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De Soto

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De Soto Flights as Low as $123

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Mon, May 12 - Fri, May 16
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$123 Roundtrip, found 1 day ago
$123
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, May 12 from O'Hare Intl. to Lambert-St. Louis Intl., returning Fri, May 16, priced at $123 found 1 day ago
Frontier Airlines
Sat, Jun 14 - Sat, Jun 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$132 Roundtrip, found 2 hours ago
$132
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Sat, Jun 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 21, priced at $132 found 2 hours ago
Southern Airways Express
Fri, May 9 - Tue, May 13
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$142 Roundtrip, found 1 day ago
$142
Roundtrip
found 1 day ago
Select Southern Airways Express flight, departing Fri, May 9 from O'Hare Intl. to Lambert-St. Louis Intl., returning Tue, May 13, priced at $142 found 1 day ago
Frontier Airlines
Sun, Jun 15 - Thu, Jun 19
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$148 Roundtrip, found 2 days ago
$148
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Sun, Jun 15 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Thu, Jun 19, priced at $148 found 2 days ago
Spirit Airlines
Wed, May 14 - Sat, May 17
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$170 Roundtrip, found 3 days ago
$170
Roundtrip
found 3 days ago
Select Spirit Airlines flight, departing Wed, May 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, May 17, priced at $170 found 3 days ago
Delta
Tue, Jun 3 - Tue, Jun 3
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$186 Roundtrip, found 19 hours ago
$186
Roundtrip
found 19 hours ago
Select Delta flight, departing Tue, Jun 3 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Tue, Jun 3, priced at $186 found 19 hours ago
United
Mon, May 12 - Fri, May 16
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$186 Roundtrip, found 1 day ago
$186
Roundtrip
found 1 day ago
Select United flight, departing Mon, May 12 from O'Hare Intl. to Lambert-St. Louis Intl., returning Fri, May 16, priced at $186 found 1 day ago
Frontier Airlines
Sat, May 24 - Wed, May 28
ONT
Los Angeles - Ontario Intl.
STL
Lambert-St. Louis Intl.
$191 Roundtrip, found 18 hours ago
$191
Roundtrip
found 18 hours ago
Select Frontier Airlines flight, departing Sat, May 24 from Los Angeles - Ontario Intl. to Lambert-St. Louis Intl., returning Wed, May 28, priced at $191 found 18 hours ago
Frontier Airlines
Sat, Apr 26 - Thu, May 1
CLT
Charlotte-Douglas Intl.
STL
Lambert-St. Louis Intl.
$213 Roundtrip, found 1 day ago
$213
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, Apr 26 from Charlotte-Douglas Intl. to Lambert-St. Louis Intl., returning Thu, May 1, priced at $213 found 1 day ago
Delta
Mon, Jul 14 - Sun, Jul 20
MSP
Minneapolis - St. Paul Intl.
STL
Lambert-St. Louis Intl.
$213 Roundtrip, found 3 days ago
$213
Roundtrip
found 3 days ago
Select Delta flight, departing Mon, Jul 14 from Minneapolis - St. Paul Intl. to Lambert-St. Louis Intl., returning Sun, Jul 20, priced at $213 found 3 days ago
Bargain Flight
Wed, Apr 23 - Wed, Apr 30
CAE
Columbia Metropolitan
STL
Lambert-St. Louis Intl.
$255 Roundtrip, found 1 day ago
$255
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Wed, Apr 23 from Columbia Metropolitan to Lambert-St. Louis Intl., returning Wed, Apr 30, priced at $255 found 1 day ago
Delta
Tue, Jun 17 - Fri, Jun 20
SAN
San Diego Intl.
STL
Lambert-St. Louis Intl.
$258 Roundtrip, found 17 hours ago
$258
Roundtrip
found 17 hours ago
Select Delta flight, departing Tue, Jun 17 from San Diego Intl. to Lambert-St. Louis Intl., returning Fri, Jun 20, priced at $258 found 17 hours ago
Delta
Sat, May 10 - Wed, May 14
DAL
Love Field
STL
Lambert-St. Louis Intl.
$275 Roundtrip, found 2 days ago
$275
Roundtrip
found 2 days ago
Select Delta flight, departing Sat, May 10 from Love Field to Lambert-St. Louis Intl., returning Wed, May 14, priced at $275 found 2 days ago
American Airlines
Sun, May 25 - Sat, May 31
CLD
McClellan-Palomar
STL
Lambert-St. Louis Intl.
$298 Roundtrip, found 3 days ago
$298
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sun, May 25 from McClellan-Palomar to Lambert-St. Louis Intl., returning Sat, May 31, priced at $298 found 3 days ago
Bargain Flight
Sat, May 3 - Sun, May 4
MEM
Memphis Intl.
STL
Lambert-St. Louis Intl.
$344 Roundtrip, found 3 days ago
$344
Roundtrip
found 3 days ago
Select Bargain Flight flight, departing Sat, May 3 from Memphis Intl. to Lambert-St. Louis Intl., returning Sun, May 4, priced at $344 found 3 days ago
Alaska Airlines
Wed, May 7 - Thu, May 15
PAE
Seattle Paine Field Intl. Airport
STL
Lambert-St. Louis Intl.
$528 Roundtrip, found 3 days ago
$528
Roundtrip
found 3 days ago
Select Alaska Airlines flight, departing Wed, May 7 from Seattle Paine Field Intl. Airport to Lambert-St. Louis Intl., returning Thu, May 15, priced at $528 found 3 days ago

