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Tuscumbia

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Tuscumbia Flights as Low as $641

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Wed, Jul 1 - Wed, Jul 8
FAY
Fayetteville Regional
MSL
Northwest Alabama Regional
$641 Roundtrip, found 2 days ago
$641
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jul 1 from Fayetteville Regional to Northwest Alabama Regional, returning Wed, Jul 8, priced at $641 found 2 days ago
American Airlines
Tue, Jun 30 - Tue, Jul 7
FAY
Fayetteville Regional
MSL
Northwest Alabama Regional
$681 Roundtrip, found 2 days ago
$681
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Jun 30 from Fayetteville Regional to Northwest Alabama Regional, returning Tue, Jul 7, priced at $681 found 2 days ago
American Airlines
Tue, Jun 30 - Tue, Jul 7
FAY
Fayetteville Regional
MSL
Northwest Alabama Regional
$699 Roundtrip, found 2 days ago
$699
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Jun 30 from Fayetteville Regional to Northwest Alabama Regional, returning Tue, Jul 7, priced at $699 found 2 days ago
American Airlines
Wed, Jul 1 - Wed, Jul 8
FAY
Fayetteville Regional
MSL
Northwest Alabama Regional
$775 Roundtrip, found 2 days ago
$775
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jul 1 from Fayetteville Regional to Northwest Alabama Regional, returning Wed, Jul 8, priced at $775 found 2 days ago
American Airlines
Wed, Jul 1 - Wed, Jul 8
FAY
Fayetteville Regional
MSL
Northwest Alabama Regional
$830 Roundtrip, found 2 days ago
$830
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jul 1 from Fayetteville Regional to Northwest Alabama Regional, returning Wed, Jul 8, priced at $830 found 2 days ago
American Airlines
Tue, Jun 30 - Wed, Jul 8
FAY
Fayetteville Regional
MSL
Northwest Alabama Regional
$850 Roundtrip, found 4 days ago
$850
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Jun 30 from Fayetteville Regional to Northwest Alabama Regional, returning Wed, Jul 8, priced at $850 found 4 days ago
American Airlines
Wed, Jul 1 - Wed, Jul 8
FAY
Fayetteville Regional
MSL
Northwest Alabama Regional
$853 Roundtrip, found 4 days ago
$853
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Jul 1 from Fayetteville Regional to Northwest Alabama Regional, returning Wed, Jul 8, priced at $853 found 4 days ago
American Airlines
Mon, Jun 29 - Wed, Jul 8
FAY
Fayetteville Regional
MSL
Northwest Alabama Regional
$875 Roundtrip, found 4 days ago
$875
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Jun 29 from Fayetteville Regional to Northwest Alabama Regional, returning Wed, Jul 8, priced at $875 found 4 days ago
American Airlines
Thu, Jul 2 - Wed, Jul 8
FAY
Fayetteville Regional
MSL
Northwest Alabama Regional
$898 Roundtrip, found 4 days ago
$898
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Jul 2 from Fayetteville Regional to Northwest Alabama Regional, returning Wed, Jul 8, priced at $898 found 4 days ago
American Airlines
Wed, Jul 1 - Wed, Jul 8
FAY
Fayetteville Regional
MSL
Northwest Alabama Regional
$950 Roundtrip, found 2 days ago
$950
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jul 1 from Fayetteville Regional to Northwest Alabama Regional, returning Wed, Jul 8, priced at $950 found 2 days ago
American Airlines
Wed, Jul 1 - Wed, Jul 8
FAY
Fayetteville Regional
MSL
Northwest Alabama Regional
$955 Roundtrip, found 2 days ago
$955
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jul 1 from Fayetteville Regional to Northwest Alabama Regional, returning Wed, Jul 8, priced at $955 found 2 days ago
American Airlines
Wed, Jul 1 - Sat, Jul 4
FAY
Fayetteville Regional
MSL
Northwest Alabama Regional
$965 Roundtrip, found 2 days ago
$965
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jul 1 from Fayetteville Regional to Northwest Alabama Regional, returning Sat, Jul 4, priced at $965 found 2 days ago
American Airlines
Wed, Jul 1 - Sat, Jul 4
FAY
Fayetteville Regional
MSL
Northwest Alabama Regional
$988 Roundtrip, found 2 days ago
$988
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jul 1 from Fayetteville Regional to Northwest Alabama Regional, returning Sat, Jul 4, priced at $988 found 2 days ago
American Airlines
Wed, Jul 1 - Wed, Jul 8
FAY
Fayetteville Regional
MSL
Northwest Alabama Regional
$998 Roundtrip, found 2 days ago
$998
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jul 1 from Fayetteville Regional to Northwest Alabama Regional, returning Wed, Jul 8, priced at $998 found 2 days ago
American Airlines
Tue, Jun 30 - Wed, Jul 8
FAY
Fayetteville Regional
MSL
Northwest Alabama Regional
$1,000 Roundtrip, found 2 days ago
$1,000
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Jun 30 from Fayetteville Regional to Northwest Alabama Regional, returning Wed, Jul 8, priced at $1,000 found 2 days ago
American Airlines
Mon, Jun 29 - Tue, Jun 30
FAY
Fayetteville Regional
MSL
Northwest Alabama Regional
$1,005 Roundtrip, found 16 hours ago
$1,005
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Mon, Jun 29 from Fayetteville Regional to Northwest Alabama Regional, returning Tue, Jun 30, priced at $1,005 found 16 hours ago

Cheap Flights to Tuscumbia

Fall in love at first flight with your vacation to Tuscumbia by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Tuscumbia on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Tuscumbia, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Tuscumbia

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Tuscumbia with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the MSL airport.

