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Mayesville

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Mayesville Flights as Low as $299

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Tue, Jul 15 - Wed, Jul 23
LGA
LaGuardia
FLO
Florence Regional
$299 Roundtrip, found 3 hours ago
$299
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Tue, Jul 15 from LaGuardia to Florence Regional, returning Wed, Jul 23, priced at $299 found 3 hours ago
American Airlines
Tue, Jul 1 - Thu, Jul 10
ICT
Wichita Dwight D. Eisenhower National
FLO
Florence Regional
$342 Roundtrip, just found
$342
Roundtrip
just found
Select American Airlines flight, departing Tue, Jul 1 from Wichita Dwight D. Eisenhower National to Florence Regional, returning Thu, Jul 10, priced at $342 just found
American Airlines
Wed, Jul 16 - Sun, Jul 20
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$348 Roundtrip, found 15 hours ago
$348
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Wed, Jul 16 from John F. Kennedy Intl. to Florence Regional, returning Sun, Jul 20, priced at $348 found 15 hours ago
American Airlines
Wed, Jul 16 - Sun, Jul 20
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$348 Roundtrip, found 15 hours ago
$348
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Wed, Jul 16 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Jul 20, priced at $348 found 15 hours ago
American Airlines
Wed, Jul 16 - Sun, Jul 20
LGA
LaGuardia
FLO
Florence Regional
$348 Roundtrip, found 2 hours ago
$348
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, Jul 16 from LaGuardia to Florence Regional, returning Sun, Jul 20, priced at $348 found 2 hours ago
American Airlines
Mon, Jun 30 - Thu, Jul 10
ICT
Wichita Dwight D. Eisenhower National
FLO
Florence Regional
$350 Roundtrip, found 3 hours ago
$350
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Mon, Jun 30 from Wichita Dwight D. Eisenhower National to Florence Regional, returning Thu, Jul 10, priced at $350 found 3 hours ago
American Airlines
Tue, Jul 15 - Wed, Jul 23
LGA
LaGuardia
FLO
Florence Regional
$351 Roundtrip, found 5 days ago
$351
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Jul 15 from LaGuardia to Florence Regional, returning Wed, Jul 23, priced at $351 found 5 days ago
American Airlines
Tue, Jul 15 - Wed, Jul 23
LGA
LaGuardia
FLO
Florence Regional
$362 Roundtrip, found 3 hours ago
$362
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Tue, Jul 15 from LaGuardia to Florence Regional, returning Wed, Jul 23, priced at $362 found 3 hours ago
American Airlines
Wed, Jul 16 - Tue, Jul 22
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$370 Roundtrip, found 3 days ago
$370
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jul 16 from Newark Liberty Intl. Airport to Florence Regional, returning Tue, Jul 22, priced at $370 found 3 days ago
American Airlines
Tue, Jul 15 - Wed, Jul 23
LGA
LaGuardia
FLO
Florence Regional
$371 Roundtrip, found 3 hours ago
$371
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Tue, Jul 15 from LaGuardia to Florence Regional, returning Wed, Jul 23, priced at $371 found 3 hours ago
American Airlines
Tue, Jul 1 - Thu, Jul 10
ICT
Wichita Dwight D. Eisenhower National
FLO
Florence Regional
$372 Roundtrip, just found
$372
Roundtrip
just found
Select American Airlines flight, departing Tue, Jul 1 from Wichita Dwight D. Eisenhower National to Florence Regional, returning Thu, Jul 10, priced at $372 just found
American Airlines
Tue, Jul 1 - Thu, Jul 10
ICT
Wichita Dwight D. Eisenhower National
FLO
Florence Regional
$377 Roundtrip, found 6 days ago
$377
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Jul 1 from Wichita Dwight D. Eisenhower National to Florence Regional, returning Thu, Jul 10, priced at $377 found 6 days ago
American Airlines
Tue, Oct 7 - Sat, Oct 11
PHL
Philadelphia Intl.
FLO
Florence Regional
$403 Roundtrip, found 16 hours ago
$403
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Tue, Oct 7 from Philadelphia Intl. to Florence Regional, returning Sat, Oct 11, priced at $403 found 16 hours ago
American Airlines
Wed, Nov 5 - Thu, Nov 13
ABQ
Albuquerque Intl. Sunport
FLO
Florence Regional
$417 Roundtrip, found 13 hours ago
$417
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Wed, Nov 5 from Albuquerque Intl. Sunport to Florence Regional, returning Thu, Nov 13, priced at $417 found 13 hours ago
American Airlines
Tue, Jun 10 - Sat, Jun 14
DFW
Dallas-Fort Worth Intl.
FLO
Florence Regional
$419 Roundtrip, found 15 hours ago
$419
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Tue, Jun 10 from Dallas-Fort Worth Intl. to Florence Regional, returning Sat, Jun 14, priced at $419 found 15 hours ago
American Airlines
Mon, Jun 16 - Sat, Jun 21
TPA
Tampa Intl.
FLO
Florence Regional
$472 Roundtrip, found 4 hours ago
$472
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Mon, Jun 16 from Tampa Intl. to Florence Regional, returning Sat, Jun 21, priced at $472 found 4 hours ago

