Search Cheap Flights to
Mayesville

Photo by Caroline Nunez

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Mayesville Flights as Low as $317

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Thu, Aug 14 - Tue, Aug 19
AUS
Austin-Bergstrom Intl.
FLO
Florence Regional
$317 Roundtrip, found 1 day ago
$317
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Aug 14 from Austin-Bergstrom Intl. to Florence Regional, returning Tue, Aug 19, priced at $317 found 1 day ago
American Airlines
Sat, Aug 16 - Tue, Aug 19
LGA
LaGuardia
FLO
Florence Regional
$327 Roundtrip, found 1 day ago
$327
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Aug 16 from LaGuardia to Florence Regional, returning Tue, Aug 19, priced at $327 found 1 day ago
American Airlines
Tue, Aug 12 - Tue, Aug 19
LGA
LaGuardia
FLO
Florence Regional
$329 Roundtrip, found 1 day ago
$329
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Aug 12 from LaGuardia to Florence Regional, returning Tue, Aug 19, priced at $329 found 1 day ago
American Airlines
Sat, Aug 16 - Tue, Aug 19
LGA
LaGuardia
FLO
Florence Regional
$361 Roundtrip, found 1 day ago
$361
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Aug 16 from LaGuardia to Florence Regional, returning Tue, Aug 19, priced at $361 found 1 day ago
American Airlines
Tue, Aug 12 - Tue, Aug 19
LGA
LaGuardia
FLO
Florence Regional
$363 Roundtrip, found 1 day ago
$363
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Aug 12 from LaGuardia to Florence Regional, returning Tue, Aug 19, priced at $363 found 1 day ago
American Airlines
Sat, Aug 9 - Mon, Aug 11
AUS
Austin-Bergstrom Intl.
FLO
Florence Regional
$373 Roundtrip, found 1 day ago
$373
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Aug 9 from Austin-Bergstrom Intl. to Florence Regional, returning Mon, Aug 11, priced at $373 found 1 day ago
American Airlines
Sat, Aug 30 - Tue, Sep 2
TPA
Tampa Intl.
FLO
Florence Regional
$387 Roundtrip, found 11 hours ago
$387
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Sat, Aug 30 from Tampa Intl. to Florence Regional, returning Tue, Sep 2, priced at $387 found 11 hours ago
American Airlines
Tue, Oct 7 - Sat, Oct 11
TTN
Mercer
FLO
Florence Regional
$389 Roundtrip, just found
$389
Roundtrip
just found
Select American Airlines flight, departing Tue, Oct 7 from Mercer to Florence Regional, returning Sat, Oct 11, priced at $389 just found
American Airlines
Sat, Aug 16 - Tue, Aug 19
LGA
LaGuardia
FLO
Florence Regional
$393 Roundtrip, found 2 days ago
$393
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Aug 16 from LaGuardia to Florence Regional, returning Tue, Aug 19, priced at $393 found 2 days ago
American Airlines
Tue, Aug 12 - Tue, Aug 19
LGA
LaGuardia
FLO
Florence Regional
$396 Roundtrip, found 1 day ago
$396
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Aug 12 from LaGuardia to Florence Regional, returning Tue, Aug 19, priced at $396 found 1 day ago
American Airlines
Fri, Aug 8 - Mon, Aug 11
AUS
Austin-Bergstrom Intl.
FLO
Florence Regional
$400 Roundtrip, found 5 days ago
$400
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Aug 8 from Austin-Bergstrom Intl. to Florence Regional, returning Mon, Aug 11, priced at $400 found 5 days ago
American Airlines
Fri, Oct 17 - Mon, Oct 20
SGU
St. George
FLO
Florence Regional
$401 Roundtrip, found 1 day ago
$401
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Oct 17 from St. George to Florence Regional, returning Mon, Oct 20, priced at $401 found 1 day ago
American Airlines
Thu, Aug 14 - Tue, Aug 19
AUS
Austin-Bergstrom Intl.
FLO
Florence Regional
$402 Roundtrip, found 5 days ago
$402
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Aug 14 from Austin-Bergstrom Intl. to Florence Regional, returning Tue, Aug 19, priced at $402 found 5 days ago
American Airlines
Tue, Oct 7 - Sat, Oct 11
PHL
Philadelphia Intl.
FLO
Florence Regional
$403 Roundtrip, just found
$403
Roundtrip
just found
Select American Airlines flight, departing Tue, Oct 7 from Philadelphia Intl. to Florence Regional, returning Sat, Oct 11, priced at $403 just found
American Airlines
Sat, Aug 16 - Tue, Aug 19
LGA
LaGuardia
FLO
Florence Regional
$403 Roundtrip, found 1 day ago
$403
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Aug 16 from LaGuardia to Florence Regional, returning Tue, Aug 19, priced at $403 found 1 day ago
American Airlines
Wed, Jul 23 - Wed, Jul 30
SHV
Shreveport Regional
FLO
Florence Regional
$431 Roundtrip, found 1 day ago
$431
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jul 23 from Shreveport Regional to Florence Regional, returning Wed, Jul 30, priced at $431 found 1 day ago

Cheap Flights to Mayesville

Fall in love at first flight with your vacation to Mayesville by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Mayesville on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Mayesville, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Mayesville

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Mayesville with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the FLO airport.

