Search Cheap Flights to
De Soto

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

De Soto Flights as Low as $38

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, Oct 28 - Wed, Nov 4
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$38 Roundtrip, found 1 day ago
$38
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, Oct 28 from Denver Intl. to Lambert-St. Louis Intl., returning Wed, Nov 4, priced at $38 found 1 day ago
Frontier Airlines
Wed, Oct 28 - Wed, Nov 4
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$38 Roundtrip, found 2 days ago
$38
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, Oct 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Nov 4, priced at $38 found 2 days ago
Frontier Airlines
Wed, Oct 28 - Mon, Nov 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$47 Roundtrip, found 1 day ago
$47
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, Oct 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, Nov 2, priced at $47 found 1 day ago
Frontier Airlines
Fri, Nov 27 - Wed, Dec 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$56 Roundtrip, found 21 hours ago
$56
Roundtrip
found 21 hours ago
Select Frontier Airlines flight, departing Fri, Nov 27 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Dec 2, priced at $56 found 21 hours ago
Frontier Airlines
Wed, Nov 4 - Wed, Nov 18
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$86 Roundtrip, found 1 day ago
$86
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, Nov 4 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Wed, Nov 18, priced at $86 found 1 day ago
United
Wed, Oct 21 - Thu, Oct 29
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$117 Roundtrip, found 8 hours ago
$117
Roundtrip
found 8 hours ago
Select United flight, departing Wed, Oct 21 from O'Hare Intl. to Lambert-St. Louis Intl., returning Thu, Oct 29, priced at $117 found 8 hours ago
Southwest Airlines
Mon, Nov 23 - Tue, Dec 8
BNA
Nashville Intl.
STL
Lambert-St. Louis Intl.
$119 Roundtrip, found 1 day ago
$119
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Mon, Nov 23 from Nashville Intl. to Lambert-St. Louis Intl., returning Tue, Dec 8, priced at $119 found 1 day ago
Frontier Airlines
Mon, Nov 16 - Wed, Nov 18
LAX
Los Angeles Intl.
STL
Lambert-St. Louis Intl.
$136 Roundtrip, found 1 day ago
$136
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Mon, Nov 16 from Los Angeles Intl. to Lambert-St. Louis Intl., returning Wed, Nov 18, priced at $136 found 1 day ago
Delta
Sat, Dec 5 - Sat, Dec 5
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$137 Roundtrip, found 4 hours ago
$137
Roundtrip
found 4 hours ago
Select Delta flight, departing Sat, Dec 5 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Dec 5, priced at $137 found 4 hours ago
American Airlines
Wed, Oct 21 - Fri, Oct 23
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$144 Roundtrip, found 9 hours ago
$144
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Wed, Oct 21 from O'Hare Intl. to Lambert-St. Louis Intl., returning Fri, Oct 23, priced at $144 found 9 hours ago
Frontier Airlines
Wed, Nov 4 - Wed, Nov 11
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$150 Roundtrip, found 18 hours ago
$150
Roundtrip
found 18 hours ago
Select Frontier Airlines flight, departing Wed, Nov 4 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Wed, Nov 11, priced at $150 found 18 hours ago
Frontier Airlines
Wed, Oct 14 - Mon, Oct 19
FLL
Fort Lauderdale - Hollywood Intl.
STL
Lambert-St. Louis Intl.
$166 Roundtrip, found 1 day ago
$166
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, Oct 14 from Fort Lauderdale - Hollywood Intl. to Lambert-St. Louis Intl., returning Mon, Oct 19, priced at $166 found 1 day ago
Frontier Airlines
Sat, Nov 14 - Wed, Nov 18
ONT
Ontario Intl. Airport
STL
Lambert-St. Louis Intl.
$174 Roundtrip, found 10 hours ago
$174
Roundtrip
found 10 hours ago
Select Frontier Airlines flight, departing Sat, Nov 14 from Ontario Intl. Airport to Lambert-St. Louis Intl., returning Wed, Nov 18, priced at $174 found 10 hours ago
Southern Airways Express
Wed, Oct 14 - Fri, Oct 30
BNA
Nashville Intl.
STL
Lambert-St. Louis Intl.
$174 Roundtrip, found 1 day ago
$174
Roundtrip
found 1 day ago
Select Southern Airways Express flight, departing Wed, Oct 14 from Nashville Intl. to Lambert-St. Louis Intl., returning Fri, Oct 30, priced at $174 found 1 day ago
Southwest Airlines
Fri, Oct 30 - Mon, Nov 16
DAL
Love Field
STL
Lambert-St. Louis Intl.
$296 Roundtrip, found 13 hours ago
$296
Roundtrip
found 13 hours ago
Select Southwest Airlines flight, departing Fri, Oct 30 from Love Field to Lambert-St. Louis Intl., returning Mon, Nov 16, priced at $296 found 13 hours ago
Alaska Airlines
Thu, Nov 12 - Tue, Nov 17
ONT
Ontario Intl. Airport
STL
Lambert-St. Louis Intl.
$417 Roundtrip, found 1 day ago
$417
Roundtrip
found 1 day ago
Select Alaska Airlines flight, departing Thu, Nov 12 from Ontario Intl. Airport to Lambert-St. Louis Intl., returning Tue, Nov 17, priced at $417 found 1 day ago

