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Hotels in Vandalia

Choose from 61 Vandalia Hotel Deals

Best Western Teal Lake Inn

Best Western Teal Lake Inn

2.5 out of 5
3602 S Clark St Mexico MO
  • 1 hour drive from Mississippi River
Book a stay at this business-friendly hotel in Mexico. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (503 reviews)
I've stayed at Best Western several times but this one needs a LOT of updating! And why on the door its has a sign, No Pets Allowed, yet I came across 2 huge dogs, (that wasn't very people friendly too I might add) but they were just 2 doors down from us, and every time someone would walk by they ...

Reviewed on Mar 8, 2026

Best Western Teal Lake Inn
Knights Inn New Florence

Knights Inn New Florence

2 out of 5
Booneslick Road, 403, 403 New Florence MO
  • 2 hours drive from Mississippi River
Stay at this hotel in New Florence. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Curling Vine Winery and Stone Hill Winery are located ...
6.8/10 (541 reviews)
room dirty/bathroom (moldy shower curtain) . Pillow are very small for king size bed , asked for extra pillows they said no ! :( 😞😓 Not coming back here .

Reviewed on Mar 1, 2026

Knights Inn New Florence
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

2.5 out of 5
4000 Market St Hannibal MO
  • 27 min drive from Mississippi River
Book a stay at this spa hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
7.6/10 Good! (678 reviews)
Clean room. Good location. Comfortable bed.

Reviewed on Feb 25, 2026

Comfort Inn & Suites - Hannibal
Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal

2.5 out of 5
4141 Market St Hannibal MO
  • 27 min drive from Mississippi River
Book a stay at this family-friendly hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
6.4/10 (743 reviews)
It was ok as a hotel stay for over night, even tho baymont took it over, it isnt any better. The owner i think lives there, there wasnt any towels in our room. I didnt get a friendly vibe from them at all.

Reviewed on Feb 23, 2026

Baymont by Wyndham Hannibal
Cannon Dam Cabins

Cannon Dam Cabins

3 out of 5
42526 Cabin Rd Perry MO
  • 23 min drive from Mississippi River
Stay at this cabin in Perry. Enjoy free WiFi, a picnic area, and patios. Popular attractions Robert E Allen Recreation Area and Perry Park are located ...
9.2/10 Wonderful! (15 reviews)
Room was spacious and clean. Ample hot water. All appliances worked as expected. I surprised there was absolutely NO kitchen supplies like coffee filters, salt/pepper, etc. Skillet was worthless. They also need a sign that states the gas station is the check-in site. Good stay overall. Would stay ...

Reviewed on Dec 25, 2025

Cannon Dam Cabins
Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal

2 out of 5
4141B MARKET ST Hannibal MO
  • 27 min drive from Mississippi River
Stay at this hotel in Hannibal. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.2/10 Good! (156 reviews)
Smoke detector hanging from ceiling. Dog poop all iver the rocks outside the room. People smoking and load right outside the room.

Reviewed on Mar 7, 2026

Howard Johnson BY Wyndham Hannibal
Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal

2 out of 5
4070 Market St Hannibal MO
  • 27 min drive from Mississippi River
Stay at this hotel in Hannibal. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions ...
7.4/10 Good! (225 reviews)
The room was clean. The staff were courteous. Breakfast was poor.

Reviewed on Feb 28, 2026

Days Inn by Wyndham Hannibal
Super 8 by Wyndham Bowling Green

Super 8 by Wyndham Bowling Green

2 out of 5
1216 E Champ Clark Dr Bowling Green MO
  • 36 min drive from Mississippi River
Stay at this hotel in Bowling Green. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our ...
8.4/10 Very Good! (491 reviews)
Hotel smelled musty

Reviewed on Feb 24, 2026

Super 8 by Wyndham Bowling Green
Days Inn by Wyndham Mexico

Days Inn by Wyndham Mexico

2 out of 5
2902 S. Clark Mexico MO
  • 1 hour drive from Mississippi River
Stay at this hotel in Mexico. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Green Estates and Lakeview Park are located nearby.
7/10 Good! (298 reviews)
None

Reviewed on Jan 3, 2026

Days Inn by Wyndham Mexico
The Junction Inn

The Junction Inn

2 out of 5
28804 MO-19 Perry MO
  • 26 min drive from Mississippi River
Stay at this hotel in Perry. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Bill Trower Memorial Park and Perry Park are located ...
The Junction Inn
Budget Inn Mexico MO on US 54

Budget Inn Mexico MO on US 54

2 out of 5
1010 E Liberty St Mexico MO
  • 1 hour drive from Mississippi River
Book a stay at this business-friendly motel in Mexico. Enjoy free breakfast, free WiFi, and free parking. Popular attractions MLK Jr. Park and Garfield Park ...
7/10 Good! (111 reviews)
The front door was locked with a note that said, will be back at 6:00 PM. That was at 1:30 the day of a funeral I needed to be at , at 2:00. I wanted to shower and get dressed by 2:00. I had to change outside in a parking lot behind a dumpster down the road. When I called to cancel my reservation ...

Reviewed on Jan 12, 2026

Budget Inn Mexico MO on US 54
Brady Hotel

Brady Hotel

2 out of 5
202 Clark Dr New Florence MO
  • 2 hours drive from Mississippi River
Stay at this motel in New Florence. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Curling Vine Winery and Stone Hill Winery are located ...
Brady Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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