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Hotels in Defiance

Choose from 819 Defiance Hotel Deals

Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. Louis
3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
  • 38 min drive from Historic Daniel Boone Home and Heritage Center
The price is $143 per night from Apr 15 to Apr 16
$143
includes taxes & fees
Apr 15 - Apr 16
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,867 reviews)
"Love all the slot machine’s and the hotel room was nice"

Reviewed on Apr 10, 2025

Hollywood Casino & Hotel St. Louis
Ameristar Casino Resort and Spa
Ameristar Casino Resort and Spa
4.5 out of 5
1 Ameristar Blvd, St. Charles, MO
  • 38 min drive from Historic Daniel Boone Home and Heritage Center
The price is $194 per night from Apr 20 to Apr 21
$194
includes taxes & fees
Apr 20 - Apr 21
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms and the property ...
8.2/10 Very Good! (1,008 reviews)
"Had to wait about an hour for an attendant to come to a machine so I could cash out. Otherwise great stay"

Reviewed on Apr 11, 2025

Ameristar Casino Resort and Spa
The Wildwood Hotel
The Wildwood Hotel
3.5 out of 5
2801 Fountain Pl, Wildwood, MO
  • 26 min drive from Historic Daniel Boone Home and Heritage Center
The price is $118 per night from Apr 15 to Apr 16
$118
includes taxes & fees
Apr 15 - Apr 16
Stay at this 3.5-star business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
9/10 Wonderful! (1,482 reviews)
"Staff was magnificent"

Reviewed on Apr 11, 2025

The Wildwood Hotel
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3 out of 5
1088 South Highway Drive, Fenton, MO
  • 44 min drive from Historic Daniel Boone Home and Heritage Center
The price is $110 per night from Apr 17 to Apr 18
$110
includes taxes & fees
Apr 17 - Apr 18
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,009 reviews)
"Good for the money"

Reviewed on Apr 11, 2025

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
La Quinta Inn & Suites by Wyndham St. Louis Westport
La Quinta Inn & Suites by Wyndham St. Louis Westport
2.5 out of 5
11805 Lackland Rd, Maryland Heights, MO
  • 40 min drive from Historic Daniel Boone Home and Heritage Center
The price is $103 per night from Apr 18 to Apr 19
$103
includes taxes & fees
Apr 18 - Apr 19
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7/10 Good! (1,004 reviews)
"It was a really smooth and easy experience. Check-in took practically no time, and the room were clean, neat, and spacious. It was also really affordable!"

Reviewed on Apr 11, 2025

La Quinta Inn & Suites by Wyndham St. Louis Westport
Wingate by Wyndham St. Louis/Fenton Route 66
Wingate by Wyndham St. Louis/Fenton Route 66
3 out of 5
1100 S Highway Dr, Fenton, MO
  • 44 min drive from Historic Daniel Boone Home and Heritage Center
The price is $91 per night from Apr 15 to Apr 16
$91
includes taxes & fees
Apr 15 - Apr 16
Stay at this 3-star business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (1,012 reviews)
"."

Reviewed on Apr 11, 2025

Wingate by Wyndham St. Louis/Fenton Route 66
Crowne Plaza St. Louis Airport by IHG
Crowne Plaza St. Louis Airport by IHG
3.5 out of 5
11228 Lone Eagle Dr, Bridgeton, MO
  • 44 min drive from Historic Daniel Boone Home and Heritage Center
The price is $162 per night from Apr 16 to Apr 17
$162
includes taxes & fees
Apr 16 - Apr 17
Stay at this 3.5-star business-friendly hotel in Bridgeton. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
8/10 Very Good! (1,000 reviews)
"Great location close to the airport. Easy in and out. Steve was very friendly and helpful. I would stay there again if I were flying into St. Louis."

Reviewed on Apr 7, 2025

Crowne Plaza St. Louis Airport by IHG
Sonesta ES Suites St. Louis - Chesterfield
Sonesta ES Suites St. Louis - Chesterfield
3 out of 5
15431 Conway Rd, Chesterfield, MO
  • 29 min drive from Historic Daniel Boone Home and Heritage Center
The price is $108 per night from Apr 21 to Apr 22
$108
includes taxes & fees
Apr 21 - Apr 22
Stay at this hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,006 reviews)
"Condo style"

Reviewed on Apr 12, 2025

Sonesta ES Suites St. Louis - Chesterfield
Hyatt Place St. Louis/Chesterfield
Hyatt Place St. Louis/Chesterfield
3 out of 5
333 Chesterfield Center East, Chesterfield, MO
  • 28 min drive from Historic Daniel Boone Home and Heritage Center
The price is $138 per night from May 4 to May 5
$138
includes taxes & fees
May 4 - May 5
Stay at this 3-star business-friendly hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,005 reviews)
"Good location. Good restaurant close by."

Reviewed on Apr 12, 2025

Hyatt Place St. Louis/Chesterfield
Hilton St. Louis Frontenac
Hilton St. Louis Frontenac
4 out of 5
1335 S Lindbergh Blvd, Frontenac, MO
  • 44 min drive from Historic Daniel Boone Home and Heritage Center
The price is $161 per night from Apr 22 to Apr 23
$161
includes taxes & fees
Apr 22 - Apr 23
Book a stay at this business-friendly hotel in Frontenac. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the property ...
8.6/10 Excellent! (1,003 reviews)
"Great location with easy access to downtown St. Louis and local medical facilities. Parking is very convenient, and the staff is nice and courteous. However, the hotel rooms are somewhat run down and need a significant facelift."

Reviewed on Apr 9, 2025

Hilton St. Louis Frontenac
Drury Plaza Hotel St. Louis St. Charles
Drury Plaza Hotel St. Louis St. Charles
3 out of 5
380 Mulholland Drive, St. Charles, MO
  • 37 min drive from Historic Daniel Boone Home and Heritage Center
The price is $128 per night from Apr 20 to Apr 21
$128
includes taxes & fees
Apr 20 - Apr 21
Stay at this 3-star business-friendly hotel in St. Charles. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,001 reviews)
"Slept great in the comfy king bed. Breakfast was hot. Super stay."

Reviewed on Apr 8, 2025

Drury Plaza Hotel St. Louis St. Charles
Drury Plaza Hotel St. Louis Chesterfield
Drury Plaza Hotel St. Louis Chesterfield
3 out of 5
355 Chesterfield Ctr, Chesterfield, MO
  • 28 min drive from Historic Daniel Boone Home and Heritage Center
The price is $151 per night from Apr 20 to Apr 21
$151
includes taxes & fees
Apr 20 - Apr 21
Stay at this 3-star business-friendly hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,001 reviews)
"poor wifi connection"

Reviewed on Apr 8, 2025

Drury Plaza Hotel St. Louis Chesterfield
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Defiance

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How many hotels are there in Defiance?

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