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Mayesville

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Mayesville Flights as Low as $321

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Tue, Jan 19 - Sat, Jan 30
DFW
Dallas-Fort Worth Intl.
FLO
Florence Regional
$321 Roundtrip, found 1 day ago
$321
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jan 19 from Dallas-Fort Worth Intl. to Florence Regional, returning Sat, Jan 30, priced at $321 found 1 day ago
American Airlines
Thu, Jan 21 - Thu, Jan 28
DFW
Dallas-Fort Worth Intl.
FLO
Florence Regional
$361 Roundtrip, found 1 day ago
$361
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Jan 21 from Dallas-Fort Worth Intl. to Florence Regional, returning Thu, Jan 28, priced at $361 found 1 day ago
American Airlines
Tue, Jan 19 - Sat, Jan 30
DFW
Dallas-Fort Worth Intl.
FLO
Florence Regional
$410 Roundtrip, found 1 day ago
$410
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jan 19 from Dallas-Fort Worth Intl. to Florence Regional, returning Sat, Jan 30, priced at $410 found 1 day ago
American Airlines
Thu, Jan 21 - Thu, Jan 28
DFW
Dallas-Fort Worth Intl.
FLO
Florence Regional
$451 Roundtrip, found 1 day ago
$451
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Jan 21 from Dallas-Fort Worth Intl. to Florence Regional, returning Thu, Jan 28, priced at $451 found 1 day ago
American Airlines
Tue, Jan 26 - Sat, Feb 13
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$461 Roundtrip, found 23 hours ago
$461
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Tue, Jan 26 from Minneapolis - St. Paul Intl. to Florence Regional, returning Sat, Feb 13, priced at $461 found 23 hours ago
American Airlines
Fri, Jan 29 - Sat, Feb 13
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$478 Roundtrip, found 1 day ago
$478
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Jan 29 from Minneapolis - St. Paul Intl. to Florence Regional, returning Sat, Feb 13, priced at $478 found 1 day ago
American Airlines
Tue, Jan 26 - Sat, Feb 13
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$479 Roundtrip, found 5 days ago
$479
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Jan 26 from Minneapolis - St. Paul Intl. to Florence Regional, returning Sat, Feb 13, priced at $479 found 5 days ago
American Airlines
Tue, Dec 22 - Thu, Dec 31
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$487 Roundtrip, found 1 day ago
$487
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Dec 22 from Minneapolis - St. Paul Intl. to Florence Regional, returning Thu, Dec 31, priced at $487 found 1 day ago
American Airlines
Tue, Jan 26 - Sat, Feb 13
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$500 Roundtrip, found 23 hours ago
$500
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Tue, Jan 26 from Minneapolis - St. Paul Intl. to Florence Regional, returning Sat, Feb 13, priced at $500 found 23 hours ago
American Airlines
Fri, Dec 25 - Thu, Dec 31
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$504 Roundtrip, found 1 hour ago
$504
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Fri, Dec 25 from Minneapolis - St. Paul Intl. to Florence Regional, returning Thu, Dec 31, priced at $504 found 1 hour ago
American Airlines
Mon, Jan 4 - Wed, Jan 20
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$506 Roundtrip, found 3 days ago
$506
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Jan 4 from Minneapolis - St. Paul Intl. to Florence Regional, returning Wed, Jan 20, priced at $506 found 3 days ago
American Airlines
Tue, Jan 26 - Sat, Feb 13
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$507 Roundtrip, found 5 days ago
$507
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Jan 26 from Minneapolis - St. Paul Intl. to Florence Regional, returning Sat, Feb 13, priced at $507 found 5 days ago
American Airlines
Tue, Dec 22 - Thu, Dec 31
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$508 Roundtrip, found 5 days ago
$508
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Dec 22 from Minneapolis - St. Paul Intl. to Florence Regional, returning Thu, Dec 31, priced at $508 found 5 days ago
American Airlines
Tue, Dec 22 - Thu, Dec 31
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$513 Roundtrip, found 4 days ago
$513
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Dec 22 from Minneapolis - St. Paul Intl. to Florence Regional, returning Thu, Dec 31, priced at $513 found 4 days ago
American Airlines
Fri, Jan 29 - Sat, Feb 13
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$517 Roundtrip, found 1 day ago
$517
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Jan 29 from Minneapolis - St. Paul Intl. to Florence Regional, returning Sat, Feb 13, priced at $517 found 1 day ago
American Airlines
Thu, Dec 24 - Tue, Jan 5
LGA
LaGuardia
FLO
Florence Regional
$580 Roundtrip, found 1 day ago
$580
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Dec 24 from LaGuardia to Florence Regional, returning Tue, Jan 5, priced at $580 found 1 day ago

Cheap Flights to Mayesville

Fall in love at first flight with your vacation to Mayesville by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Mayesville on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Mayesville, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Mayesville

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Mayesville with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the FLO airport.

