Search for Cheap Deals onHotels in Defiance
Choose from 875 Defiance Hotel Deals
Hollywood Casino & Hotel St. Louis
"Will be back for sure 😊"
Reviewed on Jul 16, 2026
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
"We needed handicap features for my husband in a wheelchair. The hotel wasn’t able to provide a shower chair that fit in the tub. We had to buy our own. There must’ve been a breakdown in communication regarding house keeping. While we hung the do not disturb sign on our door for the first 2 nights ..."
Reviewed on Jul 16, 2026
The Wildwood Hotel
"My stay was a normal stay. Nothing special."
Reviewed on Jul 17, 2026
Hilton St. Louis Frontenac
Ameristar Casino Resort and Spa
"Everything was great, just wish the kids had pool access."
Reviewed on Jul 15, 2026
Wingate by Wyndham St. Louis/Fenton Route 66
La Quinta Inn & Suites by Wyndham St. Louis Westport
Drury Plaza Hotel St. Louis Chesterfield
"Good stay, however, room was the smallest two room suite I’ve ever had at a Drury and was an odd set up."
Reviewed on Jul 16, 2026
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
"The room is very spacious, bed is comfortable. There’s a kitchen with full fridge, am sure it was fully equipped but guests have either broke the utensils and whatnot so some are missing. It helps for long stays because you can cook meals. Housekeeping personnel ( the one’s I talk to can’t speak ..."
Reviewed on Jul 16, 2026
Best Western Plus Fenton
"Staff was excellent, very friendly and helpful. The room was okay, first night the floors were fairly dirty but ok for second and third nights. A/C was good. Breakfast was pretty standard but very nice to have when getting going in the morning. The area and the hotel were quiet and in a safe location. ..."
Reviewed on Jul 17, 2026
Sleep Inn & Suites O'Fallon MO - Technology Drive
Courtyard by Marriott St Louis Westport Plaza
"Clean room helpful staff. I would stay again"
Reviewed on Jul 14, 2026
Find cheap hotels in Defiance
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Defiance hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in Defiance.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Defiance’s 875 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $99. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Defiance hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Defiance. No matter your reason for visiting Defiance, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Defiance hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Defiance for as low as $99.
How many hotels are there in Defiance?
With over 875 hotels in Defiance, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $99.
How to find cheap car rentals in Defiance?
Finding a cheap car rental deal in Defiance is as easy as scoring cheap hotels in Defiance. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
- Hotels near Chandler Hill Vineyards
- Hotels near August A. Busch Memorial Conservation Area
- Hotels near Sugar Creek Winery
- Hotels near Broemmelsiek Park
- Hotels near Yellow Farmhouse Winery
- Hotels near Historic Daniel Boone Home and Heritage Center
- Hotels near Six Flags St. Louis
- Hotels near Hollywood Casino Amphitheatre
- Hotels near Ameristar Casino St. Charles
- Hotels near Mississippi River
- Hotels near Westport Plaza
- Hotels near St Charles Convention Center
- Hotels near Magic House - St. Louis Children's Museum
- Hotels near St. Louis Premium Outlets
- Hotels near Purina Farms
- Hotels near Historic Main Street
- Hotels near Route 66 State Park
- Hotels near Hollywood Casino
- Hotels near Lindenwood University
- Hotels near The Factory
- St. Charles Hotels
- Chesterfield Hotels
- Maryland Heights Hotels
- Fenton Hotels
- Innsbrook Hotels
- St. Peters Hotels
- O'Fallon Hotels
- Ozarks Hotels
- Wentzville Hotels
- Eureka Hotels
- Hazelwood Hotels
- Kirkwood Hotels
- Washington Hotels
- Town and Country Hotels
- Bridgeton Hotels
- Ballwin Hotels
- St. Ann Hotels
- Florissant Hotels
- Wildwood Hotels
- Warrenton Hotels
