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Tuscumbia

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Tuscumbia Flights as Low as $580

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Wed, Jan 29 - Wed, Feb 5
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$580 Roundtrip, found 3 days ago
$580
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jan 29 from O'Hare Intl. to Northwest Alabama Regional, returning Wed, Feb 5, priced at $580 found 3 days ago
American Airlines
Thu, Jan 30 - Wed, Feb 5
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$585 Roundtrip, found 3 days ago
$585
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Jan 30 from O'Hare Intl. to Northwest Alabama Regional, returning Wed, Feb 5, priced at $585 found 3 days ago
American Airlines
Wed, Jan 29 - Tue, Feb 4
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$590 Roundtrip, found 3 days ago
$590
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jan 29 from O'Hare Intl. to Northwest Alabama Regional, returning Tue, Feb 4, priced at $590 found 3 days ago
American Airlines
Thu, Jan 30 - Tue, Feb 4
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$595 Roundtrip, found 3 days ago
$595
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Jan 30 from O'Hare Intl. to Northwest Alabama Regional, returning Tue, Feb 4, priced at $595 found 3 days ago
American Airlines
Wed, Jan 29 - Mon, Feb 3
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$596 Roundtrip, found 3 days ago
$596
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jan 29 from O'Hare Intl. to Northwest Alabama Regional, returning Mon, Feb 3, priced at $596 found 3 days ago
American Airlines
Wed, Jan 29 - Sun, Feb 2
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$601 Roundtrip, found 3 days ago
$601
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jan 29 from O'Hare Intl. to Northwest Alabama Regional, returning Sun, Feb 2, priced at $601 found 3 days ago
American Airlines
Thu, Jan 30 - Sun, Feb 2
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$606 Roundtrip, found 3 days ago
$606
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Jan 30 from O'Hare Intl. to Northwest Alabama Regional, returning Sun, Feb 2, priced at $606 found 3 days ago
American Airlines
Fri, Jan 31 - Wed, Feb 5
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$607 Roundtrip, found 3 days ago
$607
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Jan 31 from O'Hare Intl. to Northwest Alabama Regional, returning Wed, Feb 5, priced at $607 found 3 days ago
American Airlines
Fri, Jan 31 - Tue, Feb 4
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$617 Roundtrip, found 3 days ago
$617
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Jan 31 from O'Hare Intl. to Northwest Alabama Regional, returning Tue, Feb 4, priced at $617 found 3 days ago
American Airlines
Fri, Jan 31 - Mon, Feb 3
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$623 Roundtrip, found 3 days ago
$623
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Jan 31 from O'Hare Intl. to Northwest Alabama Regional, returning Mon, Feb 3, priced at $623 found 3 days ago
American Airlines
Tue, Jan 28 - Tue, Feb 4
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$627 Roundtrip, found 3 days ago
$627
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Jan 28 from O'Hare Intl. to Northwest Alabama Regional, returning Tue, Feb 4, priced at $627 found 3 days ago
American Airlines
Fri, Jan 31 - Sun, Feb 2
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$628 Roundtrip, found 3 days ago
$628
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Jan 31 from O'Hare Intl. to Northwest Alabama Regional, returning Sun, Feb 2, priced at $628 found 3 days ago
American Airlines
Tue, Jan 28 - Tue, Feb 4
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$632 Roundtrip, found 1 day ago
$632
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jan 28 from O'Hare Intl. to Northwest Alabama Regional, returning Tue, Feb 4, priced at $632 found 1 day ago
American Airlines
Tue, Jan 28 - Tue, Feb 4
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$637 Roundtrip, found 3 days ago
$637
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Jan 28 from O'Hare Intl. to Northwest Alabama Regional, returning Tue, Feb 4, priced at $637 found 3 days ago
American Airlines
Tue, Jan 28 - Tue, Feb 4
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$642 Roundtrip, found 1 day ago
$642
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jan 28 from O'Hare Intl. to Northwest Alabama Regional, returning Tue, Feb 4, priced at $642 found 1 day ago
American Airlines
Tue, Jan 28 - Tue, Feb 4
ORD
O'Hare Intl.
MSL
Northwest Alabama Regional
$642 Roundtrip, found 3 days ago
$642
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Jan 28 from O'Hare Intl. to Northwest Alabama Regional, returning Tue, Feb 4, priced at $642 found 3 days ago

Cheap Flights to Tuscumbia

Fall in love at first flight with your vacation to Tuscumbia by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Tuscumbia on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Tuscumbia, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Tuscumbia

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Tuscumbia with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the MSL airport.

What is the cheapest month to fly to Tuscumbia?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Tuscumbia are in January, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Tuscumbia?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Tuscumbia.

What airport is best to fly into Tuscumbia?

