Search Cheap Flights to
De Soto

Photo by Jessica King

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

De Soto Flights as Low as $88

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Tue, Apr 1 - Mon, Apr 7
MCO
Orlando Intl.
STL
Lambert-St. Louis Intl.
$88 Roundtrip, found 19 hours ago
$88
Roundtrip
found 19 hours ago
Select Frontier Airlines flight, departing Tue, Apr 1 from Orlando Intl. to Lambert-St. Louis Intl., returning Mon, Apr 7, priced at $88 found 19 hours ago
Frontier Airlines
Tue, Apr 1 - Sun, Apr 6
MCO
Orlando Intl.
STL
Lambert-St. Louis Intl.
$105 Roundtrip, found 3 days ago
$105
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Tue, Apr 1 from Orlando Intl. to Lambert-St. Louis Intl., returning Sun, Apr 6, priced at $105 found 3 days ago
Frontier Airlines
Wed, Feb 19 - Tue, Feb 25
MSP
Minneapolis - St. Paul Intl.
STL
Lambert-St. Louis Intl.
$110 Roundtrip, found 1 day ago
$110
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, Feb 19 from Minneapolis - St. Paul Intl. to Lambert-St. Louis Intl., returning Tue, Feb 25, priced at $110 found 1 day ago
Frontier Airlines
Tue, Mar 4 - Wed, Mar 5
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$119 Roundtrip, found 21 hours ago
$119
Roundtrip
found 21 hours ago
Select Frontier Airlines flight, departing Tue, Mar 4 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Wed, Mar 5, priced at $119 found 21 hours ago
Frontier Airlines
Mon, Apr 7 - Mon, Apr 14
CLE
Hopkins Intl.
STL
Lambert-St. Louis Intl.
$120 Roundtrip, found 5 hours ago
$120
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Mon, Apr 7 from Hopkins Intl. to Lambert-St. Louis Intl., returning Mon, Apr 14, priced at $120 found 5 hours ago
Frontier Airlines
Wed, May 7 - Sat, May 17
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$120 Roundtrip, found 2 days ago
$120
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, May 7 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Sat, May 17, priced at $120 found 2 days ago
Frontier Airlines
Tue, Feb 4 - Wed, Feb 12
PDX
Portland Intl.
STL
Lambert-St. Louis Intl.
$135 Roundtrip, found 4 days ago
$135
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Tue, Feb 4 from Portland Intl. to Lambert-St. Louis Intl., returning Wed, Feb 12, priced at $135 found 4 days ago
Spirit Airlines
Tue, Feb 25 - Tue, Mar 11
EWR
Newark Liberty Intl. Airport
STL
Lambert-St. Louis Intl.
$144 Roundtrip, found 7 hours ago
$144
Roundtrip
found 7 hours ago
Select Spirit Airlines flight, departing Tue, Feb 25 from Newark Liberty Intl. Airport to Lambert-St. Louis Intl., returning Tue, Mar 11, priced at $144 found 7 hours ago
United
Mon, Feb 24 - Tue, Mar 11
EWR
Newark Liberty Intl. Airport
STL
Lambert-St. Louis Intl.
$177 Roundtrip, found 7 hours ago
$177
Roundtrip
found 7 hours ago
Select United flight, departing Mon, Feb 24 from Newark Liberty Intl. Airport to Lambert-St. Louis Intl., returning Tue, Mar 11, priced at $177 found 7 hours ago
Frontier Airlines
Tue, Feb 25 - Fri, Mar 7
TTN
Mercer
STL
Lambert-St. Louis Intl.
$189 Roundtrip, found 4 days ago
$189
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Tue, Feb 25 from Mercer to Lambert-St. Louis Intl., returning Fri, Mar 7, priced at $189 found 4 days ago
Delta
Wed, Feb 19 - Tue, Feb 25
DAL
Love Field
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 4 days ago
$197
Roundtrip
found 4 days ago
Select Delta flight, departing Wed, Feb 19 from Love Field to Lambert-St. Louis Intl., returning Tue, Feb 25, priced at $197 found 4 days ago
American Airlines
Mon, Feb 24 - Tue, Mar 11
EWR
Newark Liberty Intl. Airport
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 7 hours ago
$197
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Mon, Feb 24 from Newark Liberty Intl. Airport to Lambert-St. Louis Intl., returning Tue, Mar 11, priced at $197 found 7 hours ago
Delta
Wed, Mar 5 - Mon, Mar 17
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 21 hours ago
$197
Roundtrip
found 21 hours ago
Select Delta flight, departing Wed, Mar 5 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Mon, Mar 17, priced at $197 found 21 hours ago
American Airlines
Tue, Mar 18 - Tue, Mar 25
GPT
Gulfport - Biloxi Intl.
STL
Lambert-St. Louis Intl.
$249 Roundtrip, found 19 hours ago
$249
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Tue, Mar 18 from Gulfport - Biloxi Intl. to Lambert-St. Louis Intl., returning Tue, Mar 25, priced at $249 found 19 hours ago
Alaska Airlines
Wed, Feb 26 - Mon, Mar 3
PDX
Portland Intl.
STL
Lambert-St. Louis Intl.
$316 Roundtrip, found 1 day ago
$316
Roundtrip
found 1 day ago
Select Alaska Airlines flight, departing Wed, Feb 26 from Portland Intl. to Lambert-St. Louis Intl., returning Mon, Mar 3, priced at $316 found 1 day ago
Hawaiian Airlines
Mon, Sep 8 - Mon, Sep 15
HNL
Daniel K. Inouye Intl.
STL
Lambert-St. Louis Intl.
$497 Roundtrip, found 1 hour ago
$497
Roundtrip
found 1 hour ago
Select Hawaiian Airlines flight, departing Mon, Sep 8 from Daniel K. Inouye Intl. to Lambert-St. Louis Intl., returning Mon, Sep 15, priced at $497 found 1 hour ago

