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Hollywood Casino & Hotel St. Louis
"Always love staying here! Rooms are so spacious and comfy"
Reviewed on Nov 1, 2026

Ameristar Casino Resort and Spa

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

The Wildwood Hotel

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
"Definitely feel like I got ripped off . I will not stay here again"
Reviewed on Nov 1, 2026

Sonesta ES Suites St. Louis - Chesterfield

Drury Inn & Suites St. Louis St. Peters
"We thoroughly enjoyed our stay at Drury, but we were a bit disappointed by a couple of things that were not in the management's ability to help before we came to the hotel. Their evening meal with the room was good, they are friendly as usual. But the sofa in our suite (of the sofa bed) was pretty ..."
Reviewed on Nov 2, 2026

Days Inn and Suites by Wyndham St. Louis/Westport Plaza
"Absolutely horrible"
Reviewed on Nov 1, 2026

Wingate by Wyndham St. Louis/Fenton Route 66

Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

Hampton Inn St. Charles St. Peters

Drury Plaza Hotel St. Louis Chesterfield
"The room was clean. No noises. Free breakfast was stocked. Staff were helpful and on top of everything"
Reviewed on Nov 1, 2026
Find cheap hotels in Defiance
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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Defiance.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Defiance’s 897 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $69. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Defiance hotel deals at the last minute.
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Frequently Asked Questions About Defiance hotels
Where can I find the best last-minute travel deals?
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How many hotels are there in Defiance?
With over 897 hotels in Defiance, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $69.
How to find cheap car rentals in Defiance?
Finding a cheap car rental deal in Defiance is as easy as scoring cheap hotels in Defiance. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
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