Hotels Near
Grand Center

Check Last Minute Grand Center Hotel Deals

Tonight Mar 23 - Mar 24Next weekend Mar 28 - Mar 30

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!


Featured Grand Center Hotels

Angad Arts Hotel
Angad Arts Hotel
4 out of 5
3550 Samuel Shepard Drive, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
8.8/10 Excellent! (1,072 reviews)
"One elevator was broken so it took a long time for one to come down or up"

Reviewed on Mar 17, 2025

Angad Arts Hotel
 White House at Grand Central
White House at Grand Central
4 out of 5
3805 Lindell Blvd, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star apartment in St. Louis. Enjoy free WiFi, parking (surcharge), and a garden. Popular attractions St. Louis Union Station and Busch Stadium ...
8.6/10 Excellent! (100 reviews)
"clean and comfortable"

Reviewed on Mar 21, 2025

White House at Grand Central
Hyatt Regency St. Louis at The Arch
Hyatt Regency St. Louis at The Arch
4 out of 5
315 Chestnut St, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (3,604 reviews)
"Melwin was pleasant and prompt."

Reviewed on Mar 22, 2025

Hyatt Regency St. Louis at The Arch
Clayton Plaza Hotel & Extended Stay
Clayton Plaza Hotel & Extended Stay
3.5 out of 5
7750 Carondelet Avenue, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (3,003 reviews)
"Very nice, clean and friendly . Excellent location."

Reviewed on Mar 22, 2025

Clayton Plaza Hotel & Extended Stay
Moonrise Hotel
Moonrise Hotel
4 out of 5
6177 Delmar Blvd, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star boutique hotel in St. Louis. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the restaurant and the bar in our reviews. ...
9/10 Wonderful! (1,623 reviews)
"in a nice location near transit and many good places to eat nearby"

Reviewed on Mar 21, 2025

Moonrise Hotel
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3 out of 5
1088 South Highway Drive, Fenton, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,004 reviews)
My ‘OK’ stay. Probably wouldn’t come back.
"There was someone else’s sock peeking out from under the ottoman. Obviously the room wasn’t cleaned well. In addition there was no soap dish and no drinking cups in the bathroom. We found them with the ice bucket in the bedroom. Finally the coffee pot had to be moved in order to plug in. Maybe the ..."

Reviewed on Mar 14, 2025

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Sonesta ES Suites St. Louis - Chesterfield
Sonesta ES Suites St. Louis - Chesterfield
3 out of 5
15431 Conway Rd, Chesterfield, MO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,007 reviews)
"The room was comfortable, nicely decorated and extremely clean! Bed was very comfortable. And they had real size bath towels that were soft (not scratchy compared to other places I've stayed lol) Enjoyed my stay and would definitely stay there again."

Reviewed on Mar 18, 2025

Sonesta ES Suites St. Louis - Chesterfield
Drury Plaza Hotel St. Louis at the Arch
Drury Plaza Hotel St. Louis at the Arch
3 out of 5
2 South 4th Street, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.4/10 Exceptional! (2,428 reviews)
"The only problem w head was the carpet was really wet when we arrived in between the beds and being able to get an elevator the first 2 days."

Reviewed on Mar 23, 2025

Drury Plaza Hotel St. Louis at the Arch
River City Casino & Hotel
River City Casino & Hotel
4 out of 5
777 River City Casino Blvd, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free parking, 5 restaurants, and a casino. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (1,132 reviews)
"They did not have the room available that we wanted, but was able to give us a very nice room with a king size bed like we wanted."

Reviewed on Mar 21, 2025

River City Casino & Hotel
21C Museum Hotel St Louis
21C Museum Hotel St Louis
4.5 out of 5
1528 Locust street, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...
9/10 Wonderful! (1,031 reviews)
"The property is very special, with a historic and totally renovated pool and spa, and a large art exhibit. The bar and lobby are loaded with art and beautifully designed surroundings. Only one of three elevators were working this week, so a lot of waiting and frankly feeling unsafe. The breakfast ..."

Reviewed on Mar 22, 2025

21C Museum Hotel St Louis
Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. Louis
3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,857 reviews)
"Nice and affordable"

Reviewed on Mar 22, 2025

Hollywood Casino & Hotel St. Louis
Pear Tree Inn St. Louis Near Union Station
Pear Tree Inn St. Louis Near Union Station
3 out of 5
2211 Market Street, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant ...
8.8/10 Excellent! (1,398 reviews)
"Front desk was very helpful Needed something printed off and they were very helpful."

Reviewed on Mar 20, 2025

Pear Tree Inn St. Louis Near Union Station
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Grand Center

St. Louis is a city that has a lot going on, but you have your sights set on Grand Center. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Grand Center has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Grand Center hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of St. Louis so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Grand Center underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Grand Center city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Grand Center cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Grand Center at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $103
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Grand Center hotel you want, book it, and never look back. Because your great escape is ahead of you.