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De Soto

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De Soto Flights as Low as $60

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Spirit Airlines
Fri, Aug 8 - Sun, Aug 10
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$60 Roundtrip, found 2 hours ago
$60
Roundtrip
found 2 hours ago
Select Spirit Airlines flight, departing Fri, Aug 8 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Sun, Aug 10, priced at $60 found 2 hours ago
Spirit Airlines
Thu, Aug 14 - Mon, Aug 18
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$70 Roundtrip, found 1 hour ago
$70
Roundtrip
found 1 hour ago
Select Spirit Airlines flight, departing Thu, Aug 14 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Mon, Aug 18, priced at $70 found 1 hour ago
Frontier Airlines
Thu, Aug 21 - Thu, Aug 28
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$89 Roundtrip, just found
$89
Roundtrip
just found
Select Frontier Airlines flight, departing Thu, Aug 21 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Thu, Aug 28, priced at $89 just found
Spirit Airlines
Wed, Aug 6 - Sat, Aug 9
MCO
Orlando Intl.
STL
Lambert-St. Louis Intl.
$106 Roundtrip, found 2 hours ago
$106
Roundtrip
found 2 hours ago
Select Spirit Airlines flight, departing Wed, Aug 6 from Orlando Intl. to Lambert-St. Louis Intl., returning Sat, Aug 9, priced at $106 found 2 hours ago
American Airlines
Thu, Aug 21 - Thu, Aug 28
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$119 Roundtrip, just found
$119
Roundtrip
just found
Select American Airlines flight, departing Thu, Aug 21 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Thu, Aug 28, priced at $119 just found
Delta
Thu, Aug 14 - Mon, Aug 18
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$123 Roundtrip, found 1 hour ago
$123
Roundtrip
found 1 hour ago
Select Delta flight, departing Thu, Aug 14 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Mon, Aug 18, priced at $123 found 1 hour ago
American Airlines
Thu, Sep 4 - Thu, Sep 11
BWI
Baltimore Washington Intl. Thurgood Marshall
STL
Lambert-St. Louis Intl.
$158 Roundtrip, found 6 hours ago
$158
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Thu, Sep 4 from Baltimore Washington Intl. Thurgood Marshall to Lambert-St. Louis Intl., returning Thu, Sep 11, priced at $158 found 6 hours ago
American Airlines
Tue, Nov 18 - Wed, Nov 19
SAT
San Antonio Intl.
STL
Lambert-St. Louis Intl.
$159 Roundtrip, found 1 hour ago
$159
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Tue, Nov 18 from San Antonio Intl. to Lambert-St. Louis Intl., returning Wed, Nov 19, priced at $159 found 1 hour ago
American Airlines
Thu, Aug 21 - Sun, Aug 24
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$161 Roundtrip, found 1 day ago
$161
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Aug 21 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Sun, Aug 24, priced at $161 found 1 day ago
United
Wed, Aug 27 - Thu, Sep 4
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$173 Roundtrip, just found
$173
Roundtrip
just found
Select United flight, departing Wed, Aug 27 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Thu, Sep 4, priced at $173 just found
American Airlines
Sat, Sep 20 - Mon, Sep 22
SJC
Norman Y. Mineta San Jose Intl.
STL
Lambert-St. Louis Intl.
$181 Roundtrip, just found
$181
Roundtrip
just found
Select American Airlines flight, departing Sat, Sep 20 from Norman Y. Mineta San Jose Intl. to Lambert-St. Louis Intl., returning Mon, Sep 22, priced at $181 just found
Delta
Tue, Aug 26 - Tue, Aug 26
DAL
Love Field
STL
Lambert-St. Louis Intl.
$194 Roundtrip, just found
$194
Roundtrip
just found
Select Delta flight, departing Tue, Aug 26 from Love Field to Lambert-St. Louis Intl., returning Tue, Aug 26, priced at $194 just found
United
Sat, Oct 25 - Mon, Oct 27
LAX
Los Angeles Intl.
STL
Lambert-St. Louis Intl.
$207 Roundtrip, found 1 hour ago
$207
Roundtrip
found 1 hour ago
Select United flight, departing Sat, Oct 25 from Los Angeles Intl. to Lambert-St. Louis Intl., returning Mon, Oct 27, priced at $207 found 1 hour ago
Bargain Flight
Sun, Aug 31 - Sun, Sep 7
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$228 Roundtrip, found 5 hours ago
$228
Roundtrip
found 5 hours ago
Select Bargain Flight flight, departing Sun, Aug 31 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Sun, Sep 7, priced at $228 found 5 hours ago
Hawaiian Airlines
Sun, Aug 31 - Sat, Sep 6
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$231 Roundtrip, found 2 days ago
$231
Roundtrip
found 2 days ago
Select Hawaiian Airlines flight, departing Sun, Aug 31 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Sat, Sep 6, priced at $231 found 2 days ago
Delta
Sat, Jul 12 - Wed, Jul 23
FSD
Sioux Falls Regional
STL
Lambert-St. Louis Intl.
$267 Roundtrip, found 1 day ago
$267
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Jul 12 from Sioux Falls Regional to Lambert-St. Louis Intl., returning Wed, Jul 23, priced at $267 found 1 day ago