Cheap Flights to Mayesville

Fall in love at first flight with your vacation to Mayesville by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Mayesville on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Mayesville, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Mayesville

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Mayesville with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the FLO airport.

What is the cheapest month to fly to Mayesville?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Mayesville are in July, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Mayesville?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Mayesville.

What airport is best to fly into Mayesville?

When you’re planning your trip to Mayesville, convenience is the name of the game. Luckily, Mayesville Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Mayesville must-do list.

How much are flights to Mayesville?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Mayesville on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $299, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Mayesville?

The trick to saving a stack of cash on your flight to Mayesville? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $299 right now, why wait?

Mayesville Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$299

Last Minute Hotel Deals in Mayesville

Hyatt Place Sumter / Downtown
Hyatt Place Sumter / Downtown
3 out of 5
18 N Main St, Sumter, SC
Stay at this 3-star business-friendly hotel in Sumter. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (816 reviews)
"My husband and I were very pleased with the room and facility. Breakfast was great!"

Reviewed on Jun 7, 2025

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Hyatt Place Sumter / Downtown
SureStay Hotel by Best Western Manning
SureStay Hotel by Best Western Manning
2.5 out of 5
2816 Paxville Highway, Manning, SC
Book a stay at this business-friendly hotel in Manning. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,003 reviews)
"People were very friendly and helpful"

Reviewed on Jun 6, 2025

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SureStay Hotel by Best Western Manning
Sumter Inn
Sumter Inn
2 out of 5
2390 Broad St, Sumter, SC
Stay at this motel in Sumter. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Sumter Mall and Palmetto Park are located nearby.
6.8/10 (33 reviews)
"Well the service is great they have a restaurant with good food good staff"

Reviewed on May 5, 2025

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Sumter Inn
Comfort Suites Sumter
Comfort Suites Sumter
2.5 out of 5
2500 Broad St, Sumter, SC
Book a stay at this business-friendly hotel in Sumter. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Sumter Mall and Palmetto Park are ...
7.2/10 Good! (552 reviews)
"I enjoy the convenience of staying near a few stores in the area"

Reviewed on May 20, 2025

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Comfort Suites Sumter
Super 8 by Wyndham Sumter
Super 8 by Wyndham Sumter
2 out of 5
1050 Broad St, Sumter, SC
Book a stay at this business-friendly hotel in Sumter. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Sumter Mall and Palmetto Tennis ...
7/10 Good! (379 reviews)
"I've stayed here before. The last room I was in was in better shape than this most recent one. Rooms were clean. A/C was preset to a temp much warmer than I preferred. I may give this hotel one more try on my next visit to see if improvements have been made."

Reviewed on Apr 21, 2025

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Super 8 by Wyndham Sumter
Holiday Inn Express Sumter by IHG
Holiday Inn Express Sumter by IHG
2.5 out of 5
2490 Broad St, Sumter, SC
Book a stay at this business-friendly hotel in Sumter. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (662 reviews)
"Right in middle of everything needed"

Reviewed on May 15, 2025

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Holiday Inn Express Sumter by IHG
Tru by Hilton Sumter
Tru by Hilton Sumter
2.5 out of 5
2607 Broad Street, Sumter, SC
Stay at this hotel in Sumter. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.8/10 Excellent! (625 reviews)
"I liked the overall cleanliness of the room but not the size. I liked that breakfast was included but not the pancake machine that kept malfunctioning."

Reviewed on Jun 1, 2025

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Tru by Hilton Sumter
Baymont by Wyndham Manning
Baymont by Wyndham Manning
2.5 out of 5
2284 Raccoon Road, Manning, SC
Stay at this hotel in Manning. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews.
6.8/10 (1,000 reviews)
"Convince"

Reviewed on May 18, 2025

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Baymont by Wyndham Manning
See all 80 properties in Mayesville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.