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Mayesville

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Mayesville Flights as Low as $329

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$329 Roundtrip, found 5 days ago
$329
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $329 found 5 days ago
American Airlines
Mon, Jul 20 - Sat, Jul 25
LGA
LaGuardia
FLO
Florence Regional
$336 Roundtrip, found 4 days ago
$336
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Jul 20 from LaGuardia to Florence Regional, returning Sat, Jul 25, priced at $336 found 4 days ago
American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$409 Roundtrip, found 5 days ago
$409
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $409 found 5 days ago
American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$410 Roundtrip, found 6 hours ago
$410
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $410 found 6 hours ago
American Airlines
Mon, Jul 20 - Sat, Jul 25
LGA
LaGuardia
FLO
Florence Regional
$411 Roundtrip, found 4 days ago
$411
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Jul 20 from LaGuardia to Florence Regional, returning Sat, Jul 25, priced at $411 found 4 days ago
American Airlines
Tue, Jul 21 - Tue, Jul 28
LGA
LaGuardia
FLO
Florence Regional
$416 Roundtrip, found 1 day ago
$416
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jul 21 from LaGuardia to Florence Regional, returning Tue, Jul 28, priced at $416 found 1 day ago
American Airlines
Mon, Jul 20 - Sat, Jul 25
LGA
LaGuardia
FLO
Florence Regional
$418 Roundtrip, found 4 days ago
$418
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Jul 20 from LaGuardia to Florence Regional, returning Sat, Jul 25, priced at $418 found 4 days ago
American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$443 Roundtrip, found 5 days ago
$443
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $443 found 5 days ago
American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$490 Roundtrip, found 6 hours ago
$490
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $490 found 6 hours ago
American Airlines
Tue, Jul 21 - Tue, Jul 28
LGA
LaGuardia
FLO
Florence Regional
$498 Roundtrip, found 1 day ago
$498
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jul 21 from LaGuardia to Florence Regional, returning Tue, Jul 28, priced at $498 found 1 day ago
American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$503 Roundtrip, found 5 days ago
$503
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $503 found 5 days ago
American Airlines
Wed, Aug 12 - Tue, Sep 1
BWI
Baltimore Washington Intl. Thurgood Marshall
FLO
Florence Regional
$504 Roundtrip, found 11 hours ago
$504
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Wed, Aug 12 from Baltimore Washington Intl. Thurgood Marshall to Florence Regional, returning Tue, Sep 1, priced at $504 found 11 hours ago
American Airlines
Mon, Jul 20 - Sat, Jul 25
LGA
LaGuardia
FLO
Florence Regional
$514 Roundtrip, found 4 days ago
$514
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Jul 20 from LaGuardia to Florence Regional, returning Sat, Jul 25, priced at $514 found 4 days ago
American Airlines
Fri, Oct 23 - Mon, Oct 26
FLL
Fort Lauderdale - Hollywood Intl.
FLO
Florence Regional
$515 Roundtrip, just found
$515
Roundtrip
just found
Select American Airlines flight, departing Fri, Oct 23 from Fort Lauderdale - Hollywood Intl. to Florence Regional, returning Mon, Oct 26, priced at $515 just found
American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$524 Roundtrip, found 6 hours ago
$524
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $524 found 6 hours ago
American Airlines
Tue, Jun 30 - Sat, Jul 4
AUS
Austin-Bergstrom Intl.
FLO
Florence Regional
$539 Roundtrip, found 16 hours ago
$539
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Tue, Jun 30 from Austin-Bergstrom Intl. to Florence Regional, returning Sat, Jul 4, priced at $539 found 16 hours ago

Cheap Flights to Mayesville

Fall in love at first flight with your vacation to Mayesville by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Mayesville on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Mayesville, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Mayesville

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Mayesville with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the FLO airport.

What is the cheapest month to fly to Mayesville?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Mayesville are in September, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Mayesville?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Mayesville.

What airport is best to fly into Mayesville?

When you’re planning your trip to Mayesville, convenience is the name of the game. Luckily, Mayesville Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Mayesville must-do list.

How much are flights to Mayesville?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Mayesville on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $329, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Mayesville?

The trick to saving a stack of cash on your flight to Mayesville? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $329 right now, why wait?

