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Hotels in Northeast Missouri

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Choose from 2915 Northeast Missouri Hotel Deals

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
  • 13 min drive from St. Louis Union Station
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (3,137 reviews)
Parking could be better explained

Reviewed on Apr 5, 2026

Clayton Plaza Hotel & Extended Stay
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

3 out of 5
2211 Market Street St. Louis MO
  • 5 min walk from St. Louis Union Station
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant ...
8.8/10 Excellent! (1,924 reviews)
The room was clean. The bathroom was old so the tub didn’t look as clean as desired. Overall, I enjoyed my stay.

Reviewed on Apr 5, 2026

Pear Tree Inn St. Louis Near Union Station
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
  • 5 min walk from St. Louis Union Station
Book a stay at this luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...
9/10 Wonderful! (1,724 reviews)
Good valet team, poor front desk staff, people not wanting to accommodate basic requests life towels and luggage trolley. Shooting on the street during stay and couple having 30 minute long yelling match out front of hotel at 3 am………cleaning staff and valets were great! Also they added extra fees ...

Reviewed on Apr 5, 2026

21C Museum Hotel St Louis
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
  • 32 min drive from St. Louis Union Station
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.4/10 Very Good! (2,192 reviews)
room very clean pretty plain for a suite very spacious and comfortable

Reviewed on Apr 1, 2026

Hollywood Casino & Hotel St. Louis
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln St. Ann MO
  • 24 min drive from St. Louis Union Station
Book a stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (2,891 reviews)
Extremely clean room

Reviewed on Apr 4, 2026

Pear Tree Inn St. Louis Airport
Drury Inn & Suites St. Louis Union Station

Drury Inn & Suites St. Louis Union Station

3 out of 5
201 S 20th St St. Louis MO
  • 3 min walk from St. Louis Union Station
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,346 reviews)
Welcoming, very kind staff

Reviewed on Apr 5, 2026

Drury Inn & Suites St. Louis Union Station
Hilton St. Louis Airport

Hilton St. Louis Airport

3.5 out of 5
10330 Natural Bridge Rd St. Louis MO
  • 23 min drive from St. Louis Union Station
Book a stay at this business-friendly hotel in St. Louis. Enjoy 2 restaurants, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
7.6/10 Good! (1,002 reviews)
The power was out in the dining area due to storms & the staff were wonderful & had an alternative setup for breakfast.

Reviewed on Apr 1, 2026

Hilton St. Louis Airport
River City Casino & Hotel

River City Casino & Hotel

4 out of 5
777 River City Casino Blvd St. Louis MO
  • 18 min drive from St. Louis Union Station
Book a stay at this business-friendly hotel in St. Louis. Enjoy free parking, 5 restaurants, and a casino. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (1,510 reviews)
I recommend very nice.

Reviewed on Apr 5, 2026

River City Casino & Hotel
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
  • 31 min drive from St. Louis Union Station
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,179 reviews)
Did not have breakfast

Reviewed on Apr 5, 2026

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Best Western St. Louis-Kirkwood Route 66

Best Western St. Louis-Kirkwood Route 66

3.5 out of 5
1200 S Kirkwood Road Kirkwood MO
  • 24 min drive from St. Louis Union Station
Book a stay at this business-friendly hotel in Kirkwood. Enjoy free parking, an outdoor pool, and room service. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,440 reviews)
If I could give this place zero stars I would. They sold us a room with no working A/C, knowing it doesn’t work. Said they were sold out of other rooms and we couldn’t change when we realized. Didn’t give us any compensation to make up for it except a box fan. Will never stay here or any Best Western ...

Reviewed on Apr 2, 2026

Best Western St. Louis-Kirkwood Route 66
Live by Loews - St.Louis

Live by Loews - St.Louis

4 out of 5
799 Clark ave St. Louis MO
  • 13 min walk from St. Louis Union Station
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
9.4/10 Exceptional! (1,138 reviews)
Awesome location, super clean, excellent staff! Will be back for our next stay in St Louis!

Reviewed on Apr 5, 2026

Live by Loews - St.Louis
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road St. Louis MO
  • 22 min drive from St. Louis Union Station
Book a stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
8.4/10 Very Good! (1,078 reviews)
Great staff. Accomodated my husbands request to face the airport runway. Clean rooms with comfortable bed and large tv.

Reviewed on Apr 5, 2026

Renaissance St. Louis Airport Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Northeast Missouri

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If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $103. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Northeast Missouri hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Northeast Missouri. No matter your reason for visiting Northeast Missouri, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Northeast Missouri hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Northeast Missouri?

With over 2,915 hotels in Northeast Missouri, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $103.

How to find cheap car rentals in Northeast Missouri?

Finding a cheap car rental deal in Northeast Missouri is as easy as scoring cheap hotels in Northeast Missouri. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.