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Choose from 58 Vandalia Hotel Deals

Knights Inn New Florence

Knights Inn New Florence

2 out of 5
Booneslick Road, 403, 403, New Florence, MO
  • 2 hours drive from Mississippi River
Stay at this hotel in New Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in our reviews. Popular attractions ...
6.6/10 (519 reviews)
"Pet friendly. Staff were very nice. The place itself was average. Walls are thin. Minimal updating but nothing horrible. Just a place to stop for the night. Bed was comfortable. Location just off the freeway but far enough away that you don’t hear it all night."

Reviewed on Sep 27, 2025

Knights Inn New Florence
Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal

2.5 out of 5
4141 Market St, Hannibal, MO
  • 27 min drive from Mississippi River
Book a stay at this business-friendly hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.2/10 (711 reviews)
"Good"

Reviewed on Oct 12, 2025

Baymont by Wyndham Hannibal
Best Western Teal Lake Inn

Best Western Teal Lake Inn

2.5 out of 5
3602 S Clark St, Mexico, MO
  • 1 hour drive from Mississippi River
Book a stay at this business-friendly hotel in Mexico. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (464 reviews)
"For the price it was a very pleasant stay. Staff was very friendly and helpful. Wish the pool was heated but other than that decent place to stay."

Reviewed on Oct 8, 2025

Best Western Teal Lake Inn
Days Inn by Wyndham Mexico

Days Inn by Wyndham Mexico

2 out of 5
2902 S. Clark, Mexico, MO
  • 1 hour drive from Mississippi River
Stay at this hotel in Mexico. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Green Estates and Lakeview Park are located nearby.
6.8/10 (294 reviews)
"I checked in there for 2nd time, and theres no receptionist! we need to wait for a while before they can assist you! They need to hire more people."

Reviewed on Sep 28, 2025

Days Inn by Wyndham Mexico
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

2.5 out of 5
4000 Market St, Hannibal, MO
  • 27 min drive from Mississippi River
Book a stay at this spa hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
7.6/10 Good! (639 reviews)
"Our room smelled like it had been a smoking room previously. Also the spa was nice but made a loud noise with the jets on."

Reviewed on Sep 30, 2025

Comfort Inn & Suites - Hannibal
Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal

2 out of 5
4070 Market St, Hannibal, MO
  • 27 min drive from Mississippi River
Stay at this hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions West ...
7.2/10 Good! (206 reviews)
"Staff was great."

Reviewed on Sep 16, 2025

Days Inn by Wyndham Hannibal
Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal

2 out of 5
4141B MARKET ST, Hannibal, MO
  • 27 min drive from Mississippi River
Stay at this hotel in Hannibal. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7/10 Good! (138 reviews)
"Wonderful and friendly staff, an actual hot real breakfast selection! Clean pool and gaming area, would stay again!"

Reviewed on Sep 1, 2025

Howard Johnson BY Wyndham Hannibal
The Junction Inn

The Junction Inn

2 out of 5
28804 MO-19, Perry, MO
  • 26 min drive from Mississippi River
Stay at this hotel in Perry. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Bill Trower Memorial Park and Perry Park are located ...
6.4/10 (32 reviews)
"Clean, affordable, friendly & easy access of hwy & airport/rental car area!"

Reviewed on Aug 25, 2025

The Junction Inn
Cannon Dam Cabins

Cannon Dam Cabins

3 out of 5
42526 Cabin Rd, Perry, MO
  • 23 min drive from Mississippi River
Stay at this 3-star cabin in Perry. Enjoy free WiFi, a picnic area, and patios. Popular attractions Robert E Allen Recreation Area and Perry Park are located ...
9/10 Wonderful! (11 reviews)
"management great, cabins very comfortable and roomy, good location"

Reviewed on Sep 22, 2025

Cannon Dam Cabins
Super 8 by Wyndham Bowling Green

Super 8 by Wyndham Bowling Green

2 out of 5
1216 E Champ Clark Dr, Bowling Green, MO
  • 36 min drive from Mississippi River
Stay at this hotel in Bowling Green. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our ...
8.2/10 Very Good! (466 reviews)
"It was very clean and comfortable."

Reviewed on Sep 20, 2025

Super 8 by Wyndham Bowling Green
Kennedys Red Barn Inn

Kennedys Red Barn Inn

2.5 out of 5
22748 Joanna Dr, Perry, MO
  • 23 min drive from Mississippi River
Stay at this B&B in Perry. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Robert E Allen Recreation Area and Perry Park are located ...
"Jack and Becky are warm and welcoming. The barn is close to many attractions near the lake. Guests live downstairs and the owners upstairs. The breakfast and cat are great. The room and the whole barn are all wood, very stylish and interesting for city people like me. There is also an interesting ..."

Reviewed on Dec 30, 2024

Kennedys Red Barn Inn
Budget Inn Mexico MO on US 54

Budget Inn Mexico MO on US 54

2 out of 5
1010 E Liberty St, Mexico, MO
  • 1 hour drive from Mississippi River
Book a stay at this business-friendly motel in Mexico. Enjoy free breakfast, free WiFi, and free parking. Popular attractions MLK Jr. Park and Garfield Park ...
7/10 Good! (107 reviews)
"Great"

Reviewed on May 3, 2025

Budget Inn Mexico MO on US 54
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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