Cheap Flights to De Soto

Fall in love at first flight with your vacation to De Soto by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to De Soto on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in De Soto, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to De Soto

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to De Soto with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to De Soto?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to De Soto are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to De Soto?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 14 to choose from for your flight to De Soto.

What airport is best to fly into De Soto?

When you’re planning your trip to De Soto, convenience is the name of the game. Luckily, De Soto Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your De Soto must-do list.

How much are flights to De Soto?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to De Soto on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $123, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to De Soto?

The trick to saving a stack of cash on your flight to De Soto? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $123 right now, why wait?

De Soto Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$122

Last Minute Hotel Deals in De Soto

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
3.5 out of 5
4800 U.S. Highway 67, De Soto, MO
The price is $183 per night from Apr 28 to Apr 29
$183
includes taxes & fees
Apr 28 - Apr 29
Stay at this 3.5-star family-friendly aparthotel in De Soto. Enjoy free parking, an outdoor pool, and a fitness center. Our guests praise the property condition ...
9.2/10 Wonderful! (140 reviews)
"Beautiful property. Lots to do with the kids. Would be happy to come back when I have more time to spend there."

Reviewed on Apr 11, 2025

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
The price is $63 per night from Apr 27 to Apr 28
$63
includes taxes & fees
Apr 27 - Apr 28
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (919 reviews)
"There was not a lot of places near by to eat at."

Reviewed on Apr 15, 2025

Baymont Inn and Suites by Wyndham Farmington, MO
Pear Tree Inn St. Louis Arnold
Pear Tree Inn St. Louis Arnold
2.5 out of 5
1201 Drury Ln, Arnold, MO
The price is $104 per night from Apr 23 to Apr 24
$104
includes taxes & fees
Apr 23 - Apr 24
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,003 reviews)
"We enjoyed our stay. Staff very friendly. Wished the bathrooms were alittle bigger."

Reviewed on Apr 12, 2025

Pear Tree Inn St. Louis Arnold
Drury Inn & Suites St. Louis Arnold
Drury Inn & Suites St. Louis Arnold
3 out of 5
3800 State Rt 141, Arnold, MO
The price is $146 per night from Apr 27 to Apr 28
$146
includes taxes & fees
Apr 27 - Apr 28
Stay at this 3-star business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (1,001 reviews)
"The staff was very accommodating and so friendly!"

Reviewed on Apr 13, 2025

Drury Inn & Suites St. Louis Arnold
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
2.5 out of 5
1001 Veterans Blvd, Festus, MO
The price is $121 per night from Apr 28 to Apr 29
$121
includes taxes & fees
Apr 28 - Apr 29
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (774 reviews)
"Room was decent. Could tell the hotel is older. Caulking in bathroom was horrible, lights in restroom flickering. Room and sheets were clean, bedframe creaked badly. Hallways smelled musty. For just a place to sleep and explore the area it did the job"

Reviewed on Apr 13, 2025

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Comfort Inn Festus - St Louis South
Comfort Inn Festus - St Louis South
2.5 out of 5
1303 Veterans Blvd, Festus, MO
The price is $104 per night from Apr 20 to Apr 21
$104
includes taxes & fees
Apr 20 - Apr 21
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (802 reviews)
"Friendly staff, clean and well maintained"

Reviewed on Apr 13, 2025

Comfort Inn Festus - St Louis South
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
2.5 out of 5
1802 Gamel Cemetery Road, Festus, MO
The price is $161 per night from Apr 27 to Apr 28
$161
includes taxes & fees
Apr 27 - Apr 28
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (629 reviews)
"We were in from out of state and everything went perfect!"

Reviewed on Apr 1, 2025

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Super 8 by Wyndham Farmington
Super 8 by Wyndham Farmington
2 out of 5
930 Valley Creek Dr, Farmington, MO
The price is $69 per night from Apr 19 to Apr 20
$69
includes taxes & fees
Apr 19 - Apr 20
Book a stay at this business-friendly motel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8/10 Very Good! (528 reviews)
"Clean rooms, comfortable beds, and friendly staff!!"

Reviewed on Apr 5, 2025

Super 8 by Wyndham Farmington
See all 159 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.