Hotels Near
East Main Street

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Featured East Main Street Hotels

Grand Junction Vacation Rental w/ Fire Pit!

Grand Junction Vacation Rental w/ Fire Pit!

3 out of 5
Grand Junction CO
Book a stay at this business-friendly cottage in Grand Junction. Enjoy free parking and air conditioning. Popular attractions Elliott Tennis Center and Museum ...
10/10 Exceptional! (1 review)
Beautiful home! Super clean, spacious, wonderful place to stay. My family enjoyed it so much they wany to go back. Fit our needs perfectly.

Reviewed on Dec 22, 2025

Grand Junction Vacation Rental w/ Fire Pit!
Grand Vista Hotel

Grand Vista Hotel

3.5 out of 5
2790 Crossroads Blvd Grand Junction CO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Grand Junction. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the restaurant ...
8.2/10 Very Good! (3,471 reviews)
Cool retro hotel… and friendly staff.

Reviewed on Jan 2, 2026

Grand Vista Hotel
La Quinta Inn & Suites by Wyndham Grand Junction

La Quinta Inn & Suites by Wyndham Grand Junction

3 out of 5
2761 Crossroads Blvd Grand Junction CO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Grand Junction. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (2,754 reviews)
Nice place, recommend for overnight stay for travelers. Lots of places to eat near by.

Reviewed on Jan 2, 2026

La Quinta Inn & Suites by Wyndham Grand Junction
Tru by Hilton Grand Junction Downtown

Tru by Hilton Grand Junction Downtown

2.5 out of 5
243 Colorado Ave Grand Junction CO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Grand Junction. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff ...
9/10 Wonderful! (1,010 reviews)
Clean room, friendly staff

Reviewed on Jan 4, 2026

Tru by Hilton Grand Junction Downtown
Clarion Inn Grand Junction

Clarion Inn Grand Junction

2.5 out of 5
755 Horizon Drive Grand Junction CO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Grand Junction. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the ...
8.4/10 Very Good! (1,702 reviews)
Very helpful staff. Fun facility.

Reviewed on Jan 1, 2026

Clarion Inn Grand Junction
Ramada by Wyndham Grand Junction

Ramada by Wyndham Grand Junction

2.5 out of 5
752 Horizon Dr Grand Junction CO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Grand Junction. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
8.2/10 Very Good! (1,862 reviews)
Room was clean.

Reviewed on Dec 29, 2025

Ramada by Wyndham Grand Junction
Hotel Maverick

Hotel Maverick

4 out of 5
840 Kennedy Avenue Grand Junction CO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Grand Junction. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the restaurant and the helpful staff in ...
9.6/10 Exceptional! (1,002 reviews)
Kind and attentive staff. Beautiful rooftop resterant and patio.

Reviewed on Dec 16, 2025

Hotel Maverick
Comfort Inn Grand Junction I-70

Comfort Inn Grand Junction I-70

2.5 out of 5
750 3/4 Horizon Dr. Grand Junction CO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Grand Junction. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
8.6/10 Excellent! (1,004 reviews)
Nice , clean and hot breakfast

Reviewed on Dec 30, 2025

Comfort Inn Grand Junction I-70
Quality Inn Grand Junction near University

Quality Inn Grand Junction near University

3 out of 5
733 Horizon Dr Grand Junction CO
Fully refundableReserve now, pay when you stay
Book a stay at this golf hotel in Grand Junction. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.6/10 Excellent! (1,001 reviews)
Breakfast buffet was very good. Front desk staff was very efficient.

Reviewed on Jan 4, 2026

Quality Inn Grand Junction near University
SpringHill Suites by Marriott Grand Junction Downtown/Historic Main St.

SpringHill Suites by Marriott Grand Junction Downtown/Historic Main St.

3.5 out of 5
236 Main St Grand Junction CO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Grand Junction. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff in our reviews. Popular attractions ...
9/10 Wonderful! (1,007 reviews)
Pool was broken and the sister pool heater was bad as well. A little disappointed for the pools. But everything else was great

Reviewed on Dec 28, 2025

SpringHill Suites by Marriott Grand Junction Downtown/Historic Main St.
Comfort Inn & Suites

Comfort Inn & Suites

2.5 out of 5
400 Jurassic Ave Fruita CO
Fully refundableReserve now, pay when you stay
Book a stay at this golf hotel in Fruita. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful staff in our ...
8.2/10 Very Good! (1,007 reviews)
Room clean and comfortable. Staff very friendly, safe area to stay

Reviewed on Jan 4, 2026

Comfort Inn & Suites
Hampton Inn Grand Junction Downtown/Historic Main Street

Hampton Inn Grand Junction Downtown/Historic Main Street

2.5 out of 5
205 Main St Grand Junction CO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Grand Junction. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff in ...
8.8/10 Excellent! (1,003 reviews)
Everything was great about my stay. Especially Juls.

Reviewed on Jan 3, 2026

Hampton Inn Grand Junction Downtown/Historic Main Street
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in East Main Street

Grand Junction is a city that has a lot going on, but you have your sights set on East Main Street. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that East Main Street has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of East Main Street hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Grand Junction so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the East Main Street underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the East Main Street city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of East Main Street cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in East Main Street at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $62
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the East Main Street hotel you want, book it, and never look back. Because your great escape is ahead of you.