What is the cheapest month to fly to Mayesville?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Mayesville are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Mayesville?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Mayesville.

What airport is best to fly into Mayesville?

When you’re planning your trip to Mayesville, convenience is the name of the game. Luckily, Mayesville Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Mayesville must-do list.

How much are flights to Mayesville?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Mayesville on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $317, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Mayesville?

The trick to saving a stack of cash on your flight to Mayesville? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $317 right now, why wait?

Mayesville Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$316

Last Minute Hotel Deals in Mayesville

Woodspring Suites Sumter Near Shaw Afb

Woodspring Suites Sumter Near Shaw Afb

2.5 out of 5
2715 Broad Street, Sumter, SC
Stay at this hotel in Sumter. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Sumter Mall and Palmetto Park are located nearby.
8/10 Very Good! (40 reviews)
"Clean spacious room. Great for families"

Reviewed on Jul 19, 2025

Get rates
Woodspring Suites Sumter Near Shaw Afb
Hyatt Place Sumter / Downtown

Hyatt Place Sumter / Downtown

3 out of 5
18 N Main St, Sumter, SC
Stay at this 3-star business-friendly hotel in Sumter. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9/10 Wonderful! (826 reviews)
"Friendly"

Reviewed on Jul 7, 2025

Get rates
Hyatt Place Sumter / Downtown
SureStay Hotel by Best Western Manning

SureStay Hotel by Best Western Manning

2.5 out of 5
2816 Paxville Highway, Manning, SC
Book a stay at this business-friendly hotel in Manning. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,004 reviews)
"Pet friendly, these types of hotels tend to be lower quality but SureStay is by far much better than the run of the mill pet friendly hotel. We stay here 3-4 times a year for the last 4 years"

Reviewed on Jul 13, 2025

Get rates
SureStay Hotel by Best Western Manning
Sumter Inn

Sumter Inn

2 out of 5
2390 Broad St, Sumter, SC
Stay at this motel in Sumter. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Sumter Mall and Palmetto Park are located nearby.
6.6/10 (45 reviews)
"I stayed here for four nights and cooked a meal on the last night. The property is under construction and it looked like a construction zone. There was no ventilation in my room requiring me to open the door to air out the smoke while cooking. That was when my dog got out of the room, and we returned ..."

Reviewed on Jul 16, 2025

Get rates
Sumter Inn
Comfort Suites Sumter

Comfort Suites Sumter

2.5 out of 5
2500 Broad St, Sumter, SC
Book a stay at this business-friendly hotel in Sumter. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Sumter Mall and Palmetto Park are ...
7.2/10 Good! (564 reviews)
"Front desk was very helpful"

Reviewed on Jul 13, 2025

Get rates
Comfort Suites Sumter
Hampton Inn Manning

Hampton Inn Manning

2.5 out of 5
2822 Paxville Hwy, Manning, SC
Book a stay at this business-friendly hotel in Manning. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (945 reviews)
"Room was clean, a nice breakfast was provided each morning which was great. I would stay there again."

Reviewed on Jul 8, 2025

Get rates
Hampton Inn Manning
Americas Best Value Inn & Suites Sumter

Americas Best Value Inn & Suites Sumter

2.5 out of 5
2430 Broad Street, Sumter, SC
Stay at this motel in Sumter. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Sumter Mall and Palmetto Park are located nearby.
6.6/10 (255 reviews)
"Hotel was clean no complaints"

Reviewed on Jun 22, 2025

Get rates
Americas Best Value Inn & Suites Sumter
Tru by Hilton Sumter

Tru by Hilton Sumter

2.5 out of 5
2607 Broad Street, Sumter, SC
Stay at this hotel in Sumter. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.8/10 Excellent! (628 reviews)
Good for a short solo visit
"Stayed two nights. The room was clean and comfortable, and the whole property was very bright and modern. The staff were all friendly and helpful. Check in and check out were easy. This was a good option for a solo traveler and short stay, BUT I think the small room size and lack of a closet, shelves ..."

Reviewed on Jun 30, 2025

Get rates
Tru by Hilton Sumter
See all 77 properties in Mayesville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.