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Clayton

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Featured Clayton Hotels

Casino Queen Hotel
Casino Queen Hotel
3 out of 5
200 Front Street, East St. Louis, IL
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in East St. Louis. Enjoy free WiFi, free parking, and a casino. Our guests praise the pool and the helpful staff ...
7.8/10 Good! (1,423 reviews)
"The room smelled of Marijuana. They used a heavy dose of cleaning liquid to try and cover it. The smell was all over the hotel, not just our room. Hair on the floor in the bathroom, frgot to sweep. Broken lamp. Beds were clean. For one night it was ok, ive stayed st worse."

Reviewed on Apr 15, 2024

Casino Queen Hotel
Clayton Plaza Hotel & Extended Stay
Clayton Plaza Hotel & Extended Stay
3.5 out of 5
7750 Carondelet Avenue, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (2,873 reviews)
Fantastic Staff
"First off, the lady that was working the desk around 5pm on Easter Sunday was one of the most pleasant people I have ever encountered working at a hotel. She was so kind. The rooms were updated, clean and comfortable. The lobby, halls, and pool area were very outdated. I could tell this used to be ..."

Reviewed on Apr 18, 2024

Clayton Plaza Hotel & Extended Stay
Le Méridien St. Louis Clayton
Le Méridien St. Louis Clayton
4 out of 5
7730 Bonhomme Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast, and WiFi. Popular attractions St. Louis Zoo and Forest Park are located ...
8.8/10 Excellent! (453 reviews)
"I wish the pool was open but other than that it was an amazing stay!"

Reviewed on Apr 14, 2024

Le Méridien St. Louis Clayton
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
3 out of 5
216 N Meramec Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (712 reviews)
Comfortable and Clean
"The hotel staff was friendly and accommodating. Our rooms were comfortable and clean. Kids used the pool and enjoyed themselves. We will stay again when visiting family."

Reviewed on Apr 14, 2024

Hampton Inn & Suites Clayton/St. Louis-Galleria Area
Homewood Suites by Hilton St Louis - Galleria
Homewood Suites by Hilton St Louis - Galleria
3 out of 5
8040 Clayton Road, Richmond Heights, MO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Richmond Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,001 reviews)
"Good place to stay. Good breakfast. Clean. Two complaints: the freeway was right outside our room. Super loud. Hard for kids to sleep. The other problem was that the hot tub was not hot."

Reviewed on Apr 6, 2024

Homewood Suites by Hilton St Louis - Galleria
Hyatt Regency St. Louis at The Arch
Hyatt Regency St. Louis at The Arch
4 out of 5
315 Chestnut St, St. Louis, MO
Fully refundable
Stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (2,976 reviews)
"Great location! Close to Arch, Busch Stadium, and a mile walk to Union Station. Great restaurant on location. Staff was very friendly and accommodating."

Reviewed on Apr 16, 2024

Hyatt Regency St. Louis at The Arch
Drury Plaza Hotel St. Louis at the Arch
Drury Plaza Hotel St. Louis at the Arch
3 out of 5
2 South 4th Street, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.4/10 Exceptional! (2,169 reviews)
"Nice"

Reviewed on Apr 18, 2024

Drury Plaza Hotel St. Louis at the Arch
Best Western St. Louis-Kirkwood Route 66
Best Western St. Louis-Kirkwood Route 66
2.5 out of 5
1200 S Kirkwood Road, Kirkwood, MO
Fully refundableReserve now, pay when you stay
Stay at this business-friendly hotel in Kirkwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.8/10 Excellent! (1,006 reviews)
"Nice"

Reviewed on Apr 16, 2024

Best Western St. Louis-Kirkwood Route 66
Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. Louis
3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
Fully refundableReserve now, pay when you stay
Stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the convenient ...
8/10 Very Good! (1,163 reviews)
"It was great"

Reviewed on Apr 16, 2024

Hollywood Casino & Hotel St. Louis
The Last Hotel
The Last Hotel
4.5 out of 5
1501 Washington Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, 2 bars/lounges, and breakfast. Our guests praise the pool and the bar in our reviews. Popular ...
8.4/10 Very Good! (1,001 reviews)
"Great"

Reviewed on Apr 12, 2024

The Last Hotel
Hampton Inn St. Louis-Downtown (At the Gateway Arch)
Hampton Inn St. Louis-Downtown (At the Gateway Arch)
2.5 out of 5
333 Washington Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this family-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the pool ...
8.4/10 Very Good! (1,001 reviews)
"Elevators slow !"

Reviewed on Apr 13, 2024

Hampton Inn St. Louis-Downtown (At the Gateway Arch)
21C Museum Hotel St Louis
21C Museum Hotel St Louis
4.5 out of 5
1528 Locust street, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, breakfast, and room service. Popular attractions St. Louis Union Station and Busch Stadium ...
9/10 Wonderful! (356 reviews)
"One of the most impressive hotels I've stayed in. Engaging art, beautiful lobby and bar area. Great lounge with high quality furniture and pool table. Surprisingly well curated art gallery with multiple cool works on the entire second floor. Beautiful view of the city from our room. Delicious food ..."

Reviewed on Apr 17, 2024

21C Museum Hotel St Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Clayton

St. Louis is a city that has a lot going on, but you have your sights set on Clayton. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Clayton has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Clayton hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of St. Louis so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Clayton underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Clayton city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Clayton cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Clayton at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $99
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Clayton hotel you want, book it, and never look back. Because your great escape is ahead of you.