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De Soto

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De Soto Flights as Low as $132

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Sat, Jun 14 - Sat, Jun 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$132 Roundtrip, found 4 days ago
$132
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Sat, Jun 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 21, priced at $132 found 4 days ago
Frontier Airlines
Thu, Jun 19 - Sat, Jun 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$136 Roundtrip, found 5 days ago
$136
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Thu, Jun 19 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 21, priced at $136 found 5 days ago
Frontier Airlines
Sat, Jun 14 - Sat, Jun 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$149 Roundtrip, found 4 days ago
$149
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Sat, Jun 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 21, priced at $149 found 4 days ago
Spirit Airlines
Mon, Jun 16 - Tue, Jul 15
FLL
Fort Lauderdale - Hollywood Intl.
STL
Lambert-St. Louis Intl.
$155 Roundtrip, found 1 day ago
$155
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Mon, Jun 16 from Fort Lauderdale - Hollywood Intl. to Lambert-St. Louis Intl., returning Tue, Jul 15, priced at $155 found 1 day ago
Frontier Airlines
Tue, May 13 - Thu, May 15
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$164 Roundtrip, found 2 days ago
$164
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Tue, May 13 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Thu, May 15, priced at $164 found 2 days ago
American Airlines
Thu, Jun 19 - Mon, Jun 23
FLL
Fort Lauderdale - Hollywood Intl.
STL
Lambert-St. Louis Intl.
$184 Roundtrip, found 3 days ago
$184
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Jun 19 from Fort Lauderdale - Hollywood Intl. to Lambert-St. Louis Intl., returning Mon, Jun 23, priced at $184 found 3 days ago
Frontier Airlines
Tue, May 20 - Wed, May 21
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$191 Roundtrip, found 4 days ago
$191
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Tue, May 20 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Wed, May 21, priced at $191 found 4 days ago
Delta
Mon, Sep 22 - Mon, Sep 29
DCA
Ronald Reagan Washington National
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 14 hours ago
$197
Roundtrip
found 14 hours ago
Select Delta flight, departing Mon, Sep 22 from Ronald Reagan Washington National to Lambert-St. Louis Intl., returning Mon, Sep 29, priced at $197 found 14 hours ago
Delta
Tue, Oct 7 - Tue, Oct 7
SAT
San Antonio Intl.
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 19 hours ago
$197
Roundtrip
found 19 hours ago
Select Delta flight, departing Tue, Oct 7 from San Antonio Intl. to Lambert-St. Louis Intl., returning Tue, Oct 7, priced at $197 found 19 hours ago
Bargain Flight
Sat, May 24 - Tue, May 27
DCA
Ronald Reagan Washington National
STL
Lambert-St. Louis Intl.
$204 Roundtrip, found 5 days ago
$204
Roundtrip
found 5 days ago
Select Bargain Flight flight, departing Sat, May 24 from Ronald Reagan Washington National to Lambert-St. Louis Intl., returning Tue, May 27, priced at $204 found 5 days ago
American Airlines
Wed, Jul 16 - Wed, Jul 23
BOS
Logan Intl.
STL
Lambert-St. Louis Intl.
$223 Roundtrip, found 1 day ago
$223
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jul 16 from Logan Intl. to Lambert-St. Louis Intl., returning Wed, Jul 23, priced at $223 found 1 day ago
Delta
Wed, Jun 18 - Wed, Jul 2
ABE
Lehigh Valley Intl.
STL
Lambert-St. Louis Intl.
$247 Roundtrip, found 6 days ago
$247
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Jun 18 from Lehigh Valley Intl. to Lambert-St. Louis Intl., returning Wed, Jul 2, priced at $247 found 6 days ago
American Airlines
Sun, Jul 27 - Sat, Aug 2
CHO
Charlottesville-Albemarle
STL
Lambert-St. Louis Intl.
$249 Roundtrip, just found
$249
Roundtrip
just found
Select American Airlines flight, departing Sun, Jul 27 from Charlottesville-Albemarle to Lambert-St. Louis Intl., returning Sat, Aug 2, priced at $249 just found
Delta
Wed, May 14 - Sat, May 24
CAE
Columbia Metropolitan
STL
Lambert-St. Louis Intl.
$253 Roundtrip, found 2 days ago
$253
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, May 14 from Columbia Metropolitan to Lambert-St. Louis Intl., returning Sat, May 24, priced at $253 found 2 days ago
United
Sat, Jun 28 - Sat, Jul 5
BIL
Logan Intl.
STL
Lambert-St. Louis Intl.
$318 Roundtrip, found 1 day ago
$318
Roundtrip
found 1 day ago
Select United flight, departing Sat, Jun 28 from Logan Intl. to Lambert-St. Louis Intl., returning Sat, Jul 5, priced at $318 found 1 day ago
Alaska Airlines
Sat, Jun 28 - Sat, Jul 5
BIL
Logan Intl.
STL
Lambert-St. Louis Intl.
$703 Roundtrip, found 1 day ago
$703
Roundtrip
found 1 day ago
Select Alaska Airlines flight, departing Sat, Jun 28 from Logan Intl. to Lambert-St. Louis Intl., returning Sat, Jul 5, priced at $703 found 1 day ago