Cheap Flights to De Soto

Fall in love at first flight with your vacation to De Soto by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to De Soto on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in De Soto, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to De Soto

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to De Soto with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to De Soto?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to De Soto are in October, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to De Soto?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to De Soto.

What airport is best to fly into De Soto?

When you’re planning your trip to De Soto, convenience is the name of the game. Luckily, De Soto Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your De Soto must-do list.

How much are flights to De Soto?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to De Soto on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $38, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to De Soto?

The trick to saving a stack of cash on your flight to De Soto? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $38 right now, why wait?

De Soto Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$38

Last Minute Hotel Deals in De Soto

Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold

2.5 out of 5
1201 Drury Ln Arnold MO
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Get rates
Pear Tree Inn St. Louis Arnold
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,003 reviews)
"So-so. Average hotel, decent area"

Reviewed on Oct 1, 2026

Get rates
Baymont Inn and Suites by Wyndham Farmington, MO
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

2.5 out of 5
1303 Veterans Blvd Festus MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,000 reviews)
"Needs remodeling. Carpet is old and needs replaced."

Reviewed on Sep 29, 2026

Get rates
Comfort Inn Festus - St Louis South
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

2 out of 5
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
10/10 Exceptional! (109 reviews)
"I loved everything about this cabin and I was on a high from this experience."

Reviewed on Sep 26, 2026

Get rates
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Drury Inn & Suites St. Louis Arnold

Drury Inn & Suites St. Louis Arnold

3 out of 5
3800 State Rt 141 Arnold MO
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.6/10 Exceptional! (1,000 reviews)
"Second time to stay here in 45 days. Staff is thoughtful, great location for our needs. Several resturants are yummy and easy access."

Reviewed on Sep 27, 2026

Get rates
Drury Inn & Suites St. Louis Arnold
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

2.5 out of 5
1802 Gamel Cemetery Road Festus MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (779 reviews)
"The rooms were clean and well organized"

Reviewed on Sep 26, 2026

Get rates
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection

2.5 out of 5
4245 Hunt Rd Farmington MO
Book a stay at this golf hotel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
9/10 Wonderful! (683 reviews)
"Arrived at 10 PM it was nice to have a helpful front desk person. Room was clean. However, the l ceiling light just inside the front door is a CFL and very dim the first 10 minutes. Same for the bathroom sconces on each side of the mirror. The light bulbs in two light fixtures between the beds, we’re ..."

Reviewed on Oct 1, 2026

Get rates
Crown Pointe Lodge, BW Signature Collection
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3 out of 5
1001 Veterans Blvd Festus MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,000 reviews)
"Of all the hotels we used on our trip I think this one was our favorite. It was very clean. Staff was helpful and friendly. We stopped here after picking up our dog. The dog fee was 25.00 dollars just like it said. Some places say they are pet friendly and don’t post what they charge. Then charge ..."

Reviewed on Sep 30, 2026

Get rates
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
See all 206 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.