Search Cheap Flights to
Mayesville

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Mayesville Flights as Low as $344

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
American Airlines
American Airlines
American Airlines
American Airlines
American Airlines
American Airlines
American Airlines
American Airlines
American Airlines
American Airlines
American Airlines
American Airlines
American Airlines
American Airlines
American Airlines

Cheap Flights to Mayesville

Fall in love at first flight with your vacation to Mayesville by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Mayesville on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Mayesville, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Mayesville

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Mayesville with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the FLO airport.

What is the cheapest month to fly to Mayesville?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Mayesville are in September, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Mayesville?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Mayesville.

What airport is best to fly into Mayesville?

When you’re planning your trip to Mayesville, convenience is the name of the game. Luckily, Mayesville Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Mayesville must-do list.

How much are flights to Mayesville?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Mayesville on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $344, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Mayesville?

The trick to saving a stack of cash on your flight to Mayesville? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $344 right now, why wait?

Mayesville Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$343

Last Minute Hotel Deals in Mayesville

Quality Inn Sumter near Shaw AFB

Quality Inn Sumter near Shaw AFB

2 out of 5
2390 Broad St Sumter SC
Stay at this motel in Sumter. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Sumter Mall and Palmetto Park are located nearby.
6.6/10 (105 reviews)
"Enjoyed my stay"

Reviewed on May 26, 2026

Quality Inn Sumter near Shaw AFB
SureStay Hotel by Best Western Manning

SureStay Hotel by Best Western Manning

2.5 out of 5
2816 Paxville Highway Manning SC
Book a stay at this business-friendly hotel in Manning. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,004 reviews)
"The room is clean, friendly staff, breakfast is better than acceptable, and ample parking"

Reviewed on Jun 4, 2026

SureStay Hotel by Best Western Manning
Woodspring Suites Sumter Near Shaw Afb

Woodspring Suites Sumter Near Shaw Afb

2.5 out of 5
2715 Broad Street Sumter SC
Stay at this hotel in Sumter. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Sumter Mall and Palmetto Park are located nearby.
8.2/10 Very Good! (217 reviews)
"It was clean and inviting"

Reviewed on May 31, 2026

Woodspring Suites Sumter Near Shaw Afb
Baymont by Wyndham Manning

Baymont by Wyndham Manning

2.5 out of 5
2284 Raccoon Road Manning SC
Stay at this hotel in Manning. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews.
7/10 Good! (1,000 reviews)
"So. The bed frame is essentially a metal drum. When you sit on it or roll over it kinda sounds like you’re beating the side of a barrel. Also, when I checked in the lobby just smelled weird."

Reviewed on May 29, 2026

Baymont by Wyndham Manning
Hyatt Place Sumter / Downtown

Hyatt Place Sumter / Downtown

3 out of 5
18 N Main St Sumter SC
Book a stay at this business-friendly hotel in Sumter. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (927 reviews)
"great location very new nice and clean staff extremely informative"

Reviewed on May 31, 2026

Hyatt Place Sumter / Downtown
Hampton Inn Manning

Hampton Inn Manning

2.5 out of 5
2822 Paxville Hwy Manning SC
Book a stay at this business-friendly hotel in Manning. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (1,000 reviews)
"I have no complaints about this property everything was on point."

Reviewed on May 30, 2026

Hampton Inn Manning
Holiday Inn Express Sumter by IHG

Holiday Inn Express Sumter by IHG

2.5 out of 5
2490 Broad St Sumter SC
Book a stay at this business-friendly hotel in Sumter. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (729 reviews)
"An option on Expedia was given to us to pay when arrived on site. It appears that that somehow caused Holiday Inn to not have a confirmation of stay upon arrival. So, after 8.5 hours of straight highway driving, they had to kindly ask us to drive again across the street to stay at Candlewood Suites, ..."

Reviewed on May 17, 2026

Holiday Inn Express Sumter by IHG
Comfort Suites Sumter near Shaw AFB

Comfort Suites Sumter near Shaw AFB

2.5 out of 5
2500 Broad St Sumter SC
Book a stay at this business-friendly hotel in Sumter. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Sumter Mall and Palmetto Park are ...
7.2/10 Good! (630 reviews)
"The staff was lovely, but it is an older hotel and you can tell. Needs a major update."

Reviewed on May 26, 2026

Comfort Suites Sumter near Shaw AFB
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.