What is the cheapest month to fly to Tuscumbia?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Tuscumbia are in July, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Tuscumbia?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Tuscumbia.

What airport is best to fly into Tuscumbia?

When you’re planning your trip to Tuscumbia, convenience is the name of the game. Luckily, Tuscumbia Northwest Alabama Regional Airport is nearby so you can deplane and get going on checking off everything on your Tuscumbia must-do list.

How much are flights to Tuscumbia?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Tuscumbia on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $641, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Tuscumbia?

The trick to saving a stack of cash on your flight to Tuscumbia? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $641 right now, why wait?

Tuscumbia Flight Information
Destination airport
Northwest Alabama Regional
Destination airport IATA code
MSL
Roundtrip price
$640

Last Minute Hotel Deals in Tuscumbia

Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals

Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals

2 out of 5
1852 Highway 72 E Tuscumbia AL
Book a stay at this business-friendly hotel in Tuscumbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,002 reviews)
"Well maintained"

Reviewed on Jun 26, 2026

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Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals
Spark by Hilton Tuscumbia Muscle Shoals

Spark by Hilton Tuscumbia Muscle Shoals

3.5 out of 5
712 Hwy 72 W Tuscumbia AL
Book a stay at this business-friendly hotel in Tuscumbia. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (772 reviews)
"C"

Reviewed on Jun 25, 2026

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Spark by Hilton Tuscumbia Muscle Shoals
Best Western Plus Tuscumbia Muscle Shoals Hotel and Suites

Best Western Plus Tuscumbia Muscle Shoals Hotel and Suites

2.5 out of 5
1934 Highway 20 Tuscumbia AL
Book a stay at this business-friendly hotel in Tuscumbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (660 reviews)
"There needs to be some improvements in the physical environment. Ceiling in the bedroom was peeling and upholstered chair and desk chair wear very worn."

Reviewed on Jun 22, 2026

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Best Western Plus Tuscumbia Muscle Shoals Hotel and Suites
Comfort Inn & Suites Tuscumbia - Muscle Shoals

Comfort Inn & Suites Tuscumbia - Muscle Shoals

2.5 out of 5
5101 Hwy 43 S Tuscumbia AL
Book a stay at this business-friendly hotel in Tuscumbia. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Fame Recording Studios and Alabama ...
8.2/10 Very Good! (272 reviews)
"The basic concept was Fair, at Best. The beds were uncomfortable, the bath linens were dingy, from repeated use. The bathroom was outdated, bad wall paper hanging, as well as terrible caulk repairs. The “complimentary breakfast” was again Fair. Small breakfast nook, food okay. Hotel isn’t crowded, ..."

Reviewed on Jun 20, 2026

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Comfort Inn & Suites Tuscumbia - Muscle Shoals
Keywest Inn - Tuscumbia/Muscle Shoals

Keywest Inn - Tuscumbia/Muscle Shoals

2 out of 5
1800 Hwy 72 West Tuscumbia AL
Book a stay at this business-friendly motel in Tuscumbia. Enjoy free WiFi, free parking, and room service. Popular attractions Alabama Music Hall of Fame and ...
7/10 Good! (191 reviews)
"Room clean, respectful staff"

Reviewed on Jun 4, 2026

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Keywest Inn - Tuscumbia/Muscle Shoals
Days Inn by Wyndham Muscle Shoals Florence

Days Inn by Wyndham Muscle Shoals Florence

2 out of 5
2701 Woodward Ave Muscle Shoals AL
Stay at this hotel in Muscle Shoals. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.8/10 Excellent! (1,005 reviews)
"I had a great experience staying here. Very quiet and peaceful. Got some decent rest. I misunderstood the front desk, she said breakfast was over at 10. It was actually over at 9 am. We missed breakfast. But it was ok. Will stay here again."

Reviewed on Jun 27, 2026

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Days Inn by Wyndham Muscle Shoals Florence
Clarion Inn Sheffield Muscle Shoals

Clarion Inn Sheffield Muscle Shoals

2.5 out of 5
4900 Hatch Blvd Sheffield AL
Book a stay at this business-friendly hotel in Sheffield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.2/10 Good! (1,002 reviews)
"The gentleman at the front desk was very kind and helpful. However, we had two rooms because we were in town for a softball tournament. In one room the ac went out and it was horribly hot. In the other you couldn't shower because the water was brown. These issues were reported to the desk 3 times ..."

Reviewed on Jun 19, 2026

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Clarion Inn Sheffield Muscle Shoals
Renaissance Shoals Resort & Spa

Renaissance Shoals Resort & Spa

3.5 out of 5
10 Hightower Place Florence AL
Book a stay at this spa resort in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
9.2/10 Wonderful! (792 reviews)
"One of the best places in the USA"

Reviewed on Jun 22, 2026

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Renaissance Shoals Resort & Spa
See all 314 properties in Tuscumbia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.