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Hotels in Vandalia

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Choose from 63 Vandalia Hotel Deals

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

2.5 out of 5
4000 Market St Hannibal MO
  • 27 min drive from Mississippi River
Book a stay at this spa hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
7.6/10 Good! (691 reviews)
The hotel was inexpensive, but unfortunately the overall experience reflected the price. Although smoking was prohibited, the room next to us smelled strongly of marijuana, making it seem like the policy was not enforced. There was noticeable water damage in the rooms, along with an unpleasant odor ...

Reviewed on May 16, 2026

Comfort Inn & Suites - Hannibal
Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal

2.5 out of 5
4141 Market St Hannibal MO
  • 27 min drive from Mississippi River
Book a stay at this family-friendly hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
6.4/10 (765 reviews)
Property was being updated but was very clean and accommodating staff very nice and helpful Will stay again if ever needed to

Reviewed on May 16, 2026

Baymont by Wyndham Hannibal
Knights Inn New Florence

Knights Inn New Florence

2 out of 5
Booneslick Road, 403, 403 New Florence MO
  • 2 hours drive from Mississippi River
Stay at this hotel in New Florence. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Stone Hill Winery and The Pinnacle are located ...
6.8/10 (562 reviews)
Place was dirty. Beds were worn. Carpets dirty. Breakfast bar was filthy at 7am. Coffie machine was out of service. I ate a waffle and the garbage bins were overflowing I just put my plate on the floor. Garbage bins at hotel entrance were overflowing as well.

Reviewed on May 8, 2026

Knights Inn New Florence
Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal

2 out of 5
4070 Market St Hannibal MO
  • 27 min drive from Mississippi River
Stay at this hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions West ...
7.4/10 Good! (239 reviews)
Parking was great and the hotel was easy to get to. My only issue is the bed was very uncomfortable and the mattress should be replaced. As it had a very large indent in one side.

Reviewed on May 15, 2026

Days Inn by Wyndham Hannibal
Best Western Teal Lake Inn

Best Western Teal Lake Inn

2.5 out of 5
3602 S Clark St Mexico MO
  • 1 hour drive from Mississippi River
Book a stay at this business-friendly hotel in Mexico. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (514 reviews)
Yes

Reviewed on May 12, 2026

Best Western Teal Lake Inn
Cannon Dam Cabins

Cannon Dam Cabins

3 out of 5
42526 Cabin Rd Perry MO
  • 23 min drive from Mississippi River
Stay at this cabin in Perry. Enjoy free WiFi, a picnic area, and patios. Popular attractions Robert E Allen Recreation Area and Perry Park are located ...
9/10 Wonderful! (18 reviews)
Nice quiet location. Friendly staff. Rugs were dated, but clean. Bathroom fan very loud. Toilet too close to wall. Use the website to book, not Expedia, as they charged fifteen more.

Reviewed on May 13, 2026

Cannon Dam Cabins
Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal

2 out of 5
4141B MARKET ST Hannibal MO
  • 27 min drive from Mississippi River
Stay at this hotel in Hannibal. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.4/10 Good! (166 reviews)
The room was clean . The staff was helpful on things to do in the area. It was a very relaxing and the town was beautiful

Reviewed on May 6, 2026

Howard Johnson BY Wyndham Hannibal
The Junction Inn

The Junction Inn

2 out of 5
28804 MO-19 Perry MO
  • 26 min drive from Mississippi River
Stay at this hotel in Perry. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Bill Trower Memorial Park and Perry Park are located ...
The Junction Inn
Days Inn by Wyndham Mexico

Days Inn by Wyndham Mexico

2 out of 5
2902 S. Clark Mexico MO
  • 1 hour drive from Mississippi River
Stay at this hotel in Mexico. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Green Estates and Lakeview Park are located nearby.
7/10 Good! (302 reviews)
Clean room and comfortable bed. stayed here more than once. Will again.

Reviewed on Apr 27, 2026

Days Inn by Wyndham Mexico
Budget Inn Mexico MO on US 54

Budget Inn Mexico MO on US 54

2 out of 5
1010 E Liberty St Mexico MO
  • 1 hour drive from Mississippi River
Book a stay at this business-friendly motel in Mexico. Enjoy free breakfast, free WiFi, and free parking. Popular attractions MLK Jr. Park and Garfield Park ...
7/10 Good! (112 reviews)
NOTHING

Reviewed on Apr 15, 2026

Budget Inn Mexico MO on US 54
Super 8 by Wyndham Bowling Green

Super 8 by Wyndham Bowling Green

2 out of 5
1216 E Champ Clark Dr Bowling Green MO
  • 36 min drive from Mississippi River
Stay at this hotel in Bowling Green. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our ...
Super 8 by Wyndham Bowling Green
Brady Hotel

Brady Hotel

2 out of 5
202 Clark Dr New Florence MO
  • 2 hours drive from Mississippi River
Stay at this motel in New Florence. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Curling Vine Winery and Stone Hill Winery are located ...
Brady Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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