Cheap Flights to De Soto

Fall in love at first flight with your vacation to De Soto by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to De Soto on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in De Soto, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to De Soto

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to De Soto with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to De Soto?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to De Soto are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to De Soto?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to De Soto.

What airport is best to fly into De Soto?

When you’re planning your trip to De Soto, convenience is the name of the game. Luckily, De Soto Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your De Soto must-do list.

How much are flights to De Soto?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to De Soto on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $60, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to De Soto?

The trick to saving a stack of cash on your flight to De Soto? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $60 right now, why wait?

De Soto Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$60

Last Minute Hotel Deals in De Soto

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
3.5 out of 5
4800 U.S. Highway 67, De Soto, MO
Stay at this 3.5-star family-friendly aparthotel in De Soto. Enjoy free parking, an outdoor pool, and a fitness center. Our guests praise the property condition ...
9.4/10 Exceptional! (146 reviews)
"We had a wonderful time here!! Rooms were spacious and clean. So many activities that you can stay at the resort the entire time if you don’t want to drive to town. Definitely hope to be able to go back! Thank you!!"

Reviewed on Jul 6, 2025

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Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Pear Tree Inn St. Louis Arnold
Pear Tree Inn St. Louis Arnold
2.5 out of 5
1201 Drury Ln, Arnold, MO
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,006 reviews)
"Everything was great. That's what you want in a hotel room!"

Reviewed on Jul 8, 2025

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Pear Tree Inn St. Louis Arnold
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,001 reviews)
"My stay wasn’t too bad. We had two rooms and in one of them, there was a beetle in the bed - we had to request a changing of the sheets. Next day, we requested towels/room cleaning and no one came by. We had to go and get more towels. Also, one of the key cards, which was not near a phone, became ..."

Reviewed on Jul 7, 2025

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Baymont Inn and Suites by Wyndham Farmington, MO
Drury Inn & Suites St. Louis Arnold
Drury Inn & Suites St. Louis Arnold
3 out of 5
3800 State Rt 141, Arnold, MO
Stay at this 3-star business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (1,002 reviews)
We had a wonderful time.
"My son loved the pool. We loved the hot tub. Breakfast was fresh and hot. Plenty of seating at breakfast and comfortable chairs. The staff was friendly and fast."

Reviewed on Jul 5, 2025

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Drury Inn & Suites St. Louis Arnold
Comfort Inn Festus - St Louis South
Comfort Inn Festus - St Louis South
2.5 out of 5
1303 Veterans Blvd, Festus, MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (835 reviews)
Family vaca
"Great breakfast nice layover on our way to Florida"

Reviewed on Jun 24, 2025

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Comfort Inn Festus - St Louis South
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
2.5 out of 5
1802 Gamel Cemetery Road, Festus, MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (652 reviews)
"was a little tricky to get to, but was not right on the interstate. No Road noise at all."

Reviewed on Jul 7, 2025

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Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Postcard Cabins St. Francois
Postcard Cabins St. Francois
2 out of 5
7555 State Hwy Y, French Village, MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
10/10 Exceptional! (12 reviews)
"Had a wonderful time"

Reviewed on Jul 8, 2025

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Postcard Cabins St. Francois
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3 out of 5
1001 Veterans Blvd, Festus, MO
Stay at this 3-star business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (811 reviews)
"Clean and friendly service"

Reviewed on Jul 9, 2025

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La Quinta Inn & Suites by Wyndham Festus - St. Louis South
See all 166 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.