Search for Cheap Deals on
Hotels in Louisiana

Choose from 82 Louisiana Hotel Deals

River's Edge Motel

River's Edge Motel

2 out of 5
201 Mansion St Louisiana MO
  • 16 min drive from Mississippi River
Stay at this motel in Louisiana. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews.
9/10 Wonderful! (361 reviews)
Owners were incredibly friendly and helpful. Told me about local places to and even remember my name when I went down to get another pillow. Room was clean and spacious. The only possible negative is you hear the trains going by but for me that was just added ambiance.

Reviewed on Mar 16, 2026

River's Edge Motel
The Eagles Nest Inn

The Eagles Nest Inn

3 out of 5
215 Georgia St Louisiana MO
  • 17 min drive from Mississippi River
Stay at this inn in Louisiana. Enjoy free WiFi, free parking, and bathrobes.
9.4/10 Exceptional! (22 reviews)
Best place to stay in town!

Reviewed on Mar 19, 2026

The Eagles Nest Inn
Best Western On The River

Best Western On The River

2.5 out of 5
401 North 3rd Street Hannibal MO
  • 30 min drive from Mississippi River
Book a stay at this business-friendly hotel in Hannibal. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,012 reviews)
Everything was great

Reviewed on Mar 29, 2026

Best Western On The River
Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West

2.5 out of 5
120 Lindsey Drive Hannibal MO
  • 32 min drive from Mississippi River
Book a stay at this business-friendly hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,006 reviews)
We stayed here while traveling with a small dog. It's a busy, but safe place to stay with family. There was a lot of family noise in the halls, and the doors slam hard, but inside the room it was fairly quiet. There were plenty of comfy pillows! The room was clean, and there was a new large-screen ...

Reviewed on Mar 31, 2026

Quality Inn & Suites Hannibal West
Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West

2.5 out of 5
105 Lakeside Dr Hannibal MO
  • 32 min drive from Mississippi River
Book a stay at this business-friendly hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,006 reviews)
Room was great and breakfast was fantastic

Reviewed on Mar 30, 2026

Sleep Inn & Suites Hannibal West
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

2.5 out of 5
4000 Market St Hannibal MO
  • 27 min drive from Mississippi River
Book a stay at this spa hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
7.6/10 Good! (682 reviews)
Beds comfortable- nice breakfast choices. A pleasant peaceful setting

Reviewed on Mar 30, 2026

Comfort Inn & Suites - Hannibal
Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal

2.5 out of 5
4141 Market St Hannibal MO
  • 27 min drive from Mississippi River
Book a stay at this family-friendly hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
6.2/10 (750 reviews)
Our room wasn’t even clean there was crumbs on the bed when we walked into our room at 1030 at night after checking in . The toilet paper wasn’t even changed bedding was stained so you could tell the room wasn’t even cleaned when we go back I will never stay here again I’m so disappointed and I love ...

Reviewed on Mar 30, 2026

Baymont by Wyndham Hannibal
Motel 6 Hannibal, MO

Motel 6 Hannibal, MO

2 out of 5
123 Huckleberry Heights Dr Hannibal MO
  • 29 min drive from Mississippi River
Stay at this motel in Hannibal. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.4/10 Good! (1,001 reviews)
Pool closed, looked pretty permanent but was told closed for maintenance. That was disappointing, I picked the place partly because it had a pool. Hannibal is great to explore. Motel 6 was just a place to sleep one night & shower so the place was fine for that.

Reviewed on Mar 24, 2026

Motel 6 Hannibal, MO
Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal

2 out of 5
120 Huckleberry Heights Dr Hannibal MO
  • 29 min drive from Mississippi River
Stay at this motel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7.2/10 Good! (1,000 reviews)
Very clean with friendly staff and a very reasonable price. We’ve spent a lot more on hotels that didn’t come close to this one in cleanliness. Will definitely stay here again if we are ever in the area.

Reviewed on Mar 22, 2026

Super 8 by Wyndham Hannibal
Lighthouse Inn & Suites

Lighthouse Inn & Suites

4 out of 5
612 Mark Twain Ave Hannibal MO
  • 30 min drive from Mississippi River
Stay at this aparthotel in Hannibal. Enjoy free WiFi, free parking, and dry cleaning or laundry services. Popular attractions Molly Brown Museum and Home and ...
8.8/10 Excellent! (25 reviews)
Nice room. Matched the pictures. Exactly what we were looking for.

Reviewed on Jan 18, 2026

Lighthouse Inn & Suites
Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal

2 out of 5
4141B MARKET ST Hannibal MO
  • 27 min drive from Mississippi River
Stay at this hotel in Hannibal. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.2/10 Good! (161 reviews)
Yes. The internet went in an out sometimes. The wireless Video connection would stop downloading making it impossible to watch you tube videos. The train tracks are close to the Hotel. The trains were hooking their horn off an on throughout waking me up from my sleep.

Reviewed on Mar 31, 2026

Howard Johnson BY Wyndham Hannibal
Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal

2 out of 5
4070 Market St Hannibal MO
  • 27 min drive from Mississippi River
Stay at this hotel in Hannibal. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions ...
7.4/10 Good! (229 reviews)
There were people outside our room talking very loudly for hours. I did not feel safe at this place.

Reviewed on Mar 30, 2026

Days Inn by Wyndham Hannibal
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Louisiana

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Louisiana hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Louisiana.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Louisiana’s 82 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $66. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Louisiana hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Louisiana. No matter your reason for visiting Louisiana, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Louisiana hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Louisiana for as low as $66.

How many hotels are there in Louisiana?

With over 82 hotels in Louisiana, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $66.

How to find cheap car rentals in Louisiana?

Finding a cheap car rental deal in Louisiana is as easy as scoring cheap hotels in Louisiana. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.