Hotels NearEast Main Street
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Featured East Main Street Hotels

Grand Junction Vacation Rental w/ Fire Pit!
Beautiful home! Super clean, spacious, wonderful place to stay. My family enjoyed it so much they wany to go back. Fit our needs perfectly.
Reviewed on Dec 22, 2025

Grand Vista Hotel
Cool retro hotel… and friendly staff.
Reviewed on Jan 2, 2026

La Quinta Inn & Suites by Wyndham Grand Junction
Nice place, recommend for overnight stay for travelers. Lots of places to eat near by.
Reviewed on Jan 2, 2026

Tru by Hilton Grand Junction Downtown
Clean room, friendly staff
Reviewed on Jan 4, 2026

Clarion Inn Grand Junction
Very helpful staff. Fun facility.
Reviewed on Jan 1, 2026

Ramada by Wyndham Grand Junction
Room was clean.
Reviewed on Dec 29, 2025

Hotel Maverick
Kind and attentive staff. Beautiful rooftop resterant and patio.
Reviewed on Dec 16, 2025

Comfort Inn Grand Junction I-70
Nice , clean and hot breakfast
Reviewed on Dec 30, 2025

Quality Inn Grand Junction near University
Breakfast buffet was very good. Front desk staff was very efficient.
Reviewed on Jan 4, 2026

SpringHill Suites by Marriott Grand Junction Downtown/Historic Main St.
Pool was broken and the sister pool heater was bad as well. A little disappointed for the pools. But everything else was great
Reviewed on Dec 28, 2025

Comfort Inn & Suites
Room clean and comfortable. Staff very friendly, safe area to stay
Reviewed on Jan 4, 2026

Hampton Inn Grand Junction Downtown/Historic Main Street
Everything was great about my stay. Especially Juls.
Reviewed on Jan 3, 2026
Hotels in East Main Street
Grand Junction is a city that has a lot going on, but you have your sights set on East Main Street. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that East Main Street has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of East Main Street hotels that will do the trick.
A beautiful day in the neighborhood
As much as you like getting out there, it’s also good to know a part of Grand Junction so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the East Main Street underground. What’s a journey without a good story to go with it?
Beyond the block
We’re not talking about the East Main Street city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of East Main Street cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:
- Hotwire Hot Rate: Snag some of the best hotels in East Main Street at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
- Price: You have a price in mind, and we have solutions. Hotels start as low as $62
- Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.
Find the East Main Street hotel you want, book it, and never look back. Because your great escape is ahead of you.
Hotels by Star Rating
East Main Street Neighborhoods
Top Attractions in East Main Street
- Hotels near Colorado River (399.03 mi)
- Hotels near Colorado Mesa University (0.8 mi)
- Hotels near Colorado National Monument (8.03 mi)
- Hotels near Canyon View Park (4.19 mi)
- Hotels near Two Rivers Convention Center (0.99 mi)
- Hotels near Redlands Mesa Golf Club (3.86 mi)
- Hotels near Mesa County Fairgrounds (2.31 mi)
- Hotels near Grand Junction Motor Speedway (4.07 mi)
- Hotels near Bananas Fun Park (2.67 mi)
- Hotels near Western Colorado Botanical Gardens (0.97 mi)
- Hotels near Gunnison River (33.89 mi)
- Hotels near Grand Mesa National Forest (34.93 mi)
- Hotels near Western Colorado Center for the Arts (1.26 mi)
- Hotels near High Country Orchards (8.52 mi)
- Hotels near Connected Lakes (2.59 mi)
- Hotels near Colorado Welcome Center (11.56 mi)
- Hotels near Devils Canyon Science and Learning Center (11.65 mi)
- Hotels near James M. Robb – Colorado River State Park (11.65 mi)
- Hotels near Cross Orchards Historic Site (4.03 mi)
Cities near East Main Street
- Grand Junction Hotels (0.24 mi)
- Fruita Hotels (11.42 mi)
- Rocky Mountains Hotels (690.09 mi)
- Palisade Hotels (11.15 mi)
- Mesa Hotels (23.13 mi)
- Clifton Hotels (5.75 mi)
- Western United States Hotels (267.72 mi)
- Gateway Hotels (35.15 mi)
- Southern Rocky Mountains Hotels (91.36 mi)
- Loma Hotels (16.59 mi)
- Whitewater Hotels (21.99 mi)
- De Beque Hotels (26.64 mi)
- Colorado Western Slope Hotels (56.03 mi)
- Glade Park Hotels (11.35 mi)
- Southwest Colorado Hotels (89.18 mi)
- Mountain States Hotels (264.26 mi)
- Northwest Colorado Hotels (84.66 mi)
- Central Colorado Hotels (95.96 mi)
- Southeastern Utah - Glen Canyon National Recreation Area Hotels (103.98 mi)
- Dinosaur Diamond Prehistoric Highway Hotels (66.55 mi)
