Hotels Near
Medical District

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Featured Medical District Hotels

Courtyard Marriott Greenville
Courtyard Marriott Greenville
3 out of 5
2225 Stantonsburg Rd, Greenville, NC
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Greenville. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
8.6/10 Excellent! (849 reviews)
"Clean"

Reviewed on Mar 1, 2025

Courtyard Marriott Greenville
Microtel Inn & Suites by Wyndham Greenville/University Medic
Microtel Inn & Suites by Wyndham Greenville/University Medic
2 out of 5
450 Moye Blvd, Greenville, NC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.2/10 Good! (1,000 reviews)
"This was a nice place to stay. The rooms are kind of small and basic, but the price is definitely right. Breakfast was very minimal and the waffle machine was apparently not working while I was there. It was clean and co.fortable, which is all I needed for the weekend"

Reviewed on Mar 9, 2025

Microtel Inn & Suites by Wyndham Greenville/University Medic
Holiday Inn Greenville by IHG
Holiday Inn Greenville by IHG
3 out of 5
203 Greenville Blvd SW, Greenville, NC
Fully refundable
Stay at this 3-star business-friendly hotel in Greenville. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,002 reviews)
"Pretty busy area, there's a Walmart right across the street. Pretty convenient for anywhere you might need to go in Greenville NC. Highway 11, 264 Business, and Evans Street nearby. Accommodations are clean every time I've stayed here have been quiet. There's a small gym, laundry, restaurant and ..."

Reviewed on Mar 12, 2025

Holiday Inn Greenville by IHG
Best Western Plus Suites-Greenville
Best Western Plus Suites-Greenville
2.5 out of 5
2310 Greenville Boulevard NE, Greenville, NC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,000 reviews)
"My only complaint is that the outside key card operated security door would open without using the card. Anyone had access into the building through a door located at the back of the building. Otherwise, the place was great."

Reviewed on Mar 10, 2025

Best Western Plus Suites-Greenville
Country Inn & Suites by Radisson, Greenville, NC
Country Inn & Suites by Radisson, Greenville, NC
3 out of 5
3900 S Memorial Dr, Winterville, NC
Fully refundable
Stay at this 3-star business-friendly hotel in Winterville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (694 reviews)
"The staff was very friendly and helpful. The ice machine wasn't working, but the woman at the front desk brought a bag of ice to our door after we checked-in. However, we could not get the TV to work in our room. Overall, it was a great stay. Thank you!"

Reviewed on Mar 2, 2025

Country Inn & Suites by Radisson, Greenville, NC
Baymont by Wyndham Greenville
Baymont by Wyndham Greenville
2.5 out of 5
3439 S Memorial Drive, Greenville, NC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
6.4/10 (1,000 reviews)
"Front desk person great room not so clean good breakfast"

Reviewed on Mar 1, 2025

Baymont by Wyndham Greenville
Comfort Inn & Suites Greenville Near Convention Center
Comfort Inn & Suites Greenville Near Convention Center
2.5 out of 5
3212 S Memorial Dr, Greenville, NC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (273 reviews)
"A very convenient location especially for business in a central area where people can easily get access."

Reviewed on Mar 8, 2025

Comfort Inn & Suites Greenville Near Convention Center
Quality Inn Greenville near University
Quality Inn Greenville near University
2.5 out of 5
821 Memorial Dr, Greenville, NC
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (914 reviews)
"Everything"

Reviewed on Mar 11, 2025

Quality Inn Greenville near University
Homewood Suites By Hilton Greenville, NC
Homewood Suites By Hilton Greenville, NC
3 out of 5
420 Moye Blvd, Greenville, NC
Fully refundableReserve now, pay when you stay
Stay at this 3-star golf hotel in Greenville. Enjoy free breakfast, free parking, and a 24-hour fitness center. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (206 reviews)
"The area and it surroundings are clean and quiet."

Reviewed on Mar 5, 2025

Homewood Suites By Hilton Greenville, NC
Holiday Inn Express Greenville by IHG
Holiday Inn Express Greenville by IHG
2.5 out of 5
909 Moye Blvd, Greenville, NC
Fully refundable
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free parking, and a free airport shuttle. Our guests praise the breakfast and ...
8.4/10 Very Good! (885 reviews)
"Construction"

Reviewed on Mar 4, 2025

Holiday Inn Express Greenville by IHG
Residence Inn by Marriott Greenville
Residence Inn by Marriott Greenville
3 out of 5
1820 W 5th St, Greenville, NC
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.6/10 Excellent! (392 reviews)
"Good location. Nice room. Pretty good breakfast. Clean & friendly"

Reviewed on Mar 12, 2025

Residence Inn by Marriott Greenville
Staybridge Suites Greenville Medical Center by IHG
Staybridge Suites Greenville Medical Center by IHG
3 out of 5
930 Crosswind Street, Greenville, NC
Fully refundable
Stay at this 3-star hotel in Greenville. Enjoy free breakfast. Popular attractions Guy Smith Stadium and North Pines are located nearby.
7.8/10 Good! (9 reviews)
New
"It’s new so they have some kinks to fix but overall is was good"

Reviewed on Mar 3, 2025

Staybridge Suites Greenville Medical Center by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Medical District

Greenville is a city that has a lot going on, but you have your sights set on Medical District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical District hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Greenville so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical District underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Medical District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Medical District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $67
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Medical District hotel you want, book it, and never look back. Because your great escape is ahead of you.