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Hotels in Hannibal

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Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West

2.5 out of 5
120 Lindsey Drive Hannibal MO
  • 5 min drive from Mark Twain Boyhood Home and Museum
Book a stay at this business-friendly hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,012 reviews)
The room we reserved on Expedia was not available and we had to take an another room.

Reviewed on Feb 22, 2026

Quality Inn & Suites Hannibal West
Best Western On The River

Best Western On The River

2.5 out of 5
401 North 3rd Street Hannibal MO
  • 1 min walk from Mark Twain Boyhood Home and Museum
Book a stay at this business-friendly hotel in Hannibal. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,008 reviews)
The staff was pleasant and courteous - both the woman who checked us in and the breakfast attendant.

Reviewed on Feb 23, 2026

Best Western On The River
Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West

2.5 out of 5
105 Lakeside Dr Hannibal MO
  • 6 min drive from Mark Twain Boyhood Home and Museum
Book a stay at this business-friendly hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,003 reviews)
clean rooms & friendly front staff, excellent stay. (:

Reviewed on Feb 23, 2026

Sleep Inn & Suites Hannibal West
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

2.5 out of 5
4000 Market St Hannibal MO
  • 5 min drive from Mark Twain Boyhood Home and Museum
Book a stay at this spa hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
7.6/10 Good! (674 reviews)
Everything was clean and staff was friendly. Just needed some updates.

Reviewed on Feb 5, 2026

Comfort Inn & Suites - Hannibal
Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal

2.5 out of 5
4141 Market St Hannibal MO
  • 6 min drive from Mark Twain Boyhood Home and Museum
Book a stay at this business-friendly hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.4/10 (742 reviews)
It was ok as a hotel stay for over night, even tho baymont took it over, it isnt any better. The owner i think lives there, there wasnt any towels in our room. I didnt get a friendly vibe from them at all.

Reviewed on Feb 23, 2026

Baymont by Wyndham Hannibal
Motel 6 Hannibal, MO

Motel 6 Hannibal, MO

2 out of 5
123 Huckleberry Heights Dr Hannibal MO
  • 24 min walk from Mark Twain Boyhood Home and Museum
Stay at this motel in Hannibal. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.4/10 Good! (1,003 reviews)
Very clean room and great customer service. No breakfast but fresh coffee at 6am

Reviewed on Feb 18, 2026

Motel 6 Hannibal, MO
Lighthouse Inn & Suites

Lighthouse Inn & Suites

4 out of 5
612 Mark Twain Ave Hannibal MO
  • 5 min walk from Mark Twain Boyhood Home and Museum
Stay at this aparthotel in Hannibal. Enjoy free WiFi, free parking, and dry cleaning or laundry services. Popular attractions Molly Brown Museum and Home and ...
8.8/10 Excellent! (25 reviews)
Nice room. Matched the pictures. Exactly what we were looking for.

Reviewed on Jan 18, 2026

Lighthouse Inn & Suites
Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal

2 out of 5
4070 Market St Hannibal MO
  • 6 min drive from Mark Twain Boyhood Home and Museum
Stay at this hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions West ...
Days Inn by Wyndham Hannibal
Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal

2 out of 5
120 Huckleberry Heights Dr Hannibal MO
  • 24 min walk from Mark Twain Boyhood Home and Museum
Stay at this motel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7.2/10 Good! (1,002 reviews)
Great place to stay

Reviewed on Feb 20, 2026

Super 8 by Wyndham Hannibal
Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal

2 out of 5
4141B MARKET ST Hannibal MO
  • 6 min drive from Mark Twain Boyhood Home and Museum
Stay at this hotel in Hannibal. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.2/10 Good! (154 reviews)
It looked as if the hotel was undergoing some renovations. The outside of the hotel does not look like much, but it was surprising when we checked-in we were pleasantly surprised. Spacious clean lobby and breakfast room. Pool area was indoors and kept clean and spacious. Room was clean, but typical... ...

Reviewed on Feb 12, 2026

Howard Johnson BY Wyndham Hannibal
Riverside Inn Hannibal

Riverside Inn Hannibal

2.5 out of 5
111 Bird St Hannibal MO
  • 2 min walk from Mark Twain Boyhood Home and Museum
Stay at this guesthouse in Hannibal. Enjoy free WiFi, free parking, and Netflix. Popular attractions Planters Barn Theater and Mark Twain Boyhood Home and Museum ...
9.4/10 Exceptional! (167 reviews)
Courteous staff, clean room

Reviewed on Feb 11, 2026

Riverside Inn Hannibal
Garth Woodside Mansion B&B

Garth Woodside Mansion B&B

4 out of 5
11069 New London Gravel Rd Hannibal MO
  • 8 min drive from Mark Twain Boyhood Home and Museum
Stay at this B&B in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Bear Creek Park and West Ely Park are located nearby.
9.6/10 Exceptional! (21 reviews)
Garth Mansion is Perfect
The Mansion is spectacular, our room was perfect and the on suite bathroom/shower, fireplace bed, everything was and is fantastic. The staff and the other guests were so friendly they felt like family.

Reviewed on Oct 17, 2025

Garth Woodside Mansion B&B
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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