Hotels Near
East Main Street

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Featured East Main Street Hotels

Adventure Home Base - 7 Blocks to Downtown!
Adventure Home Base - 7 Blocks to Downtown!
3 out of 5
Grand Junction
Stay at this 3-star cottage in Grand Junction. Enjoy free parking, patios, and in-room fireplaces. Popular attractions Museum of the West and Western Colorado ...
Adventure Home Base - 7 Blocks to Downtown!
Grand Vista Hotel
Grand Vista Hotel
3.5 out of 5
2790 Crossroads Blvd, Grand Junction, CO
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in Grand Junction. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the restaurant ...
8.2/10 Very Good! (3,135 reviews)
"Furniture in the rooms is old and carpet felt dirty."

Reviewed on Jun 20, 2025

Grand Vista Hotel
Ramada by Wyndham Grand Junction
Ramada by Wyndham Grand Junction
2.5 out of 5
752 Horizon Dr, I-70 at Exit 31, Grand Junction, CO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Grand Junction. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
8.4/10 Very Good! (1,596 reviews)
"The room was clean and had plenty of outlets to charge electronics and in very convenient spots. Pet friendly if you have a pet and nice grassy area for your dog. I didn't like that there was no elevator, so you had to carry your luggage up the stairs. The bed was a little too soft for me and the ..."

Reviewed on Jun 22, 2025

Ramada by Wyndham Grand Junction
Clarion Inn Grand Junction
Clarion Inn Grand Junction
2.5 out of 5
755 Horizon Drive, Grand Junction, CO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Grand Junction. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
8.6/10 Excellent! (1,495 reviews)
Visiting grandkids
"Room clean and comfortable"

Reviewed on Jun 19, 2025

Clarion Inn Grand Junction
Super 8 by Wyndham Grand Junction Colorado
Super 8 by Wyndham Grand Junction Colorado
2 out of 5
728 Horizon Drive, Grand Junction, CO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Grand Junction. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.4/10 Good! (1,001 reviews)
"Love to stay here personnel is wonderful very helpful my only suggestion need an update on AC and carpet"

Reviewed on Jun 16, 2025

Super 8 by Wyndham Grand Junction Colorado
Studio 6 Grand Junction, CO
Studio 6 Grand Junction, CO
2 out of 5
704 Horizon Dr, Grand Junction, CO
Fully refundable
Book a stay at this business-friendly motel in Grand Junction. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
7.4/10 Good! (1,001 reviews)
"A refurbished Motel 6, but this has been done well and the room inside feels modern and has everything you need. Beds were comfy. Aircon worked fine. Full sized fridge in the room. Helpful front desk staff. Only complaint was some noise overnight (probably from the long term residents), but apart ..."

Reviewed on Jun 17, 2025

Studio 6 Grand Junction, CO
La Quinta Inn & Suites by Wyndham Grand Junction
La Quinta Inn & Suites by Wyndham Grand Junction
3 out of 5
2761 Crossroads Blvd, Grand Junction, CO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Grand Junction. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (2,469 reviews)
"I’m n a nice area. Not congested"

Reviewed on Jun 21, 2025

La Quinta Inn & Suites by Wyndham Grand Junction
Doubletree Hotel Grand Junction
Doubletree Hotel Grand Junction
4 out of 5
743 Horizon Dr, Grand Junction, CO
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in Grand Junction. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff ...
8/10 Very Good! (1,001 reviews)
"It was quite a little kept"

Reviewed on Jun 21, 2025

Doubletree Hotel Grand Junction
Comfort Inn & Suites
Comfort Inn & Suites
2.5 out of 5
400 Jurassic Ave, Fruita, CO
Fully refundableReserve now, pay when you stay
Book a stay at this golf hotel in Fruita. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,002 reviews)
"Decent place to stay for a night"

Reviewed on Jun 18, 2025

Comfort Inn & Suites
Red Roof Inn Grand Junction
Red Roof Inn Grand Junction
2 out of 5
2210 Hwy 6 and 50, Grand Junction, CO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Grand Junction. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
7.2/10 Good! (1,002 reviews)
"The gentleman who check us in was exceptionally friendly and helpful. The room was clean and comfortable."

Reviewed on May 30, 2025

Red Roof Inn Grand Junction
Wine Country Inn Palisade
Wine Country Inn Palisade
3.5 out of 5
777 Grande River Drive, Palisade, CO
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in Palisade. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
9.4/10 Exceptional! (1,013 reviews)
"Great time"

Reviewed on Jun 23, 2025

Wine Country Inn Palisade
Super 8 by Wyndham Fruita
Super 8 by Wyndham Fruita
2 out of 5
399 Jurassic Ave, I-70 Exit 19, Fruita, CO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Fruita. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.4/10 Very Good! (1,005 reviews)
"Great stay"

Reviewed on Jun 21, 2025

Super 8 by Wyndham Fruita
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in East Main Street

Grand Junction is a city that has a lot going on, but you have your sights set on East Main Street. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that East Main Street has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of East Main Street hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Grand Junction so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the East Main Street underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the East Main Street city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of East Main Street cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in East Main Street at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the East Main Street hotel you want, book it, and never look back. Because your great escape is ahead of you.