Search Cheap Flights to
De Soto

Photo by Jessica King

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

De Soto Flights as Low as $60

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Spirit Airlines
Spirit Airlines
Frontier Airlines
Frontier Airlines
American Airlines
Delta
American Airlines
American Airlines
American Airlines
United
American Airlines
Delta
United
Bargain Flight
Hawaiian Airlines
Delta

Cheap Flights to De Soto

Fall in love at first flight with your vacation to De Soto by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to De Soto on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in De Soto, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to De Soto

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to De Soto with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to De Soto?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to De Soto are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to De Soto?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to De Soto.

What airport is best to fly into De Soto?

When you’re planning your trip to De Soto, convenience is the name of the game. Luckily, De Soto Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your De Soto must-do list.

How much are flights to De Soto?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to De Soto on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $60, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to De Soto?

The trick to saving a stack of cash on your flight to De Soto? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $60 right now, why wait?

De Soto Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$60

Last Minute Hotel Deals in De Soto

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
3.5 out of 5
4800 U.S. Highway 67, De Soto, MO
Stay at this 3.5-star family-friendly aparthotel in De Soto. Enjoy free parking, an outdoor pool, and a fitness center. Our guests praise the property condition ...
9.4/10 Exceptional! (146 reviews)
"We had a wonderful time here!! Rooms were spacious and clean. So many activities that you can stay at the resort the entire time if you don’t want to drive to town. Definitely hope to be able to go back! Thank you!!"

Reviewed on Jul 6, 2025

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Pear Tree Inn St. Louis Arnold
Pear Tree Inn St. Louis Arnold
2.5 out of 5
1201 Drury Ln, Arnold, MO
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,006 reviews)
"Everything was great. That's what you want in a hotel room!"

Reviewed on Jul 8, 2025

Pear Tree Inn St. Louis Arnold
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,001 reviews)
"My stay wasn’t too bad. We had two rooms and in one of them, there was a beetle in the bed - we had to request a changing of the sheets. Next day, we requested towels/room cleaning and no one came by. We had to go and get more towels. Also, one of the key cards, which was not near a phone, became ..."

Reviewed on Jul 7, 2025

Baymont Inn and Suites by Wyndham Farmington, MO
Drury Inn & Suites St. Louis Arnold
Drury Inn & Suites St. Louis Arnold
3 out of 5
3800 State Rt 141, Arnold, MO
Stay at this 3-star business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (1,002 reviews)
We had a wonderful time.
"My son loved the pool. We loved the hot tub. Breakfast was fresh and hot. Plenty of seating at breakfast and comfortable chairs. The staff was friendly and fast."

Reviewed on Jul 5, 2025

Drury Inn & Suites St. Louis Arnold
Comfort Inn Festus - St Louis South
Comfort Inn Festus - St Louis South
2.5 out of 5
1303 Veterans Blvd, Festus, MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (835 reviews)
Family vaca
"Great breakfast nice layover on our way to Florida"

Reviewed on Jun 24, 2025

Comfort Inn Festus - St Louis South
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
2.5 out of 5
1802 Gamel Cemetery Road, Festus, MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (652 reviews)
"was a little tricky to get to, but was not right on the interstate. No Road noise at all."

Reviewed on Jul 7, 2025

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Postcard Cabins St. Francois
Postcard Cabins St. Francois
2 out of 5
7555 State Hwy Y, French Village, MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
10/10 Exceptional! (12 reviews)
"Had a wonderful time"

Reviewed on Jul 8, 2025

Postcard Cabins St. Francois
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3 out of 5
1001 Veterans Blvd, Festus, MO
Stay at this 3-star business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (811 reviews)
"Clean and friendly service"

Reviewed on Jul 9, 2025

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.