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Hotels in Defiance

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Choose from 828 Defiance Hotel Deals

Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. Louis
3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
  • 24 min drive from August A. Busch Memorial Conservation Area
The price is $127 per night from Nov 24 to Nov 25
$127
includes taxes & fees
Nov 24 - Nov 25
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,687 reviews)
"Was a get away and found what I needed here at this casino great food and great people"

Reviewed on Nov 21, 2024

Hollywood Casino & Hotel St. Louis
La Quinta Inn & Suites by Wyndham St. Louis Westport
La Quinta Inn & Suites by Wyndham St. Louis Westport
2.5 out of 5
11805 Lackland Rd, Maryland Heights, MO
  • 29 min drive from August A. Busch Memorial Conservation Area
The price is $88 per night from Nov 25 to Nov 26
$88
includes taxes & fees
Nov 25 - Nov 26
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.2/10 Good! (1,002 reviews)
"Property appears to be primarily for extended stay and pets. The first room I was placed in smelled like dog, the concierge immediately found me a new room, no animal smell. Room was very clean!"

Reviewed on Nov 13, 2024

La Quinta Inn & Suites by Wyndham St. Louis Westport
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3 out of 5
1088 South Highway Drive, Fenton, MO
  • 41 min drive from August A. Busch Memorial Conservation Area
The price is $103 per night from Nov 24 to Nov 25
$103
includes taxes & fees
Nov 24 - Nov 25
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9/10 Wonderful! (1,002 reviews)
"The indoor/outdoor pool was nice but was not heated though."

Reviewed on Nov 20, 2024

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
The Wildwood Hotel
The Wildwood Hotel
3.5 out of 5
2801 Fountain Pl, Wildwood, MO
  • 26 min drive from August A. Busch Memorial Conservation Area
The price is $130 per night from Nov 24 to Nov 25
$130
includes taxes & fees
Nov 24 - Nov 25
Stay at this 3.5-star business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
9/10 Wonderful! (1,417 reviews)
"Very clean and accomodating hotel. Nice furniture and comfortable bed."

Reviewed on Nov 21, 2024

The Wildwood Hotel
Ameristar Casino Resort and Spa
Ameristar Casino Resort and Spa
4.5 out of 5
1 Ameristar Blvd, St. Charles, MO
  • 24 min drive from August A. Busch Memorial Conservation Area
The price is $203 per night from Dec 3 to Dec 4
$203
includes taxes & fees
Dec 3 - Dec 4
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 5 restaurants. Our guests praise the clean rooms and the property ...
8.2/10 Very Good! (1,000 reviews)
"Qhite"

Reviewed on Nov 18, 2024

Ameristar Casino Resort and Spa
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
2.5 out of 5
1970 Craig Rd, Maryland Heights, MO
  • 28 min drive from August A. Busch Memorial Conservation Area
The price is $69 per night from Nov 25 to Nov 26
$69
includes taxes & fees
Nov 25 - Nov 26
Stay at this hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
4.6/10 (1,000 reviews)
"Cool place"

Reviewed on Nov 15, 2024

Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Sonesta ES Suites St. Louis - Chesterfield
Sonesta ES Suites St. Louis - Chesterfield
3 out of 5
15431 Conway Rd, Chesterfield, MO
  • 22 min drive from August A. Busch Memorial Conservation Area
The price is $104 per night from Dec 8 to Dec 9
$104
includes taxes & fees
Dec 8 - Dec 9
Stay at this hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,000 reviews)
"Easy check in, clean and quiet."

Reviewed on Nov 18, 2024

Sonesta ES Suites St. Louis - Chesterfield
Drury Plaza Hotel St. Louis Chesterfield
Drury Plaza Hotel St. Louis Chesterfield
3 out of 5
355 Chesterfield Ctr, Chesterfield, MO
  • 21 min drive from August A. Busch Memorial Conservation Area
The price is $146 per night from Nov 27 to Nov 28
$146
includes taxes & fees
Nov 27 - Nov 28
Stay at this 3-star business-friendly hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,000 reviews)
Best hotel in the area
"The desk staff, Jim and Gabe, were amazing and friendly. Attentive to a slight room mishap and provided care packages. The free dinner, happy hour and breakfast was great. New favorite hotel in the area!"

Reviewed on Nov 16, 2024

Drury Plaza Hotel St. Louis Chesterfield
Embassy Suites by Hilton St. Louis St. Charles
Embassy Suites by Hilton St. Louis St. Charles
3.5 out of 5
2 Convention Center Plz, St. Charles, MO
  • 23 min drive from August A. Busch Memorial Conservation Area
The price is $120 per night from Nov 25 to Nov 26
$120
includes taxes & fees
Nov 25 - Nov 26
Stay at this 3.5-star business-friendly hotel in St. Charles. Enjoy free breakfast, free parking, and a free area shuttle. Our guests praise the breakfast and ...
8.8/10 Excellent! (1,150 reviews)
"Everyone was great"

Reviewed on Nov 18, 2024

Embassy Suites by Hilton St. Louis St. Charles
Wingate by Wyndham St. Louis/Fenton Route 66
Wingate by Wyndham St. Louis/Fenton Route 66
2.5 out of 5
1100 S Highway Dr, Fenton, MO
  • 41 min drive from August A. Busch Memorial Conservation Area
The price is $90 per night from Nov 25 to Nov 26
$90
includes taxes & fees
Nov 25 - Nov 26
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (1,008 reviews)
"."

Reviewed on Nov 23, 2024

Wingate by Wyndham St. Louis/Fenton Route 66
Crowne Plaza St. Louis Airport, an IHG Hotel
Crowne Plaza St. Louis Airport, an IHG Hotel
3.5 out of 5
11228 Lone Eagle Dr, Bridgeton, MO
  • 31 min drive from August A. Busch Memorial Conservation Area
The price is $138 per night from Dec 8 to Dec 9
$138
includes taxes & fees
Dec 8 - Dec 9
Stay at this 3.5-star business-friendly hotel in Bridgeton. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
7.8/10 Good! (1,001 reviews)
"Staff was nice"

Reviewed on Nov 19, 2024

Crowne Plaza St. Louis Airport, an IHG Hotel
Best Western Plus The Charles Hotel
Best Western Plus The Charles Hotel
3 out of 5
1425 South 5th Street, St. Charles, MO
  • 24 min drive from August A. Busch Memorial Conservation Area
The price is $110 per night from Nov 27 to Nov 28
$110
includes taxes & fees
Nov 27 - Nov 28
Book a stay at this business-friendly hotel in St. Charles. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.8/10 Good! (1,001 reviews)
"Hotel was convenient for our needs and plenty of choices for dining close by."

Reviewed on Nov 18, 2024

Best Western Plus The Charles Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Defiance

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Defiance.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Defiance’s 828 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $69. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Defiance hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Defiance. No matter your reason for visiting Defiance, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Defiance hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Defiance for as low as $69.

How many hotels are there in Defiance?

With over 828 hotels in Defiance, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $69.

How to find cheap car rentals in Defiance?

Finding a cheap car rental deal in Defiance is as easy as scoring cheap hotels in Defiance. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Defiance now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Defiance right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.