Search for Cheap Deals onHotels in Defiance
Choose from 877 Defiance Hotel Deals
Hollywood Casino & Hotel St. Louis
"Everyone there was Great!"
Reviewed on Jun 26, 2026
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
"Great location"
Reviewed on Jun 25, 2026
The Wildwood Hotel
"No hotel only parking, must use public parking."
Reviewed on Jun 25, 2026
Hilton St. Louis Frontenac
"Rooms in the villa portion o g the hotel are old and smell like mold. They had a febreeze car air freshener in the AC unit to make the room smell better. I asked to be moved and the main hotel was much nicer and cleaner."
Reviewed on Jun 23, 2026
Ameristar Casino Resort and Spa
"Upon arrival, we observed several cleanliness and maintenance issues in the room. The couch had visible spots and hair on it. There appeared to be red stains or residue on the curtains. Additionally, the toilet was not functioning properly. These conditions did not meet our expectations for cleanliness ..."
Reviewed on Jun 24, 2026
WoodSpring Suites St Peters-OFallon
"The hotel is clean well maintained and convenient. The staff were friendly and professional. I enjoyed my stay and look forward for staying again when visiting St. Louis Mo."
Reviewed on Jun 26, 2026
Sonesta ES Suites St. Louis - Chesterfield
"Great for families. Good breakfast and pool."
Reviewed on Jun 24, 2026
Courtyard by Marriott St Louis Westport Plaza
"There was a loud intermittent noise from the HVAC or the neighbors air conditioner."
Reviewed on Jun 18, 2026
La Quinta Inn & Suites by Wyndham St. Louis Westport
"Very little won’t be back"
Reviewed on Jun 25, 2026
Sleep Inn & Suites O'Fallon MO - Technology Drive
"Pool was dirty. Lots of ants in the room."
Reviewed on Jun 25, 2026
Wingate by Wyndham St. Louis/Fenton Route 66
"On my second night someone entered my room after 10:00 and claimed they had put their belongings in the room earlier. No one answered at the desk when my husband called to find out how someone else had a card to get in our room. Upon checking out the next morning, we told the clerk what happened ..."
Reviewed on Jun 25, 2026
Drury Plaza Hotel St. Louis Chesterfield
"Great place to stay not as busy as downtown locations. Convenient parking."
Reviewed on Jun 26, 2026
Find cheap hotels in Defiance
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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Defiance.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Defiance’s 877 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $99. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Defiance hotel deals at the last minute.
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Frequently Asked Questions About Defiance hotels
Where can I find the best last-minute travel deals?
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How many hotels are there in Defiance?
With over 877 hotels in Defiance, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $99.
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