Mayesville Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$328

Last Minute Hotel Deals in Mayesville

SureStay Hotel by Best Western Manning

SureStay Hotel by Best Western Manning

2.5 out of 5
2816 Paxville Highway Manning SC
Book a stay at this business-friendly hotel in Manning. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,000 reviews)
"Let's clarify, this is not a hotel. It's really a motel as all of the doors face the parking lot. So safety and security are a problem. The lobby was underwhelming but served its purpose. No elevators. Luckily we were on the first floor but the family we were traveling with has kids and had to carry ..."

Reviewed on Jun 22, 2026

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SureStay Hotel by Best Western Manning
Quality Inn Sumter near Shaw AFB

Quality Inn Sumter near Shaw AFB

2 out of 5
2390 Broad St Sumter SC
Stay at this motel in Sumter. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Sumter Mall and Palmetto Park are located nearby.
6.6/10 (113 reviews)
">The room was clean, and quiet. >The staff was friendly. I did a late check in, and the lobby doors were locked, the front desk clerk was ready and available to open the doors quickly for me. >Parking was open and close to the room. >The pool... 30% of my decision to stay here was because it had ..."

Reviewed on Jun 25, 2026

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Quality Inn Sumter near Shaw AFB
Hyatt Place Sumter / Downtown

Hyatt Place Sumter / Downtown

3 out of 5
18 N Main St Sumter SC
Book a stay at this business-friendly hotel in Sumter. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (941 reviews)
"The staff were so welcoming, kind, friendly and always willing to help. The food was good- my kids weren’t fans but they are so picky!! lol The room was clean and spacious! Our only complaint would be the maintenance for our room. The TV didn’t work, the blind was broken, the lock on the door didn’t ..."

Reviewed on Jun 25, 2026

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Hyatt Place Sumter / Downtown
Woodspring Suites Sumter Near Shaw Afb

Woodspring Suites Sumter Near Shaw Afb

2.5 out of 5
2715 Broad Street Sumter SC
Stay at this hotel in Sumter. Enjoy free WiFi, free parking, and a fitness center. Popular attractions Sumter Mall and Palmetto Park are located nearby.
8.2/10 Very Good! (225 reviews)
"Hotel and rooms were spacious and clean when I checked in there was a person at the desk. I went down 2 times and there were several new guests waiting on someone to come check them in. Several minutes later a staff member showed. I didn’t like the fact that my towels weren’t exchanged for a two ..."

Reviewed on Jun 27, 2026

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Woodspring Suites Sumter Near Shaw Afb
Hampton Inn Manning

Hampton Inn Manning

2.5 out of 5
2822 Paxville Hwy Manning SC
Book a stay at this business-friendly hotel in Manning. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (1,000 reviews)
"We enjoyed our stay. It was clean, safe and easy to find. We enjoyed the free breakfast as well."

Reviewed on Jun 23, 2026

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Hampton Inn Manning
Baymont by Wyndham Manning

Baymont by Wyndham Manning

2.5 out of 5
2284 Raccoon Road Manning SC
Stay at this hotel in Manning. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews.
7/10 Good! (1,000 reviews)
"Dead roaches are better than alive ones I guess? The room was so, so dirty and the smell was AWFUL."

Reviewed on Jun 16, 2026

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Baymont by Wyndham Manning
Gerner by IHG

Gerner by IHG

2.5 out of 5
2510 Broad St Sumter SC
Book a stay at this business-friendly hotel in Sumter. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
6.4/10 (608 reviews)
"The room key had to be redone every day. Also room had large portion of room by window ac that was soaked with water and I couldn’t use. Breakfast good with eggs but needed bacon that wasn’t crumbled."

Reviewed on Jun 20, 2026

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Gerner by IHG
Comfort Suites Sumter near Shaw AFB

Comfort Suites Sumter near Shaw AFB

2.5 out of 5
2500 Broad St Sumter SC
Book a stay at this business-friendly hotel in Sumter. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Sumter Mall and Palmetto Park are ...
7.2/10 Good! (638 reviews)
"Pool was dirty and we had to change out our room due to the bed having a strong urine smell."

Reviewed on Jun 13, 2026

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Comfort Suites Sumter near Shaw AFB
See all 77 properties in Mayesville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.