert-St. Louis Intl.
$230 Roundtrip, found 1 day ago
$230
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Fri, Apr 18 from Norfolk Intl. to Lambert-St. Louis Intl., returning Wed, Apr 23, priced at $230 found 1 day ago
Frontier Airlines
Tue, May 13 - Fri, May 16
SNA
John Wayne
STL
Lambert-St. Louis Intl.
$248 Roundtrip, found 5 days ago
$248
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Tue, May 13 from John Wayne to Lambert-St. Louis Intl., returning Fri, May 16, priced at $248 found 5 days ago
Frontier Airlines
Wed, Apr 23 - Fri, Apr 25
ONT
Los Angeles - Ontario Intl.
STL
Lambert-St. Louis Intl.
$248 Roundtrip, found 3 days ago
$248
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Wed, Apr 23 from Los Angeles - Ontario Intl. to Lambert-St. Louis Intl., returning Fri, Apr 25, priced at $248 found 3 days ago
Frontier Airlines
Thu, May 1 - Sun, May 4
LAX
Los Angeles Intl.
STL
Lambert-St. Louis Intl.
$248 Roundtrip, found 3 days ago
$248
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Thu, May 1 from Los Angeles Intl. to Lambert-St. Louis Intl., returning Sun, May 4, priced at $248 found 3 days ago
United
Fri, Sep 5 - Mon, Sep 8
DCA
Ronald Reagan Washington National
STL
Lambert-St. Louis Intl.
$249 Roundtrip, found 3 days ago
$249
Roundtrip
found 3 days ago
Select United flight, departing Fri, Sep 5 from Ronald Reagan Washington National to Lambert-St. Louis Intl., returning Mon, Sep 8, priced at $249 found 3 days ago
Delta
Sat, Jun 14 - Tue, Jun 17
SAN
San Diego Intl.
STL
Lambert-St. Louis Intl.
$257 Roundtrip, found 16 hours ago
$257
Roundtrip
found 16 hours ago
Select Delta flight, departing Sat, Jun 14 from San Diego Intl. to Lambert-St. Louis Intl., returning Tue, Jun 17, priced at $257 found 16 hours ago
American Airlines
Thu, Jun 12 - Tue, Jun 17
CLD
McClellan-Palomar
STL
Lambert-St. Louis Intl.
$334 Roundtrip, found 16 hours ago
$334
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Thu, Jun 12 from McClellan-Palomar to Lambert-St. Louis Intl., returning Tue, Jun 17, priced at $334 found 16 hours ago
Alaska Airlines
Wed, Apr 16 - Wed, Apr 30
LAS
Harry Reid Intl.
STL
Lambert-St. Louis Intl.
$420 Roundtrip, found 1 day ago
$420
Roundtrip
found 1 day ago
Select Alaska Airlines flight, departing Wed, Apr 16 from Harry Reid Intl. to Lambert-St. Louis Intl., returning Wed, Apr 30, priced at $420 found 1 day ago
Hawaiian Airlines
Thu, Apr 17 - Fri, Apr 18
ONT
Los Angeles - Ontario Intl.
STL
Lambert-St. Louis Intl.
$516 Roundtrip, found 5 days ago
$516
Roundtrip
found 5 days ago
Select Hawaiian Airlines flight, departing Thu, Apr 17 from Los Angeles - Ontario Intl. to Lambert-St. Louis Intl., returning Fri, Apr 18, priced at $516 found 5 days ago

Cheap Flights to Defiance

Fall in love at first flight with your vacation to Defiance by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Defiance on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Defiance, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Defiance

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Defiance with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Defiance?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Defiance are in April, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Defiance?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Defiance.

What airport is best to fly into Defiance?

When you’re planning your trip to Defiance, convenience is the name of the game. Luckily, Defiance Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your Defiance must-do list.

How much are flights to Defiance?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Defiance on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $128, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Defiance?

The trick to saving a stack of cash on your flight to Defiance? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $128 right now, why wait?

Defiance Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$128

Last Minute Hotel Deals in Defiance

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3 out of 5
1088 South Highway Drive, Fenton, MO
The price is $110 per night from Apr 7 to Apr 8
$110
includes taxes & fees
Apr 7 - Apr 8
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,005 reviews)
A Good Deal
"We were very pleased with this hotel overall, and the price was quite reasonable. No big complaints at all, although most of the breakfast was overcooked...."

Reviewed on Mar 30, 2025

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Ameristar Casino Resort and Spa
Ameristar Casino Resort and Spa
4.5 out of 5
1 Ameristar Blvd, St. Charles, MO
The price is $194 per night from Apr 20 to Apr 21
$194
includes taxes & fees
Apr 20 - Apr 21
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms and the property ...
8.2/10 Very Good! (1,003 reviews)
"The staff was very helpful and friendly. The room was clean and up to date. Love are stay and would recommend this establishment to others!"

Reviewed on Apr 2, 2025

Ameristar Casino Resort and Spa
The Wildwood Hotel
The Wildwood Hotel
3.5 out of 5
2801 Fountain Pl, Wildwood, MO
The price is $118 per night from Apr 8 to Apr 9
$118
includes taxes & fees
Apr 8 - Apr 9
Stay at this 3.5-star business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
9/10 Wonderful! (1,473 reviews)
"Very clean, polite staff, excellent breakfast, and beautiful rooms."

Reviewed on Apr 4, 2025

The Wildwood Hotel
La Quinta Inn & Suites by Wyndham St. Louis Westport
La Quinta Inn & Suites by Wyndham St. Louis Westport
2.5 out of 5
11805 Lackland Rd, Maryland Heights, MO
The price is $102 per night from May 4 to May 5
$102
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.2/10 Good! (1,003 reviews)
"Good enough, some older items in some disrepair"

Reviewed on Apr 3, 2025

La Quinta Inn & Suites by Wyndham St. Louis Westport
Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. Louis
3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
The price is $155 per night from Apr 13 to Apr 14
$155
includes taxes & fees
Apr 13 - Apr 14
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,863 reviews)
"We enjoyed dinner at the Italian restaurant. We had a wonderful server."

Reviewed on Apr 2, 2025

Hollywood Casino & Hotel St. Louis
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
2.5 out of 5
1970 Craig Rd, Maryland Heights, MO
The price is $70 per night from Apr 20 to Apr 21
$70
includes taxes & fees
Apr 20 - Apr 21
Stay at this hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
4.6/10 (1,000 reviews)
"helpful and chill"

Reviewed on Mar 29, 2025

Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Wingate by Wyndham St. Louis/Fenton Route 66
Wingate by Wyndham St. Louis/Fenton Route 66
3 out of 5
1100 S Highway Dr, Fenton, MO
The price is $91 per night from Apr 13 to Apr 14
$91
includes taxes & fees
Apr 13 - Apr 14
Stay at this 3-star business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (1,004 reviews)
"Excellent attendance, all employees are very kind."

Reviewed on Mar 31, 2025

Wingate by Wyndham St. Louis/Fenton Route 66
Crowne Plaza St. Louis Airport by IHG
Crowne Plaza St. Louis Airport by IHG
3.5 out of 5
11228 Lone Eagle Dr, Bridgeton, MO
The price is $163 per night from Apr 18 to Apr 19
$163
includes taxes & fees
Apr 18 - Apr 19
Stay at this 3.5-star business-friendly hotel in Bridgeton. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
8/10 Very Good! (1,003 reviews)
"Nice hotel"

Reviewed on Apr 4, 2025

Crowne Plaza St. Louis Airport by IHG
See all 815 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.