What is the cheapest month to fly to Mayesville?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Mayesville are in January, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Mayesville?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Mayesville.

What airport is best to fly into Mayesville?

When you’re planning your trip to Mayesville, convenience is the name of the game. Luckily, Mayesville Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Mayesville must-do list.

How much are flights to Mayesville?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Mayesville on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $321, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Mayesville?

The trick to saving a stack of cash on your flight to Mayesville? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $321 right now, why wait?

Mayesville Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$320

Last Minute Hotel Deals in Mayesville

Quality Inn Sumter near Shaw AFB

Quality Inn Sumter near Shaw AFB

2.5 out of 5
2390 Broad St Sumter SC
Stay at this motel in Sumter. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Sumter Mall and Palmetto Park are located nearby.
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Quality Inn Sumter near Shaw AFB
Woodspring Suites Sumter Near Shaw Afb

Woodspring Suites Sumter Near Shaw Afb

2.5 out of 5
2715 Broad Street Sumter SC
Stay at this hotel in Sumter. Enjoy free WiFi, free parking, and a fitness center. Popular attractions Sumter Mall and Palmetto Park are located nearby.
8.2/10 Very Good! (293 reviews)
"I loved my stay, especially the night staff. I arrived late and she welcome to me with a lovely greeting got me checked in promptly and assisted me with everything that I needed."

Reviewed on Nov 1, 2026

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Woodspring Suites Sumter Near Shaw Afb
SureStay Hotel by Best Western Manning

SureStay Hotel by Best Western Manning

2.5 out of 5
2816 Paxville Highway Manning SC
Book a stay at this business-friendly hotel in Manning. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,005 reviews)
"The front desk staff was great, the room was very clean. I had booked one night with Expedia, decided to add one night with the hotel,somehow there was a mixup. The hotel called me Saturday evening and we're going to set my belongings outside for not having a booked room. I was charged by the hotel ..."

Reviewed on Nov 8, 2026

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SureStay Hotel by Best Western Manning
1912 Bed and Breakfast

1912 Bed and Breakfast

3.5 out of 5
24 Warren St Sumter SC
Book a stay at this business-friendly B&B in Sumter. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
10/10 Exceptional! (335 reviews)
"Loved the room and the Southern Hospitality"

Reviewed on Oct 14, 2026

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1912 Bed and Breakfast
Hyatt Place Sumter / Downtown

Hyatt Place Sumter / Downtown

3 out of 5
18 N Main St Sumter SC
Book a stay at this business-friendly hotel in Sumter. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
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Hyatt Place Sumter / Downtown
Red Roof Inn Sumter

Red Roof Inn Sumter

2 out of 5
1211 Camden Highway Sumter SC
Stay at this hotel in Sumter. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Sumter Mall and Palmetto Park are located nearby.
6.8/10 (328 reviews)
"The property was completely misrepresented. It was full of people smoking pot and doing drugs and screaming all night in the parking lot. Would not give me change for a 10 so when I tried to buy a water and get change that way he would not sell me the water because he said I was just trying to scam ..."

Reviewed on Nov 9, 2026

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Red Roof Inn Sumter
Hampton Inn Manning

Hampton Inn Manning

2.5 out of 5
2822 Paxville Hwy Manning SC
Book a stay at this business-friendly hotel in Manning. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
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Hampton Inn Manning
Spark by Hilton Sumter

Spark by Hilton Sumter

2.5 out of 5
2491 Broad St Sumter SC
Stay at this hotel in Sumter. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Sumter ...
7.6/10 Good! (68 reviews)
"I requested a late checkout, but they removed me from the room as if I were a criminal—they even threatened to call the police if I didn’t leave immediately."

Reviewed on Nov 5, 2026

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Spark by Hilton Sumter
See all 82 properties in Mayesville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.