Hotels Near
Central West End

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Featured Central West End Hotels

DoubleTree by Hilton St. Louis Forest Park

DoubleTree by Hilton St. Louis Forest Park

4 out of 5
4550 Forest Park Ave St. Louis MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,000 reviews)
No free breakfast but perfect location for Barnes Hospital as it is attached by an interior walkway. Not sure if this is the norm but we were there for 3 nights and no one ever serviced the room.

Reviewed on Dec 8, 2025

DoubleTree by Hilton St. Louis Forest Park
 The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
212 N Kingshighway St. Louis MO
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in St. Louis. Enjoy free WiFi, an outdoor pool, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (1,000 reviews)
Everything was excellent.

Reviewed on Dec 10, 2025

The Royal Sonesta Chase Park Plaza St. Louis
AC Hotel St. Louis Central West End

AC Hotel St. Louis Central West End

4 out of 5
215 YORK AVENUE St. Louis MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the helpful staff and ...
9/10 Wonderful! (683 reviews)
The room was clean and appeared to have been recently updated. The staff were especially courteous and accommodating during my stay.

Reviewed on Dec 11, 2025

AC Hotel St. Louis Central West End
Aloft St. Louis Cortex

Aloft St. Louis Cortex

3 out of 5
4245 Duncan Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
Stay at this hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in ...
8.6/10 Excellent! (828 reviews)
Great Stay

Reviewed on Dec 12, 2025

Aloft St. Louis Cortex
The West End

The West End

2 out of 5
4215 Lindell Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
Stay at this hotel in St. Louis. Enjoy free WiFi, a 24-hour fitness center, and parking (surcharge). Popular attractions St. Louis Union Station and Gateway ...
8.4/10 Very Good! (406 reviews)
The only thing I did not like was having to pay to park per night when already paying for a room

Reviewed on Dec 10, 2025

The West End
Hotel Indigo St Louis - Central West End by IHG

Hotel Indigo St Louis - Central West End by IHG

3.5 out of 5
4630 Lindell St. Louis MO
Fully refundable
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 4 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.2/10 Very Good! (1,000 reviews)
It was a very nice stay . From Tay, the front desk clerk , super nice . Excellent customer service. The room nice and clean . Bed very nice

Reviewed on Dec 6, 2025

Hotel Indigo St Louis - Central West End by IHG
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (4,011 reviews)
Both bars had great selections!

Reviewed on Dec 15, 2025

Hyatt Regency St. Louis at The Arch
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St St. Louis MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
8.6/10 Excellent! (1,147 reviews)
Convenient

Reviewed on Dec 10, 2025

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Hilton St. Louis Airport

Hilton St. Louis Airport

3.5 out of 5
10330 Natural Bridge Rd St. Louis MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Louis. Enjoy 2 restaurants, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
7.4/10 Good! (1,006 reviews)
Tesla charger does not agrr

Reviewed on Dec 3, 2025

Hilton St. Louis Airport
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

3 out of 5
2 South 4th Street St. Louis MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.4/10 Exceptional! (3,281 reviews)
Parking was rough, but the staff was super sweet & did a wonderful job warning me of it.

Reviewed on Dec 14, 2025

Drury Plaza Hotel St. Louis at the Arch
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (3,030 reviews)
Yes the rooms were adequately clean and the staff was courteous

Reviewed on Dec 10, 2025

Clayton Plaza Hotel & Extended Stay
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...
9/10 Wonderful! (1,500 reviews)
Hotel was very cool, certainly niche. Service was not the best. There was a language barrier between us and the receptionist. Definitely scour the area before arrival to find parking, otherwise you'll have to pay to park. the restaurants inside are really great, food and drinks are highly recommended. ...

Reviewed on Dec 13, 2025

21C Museum Hotel St Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Central West End

St. Louis is a city that has a lot going on, but you have your sights set on Central West End. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Central West End has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Central West End hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of St. Louis so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Central West End underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Central West End city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Central West End cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Central West End at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $99
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Central West End hotel you want, book it, and never look back. Because your great escape is ahead of you.