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De Soto

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De Soto Flights as Low as $122

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Sat, Jun 14 - Sat, Jun 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$122 Roundtrip, found 1 day ago
$122
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, Jun 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 21, priced at $122 found 1 day ago
Frontier Airlines
Sat, Jul 19 - Sun, Jul 20
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$145 Roundtrip, found 3 days ago
$145
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Sat, Jul 19 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sun, Jul 20, priced at $145 found 3 days ago
Spirit Airlines
Tue, Apr 29 - Thu, May 8
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$151 Roundtrip, found 20 hours ago
$151
Roundtrip
found 20 hours ago
Select Spirit Airlines flight, departing Tue, Apr 29 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Thu, May 8, priced at $151 found 20 hours ago
Frontier Airlines
Wed, Apr 2 - Wed, Apr 9
CLE
Hopkins Intl.
STL
Lambert-St. Louis Intl.
$160 Roundtrip, found 22 hours ago
$160
Roundtrip
found 22 hours ago
Select Frontier Airlines flight, departing Wed, Apr 2 from Hopkins Intl. to Lambert-St. Louis Intl., returning Wed, Apr 9, priced at $160 found 22 hours ago
Frontier Airlines
Wed, May 7 - Tue, May 20
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$160 Roundtrip, found 5 days ago
$160
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Wed, May 7 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Tue, May 20, priced at $160 found 5 days ago
Frontier Airlines
Tue, Apr 1 - Wed, Apr 2
SAT
San Antonio Intl.
STL
Lambert-St. Louis Intl.
$161 Roundtrip, found 1 day ago
$161
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Tue, Apr 1 from San Antonio Intl. to Lambert-St. Louis Intl., returning Wed, Apr 2, priced at $161 found 1 day ago
Frontier Airlines
Mon, Apr 7 - Tue, Apr 15
TTN
Mercer
STL
Lambert-St. Louis Intl.
$170 Roundtrip, found 2 days ago
$170
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Mon, Apr 7 from Mercer to Lambert-St. Louis Intl., returning Tue, Apr 15, priced at $170 found 2 days ago
Frontier Airlines
Thu, Mar 27 - Wed, Apr 9
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$170 Roundtrip, found 1 day ago
$170
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Mar 27 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Wed, Apr 9, priced at $170 found 1 day ago
Delta
Tue, Apr 8 - Tue, Apr 8
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$183 Roundtrip, found 4 days ago
$183
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Apr 8 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Tue, Apr 8, priced at $183 found 4 days ago
Frontier Airlines
Sun, Apr 27 - Thu, May 8
SMF
Sacramento Intl.
STL
Lambert-St. Louis Intl.
$191 Roundtrip, found 6 days ago
$191
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Sun, Apr 27 from Sacramento Intl. to Lambert-St. Louis Intl., returning Thu, May 8, priced at $191 found 6 days ago
American Airlines
Mon, Apr 28 - Tue, Apr 29
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$214 Roundtrip, found 20 hours ago
$214
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Mon, Apr 28 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Tue, Apr 29, priced at $214 found 20 hours ago
United
Tue, Apr 1 - Thu, Apr 3
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$217 Roundtrip, found 4 days ago
$217
Roundtrip
found 4 days ago
Select United flight, departing Tue, Apr 1 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Thu, Apr 3, priced at $217 found 4 days ago
Frontier Airlines
Sun, Aug 3 - Thu, Aug 14
OKC
Will Rogers World
STL
Lambert-St. Louis Intl.
$220 Roundtrip, found 23 hours ago
$220
Roundtrip
found 23 hours ago
Select Frontier Airlines flight, departing Sun, Aug 3 from Will Rogers World to Lambert-St. Louis Intl., returning Thu, Aug 14, priced at $220 found 23 hours ago
Hawaiian Airlines
Wed, Apr 9 - Tue, Apr 15
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$238 Roundtrip, found 4 days ago
$238
Roundtrip
found 4 days ago
Select Hawaiian Airlines flight, departing Wed, Apr 9 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Tue, Apr 15, priced at $238 found 4 days ago
Alaska Airlines
Tue, Apr 8 - Thu, Apr 10
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$243 Roundtrip, found 4 days ago
$243
Roundtrip
found 4 days ago
Select Alaska Airlines flight, departing Tue, Apr 8 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Thu, Apr 10, priced at $243 found 4 days ago
American Airlines
Sat, Mar 15 - Tue, Mar 18
JAN
Evers Intl.
STL
Lambert-St. Louis Intl.
$490 Roundtrip, found 18 hours ago
$490
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Sat, Mar 15 from Evers Intl. to Lambert-St. Louis Intl., returning Tue, Mar 18, priced at $490 found 18 hours ago

Cheap Flights to De Soto

Fall in love at first flight with your vacation to De Soto by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to De Soto on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in De Soto, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to De Soto

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to De Soto with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to De Soto?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to De Soto are in June, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to De Soto?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to De Soto.