Cheap Flights to De Soto

Fall in love at first flight with your vacation to De Soto by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to De Soto on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in De Soto, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to De Soto

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to De Soto with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to De Soto?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to De Soto are in April, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to De Soto?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to De Soto.

What airport is best to fly into De Soto?

When you’re planning your trip to De Soto, convenience is the name of the game. Luckily, De Soto Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your De Soto must-do list.

How much are flights to De Soto?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to De Soto on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $88, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to De Soto?

The trick to saving a stack of cash on your flight to De Soto? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $88 right now, why wait?

De Soto Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$88

Last Minute Hotel Deals in De Soto

Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel
Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel
3.5 out of 5
4800 U.S. Highway 67, De Soto, MO
The price is $183 per night from Feb 4 to Feb 5
$183
includes taxes & fees
Feb 4 - Feb 5
Stay at this 3.5-star family-friendly aparthotel in De Soto. Enjoy free parking, an outdoor pool, and a fitness center. Our guests praise the property condition ...
9.2/10 Wonderful! (139 reviews)
"Many things to do if you don't want to go anywhere. Close to shopping, restaurant."

Reviewed on Dec 30, 2024

Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
The price is $60 per night from Feb 9 to Feb 10
$60
includes taxes & fees
Feb 9 - Feb 10
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (846 reviews)
"Friendly staff and full size bath tubs"

Reviewed on Jan 25, 2025

Baymont Inn and Suites by Wyndham Farmington, MO
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
2.5 out of 5
1001 Veterans Blvd, Festus, MO
The price is $99 per night from Feb 5 to Feb 6
$99
includes taxes & fees
Feb 5 - Feb 6
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (740 reviews)
"Clean, nice furnishings. Thick plush towels Bathroom sink space small."

Reviewed on Jan 30, 2025

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Pear Tree Inn St. Louis Arnold
Pear Tree Inn St. Louis Arnold
2.5 out of 5
1201 Drury Ln, Arnold, MO
The price is $99 per night from Feb 8 to Feb 9
$99
includes taxes & fees
Feb 8 - Feb 9
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,005 reviews)
"Had a nice stay"

Reviewed on Jan 24, 2025

Pear Tree Inn St. Louis Arnold
Drury Inn & Suites St. Louis Arnold
Drury Inn & Suites St. Louis Arnold
3 out of 5
3800 State Rt 141, Arnold, MO
The price is $135 per night from Feb 9 to Feb 10
$135
includes taxes & fees
Feb 9 - Feb 10
Stay at this 3-star business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (1,004 reviews)
"We love to stay here.."

Reviewed on Feb 1, 2025

Drury Inn & Suites St. Louis Arnold
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel
2.5 out of 5
1802 Gamel Cemetery Road, Festus, MO
The price is $153 per night from Feb 8 to Feb 9
$153
includes taxes & fees
Feb 8 - Feb 9
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (615 reviews)
Great stay in St Louis area!
"Great stay! Very nice and welcoming hotel. Great breakfast! Many choices!"

Reviewed on Feb 1, 2025

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel
Postcard Cabins St. Francois
Postcard Cabins St. Francois
2 out of 5
7555 State Hwy Y, French Village, MO
The price is $86 per night from Feb 4 to Feb 5
$86
includes taxes & fees
Feb 4 - Feb 5
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
Postcard Cabins St. Francois
WoodSpring Suites St. Louis Arnold
WoodSpring Suites St. Louis Arnold
2.5 out of 5
888 Arnold Commons Dr., Arnold, MO
The price is $82 per night from Feb 4 to Feb 5
$82
includes taxes & fees
Feb 4 - Feb 5
Stay at this hotel in Arnold. Enjoy free WiFi, free parking, and laundry facilities. Our guests praise the helpful staff in our reviews. Popular attractions ...
5.8/10 (385 reviews)
"Everything"

Reviewed on Jan 13, 2025

WoodSpring Suites St. Louis Arnold
See all 142 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.