When you’re planning your trip to Tuscumbia, convenience is the name of the game. Luckily, Tuscumbia Northwest Alabama Regional Airport is nearby so you can deplane and get going on checking off everything on your Tuscumbia must-do list.

How much are flights to Tuscumbia?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Tuscumbia on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $580, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Tuscumbia?

The trick to saving a stack of cash on your flight to Tuscumbia? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $580 right now, why wait?

Tuscumbia Flight Information
Destination airport
Northwest Alabama Regional
Destination airport IATA code
MSL
Roundtrip price
$580

Last Minute Hotel Deals in Tuscumbia

Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals
Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals
2 out of 5
1852 Highway 72 E, Tuscumbia, AL
The price is $70 per night from Jan 21 to Jan 22
$70
includes taxes & fees
Jan 21 - Jan 22
Book a stay at this business-friendly hotel in Tuscumbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,000 reviews)
"Everything was nice and clean. I had no issues however you always gonna heard the house keeping people talking in the morning."

Reviewed on Jan 7, 2025

Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals
Best Western Plus Tuscumbia Muscle Shoals Hotel and Suites
Best Western Plus Tuscumbia Muscle Shoals Hotel and Suites
2.5 out of 5
1934 Highway 20, Tuscumbia, AL
The price is $128 per night from Jan 25 to Jan 26
$128
includes taxes & fees
Jan 25 - Jan 26
Book a stay at this business-friendly hotel in Tuscumbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (522 reviews)
"Great stay"

Reviewed on Dec 5, 2024

Best Western Plus Tuscumbia Muscle Shoals Hotel and Suites
The ColdWater Inn
The ColdWater Inn
3.5 out of 5
712 Hwy 72 W, Tuscumbia, AL
The price is $154 per night from Jan 19 to Jan 20
$154
includes taxes & fees
Jan 19 - Jan 20
Stay at this 3.5-star business-friendly hotel in Tuscumbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (401 reviews)
"The property was nice and clean. The clerk was very helpful."

Reviewed on Jan 2, 2025

The ColdWater Inn
Comfort Inn & Suites Tuscumbia - Muscle Shoals
Comfort Inn & Suites Tuscumbia - Muscle Shoals
2.5 out of 5
5101 Hwy 43 S, Tuscumbia, AL
The price is $117 per night from Feb 16 to Feb 17
$117
includes taxes & fees
Feb 16 - Feb 17
Book a stay at this business-friendly hotel in Tuscumbia. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Alabama Music Hall of Fame and ...
8.2/10 Very Good! (221 reviews)
"Martha and Jennifer were awesome! The breakfast was great, check-in and out was nice and easy. The beds were comfy. AC cooled nicely. The only negatives were a bit of a design flaw on the refrigerator under the shelf as it caught our fingers in the small space for door opening, and there was a small ..."

Reviewed on Sep 1, 2024

Comfort Inn & Suites Tuscumbia - Muscle Shoals
Key West Inn
Key West Inn
2 out of 5
1800 Hwy 72 West, Tuscumbia, AL
The price is $83 per night from Jan 19 to Jan 20
$83
includes taxes & fees
Jan 19 - Jan 20
Book a stay at this business-friendly motel in Tuscumbia. Enjoy free WiFi, free parking, and room service. Popular attractions Alabama Music Hall of Fame and ...
6.8/10 (162 reviews)
"Nice people"

Reviewed on Jan 1, 2025

Key West Inn
The Stricklin Hotel
The Stricklin Hotel
3.5 out of 5
317 N Court St, Florence, AL
The price is $184 per night from Jan 19 to Jan 20
$184
includes taxes & fees
Jan 19 - Jan 20
Stay at this 3.5-star business-friendly hotel in Florence. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (623 reviews)
"Very nice hotel. Very nice and close to food and fun."

Reviewed on Jan 5, 2025

The Stricklin Hotel
Clarion Inn Sheffield Muscle Shoals
Clarion Inn Sheffield Muscle Shoals
2.5 out of 5
4900 Hatch Blvd, Sheffield, AL
The price is $85 per night from Feb 2 to Feb 3
$85
includes taxes & fees
Feb 2 - Feb 3
Book a stay at this business-friendly hotel in Sheffield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.2/10 Good! (809 reviews)
"Dated and not clean."

Reviewed on Dec 26, 2024

Clarion Inn Sheffield Muscle Shoals
Comfort Suites Florence Shoals Area
Comfort Suites Florence Shoals Area
2.5 out of 5
140 Matthew Paul Ct, Florence, AL
The price is $128 per night from Feb 15 to Feb 16
$128
includes taxes & fees
Feb 15 - Feb 16
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (636 reviews)
Honest review
"It was ok. Breakfast needs more options. Morning staff not so friendly."

Reviewed on Dec 26, 2024

Comfort Suites Florence Shoals Area
See all 247 properties in Tuscumbia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.