Hotels Near
East Main Street

Check Last Minute East Main Street Hotel Deals

Tonight May 4 - May 5Next weekend May 9 - May 11

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!


Featured East Main Street Hotels

Grand Vista Hotel
Grand Vista Hotel
3.5 out of 5
2790 Crossroads Blvd, Grand Junction, CO
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in Grand Junction. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the restaurant ...
8.2/10 Very Good! (3,054 reviews)
Very nice!
"Spacious fourth floor room at a great price the night the stayed there. Be aware that parking is at an additional charge, so you can choose to park on the street and walk a few extra steps."

Reviewed on May 3, 2025

Grand Vista Hotel
La Quinta Inn & Suites by Wyndham Grand Junction
La Quinta Inn & Suites by Wyndham Grand Junction
2.5 out of 5
2761 Crossroads Blvd, Grand Junction, CO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Grand Junction. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (2,418 reviews)
"We stayed several times last fall good clean etc but this time neither of the outer doors locked. One didn’t have any hardware. Always clean but our toilet kept flushing. Elevator didn’t work and we were on 5th floor"

Reviewed on May 3, 2025

La Quinta Inn & Suites by Wyndham Grand Junction
Clarion Inn Grand Junction
Clarion Inn Grand Junction
2.5 out of 5
755 Horizon Drive, Grand Junction, CO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Grand Junction. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
8.6/10 Excellent! (1,395 reviews)
Seriously impressed, will come back!
"I love this hotel. I honestly had fairly low expectations, but the Clarion Inn in GJ really impressed me. Check-in was a breeze. My room was updated and clean, and even had art on the wall that I sincerely enjoyed looking at (Douglas Chun). The included breakfast had waffles, B&G, sausage, eggs, ..."

Reviewed on May 1, 2025

Clarion Inn Grand Junction
Ramada by Wyndham Grand Junction
Ramada by Wyndham Grand Junction
2.5 out of 5
752 Horizon Dr, I-70 at Exit 31, Grand Junction, CO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Grand Junction. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
8.4/10 Very Good! (1,565 reviews)
"It's outdated, but for the price it was fine. It's very clean. The young gentleman that checked me in was very nice and helpful."

Reviewed on May 3, 2025

Ramada by Wyndham Grand Junction
Wine Country Inn Palisade
Wine Country Inn Palisade
3.5 out of 5
777 Grande River Drive, Palisade, CO
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in Palisade. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
9.6/10 Exceptional! (1,007 reviews)
"This place is beautiful. I highly recommend staying there."

Reviewed on May 1, 2025

Wine Country Inn Palisade
La Quinta Inn & Suites by Wyndham Fruita
La Quinta Inn & Suites by Wyndham Fruita
2.5 out of 5
570 Raptor Rd, Fruita, CO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Fruita. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (1,004 reviews)
"We were very happy - good price for a good room."

Reviewed on May 2, 2025

La Quinta Inn & Suites by Wyndham Fruita
Comfort Inn & Suites
Comfort Inn & Suites
2.5 out of 5
400 Jurassic Ave, Fruita, CO
Fully refundableReserve now, pay when you stay
Book a stay at this golf hotel in Fruita. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,002 reviews)
"No"

Reviewed on May 2, 2025

Comfort Inn & Suites
Studio 6 Grand Junction, CO
Studio 6 Grand Junction, CO
2 out of 5
704 Horizon Dr, Grand Junction, CO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly motel in Grand Junction. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
7.4/10 Good! (1,006 reviews)
"They have updated these rooms. The rooms are clean, modern, and have fridge, toaster, microwave and coffee pot."

Reviewed on May 2, 2025

Studio 6 Grand Junction, CO
Courtyard by Marriott Grand Junction
Courtyard by Marriott Grand Junction
3 out of 5
765 Horizon Drive, Grand Junction, CO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Grand Junction. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
8.4/10 Very Good! (1,003 reviews)
"Staff was exceptionally helpful and very kind; at the front desk, and in their Bistro."

Reviewed on Apr 25, 2025

Courtyard by Marriott Grand Junction
Hotel Maverick
Hotel Maverick
4 out of 5
840 Kennedy Avenue, Grand Junction, CO
Stay at this 4-star hotel in Grand Junction. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the restaurant and the helpful staff ...
9.6/10 Exceptional! (1,001 reviews)
"Great new option in Grand Junction. Really impressed with the connection to Colorado Mesa University. Great setting."

Reviewed on Apr 27, 2025

Hotel Maverick
Doubletree Hotel Grand Junction
Doubletree Hotel Grand Junction
4 out of 5
743 Horizon Dr, Grand Junction, CO
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in Grand Junction. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff ...
8/10 Very Good! (1,003 reviews)
"We stayed there for the convince of getting to the airport. It was amazing."

Reviewed on May 3, 2025

Doubletree Hotel Grand Junction
Comfort Inn Grand Junction I-70
Comfort Inn Grand Junction I-70
2.5 out of 5
750 3/4 Horizon Dr., Grand Junction, CO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Grand Junction. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
8.4/10 Very Good! (1,001 reviews)
"Experience was nice, but when entering the room there was a perfumed smell as if trying to cover up oders."

Reviewed on Apr 27, 2025

Comfort Inn Grand Junction I-70
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in East Main Street

Grand Junction is a city that has a lot going on, but you have your sights set on East Main Street. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that East Main Street has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of East Main Street hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Grand Junction so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the East Main Street underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the East Main Street city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of East Main Street cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in East Main Street at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $76
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the East Main Street hotel you want, book it, and never look back. Because your great escape is ahead of you.