What airport is best to fly into De Soto?

When you’re planning your trip to De Soto, convenience is the name of the game. Luckily, De Soto Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your De Soto must-do list.

How much are flights to De Soto?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to De Soto on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $122, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to De Soto?

The trick to saving a stack of cash on your flight to De Soto? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $122 right now, why wait?

De Soto Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$122

Last Minute Hotel Deals in De Soto

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
3.5 out of 5
4800 U.S. Highway 67, De Soto, MO
The price is $183 per night from Mar 23 to Mar 24
$183
includes taxes & fees
Mar 23 - Mar 24
Stay at this 3.5-star family-friendly aparthotel in De Soto. Enjoy free parking, an outdoor pool, and a fitness center. Our guests praise the property condition ...
9.2/10 Wonderful! (139 reviews)
"Many things to do if you don't want to go anywhere. Close to shopping, restaurant."

Reviewed on Dec 30, 2024

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
The price is $61 per night from Mar 23 to Mar 24
$61
includes taxes & fees
Mar 23 - Mar 24
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (870 reviews)
"Pleasantly surprised by how great everything was! Will definitely stay here again when in the area."

Reviewed on Mar 4, 2025

Baymont Inn and Suites by Wyndham Farmington, MO
Pear Tree Inn St. Louis Arnold
Pear Tree Inn St. Louis Arnold
2.5 out of 5
1201 Drury Ln, Arnold, MO
The price is $99 per night from Mar 16 to Mar 17
$99
includes taxes & fees
Mar 16 - Mar 17
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,001 reviews)
"Front desk gals were wonderful and gave me much needed laughter after a 10 hour drive with the family."

Reviewed on Mar 8, 2025

Pear Tree Inn St. Louis Arnold
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
2.5 out of 5
1001 Veterans Blvd, Festus, MO
The price is $150 per night from Mar 22 to Mar 23
$150
includes taxes & fees
Mar 22 - Mar 23
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (757 reviews)
"This was a very nice place to stay. Very clean."

Reviewed on Feb 25, 2025

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Drury Inn & Suites St. Louis Arnold
Drury Inn & Suites St. Louis Arnold
3 out of 5
3800 State Rt 141, Arnold, MO
The price is $156 per night from Mar 17 to Mar 18
$156
includes taxes & fees
Mar 17 - Mar 18
Stay at this 3-star business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (1,004 reviews)
Overnight stop
"Very clean easy check in happy hour was a nice surprise and the breakfast buffett was great"

Reviewed on Mar 5, 2025

Drury Inn & Suites St. Louis Arnold
Comfort Inn Festus - St Louis South
Comfort Inn Festus - St Louis South
2.5 out of 5
1303 Veterans Blvd, Festus, MO
The price is $104 per night from Apr 1 to Apr 2
$104
includes taxes & fees
Apr 1 - Apr 2
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (786 reviews)
"They had a nice breakfast with many options. Good place to stop."

Reviewed on Mar 11, 2025

Comfort Inn Festus - St Louis South
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
2.5 out of 5
1802 Gamel Cemetery Road, Festus, MO
The price is $170 per night from Apr 4 to Apr 5
$170
includes taxes & fees
Apr 4 - Apr 5
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (623 reviews)
"Good property! Safe and convenient!"

Reviewed on Mar 10, 2025

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Postcard Cabins St. Francois
Postcard Cabins St. Francois
2 out of 5
7555 State Hwy Y, French Village, MO
The price is $108 per night from Mar 13 to Mar 14
$108
includes taxes & fees
Mar 13 - Mar 14
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
10/10 Exceptional! (3 reviews)
"This place made me look like a rockstar to my wife. I surprised her with a V day getaway. The cabin was awesome. We loved the view of nature from the large window. I made dinner reservations nearby at the weingarten vineyard. The hiking trail along the creek was fun. We ate breakfast right down the ..."

Reviewed on Feb 17, 2025

Postcard Cabins St. Francois
See all 142 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.