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Hotels in Defiance

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Tonight Jan 11 - Jan 12Next weekend Jan 17 - Jan 19

Choose from 826 Defiance Hotel Deals

Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. Louis
3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
  • 24 min drive from August A. Busch Memorial Conservation Area
The price is $114 per night from Jan 12 to Jan 13
$114
includes taxes & fees
Jan 12 - Jan 13
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,767 reviews)
"Nice room. Fun slot games"

Reviewed on Jan 9, 2025

Hollywood Casino & Hotel St. Louis
La Quinta Inn & Suites by Wyndham St. Louis Westport
La Quinta Inn & Suites by Wyndham St. Louis Westport
2.5 out of 5
11805 Lackland Rd, Maryland Heights, MO
  • 29 min drive from August A. Busch Memorial Conservation Area
The price is $89 per night from Jan 13 to Jan 14
$89
includes taxes & fees
Jan 13 - Jan 14
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.2/10 Good! (1,003 reviews)
"It’s been good"

Reviewed on Jan 8, 2025

La Quinta Inn & Suites by Wyndham St. Louis Westport
The Wildwood Hotel
The Wildwood Hotel
3.5 out of 5
2801 Fountain Pl, Wildwood, MO
  • 26 min drive from August A. Busch Memorial Conservation Area
The price is $118 per night from Jan 12 to Jan 13
$118
includes taxes & fees
Jan 12 - Jan 13
Stay at this 3.5-star business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
9/10 Wonderful! (1,432 reviews)
"It was great! The breakfast was a little lacking and the hot tub was small and more warm than hot, but still a wonderful stay!"

Reviewed on Jan 7, 2025

The Wildwood Hotel
Sonesta ES Suites St. Louis - Chesterfield
Sonesta ES Suites St. Louis - Chesterfield
3 out of 5
15431 Conway Rd, Chesterfield, MO
  • 22 min drive from August A. Busch Memorial Conservation Area
The price is $108 per night from Jan 20 to Jan 21
$108
includes taxes & fees
Jan 20 - Jan 21
Stay at this hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,002 reviews)
Good for our purposes
"Didn't use the kitchen, or the breakfast so I cannot comment on it. Bed was comfortable, lots of closet and drawer space. The shower controls were faulty, but be contacted the front desk and they got it fixed. The water pressure from the sink was minimal"

Reviewed on Dec 30, 2024

Sonesta ES Suites St. Louis - Chesterfield
Ameristar Casino Resort and Spa
Ameristar Casino Resort and Spa
4.5 out of 5
1 Ameristar Blvd, St. Charles, MO
  • 24 min drive from August A. Busch Memorial Conservation Area
The price is $214 per night from Jan 20 to Jan 21
$214
includes taxes & fees
Jan 20 - Jan 21
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms and the property ...
8.2/10 Very Good! (1,003 reviews)
Excellent
"Our state was just amazing. We were very impressed with our room and the customer service."

Reviewed on Jan 3, 2025

Ameristar Casino Resort and Spa
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
2.5 out of 5
1970 Craig Rd, Maryland Heights, MO
  • 28 min drive from August A. Busch Memorial Conservation Area
The price is $69 per night from Jan 13 to Jan 14
$69
includes taxes & fees
Jan 13 - Jan 14
Stay at this hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
4.6/10 (1,001 reviews)
"As someone who travels by car and loves road trips, I am familiar with the overall quality of affordable motels in the US. My adult son and I stopped at this place on our cross country road trip. If you are on a budget but want clean, safe, convenient--this place is great. The fact that there was ..."

Reviewed on Dec 9, 2024

Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Drury Plaza Hotel St. Louis Chesterfield
Drury Plaza Hotel St. Louis Chesterfield
3 out of 5
355 Chesterfield Ctr, Chesterfield, MO
  • 21 min drive from August A. Busch Memorial Conservation Area
The price is $146 per night from Jan 26 to Jan 27
$146
includes taxes & fees
Jan 26 - Jan 27
Stay at this 3-star business-friendly hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,001 reviews)
"everything was great"

Reviewed on Jan 7, 2025

Drury Plaza Hotel St. Louis Chesterfield
Embassy Suites by Hilton St. Louis St. Charles
Embassy Suites by Hilton St. Louis St. Charles
3.5 out of 5
2 Convention Center Plz, St. Charles, MO
  • 23 min drive from August A. Busch Memorial Conservation Area
The price is $150 per night from Jan 26 to Jan 27
$150
includes taxes & fees
Jan 26 - Jan 27
Stay at this 3.5-star business-friendly hotel in St. Charles. Enjoy free breakfast, free parking, and a free area shuttle. Our guests praise the breakfast and ...
8.8/10 Excellent! (1,164 reviews)
"Very nice rooms felt like I was home"

Reviewed on Jan 10, 2025

Embassy Suites by Hilton St. Louis St. Charles
Crowne Plaza St. Louis Airport, an IHG Hotel
Crowne Plaza St. Louis Airport, an IHG Hotel
3.5 out of 5
11228 Lone Eagle Dr, Bridgeton, MO
  • 31 min drive from August A. Busch Memorial Conservation Area
The price is $157 per night from Jan 13 to Jan 14
$157
includes taxes & fees
Jan 13 - Jan 14
Stay at this 3.5-star business-friendly hotel in Bridgeton. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
7.8/10 Good! (1,005 reviews)
"Close to the airport with frequent shuttle runs. Hotel was pretty. Breakfast buffet was good."

Reviewed on Jan 10, 2025

Crowne Plaza St. Louis Airport, an IHG Hotel
Hilton St. Louis Frontenac
Hilton St. Louis Frontenac
4 out of 5
1335 S Lindbergh Blvd, Frontenac, MO
  • 36 min drive from August A. Busch Memorial Conservation Area
The price is $148 per night from Jan 19 to Jan 20
$148
includes taxes & fees
Jan 19 - Jan 20
Book a stay at this business-friendly hotel in Frontenac. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the property ...
8.6/10 Excellent! (1,000 reviews)
"The hotel was excellent."

Reviewed on Jan 6, 2025

Hilton St. Louis Frontenac
Wingate by Wyndham St. Louis/Fenton Route 66
Wingate by Wyndham St. Louis/Fenton Route 66
2.5 out of 5
1100 S Highway Dr, Fenton, MO
  • 41 min drive from August A. Busch Memorial Conservation Area
The price is $87 per night from Jan 12 to Jan 13
$87
includes taxes & fees
Jan 12 - Jan 13
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (1,003 reviews)
"Very clean and peaceful. Comfortable stay every time. The staff is outstanding"

Reviewed on Jan 9, 2025

Wingate by Wyndham St. Louis/Fenton Route 66
DoubleTree by Hilton Hotel St. Louis - Chesterfield
DoubleTree by Hilton Hotel St. Louis - Chesterfield
4 out of 5
16625 Swingley Ridge Rd, Chesterfield, MO
  • 20 min drive from August A. Busch Memorial Conservation Area
The price is $138 per night from Feb 1 to Feb 2
$138
includes taxes & fees
Feb 1 - Feb 2
Book a stay at this business-friendly hotel in Chesterfield. Enjoy free parking, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff ...
8.6/10 Excellent! (1,000 reviews)
"Nice place great staff super friendly"

Reviewed on Jan 2, 2025

DoubleTree by Hilton Hotel St. Louis - Chesterfield
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Defiance

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If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $69. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Defiance hotel deals at the last minute.

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Frequently Asked Questions About Defiance hotels

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How many hotels are there in Defiance?

With over 826 hotels in Defiance, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $69.

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