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Choose from 15460 Panama City Hotel Deals

La Quinta Inn & Suites by Wyndham Panama City
"Good"
Reviewed on Nov 15, 2026

Red Roof Inn Panama City

Hilton Garden Inn Panama City Airport
"Very clean property with great amenities and so close to the airport. The shuttle was fast and convenient and the staff were all so nice!"
Reviewed on Nov 12, 2026

Hotel Indigo Panama City Marina by IHG

Comfort Suites

Quality Inn Panama City North

Courtyard by Marriott Panama City

Comfort Inn & Suites Panama City North

Holiday Inn Panama City by IHG

Econo Lodge Panama City St. Andrews

Comfort Inn & Suites

Extended Stay America Select Suites - Panama City - Callaway
Find cheap hotels in Panama City
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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Panama City.
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Frequently Asked Questions About Panama City hotels
Where can I find the best last-minute travel deals?
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How many hotels are there in Panama City?
With over 15,460 hotels in Panama City, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $55.
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Finding a cheap car rental deal in Panama City is as easy as scoring cheap hotels in Panama City. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
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