Cheap Flights to De Soto

Fall in love at first flight with your vacation to De Soto by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to De Soto on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in De Soto, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to De Soto

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to De Soto with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to De Soto?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to De Soto are in June, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to De Soto?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to De Soto.

What airport is best to fly into De Soto?

When you’re planning your trip to De Soto, convenience is the name of the game. Luckily, De Soto Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your De Soto must-do list.

How much are flights to De Soto?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to De Soto on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $132, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to De Soto?

The trick to saving a stack of cash on your flight to De Soto? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $132 right now, why wait?

Last Minute Hotel Deals in De Soto

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
3.5 out of 5
4800 U.S. Highway 67, De Soto, MO
Stay at this 3.5-star family-friendly aparthotel in De Soto. Enjoy free parking, an outdoor pool, and a fitness center. Our guests praise the property condition ...
"Beautiful property. Lots to do with the kids. Would be happy to come back when I have more time to spend there."

Reviewed on Apr 11, 2025

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Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (935 reviews)
"Was really impressed with this place. Rooms were clean, staff was friendly and breakfast was really good. Scrambled eggs, sausage, gravy, bisquits, toast, yogurt, 3 different cereals and of course coffee."

Reviewed on May 8, 2025

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Baymont Inn and Suites by Wyndham Farmington, MO
Pear Tree Inn St. Louis Arnold
Pear Tree Inn St. Louis Arnold
2.5 out of 5
1201 Drury Ln, Arnold, MO
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,001 reviews)
"Breakfast was very good. They had scrambled eggs and sausage and biscuits and gravy, along with other choices. There are also several restaurants within walking distance. Staff always had a smile and willing to help."

Reviewed on May 7, 2025

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Pear Tree Inn St. Louis Arnold
Drury Inn & Suites St. Louis Arnold
Drury Inn & Suites St. Louis Arnold
3 out of 5
3800 State Rt 141, Arnold, MO
Stay at this 3-star business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (1,000 reviews)
"Nice surprise. First stay at a Drury. I usually stay at Hilton brands, but when I come to St. Louis, I will stay at Drury from now on."

Reviewed on May 2, 2025

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Drury Inn & Suites St. Louis Arnold
Comfort Inn Festus - St Louis South
Comfort Inn Festus - St Louis South
2.5 out of 5
1303 Veterans Blvd, Festus, MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (810 reviews)
"I like the location of the hotel. It was clean and staff was friendly and helpful."

Reviewed on Apr 27, 2025

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Comfort Inn Festus - St Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
2.5 out of 5
1001 Veterans Blvd, Festus, MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (784 reviews)
"Great place to stay"

Reviewed on May 4, 2025

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La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Super 8 by Wyndham Farmington
Super 8 by Wyndham Farmington
2 out of 5
930 Valley Creek Dr, Farmington, MO
Book a stay at this business-friendly motel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8/10 Very Good! (534 reviews)
"The hotel was alright. The hotel needs a little TLC, but overall was fine for what we paid for. We felt safe & enjoyed the many restaurants & amenities around the hotel."

Reviewed on Apr 27, 2025

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Super 8 by Wyndham Farmington
Super 8 by Wyndham Bonne Terre
Super 8 by Wyndham Bonne Terre
2 out of 5
8 Northwood Drive Highway 67 A, Bonne Terre, MO
Stay at this motel in Bonne Terre. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
6.8/10 (460 reviews)
"Overall great stay"

Reviewed on Apr 27, 2025

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Super 8 by Wyndham Bonne Terre
See all 162 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.