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Featured Main Street Hyannis Resorts & Hotels with Spas
Hyannis Plaza Hotel
662 Main Street, Hyannis, MA
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Hyannis. Enjoy free parking, an outdoor pool, and a 24-hour front desk. Popular attractions Hyannis Harbor and Cape Codder ...
Comfort Inn Hyannis - Cape Cod
259 Main Street, Hyannis, MA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Hyannis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
Top Points of Interests in Main Street Hyannis
- Hotels near John F. Kennedy Hyannis Museum
- Hotels near Cape Cod Baseball Hall of Fame
- Hotels near Wackenhammer's Clockwork Arcade
- Hotels near Hyannis Harbor
- Hotels near Cape Cod National Seashore
- Hotels near Nauset Beach
- Hotels near Cape Cod Melody Tent
- Hotels near Harwich Port
- Hotels near Mayflower Beach
- Hotels near Cape Cod Inflatable Park
- Hotels near Old Silver Beach
- Hotels near Craigville Beach
- Hotels near Skaket Beach
- Hotels near Mashpee Commons
- Hotels near Island Queen Ferry
- Hotels near Sandy Neck Beach
- Hotels near Cape Cod Rail Trail
- Hotels near West Dennis Beach
- Hotels near Ocean Edge Golf Club
- Hotels near Falmouth Heights Beach
Cities near Main Street Hyannis
- Cape Cod Hotels (2.47 mi)
- Martha's Vineyard Hotels (26.53 mi)
- Hyannis Hotels (0.08 mi)
- East Sandwich Hotels (9.82 mi)
- Eastham Hotels (20.09 mi)
- Chatham Hotels (16.72 mi)
- Plymouth Hotels (28.75 mi)
- Falmouth Hotels (18.52 mi)
- South Yarmouth Hotels (4.61 mi)
- Edgartown Hotels (21.74 mi)
- Dennis Port Hotels (7.99 mi)
- Oak Bluffs Hotels (19.87 mi)
- West Yarmouth Hotels (2.18 mi)
- Brewster Hotels (12.72 mi)
- Wellfleet Hotels (23.17 mi)
- Orleans Hotels (17.85 mi)
- Mashpee Hotels (10.26 mi)
- Harwich Hotels (11.85 mi)
- Sandwich Hotels (13.11 mi)
- Dennis Hotels (7.34 mi)
Car Rentals Near Main Street Hyannis
- Car rentals in Cape Cod
- Car rentals in Martha's Vineyard
- Car rentals in Hyannis
- Car rentals in East Sandwich
- Car rentals in Eastham
- Car rentals in Chatham
- Car rentals in Plymouth
- Car rentals in Falmouth
- Car rentals in South Yarmouth
- Car rentals in Edgartown
- Car rentals in Dennis Port
- Car rentals in Oak Bluffs
- Car rentals in West Yarmouth
- Car rentals in Brewster
- Car rentals in Wellfleet
- Car rentals in Orleans
Top Spa Resort Destinations
- Annapolis Spa Hotels
- Ottawa Valley Spa Hotels
- Tallahassee Spa Hotels
- Appalachian Mountains Spa Hotels
- Corpus Christi Spa Hotels
- Raleigh Spa Hotels
- Syracuse Spa Hotels
- Chattanooga Spa Hotels
- Grand Canyon Spa Hotels
- Toledo Spa Hotels
- Edmonton Spa Hotels
- El Paso Spa Hotels
- Omaha Spa Hotels
- Cincinnati Spa Hotels
- Fargo Spa Hotels
- Des Moines Spa Hotels
- Dayton Spa Hotels
- Flagstaff Spa Hotels
- Little Rock Spa Hotels
- Waco Spa Hotels